[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"McMaster Children's Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100513622","phase-1-pilot-feasibility-study-of-fecal-microbiota-transplant-for-the-treatment-of-small-intestinal-bacterial-overgrowth-100513622",false,"NCT05967871","Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth","Inclusion Criteria:\n\n* Patients 3-18 years old\n* Patients will discontinue antibiotics for at least 1 week prior to FMT\n* A diagnosis of SIBO established through lactose breath test (LBT), and showing of symptoms of SIBO\n\nExclusion Criteria:\n\n* Participants will not be permitted to start any new treatments (including antibiotics, probiotics, antacid treatments, or antimotility treatments) until Week 8, unless clinically indicated\n* We will exclude participants \\\u003C3yo to avoid potential concerns of microbial transmission in young children, and to ensure participants are developmentally able to perform LBT\n\n  * All potential participants should request a referral through their primary, or subspecialty physician. We would be pleased to help facilitate this contact if needed, provided the appropriate contact information can be sent.","ALL","3 Years","18 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","The objective of the study is to assess feasibility, and clinical efficacy of a novel Fecal Microbiota Transplantation protocol for the treatment of pediatric small intestinal bacterial overgrowth (SIBO).",[26],"Small Intestinal Bacterial Overgrowth","RECRUITING","2025-08-15",{"date":30,"type":31},"2025-08-21","ACTUAL",{"date":33,"type":31},"2024-03-11",{"date":35,"type":20},"2026-12-31",{"name":37,"class":38},"McMaster Children's Hospital","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":4,"briefSummary":49,"conditions":50,"keywords":54,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100558541","post-extubation-pressures-in-preterm-neonates-a-cer-study-100558541","NCT06552455","Post-extubation Pressures in Preterm Neonates: A CER Study","Post-extubation Pressures on Non-invasive Respiratory Support in Preterm Neonates: A Prospective Comparative Effectiveness Research Study","Inclusion Criteria:\n\n* Preterm neonates GA \\\u003C28 weeks' gestation, admitted to a participating centre who received any duration of mechanical ventilation.\n\nExclusion Criteria:\n\n* Major chromosomal\u002Fgenetic\u002Fcongenital abnormalities\n* Never received invasive mechanical ventilation (IMV)\n* Received IMV, but never extubated to non-invasive respiratory support (NRS)\n\n  * Transferred to non-participating site while intubated\n  * Death prior to extubation\n  * Initial extubation was for withdrawal of care\n* Lack of any eligible extubation, eligible defined as ALL of the following: (i) ≥36 continuous hours on IMV; (ii) pre-extubation MAP ≤13 cmH2O; and (iii) on post-extubation NRS for ≥1 hour.",{"count":47,"type":20},1050,"OBSERVATIONAL","The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains unknown.\n\nThe investigators aim to determine the optimal initial non-invasive pressure support level post-extubation in preterm neonates, in relation to the pre-extubation measured mean airway pressures (Paw). The hypothesis is that use of higher pressures will lead to fewer re-intubations.\n\nThis will be a prospective comparative effectiveness study across participating tertiary NICUs across Canada. Centres will self-select whether to use Higher or Equal\u002FLower pressure levels as well as the initial post-extubation mode (NIPPV or CPAP) for the study duration. Only the first eligible extubation will be included for analysis. Eligible patients \\\u003C28 weeks' gestational age at birth undergoing an eligible extubation (from a mean airway pressure \\\u003C\u002F= 13 cmH2O) will be included. The primary outcome will be re-intubation within 7 days. Secondary outcomes will include other neonatal morbidities.",[51,52,53],"Respiratory Distress Syndrome","Bronchopulmonary Dysplasia","Preterm Birth",[55,56,57,58],"Extubation Failure","Non-invasive respiratory support","Prematurity","Post-extubation pressures","NOT_YET_RECRUITING","2024-08-09",{"date":62,"type":31},"2024-08-14",{"date":64,"type":20},"2024-11-01",{"date":66,"type":20},"2028-12-31",{"name":37,"class":38},""]