[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Maurizio F. Cereda, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100594468","a-study-of-body-fat-distribution-and-airway-mechanics-in-healthy-adults-100594468",false,"NCT07019831","A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults","Imaging the Respiratory Effects of Truncal Adiposity in Healthy Subjects","Inclusion Criteria\n\n• Healthy subjects older than 18 years and younger than 80.\n\nExclusion Criteria\n\n* Pre-existing cardiopulmonary disease\n* history of tobacco or ecigarette smoking",true,"ALL","18 Years","80 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to characterize how varying BMI and fat topography influence regional ventilation and airway collapse in supine and prone positions. Healthy volunteers with a range of BMIs will undergo a 2-hour imaging session with noninvasive and minimally invasive monitoring.",[28],"Healthy Volunteers Only",[30,31,32,33,34],"obesity","electrical impedance tomography","computed tomography","esophageal manometry","airway geometry","NOT_YET_RECRUITING","2025-06-16",{"date":38,"type":39},"2025-06-18","ACTUAL",{"date":41,"type":22},"2028-01-01",{"date":43,"type":22},"2030-06-30",{"name":45,"class":46},"Maurizio F. Cereda, MD","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":70,"leadSponsor":71,"locationsCount":72},"100594480","adiposity-distribution-in-acute-respiratory-failure-100594480","NCT07019987","Adiposity Distribution in Acute Respiratory Failure","Imaging the Respiratory Effects of Truncal Adiposity in Acute Hypoxemic Respiratory Failure","Inclusion Criteria:\n\n* AHRF with PaO2\u002FFiO2 \\\u003C= 300 mmHg) intubated for less than 72 hours\n* Presence of an arterial line for blood gas measurement and blood pressure monitoring\n* 18 years or older\n\nExclusion Criteria:\n\n* Suspected pregnancy, pregnancy or less than six weeks postpartum\n* Younger than 18 years or older than 80 years.\n* Subject enrolled in another interventional research study\n* Presence of pneumothorax\n* Usage of any devices with electric current generation such as pacemaker or internal cardiac defibrillator\n* Preexisting chronic lung disease or pulmonary hypertension\n* Acute cardiac failure causing pulmonary edema\n* Past medical history of lung malignancy or pneumonectomy, or lung transplant\n* Hemodynamic instability, defined as:\n\n  * Persistent systolic blood pressure \\\u003C90 mmHg and\u002For \\>180 mmHg despite the use of vasopressor or vasodilators, or\n  * Requiring an increment in inotropic-vasopressors over the past two hours just before enrollment: more than 15 mcg\u002Fmin for norepinephrine and dopamine, more than 10 mcg\u002Fmin in epinephrine; and more than 50 mcg\u002F min for phenylephrine.\n* Contraindications to placement in the prone position: complex abdominal surgical dressing, recent sternotomy, unstable spine or pelvic fractures, intracranial hypertension, serious facial injury\n* Extracorporeal life support",{"count":55,"type":22},80,[25],"Acute Hypoxemic Respiratory Failure (AHRF) is a condition in which injury to the lungs impairs the ability of the air sacs (alveoli) to ventilate and exchange oxygen. This impairment may be worsened in individuals with elevated body weight, particularly when fat tissue compresses the lungs and promotes alveolar collapse. The impact of body weight on lung function may be greater in individuals with upper-body fat distribution.\n\nTwo common interventions for AHRF-positive end-expiratory pressure (PEEP) and prone positioning-are used to improve lung ventilation. However, it is unclear whether these therapies are equally effective across different body weight categories and fat distributions.\n\nThis study will evaluate whether body weight and fat distribution affect patients' lung inflation responses to PEEP and prone positioning. Lung inflation will be assessed using electrical impedance tomography (EIT), a bedside imaging tool that maps lung ventilation, and esophageal manometry, which estimates lung compression through a thin catheter placed in the esophagus. Laboratory tests will also be used to measure markers of inflammation and AHRF severity and find correlations with fat distribution and responses to the tested treatments..\n\nPatients with AHRF requiring mechanical ventilation will be enrolled across a range of body weights. Each participant will undergo combinations of two PEEP levels and two body positions (supine and prone) for 30 minutes each. At the end of the study procedures, clinical care will continue as determined by the treating team.",[59,60],"Acute Hypoxemic Respiratory Failure","Obesity",[62,30,31,33,63,64,65],"acute hypoxemic respiratory failure","mechanical ventilation","prone positioning","positive end expiratory pressure","2025-06-05",{"date":68,"type":39},"2025-06-13",{"date":41,"type":22},{"date":43,"type":22},{"name":45,"class":46},1,""]