[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"McMaster University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":732},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,97,0,25,[9,48,76,104,135,170,200,231,260,296,337,365,393,412,442,465,490,511,539,566,593,615,643,669,696],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100053400","fatigue-in-long-covid-100053400",false,"NCT07697261","Fatigue in Long COVID","Fatigue in Long COVID Managed With Conservative Care: An International, Randomized Controlled Trial (FALCON Trial)","FALCON","Inclusion Criteria:\n\n* The inclusion criteria for participants are:\n\n  1. Adults aged 18 to 65 years\n  2. Meeting the WHO clinical case definition for long COVID and\n  3. Self-reported experiencing long COVID symptoms such as fatigue, muscle pain, and brain fog.\n  4. Reporting a minimum score of ≥35 on the Checklist Individual Strength CIS-fatigue domain.\n  5. Able to speak and read English\n  6. Scoring higher in contemplation, action or maintenance scores than the precontemplation phase on the readiness to change questionnaire\n  7. Provides consent for study participation.\n  8. Consistent access to an internet-connected device (e.g., smartphone, tablet, laptop) that can facilitate access to the study interventions.\n\nExclusion Criteria:\n\n* The exclusion criteria are:\n\n  1. Long COVID participants whose presentation is primarily restricted to anosmia.\n  2. Participants with Post-Intensive Care Syndrome (PICS) or serious organic sequelae of COVID-19, such as structural lung injury attributable to mechanical ventilation or other organ damage requiring ongoing specialist management.\n  3. Participants who will not be able to attend intervention sessions or follow up visits due to anticipated significant life changes or relocation.\n  4. Unable to provide informed consent (e.g. cognitive disability, language barrier)\n  5. Co-morbidities that likely to impair function for as long or longer than long COVID\n  6. Current participation in psychotherapy, structured physical rehabilitation (e.g., physiotherapy or occupational therapy), or another trial that does not permit co-enrollment.","ALL","18 Years","65 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","Long COVID affects about 6 in 100 people after a COVID-19 infection. It can cause ongoing problems like ongoing tiredness, muscle pain, and \"brain fog.\" We know very little about which treatments might be helpful for long COVID.\n\nThe goal of this trial is to compare two treatments for people with long COVID to try to manage their symptoms. The main question is to assess whether the Lightning Process is effective for people living with long COVID compared to activity pacing. Each person will be placed into one of the two groups randomly (by chance, like flipping a coin). Activity pacing helps people balance rest and daily activities. The Lightning Process teaches ways to change thought patterns and body responses to symptoms. We will include 100 adults with long COVID. Everything will be done online, including filling out surveys about health and daily life. The goal is to find out which approach helps people feel better and improve their daily activities.",[29],"Long COVID",[31,32,33,34,35],"long COVID","Lightning Process","activity pacing","post-exertional malaise","fatigue","NOT_YET_RECRUITING","2026-07-07",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":23},"2026-11",{"date":44,"type":23},"2028-12",{"name":46,"class":47},"McMaster University","OTHER",{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100644478","phase-3-tirzepatide-in-the-treatment-of-cannabis-use-disorder-100644478","NCT07671248","Tirzepatide in the Treatment of Cannabis Use Disorder","A 12-Week Phase 3 Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of Tirzepatide-Assisted-Psychotherapy in Adults With Cannabis Use Disorder: A Proof-of-Concept Study","Inclusion Criteria:\n\n* Adults aged 18 and above\n* DSM-5 Cannabis Use Disorder diagnosis of at least moderate severity (4+ DSM-5 symptoms)\n* 4 or more days of cannabis use per week\n* Treatment seeking\n* A Body Mass Index (BMI) ≥ 22\n\nExclusion Criteria:\n\n* Meet DSM-5 criteria for Cluster A or B personality disorders and\u002For unstable current bipolar disorder, schizophrenia, or psychotic disorder\n* Comorbid severe DSM-5 Major Depressive Disorder\n* Present a serious suicide risk or who are likely to require psychiatric hospitalization during the course of the study, as determined by the study physician and Columbia Suicide Severity Rating Scale\n* Any other mental health condition deemed incompatible by the study team\n* Meet DSM-5 criteria for alcohol or substance use disorder for any substance other than cannabis or tobacco in the past 6 months\n* Positive urine drug screen for any substance except cannabis\n* Concurrent addiction-focused psychotherapy in the past 6 months\n* Unstable management of an existing mental health condition or anticipation of a change to the treatment over the next 3 months\n* A personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2\n* Current unstable medical condition\n* A lifetime diagnosis of Diabetes\n* Females who are pregnant\u002Fnursing, or individuals in reproductive age who do not consent to using birth control during the study\n* Concomitant treatment with: other GLP-1 agonists, Contrave, bupropion, naltrexone, acamprosate within the past year. No lifetime treatment with tirzepatide.\n* Significant literacy, visual, or hearing problems\n* Co-enrollment in a clinical drug trial",{"count":56,"type":23},15,[58],"PHASE3","Cannabis is the most commonly used psychoactive substance in Canada. A sub-group of cannabis users develop Cannabis Use Disorder (CUD). CUD is a pattern of cannabis use that results in impairment in functioning, symptoms of tolerance, withdrawal, and distress. Several pharmacological and psychosocial interventions have been evaluated for their efficacy in treating CUD, however they lack high success rates. GLP-1RA's have shown promising results in reducing food and alcohol cravings and intake. Tirzepatide acts as both a GLP-1RA and a glucose-dependent insulinotropic polypeptide receptor agonist. Tirzepatide has been reported to reduce alcohol consumption, and therefore may have promising effects as a treatment for CUD. This study aims to evaluate the feasibility and tolerability of weekly injections of Tirzepatide combined with Motivational Enhancement Therapy in adults with CUD. This trial will be the first to examine the potential therapeutic effects of Tirzepatide in CUD.",[61,62],"Cannabis Use Disorder, Moderate","Cannabis Use Disorder, Severe",[64,65,66],"Cannabis Use Disorder","Motivational Enhancement Therapy","Tirzepatide","2026-06-29",{"date":69,"type":40},"2026-07-01",{"date":71,"type":23},"2026-08-01",{"date":73,"type":23},"2028-07-31",{"name":46,"class":47},1,{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":18,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":24,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":75},"100644705","brain-wave-informed-non-invasive-brain-stimulation-improving-neural-networks-of-working-memory-in-dementia-a-proof-of-concept-study-100644705","NCT07673770","Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study","BWIBS-WM","Inclusion Criteria:\n\n* Individuals must be diagnosed with Alzheimer's Disease or related dementias by a clinician.\n* Individuals must exhibit adequate oral communication skills and cognitive function sufficient to obtain a score above 10 on the MMSE\n* Instructions will be delivered in English; therefore participants must demonstrate an understanding of instruction provided in English.\n* Individuals must be at least 55 years or older\n\nExclusion Criteria:\n\n* Contraindications to TMS; presence of a pacemaker, metal\u002Felectrical\u002Fmagnetic implants not including titanium, known history of untreated or uncontrolled psychological disorders, pregnancy, history of seizure or diagnoses of epilepsy, are taking any prescription medications that increase the risk of seizure.\n* Allergy to rubbing alcohol, which is needed to prepare electromyography for TMS","55 Years",{"count":85,"type":23},30,[26],"Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker. In people with dementia, it gets much worse, making it harder to talk with others, follow directions, or remember things like shopping lists.\n\nThis may happen because brain waves that support working memory fall out of sync. Researchers can see these brain waves using a test called EEG. In this study, the investigators will try to get these brain waves back in sync using a safe, non-invasive form of brain stimulation called transcranial magnetic stimulation (TMS), and will time it to each person's brain waves to make it more effective. The goal is to improve working memory in people with dementia. If successful, dementia patients may be able to be more independent taking pressure off their families.",[89,90],"Dementia","Alzheimer s Disease",[89,92,93,94,95],"Alzheimer's Disease","transcranial magnetic stimulation","eeg","electroencephalography","RECRUITING","2026-06-24",{"date":67,"type":40},{"date":100,"type":23},"2026-06-01",{"date":102,"type":23},"2028-08-01",{"name":46,"class":47},{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":24,"phases":114,"briefSummary":115,"conditions":116,"keywords":122,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":134},"100641615","antireflux-surgery-without-preoperative-esophageal-manometry-100641615","NCT07659080","Antireflux Surgery Without Preoperative Esophageal Manometry","Laparoscopic Toupet Fundoplication With or Without Preoperative Esophageal Manometry in Patients With GERD and Hiatal Hernia","NOMA","Inclusion Criteria\n\n1. Age ≥ 18 years\n2. Documented GERD and\u002For hiatal hernia (Type I, II, or small Type III) confirmed on EGD and\u002For imaging (i.e. CT scan or upper GI study) within 12 months\n3. Presence of at least one guideline-based indication for antireflux surgery:\n\n   1. Typical GERD symptoms (heartburn and\u002For regurgitation) refractory to or recurrent after adequate PPI therapy\n   2. PPI-dependent GERD with patient preference for surgical management\n   3. Extra-esophageal GERD symptoms (chronic cough, laryngitis, asthma) with pathologic reflux confirmed on ambulatory pH study\n   4. Symptomatic Type II\u002FIII paraesophageal hernia (postprandial pain, early satiety, dysphagia to solids)\n   5. Objective documentation of pathologic esophageal acid exposure on ambulatory reflux monitoring (24-hour pH-impedance or 48-hour Bravo pH capsule) confirming GERD diagnosis, performed within 12 months of enrollment\n4. Mellow-Pinkas dysphagia score = 0 at baseline (no overt dysphagia)\n5. Eckardt score \\\u003C 1 (achalasia screening)\n6. Ability to provide informed consent and comply with 12-month follow-up.\n\nExclusion Criteria:\n\n1. Overt dysphagia (Mellow-Pinkas ≥ 1 or Eckardt ≥ 1)\n2. Prior esophageal or gastric surgery\n3. Known or clinically suspected achalasia or primary motility disorder\n4. Endoscopic stricture, mass, or luminal obstruction\n5. Giant paraesophageal hernia (Type IV, or Type III with \\>50% of stomach herniated intrathoracically)\n6. Connective tissue disease with esophageal involvement (e.g., scleroderma\u002FCREST)\n7. Active esophageal or gastric malignancy\n8. Pregnancy\n9. BMI \\> 40 kg\u002Fm² (patients with severe obesity who would be candidates for bariatric surgery should be referred for metabolic\u002Fbariatric evaluation, as per the multi-society GERD guideline recommending weight-loss surgery consideration in this population)\n10. Participation in another interventional trial within 30 days\n11. Prior esophageal manometry within 12 months demonstrating a major motility disorder (achalasia, absent contractility, distal esophageal spasm, hypercontractile esophagus); such patients should be managed per standard motility disorder pathways and are not candidates for this trial.",{"count":113,"type":23},96,[26],"The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia. Manometry measures the muscles of the food pipe using a thin tube passed through the nose. The test can be uncomfortable and can delay surgery. The main questions this study aims to answer are whether people can skip manometry and still have good swallowing one year after surgery, and whether skipping the test lowers discomfort, shortens the wait for surgery, and lowers cost. To answer this, researchers will compare two groups. One group will have surgery without manometry. The other group will have manometry first, the way it is usually done. Everyone will get the same operation, a partial wrap called a Toupet fundoplication, so the study tests the value of the test and not the surgery. Participants will be placed by chance into one of the two groups, have the same standard operation, and fill out short questionnaires about their swallowing before surgery and again at 3, 6, and 12 months after surgery. Researchers want to find out if skipping manometry works just as well as the usual approach for people who do not have trouble swallowing before surgery.",[117,118,119,120,121],"GERD","Hiatal Hernia","Heartburn","Paraesophageal Hernia","Gastroesophageal Reflux",[117,123,124,125,120],"hiatal hernia","fundoplication","Gastroesophageal Reflux Disease","2026-06-16",{"date":128,"type":40},"2026-06-22",{"date":130,"type":23},"2026-10-01",{"date":132,"type":23},"2028-04-30",{"name":46,"class":47},2,{"id":136,"slug":137,"hasResults":12,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":24,"phases":142,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":134},"100642424","feasibility-of-a-community-integrated-isometric-handgrip-exercise-program-and-its-preliminary-effects-on-blood-pressure-and-cognitive-function-in-older-adults-100642424","NCT07648498","Feasibility of a Community-Integrated Isometric Handgrip Exercise Program and Its Preliminary Effects on Blood Pressure and Cognitive Function in Older Adults","Inclusion Criteria:\n\n* 65 years of age or older\n* Currently attending the Physical Activity Centre of Excellence at McMaster University\n* English speaking\n* Diagnosed with hypertension or elevated blood pressure\n\nExclusion Criteria:\n\n* Current or prior participation in chronic isometric exercise\n* Unstable angina.\n* Uncontrolled hypertension\n* Uncontrolled heart failure and\u002For arrhythmias\n* Recent myocardial infarction or electrocardiography changes\n* Complete heart block\n* Carpal tunnel syndrome\n* Arthritis that may be aggravated by handgrip exercise\n* Changes to the type and\u002For dose of blood pressure medications within 3 months of starting the study.",{"count":85,"type":23},[26],"The goal of this clinical trial is to evaluate whether a short, supervised isometric handgrip exercise program is feasible and acceptable for older adults with elevated blood pressure or hypertension. It will also explore whether this type of exercise may improve blood pressure and cognitive function.\n\nThe main questions it aims to answer are:\n\n* Is this handgrip exercise program practical and acceptable for older adults to participate in within a community exercise setting?\n* Does participation in the program lead to changes in blood pressure and cognitive function?\n\nResearchers will compare two handgrip devices to determine whether the method of delivering the exercise influences feasibility and outcomes.\n\nParticipants will:\n\n* Be randomly assigned to use one of two handgrip devices.\n* Complete supervised exercise sessions twice per week for 4 weeks.\n* Perform brief handgrip contractions at a set intensity during each session.\n* Complete blood pressure and cognitive assessments before and after the program.",[145,146],"Hypertension","Elevated Blood Pressure",[148,149,145,150,151,152,153,154,155,156,157,158,159,160,161],"Older Adults","Isometric Handgrip Exercise","Feasibility","Cognition","Exercise Intervention","Blood Pressure","Community-based exercise","Pilot study","Aging","Acceptability","Handgrip training","Isometric Exercise","Cognitive function","Cardiovascular health","2026-06-11",{"date":164,"type":40},"2026-06-15",{"date":166,"type":23},"2026-07-28",{"date":168,"type":23},"2026-09-15",{"name":46,"class":47},{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":18,"minAge":177,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":24,"phases":181,"briefSummary":182,"conditions":183,"keywords":185,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":75},"100642045","rhythm-psychophysics-with-parkinsons-patients-100642045","NCT07647913","Rhythm Psychophysics With Parkinson's Patients","RPPD","Inclusion Criteria:\n\n* Parkinson's Disease diagnostic\n* Stage 1 or 2 Hoenh-Yahr scale\n* Taking immediate-release Levodopa\n* MoCA score of 26 or above\n\nExclusion Criteria:\n\n* Dementia\n* Other neurodegenerative disease\n* History of substance abuse\n* History of hearing disorders\n* History of neuropsychiatric disease","40 Years","80 Years",{"count":180,"type":23},34,[26],"The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine. The main questions it aims to answer are:\n\n* Does dopamine shelter the ability to generate and maintain a regular tapping rhythm in the presence of disrupting sensory information?\n* Does dopamine allow the adaptation of tapping speed in the presence of changing sensory information?\n* Is the engagement of the motor system useful to improve the detection of changes in the tempo of sensory information?\n\nParticipants will be asked to perform a battery of simple rhythmic tasks On and Off medication to evaluate the effect of dopamine on their rhythmic skills.",[184],"Parkinson Disease(PD)",[186,187,188,189,190,191,192],"Parkinson Disease","PD","Rhythm","Sensorymotor synchronization","Perceptual timing","Motor timing","Interval timing","2026-06-09",{"date":164,"type":40},{"date":196,"type":23},"2026-09-01",{"date":198,"type":23},"2027-10-31",{"name":46,"class":47},{"id":201,"slug":202,"hasResults":12,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":12,"sex":18,"minAge":208,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":24,"phases":212,"briefSummary":213,"conditions":214,"keywords":216,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":75},"100581512","guided-self-help-for-eating-disorders-implementation-study-100581512","NCT06851273","Guided Self Help for Eating Disorders Implementation Study","National Implementation of Highly Efficient Evidence-Informed Treatment for Youth With Eating Disorders","GSHimplement","Inclusion Criteria:\n\n* Family including an adolescent with a confirmed diagnosis of Anorexia nervosa according to DSM-5-TR criteria.\n* Access to computer and internet connection\n* Have the capacity to speak, write, and understand English or French\n* Therapist\u002Fcoaches are licensed mental health clinician with experience in eating disorder treatment\n\nExclusion Criteria:\n\n* Adolescent has a current physical or mental disorder that requires hospitalization and\u002For prohibits the use of psychotherapy\n* Adolescent has a current dependence on drugs or alcohol\n* Adolescent has a current physical condition known to influence weight or eating (pregnancy, diabetes mellitus)\n* Adolescent has expected body weight of less than 75%\n* Adolescent\u002Ffamily has undergone four or more sessions of FBT for anorexia nervosa at any time\n* Does not have the capacity to speak, write, and understand English or French\n* Does not have access to computer and internet connection\n* Professionals are not licensed mental health professionals with experience in eating disorder treatment.","12 Years","100 Years",{"count":211,"type":23},90,[26],"Eating disorders are amongst the most understudied illnesses affecting young women in Canada. Further, mortality rates are amongst the highest of all psychiatric illnesses. Despite their high prevalence and mortality rates, research into adolescent eating disorders is underfunded in Canada. In addition to the problem of research underfunding, healthcare system underfunding exists - creating long waiting lists and fragmented care for children and youth with eating disorders. More efficient treatments are urgently needed to reduce wait times and provide expedited care to adolescents on eating disorder waitlists. The current study aims to assess whether implementing a virtual parent-lead therapy, Guided Self Help Family-Based Therapy (GSH FBT) might alleviate wait times for eating disorder services and also reduce eating disorder symptomatology in young people with anorexia nervosa. This study also aims to determine the experiences of both families and medical teams of GSH FBT implementation as an intervention.",[215],"Eating Disorders",[217,218,219,220,221,222],"Anorexia nervosa","Mental disorders","Adolescent eating disorders","Psychotherapy intervention","Guided self help therapy","Family-based treatment","2026-05-01",{"date":225,"type":40},"2026-05-07",{"date":227,"type":40},"2026-04-28",{"date":229,"type":23},"2027-12-30",{"name":46,"class":47},{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":24,"phases":240,"briefSummary":241,"conditions":242,"keywords":245,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":259},"100638954","optimized-recruitment-to-drive-equitable-research-in-stroke-empowering-decision-making-ordered-100638954","NCT07576647","Optimized Recruitment to Drive Equitable Research in Stroke, Empowering Decision-making (ORDERed)","ORDERed","Participants eligible for StrokeGoRed hospitalized cohort are eligible for ORDERed:\n\nInclusion Criteria:\n\n* All patients, regardless of age or baseline disability, seen in urgent TIA\u002Fstroke clinics and referred from the emergency department for suspected TIA or minor stroke will be included over one calendar year\n\nExclusion Criteria:\n\n* There are no exclusion criteria\n\nParticipants eligible for StrokeGoRed hospitalized cohort are eligible for ORDERed:\n\nInclusion Criteria:\n\n* Ischemic stroke\n* Intracerebral hemorrhage\n\nExclusion Criteria:\n\n* Cerebral venous thrombosis\n* Subarachnoid hemorrhage\n* Subdural hemorrhage\n* Intracranial hemorrhage due to trauma or underlying mass\n* Clinical transient ischemic attack without evidence of infarct on neuroimaging\n* Imaging abnormality (e.g., dissection, carotid stenosis, vessel irregularity) without imaging or clinical evidence of stroke\n* Stroke that occurred while being admitted for another reason\n* Stroke that started more than 14 days prior to admission\n* Stroke initially treated outside of Canada\n* Stroke where inpatient stroke or neurology service was not consulted",{"count":239,"type":23},1600,[26],"Stroke is a major health issue, especially for women, who are more likely than men to have worse outcomes and lower quality of life after a stroke. Yet, women are under-represented in stroke research, which limits how well treatments work for them. This study aims to change that by testing a new way to recruit women into stroke research using the ORDER toolkit, a set of easy-to-understand, women-focused materials like brochures and videos co-designed with patients. This new approach will be compared to the usual way of recruiting patients. The study will track how many people join, how long it takes to make a decision, and what influences participation. Patients and research coordinators will also share their feedback on the process. Our goal is to make stroke studies more inclusive so that research findings benefit everyone equally.",[243,244],"Stroke","Stroke (CVA) or Transient Ischemic Attack",[246,247,248,249,250],"Stroke rehabilitation","Clinical Trial","Informed consent","Diversity, Equity, Inclusion","Sex","2026-04-30",{"date":253,"type":40},"2026-05-08",{"date":255,"type":23},"2026-04",{"date":257,"type":23},"2029-08",{"name":46,"class":47},3,{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":24,"phases":270,"briefSummary":271,"conditions":272,"keywords":282,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":293,"leadSponsor":295,"locationsCount":75},"100630348","mindfulness-in-fracture-recovery-and-reduction-of-opioid-reliance-evaluating-the-feasibility-of-implementing-a-brief-mindfulness-based-intervention-to-manage-pain-and-anxiety-before-and-after-fracture-surgery-100630348","NCT07486505","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance (MIRROR): Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","MIRROR","The inclusion criteria are:\n\n1. Adults 18 years of age or older; and\n2. Presenting to the hospital with an open or closed appendicular fracture requiring internal fixation. Patients with multiple fractures may be included.\n\nThe exclusion criteria are:\n\n1. Does not have the English-language skills required to participate in trial interventions (in the judgement of site research personnel);\n2. Cognitive impairment (including traumatic brain injury);\n3. Auditory or visual impairment that would inhibit ability to receive intervention;\n4. Current incarceration;\n5. Concomitant injury which, in the opinion of the attending surgeon, is likely to impair function for as long as or longer than the patient's extremity fracture;\n6. Previously completed a standardized mindfulness program (e.g., MBSR) or regularly (e.g., daily) practice mindfulness;\n7. Active psychosis;\n8. Active suicidality;\n9. Stress fracture;\n10. Fragility fracture;\n11. Currently enrolled in a study that does not permit co-enrolment in other trials;\n12. Not willing to participate in the intervention;\n13. No provision of informed consent; or\n14. Other reason as approved by the Data Coordinating Centre.",{"count":269,"type":23},50,[26],"Breaking a bone is not only physically painful but also emotionally overwhelming. Patients often experience intense pain, anxiety, and uncertainty as they are rushed to hospital, undergo emergency treatment, and prepare for surgery. After surgery, many continue to struggle with pain and rely on opioid medications, which carry serious risks including addiction. In the context of our current opioid epidemic, it's critical that alternative treatment strategies are urgently evaluated.\n\nMindfulness is a practice that helps people focus on the present and has been shown to reduce stress and pain in other settings. In this trial, patients with broken arms or legs who need surgery at Hamilton General Hospital will be randomly assigned to one of two groups who will listen to a two-part, audio recording before and after surgery. Those in the interventional group will engage in a 7-minute audio-guided mindfulness exercise before surgery to help reduce anxiety, and another 7-minute audio-guided mindfulness exercise after surgery to help manage pain. Those in the control group will listen to a 7-minute educational audio recording before surgery and again after surgery.\n\nThe main goal is to see if this approach is practical-can enough patients be recruited, and will they complete the audio recordings? The study will also look at early signs of whether the intervention helps reduce pain, anxiety, and opioid use six weeks after surgery. If feasible, a larger study can be conducted to determine if these exercises can help patients manage pain and reduce their need for opioids after surgery.\n\nIf successful, this simple, low-cost approach could be widely used in hospitals to support recovery and reduce reliance on pain medications.",[273,274,275,276,277,278,279,280,281],"Orthopaedic Fractures","Orthopaedic Trauma Fractures and Non-unions","Orthopaedic Trauma","Orthopaedic Surgery","Orthopaedic Related Pain (Musculoskeletal Pain)","Anxiety Acute","Anxiety After Surgery","Opioid Use","Opioid Use After Surgery",[283,284,285,286,287,288],"fractures","mindfulness","pain management","fracture surgery","opioid use","anxiety","2026-04-06",{"date":291,"type":40},"2026-04-07",{"date":223,"type":23},{"date":294,"type":23},"2026-10-30",{"name":46,"class":47},{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":18,"minAge":303,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":24,"phases":306,"briefSummary":307,"conditions":308,"keywords":311,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":134},"100632819","feasibility-of-the-transitioned-framework-for-youth-and-young-adults-with-eating-disorders-100632819","NCT07518641","Feasibility of the TransitionED Framework for Youth and Young Adults With Eating Disorders","TransitionED 3","Inclusion Criteria:\n\nYouth and Young Adults (YYA):\n\n* Currently receiving paediatric eating disorder care at a participating study site.\n* Age 16 years or or older (approaching age-based transition to adult-care)\n* Expressed interest in transitioning to adult eating disorder care or other appropriate adult mental health services\n* Identified by the clinical team as appropriate to begin formal transition planning (e.g., sufficient transition readiness and interest in ongoing care)\n* Able and willing to provide informed consent\u002Fassent (as applicable at the site) and participate in study procedures\n\nCaregivers:\n\n* One caregiver (e.g., parent\u002Flegal guardian) of a participating YYA\n* Able and willing to provide informed consent and participate in study procedures (including questionnaires and interviews)\n\nClinicians (intervention deliverers):\n\n* Patient facing clinician at a participating site who provides transition support for participating YYA\u002Fcaregivers and is responsible for delivering intervention components (e.g., joint meeting(s), communication\u002Fcoordination related to the transition).\n* Able and willing to provide informed consent and participate in study procedures (e.g., focus groups)\n\nImplementation Team Members:\n\n* Program leadership\u002Fmanagers\u002Fsenior clinicians at a participating site involved in implementation of the intervention at that site.\n* Able and willing to provide informed consent and participate in study procedures (e.g., focus group).\n\nExclusion Criteria:\n\nYYA:\n\n* Not receiving pediatric eating disorder care at a participating site.\n* Under age 16 years\n* Does not express interest in transitioning to adult eating disorder care or other appropriate adult mental health services.\n* Not identified by the clinical team as ready\u002Fappropriate to engage in formal transition planning during the study period (e.g., insufficient transition readiness or not currently at the transition-planning stage).\n* Unable to provide informed consent\u002Fassent or unable to participate in study procedures (e.g., due to significant cognitive\u002Fcommunication barriers as determined by the clinical\u002Fresearch team).\n\nCaregivers:\n\n* Not the caregiver of an enrolled YYA (only one caregiver per YYA is enrolled).\n* Unable to provide informed consent or participate in study procedures.\n\nClinicians and Implementation Team Members:\n\n* Not affiliated with a participating site or not in an eligible role as defined above.\n* Peripheral providers who may be involved in care but are not enrolled as participants (e.g., family physicians or adult providers who might attend a joint meeting).\n* Unable to provide informed consent or participate in study procedures.","16 Years",{"count":305,"type":23},60,[26],"Moving from pediatric (children's) health care to adult health care can be challenging for youth and young adults with eating disorders. Many young people and families report feeling unprepared, unsure of what to expect, and worried about losing support during this time. Gaps in care during this transition can increase stress and make recovery more difficult.\n\nThis study is testing a structured transition support program called the TransitionED framework. The goal is to see whether this program can be successfully used in real hospital settings and whether youth, caregivers, and clinicians find it helpful.\n\nThe TransitionED framework is designed to help youth and families prepare for the move to adult care. It includes:\n\n1. A transition planning package for youth\n2. A separate planning package for caregivers\n3. At least two guided transition meetings with a clinician\n4. A short \"Personal Transition Profile\" written by the youth to help new adult providers understand them better\n5. Optional virtual peer support sessions for youth and for caregivers\n6. Tools to help pediatric and adult providers communicate more clearly\n\nYouth who are 16 years or older and currently receiving care in a participating pediatric eating disorder program may be invited to join, along with one caregiver. Clinicians and program leaders will also take part to help deliver and evaluate the program.\n\nParticipants will complete surveys at the beginning of the study, about two months later, and six months after finishing the program. Some participants will also take part in interviews to share their experiences.\n\nThis study is focused on feasibility. That means the main goal is to learn whether this transition program is practical, acceptable, and workable in everyday clinical care. What we learn will help improve transition support for youth and young adults with eating disorders in the future.",[309,310],"Eating Disorders in Adolescence","Transition of Care",[312,313,314,315,316,317,318,319,320,321,322,323,324,325,326,327,328],"eating disorders","healthcare transitions","Transition to Adult Care","Adolescent health","Young adults","Paediatric to adult care","Continuity of care","Mental Health Services","Implementation science","Feasibility study","Mixed Methods","Clinical Practice guidelines","Transition readiness","TRAQ","Peer support","Eating disorder treatment","Knowledge translation","2026-04-02",{"date":331,"type":40},"2026-04-08",{"date":333,"type":23},"2026-05",{"date":335,"type":23},"2028-03-31",{"name":46,"class":47},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":18,"minAge":345,"maxAge":346,"enrollmentInfo":347,"targetDuration":4,"studyType":24,"phases":349,"briefSummary":350,"conditions":351,"keywords":353,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":75},"100630543","shape-trial-skin-health-and-allergy-prevention-exposure-100630543","NCT07489040","SHAPE Trial: Skin Health and Allergy Prevention Exposure","Multi-component Package for Skin Health and Allergen Exposure Strategy to Prevent Food Allergy","SHAPE","Inclusion Criteria:\n\n1. Healthy singleton, neonates born at term (gestational age ≥37 weeks) (e.g. newborn without complications such as severe respiratory conditions, major congenital abnormalities, severe inborn errors of immunity \\[e.g. severe combined immunodeficiency\\], severe neonatal infections, neurologic impairment, and major gastrointestinal disorders).\n2. The newborn has any or at least one of the following risk factors: is an only child (no live siblings); first-degree relatives (parents and\u002For siblings) with history of food allergy, allergic rhinitis\u002Fconjunctivitis, asthma, or atopic dermatitis.\n3. Parent(s)\u002Fguardian provided informed consent for the child's study participation.\n\nExclusion Criteria:\n\n1. Newborns born to mothers with positive routine prenatal screening for any of the vertically transmitted diseases (e.g. hepatitis B, hepatitis C, active syphilis or genital herpes simplex, Chlamydia trachomatis, gonorrhea and human immunodeficiency virus \\[HIV\\]) that may prevent adherence to any of the recommendations of the environmental packages.\n2. Inability to adhere to the study procedures, e.g. severe maternal conditions (e.g. eclampsia, life-threatening conditions requiring intensive care admission) or neonatal skin conditions that require specific care practices.\n3. Ongoing participation in another interventional study (e.g. trials involving skin care with topical creams, medication or interventions related to allergy prevention) that may interfere with the current study.\n4. No access to phone, internet, or email (requirements to contact participant\u002Fguardian).\n5. Planning to move out of the province within 12 months of study enrollment.","37 Weeks","42 Weeks",{"count":348,"type":23},64,[26],"The goal of this clinical trial is to determine if a multi-component environmental package (MEP) can prevent food allergies among infants at risk of developing food allergies in early life.\n\nResearchers will compare the multi-component environmental package to regular care to see if the MEP works to prevent food allergies. Participants will:\n\n* Be assigned to the multi-component environmental package or regular care once their baby is born\n* Complete a weekly diary\n* Attend in-office visits at 4 and 12 months of age\n* Complete web-based questionnaires at 4, 6, 9 and 12 months of age",[352],"Allergy and Immunology",[354,355,356,357],"Allergy","Allergy prevention","Skin health","Food allergy","2026-03-31",{"date":289,"type":40},{"date":361,"type":23},"2026-04-01",{"date":363,"type":23},"2028-12-31",{"name":46,"class":47},{"id":366,"slug":367,"hasResults":12,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":371,"eligibilityCriteria":372,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":24,"phases":375,"briefSummary":376,"conditions":377,"keywords":381,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":75},"100606923","technology-enabled-collaborative-care-for-diabetes-and-mental-health-100606923","NCT07181863","Technology-Enabled Collaborative Care for Diabetes and Mental Health","Bridging Gaps, Enhancing Wellbeing: Examining the Effectiveness of the Technology-Enabled Collaborative Care for Diabetes and Mental Health (TECC-DM) Model","TECC-DM","Inclusion Criteria:\n\n* Adults ≥18 years old\n* Diagnosed with type 2 diabetes (T2D)\n* Experiencing mental health challenges, defined as:\n* Hospital Anxiety and Depression Scale (HADS) score ≥8 on either subscale OR\n* Diabetes Distress Scale (DDS) score ≥2\n* Community-living\n* Able to communicate verbally in English\n* Residing in Ontario during study participation\n\nExclusion Criteria:\n\n* Diagnosis of severe mental illness (e.g., schizophrenia, psychotic disorder)",{"count":374,"type":23},160,[26],"Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both. This study looks at how virtual health coaching and support from interdisciplinary care teams can help people better manage their health.\n\nThe purpose of this study is to test the effectiveness of a virtual health coaching program for adults living with type 2 diabetes and mental health challenges compared to usual care. The Technology-Enabled Collaborative Care for type 2 Diabetes and Mental health (TECC-DM) program includes weekly coaching calls, support from an interdisciplinary care team, and online tools to aid self-management. The findings from this study will be used to help improve services for people who have type 2 diabetes and co-occurring mental health symptoms.",[378,379,380],"Type 2 Diabetes","Mental Health","Diabetes Distress",[382,383,384,385],"type 2 diabetes","diabetes distress","technology","collaborative care","2026-03-28",{"date":329,"type":40},{"date":389,"type":40},"2025-03-16",{"date":391,"type":23},"2027-12",{"name":46,"class":47},{"id":394,"slug":395,"hasResults":12,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":399,"eligibilityCriteria":400,"healthyVolunteers":12,"sex":18,"minAge":208,"maxAge":19,"enrollmentInfo":401,"targetDuration":4,"studyType":24,"phases":402,"briefSummary":403,"conditions":404,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":410,"leadSponsor":411,"locationsCount":75},"100628295","early-arthroscopic-stabilization-versus-rehabilitation-of-the-shoulder-in-adolescents-with-a-traumatic-first-time-anterior-shoulder-dislocation-episode-100628295","NCT07459777","Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode.","Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode: A Pilot Prospective CohorT Study (PROMPT-Cohort)","PROMPTCohort","Inclusion Criteria:\n\n1. Males and females between the ages of 12 and 18, inclusive\n2. Patients with a first-time traumatic anterior glenohumeral dislocation within the past 5 months\n3. Anterior glenohumeral dislocation confirmed by radiography, reduction required by medical personnel, or demonstration of anterior apprehension on physical examination following injury to the shoulder\n4. MRI or MRA demonstrating disruption of the glenohumeral soft tissues (including the labrum, periosteum, or inferior glenohumeral ligament)34 relating to instability\n5. Patients who have the ability to speak, understand, and read the language of the clinical site\n6. Provision of informed consent (age 18) or parental consent (ages 12-17, inclusive)\n7. Provision of informed child assent (ages 12-17, inclusive)\n\nExclusion Criteria:\n\n1. Previous dislocation episodes or instability of the affected shoulder\n2. Previous surgeries involving the affected shoulder\n3. History or clinical exam findings of generalized ligamentous laxity (defined as a Beighton score of 4 or more points)35\n4. History of multi-directional instability of either shoulder\n5. Concomitant fracture of the tuberosity, humerus, or glenoid (excluding a Bankart or Hill Sachs lesion)\n6. Bony Bankart lesion exceeding 15% of the glenoid surface (using the best-fit circle method on MRI)36\n7. Hill Sachs lesion exceeding 15% of the humeral diameter (Measured on transaxial slice of MRI similar to Salomonsson et al.)37\n8. A neurological injury of the affected arm\n9. Patients who will likely have problems, in the judgement of the investigator, with maintaining follow-up\n10. Any other reason(s) the investigator feels is relevant for excluding the patient",{"count":85,"type":23},[26],"Each year within Canada and the US, more than 30,000 children and adolescents will have an injury to their shoulder resulting in a shoulder dislocation. Although the current practice is to manage this initial dislocation without surgery, the vast majority of these children and adolescents will, unfortunately continue to have instability episodes of their shoulder. Recurrent instability can cause damage to the bones and cartilage that form the shoulder resulting in potentially more difficult surgical stabilization, and possibly long-term sequela. To that effect, there is increasing interest to consider early surgical stabilization in this population. This pilot randomized controlled trial (RCT) will evaluate the feasibility of conducting a larger RCT assessing the effect of early arthroscopic stabilization compared to rehabilitation on the rate of repeat shoulder dislocations (recurrent instability), pain, and shoulder function among adolescents (aged 12-18 years) with first-time shoulder dislocations. These patients will be followed for one year.",[405],"Shoulder Dislocation","2026-03-09",{"date":408,"type":40},"2026-03-11",{"date":361,"type":23},{"date":102,"type":23},{"name":46,"class":47},{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":12,"sex":18,"minAge":419,"maxAge":4,"enrollmentInfo":420,"targetDuration":4,"studyType":24,"phases":421,"briefSummary":422,"conditions":423,"keywords":427,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":438,"leadSponsor":440,"locationsCount":441},"100628052","using-music-during-wound-care-among-seniors-with-pressure-injuries-100628052","NCT07456618","Using Music During Wound Care Among Seniors With Pressure Injuries","Investigating the Use of Music During Wound Care","Inclusion Criteria:\n\n* 60 years or older\n* Has a stage II, III, or IV pressure injury\n\nExclusion Criteria:\n\n* Designated as end of life and\u002For has a Kennedy terminal pressure injury\n* Has an unstageable pressure injury\n* The pressure injury has necrotic tissue or necrotic bone present\n* The pressure injury is infected\n* The pressure injury is caused by a medical device in that area\n* Severe to profound hearing loss that is not corrected by a hearing aid or other assistive hearing device.","60 Years",{"count":269,"type":23},[26],"Pressure injuries (also known as pressure wounds or bed sores) are increasingly common among older adults living in care homes. These wounds often require regular dressing changes, which can be uncomfortable for some.\n\nThe researchers believe that listening to music during wound care may have an effect on pain, wound healing, and the overall wound care experience, compared with wound care without music.\n\nThe goal of this clinical study is to test this idea by examining whether listening to music before and during wound care is linked to differences in pain, wound healing, and the overall wound care experience in older adults with pressure injuries.\n\nThe main questions this study aims to answer are:\n\nDoes listening to music before and during pressure injury care affect pain during wound care? Does listening to music before and during pressure injury care affect how pressure injuries heal over time? Does listening to music affect the overall experience of pressure injury care? Researchers will compare wound care with music to wound care without music to better understand whether music makes a difference.\n\nThe study will take place in eleven long-term care homes in Ontario. Participants will be residents aged 60 years and older who have a stage II, III, or IV pressure injury and who are already receiving regular wound care as part of their usual care. This study will not include residents who have infected or necrotic wounds, or who are at the end of life.\n\nParticipants will continue to receive the same wound care they would normally receive. Some homes will include music during wound care, and some homes will not.\n\nParticipants in homes using music will:\n\nListen to a playlist of music they personally enjoy for about 15 minutes before wound care begins Continue listening to the music during the wound care procedure Be able to change the volume or stop the music at any time Participants in homes not using music will receive the same standard pressure injury care without music.\n\nInformation for the study will come from clinical records that nurses already complete during routine wound care, such as notes about pain and wound healing. Staff involved in playing the music will also complete a short questionnaire about their observations of the wound care experience. Photos of wounds that are already taken as part of usual care may be reviewed to look at healing over time.\n\nParticipants may take part in the study for up to six months or until their wound has healed. Taking part is voluntary, and participants or their decision-makers can choose to stop at any time. The study does not change the medical care participants receive.",[424,425,426],"Pressure Injuries","Pressure Injury","Pressure Ulcer (PU)",[428,425,429,430,431,432,433],"Pressure Ulcer","Music","Wound Care","Long-Term Care","Aged","Quality of Life","2026-03-03",{"date":436,"type":40},"2026-03-06",{"date":361,"type":23},{"date":439,"type":23},"2027-06-01",{"name":46,"class":47},11,{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":448,"eligibilityCriteria":449,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":209,"enrollmentInfo":450,"targetDuration":4,"studyType":24,"phases":452,"briefSummary":454,"conditions":455,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":75},"100474115","phase-1-intravenous-dnase-i-for-the-treatment-of-sepsis-idealsepsisi-100474115","NCT05453695","Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)","Intravenous DNase I for the Treatment of Sepsis: A Phase I Safety and Feasibility Study in ICU Patients","IDEALSepsisI","Inclusion Criteria:\n\n1. Age of ≥18 years\n2. Admitted to the ICU in the last 48 hours\n3. Suspected or proven infection as the admitting diagnosis\n4. A sequential (sepsis) organ function assessment (SOFA) score of ≥2 above baseline\n5. Expected to remain in the ICU for ≥ 72 hours\n\nExclusion Criteria:\n\n1. No consent\u002Finability to obtain consent from a substitute decision-maker\n2. Have other forms of clinically apparent shock, including cardiogenic, obstructive (massive pulmonary embolism, cardiac tamponade, tension pneumothorax), hemorrhagic, neurogenic, or anaphylactic shock\n3. Have a significant risk of bleeding as evidenced by one of the following:\n\n   * Surgery requiring general or spinal anesthesia within 24 hours before enrolment\n   * The potential need for surgery in the next 24 hours\n   * Evidence of active bleeding\n   * A history of severe head trauma requiring hospitalization\n   * Intracranial surgery, or stroke within three months before the study\n   * Any history of intracerebral arteriovenous malformation, cerebral aneurysm, or mass lesions of the central nervous system\n   * A history of congenital bleeding diatheses\n   * Gastrointestinal bleeding within five weeks before the study unless corrective surgery had been performed\n   * Trauma is considered to increase the risk of bleeding\n   * Presence of an epidural catheter\n   * Need for therapeutic anticoagulation\n4. Receiving DNase I by inhalation\n5. Terminal illness with a life expectancy of fewer than three months\n6. Pregnant and\u002For breastfeeding",{"count":451,"type":23},36,[453],"PHASE1","Phase I dose-escalation safety and feasibility of IV DNase I in ICU septic patients.",[456,457],"Sepsis","Critical Illness","2026-03-02",{"date":434,"type":40},{"date":461,"type":40},"2023-01-17",{"date":463,"type":23},"2026-09-30",{"name":46,"class":47},{"id":466,"slug":467,"hasResults":12,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":4,"eligibilityCriteria":471,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":472,"targetDuration":4,"studyType":24,"phases":473,"briefSummary":474,"conditions":475,"keywords":478,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":4},"100624858","written-sepsis-education-for-patients-100624858","NCT07415096","Written Sepsis Education for Patients","Setting Up For Success: A Pilot Feasibility Randomized Controlled Trial of Written Education for Sepsis Survivors","Inclusion Criteria:\n\n* Confirmed diagnosis of sepsis based on the sepsis-3 definition (infection + Sequential Organ Failure Assessment \\[SOFA\\] increase \\>2)\n* Admitted to an ICU\n* At least 18 years old at study commencement\n\nExclusion Criteria:\n\n* Unable to read basic English\n* Despite available accommodations, they lack the cognitive, mental, or physical capacity to complete study assessments by ICU discharge\n* Readmitted to ICU during their index hospital stay\n* Hospital length of stay surpasses 30 days.",{"count":85,"type":23},[26],"This pilot feasibility randomized controlled trial (RCT) aims to determine if it feasible to recruit, deliver, and evaluate a written discharge educational material (a brochure) to adult Intensive Care Unit (ICU) patients diagnosed with sepsis.\n\nThe main questions it aims to answer are:\n\n1. Feasibility to identify and enroll \\>80% of eligible participants\n2. Feasibility to recruit 30 participants over a 6-month period\n3. Fidelity of intervention, assessed as \\>75% of participants receiving assigned intervention Researchers will assess the feasibility of comparing two groups: (1) Control - usual ICU discharge care, and (2) Intervention - usual ICU discharge care plus the receipt of an educational sepsis brochure and an explicit opportunity to ask questions about sepsis, answered by a trained intensive care unit (ICU) Registered Nurse.\n\nParticipants will receive intervention or control just prior to their discharge from ICU. They will complete online or phone survey assessments 24-48 hours post ICU discharge and 15-days post hospital discharge. Mortality and readmission data will additionally be assessed at 30-days post-discharge.",[456,476,477],"Sepsis and Septic Shock","Sepsis at Intensive Care Unit",[456,479,480,481,482],"Post-Sepsis Syndrome","Patient Education","Sepsis Rehabilitation","Care Transitions","2026-03-01",{"date":434,"type":40},{"date":486,"type":23},"2026-02",{"date":488,"type":23},"2026-09",{"name":46,"class":47},{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":494,"acronym":4,"eligibilityCriteria":495,"healthyVolunteers":12,"sex":18,"minAge":496,"maxAge":178,"enrollmentInfo":497,"targetDuration":4,"studyType":24,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":510,"locationsCount":75},"100626576","evaluation-of-food-additive-contributions-to-obesity-pilot-study-1-100626576","NCT07437430","Evaluation of Food Additive Contributions to Obesity: Pilot Study 1","Inclusion Criteria:\n\n* Males and females age 20-80; BMI 30-39 kg\u002Fm2 inclusive; willingness and ability to follow the proposed study interventions and procedures; informed consent.\n\nExclusion Criteria:\n\n* Weight loss of ≥3% in the last 3 months; previous or planned bariatric surgery in the next 1 year; current or planned participation in any structured weight-loss programs; current or recent (within the last 6 months) use of weight-loss-inducing drugs (including GLP-1 agonists); history of frequent intermittent or continuous use of systemic steroids; excessive alcohol consumption; recent or anticipated adjustments to mood, anxiety or anti-psychotic medications; untreated bipolar disorder or attention deficit hyperactivity disorder; eating disorder or any other disorder that may lead to significant weight changes; breastfeeding, pregnancy, planned pregnancy or planned fatherhood in the next 6 months; type 1 diabetes; uncontrolled diabetes mellitus (HbA1C≥9%); diabetes requiring treatment with insulin; aversion to foods that will be served during testing sessions.","20 Years",{"count":498,"type":23},20,[26],"The effects of food additives on body weight in humans are largely unknown. This is a pilot cross-over double blind RCT in obese adults aimed to test the feasibility of measuring food consumption over 24 hours after one-time administration of K sorbate versus placebo after participants reduce the background consumption of related food additives.",[502],"Obesity (Disorder)","2026-02-21",{"date":505,"type":40},"2026-02-27",{"date":507,"type":40},"2026-02-10",{"date":509,"type":23},"2026-06",{"name":46,"class":47},{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":517,"eligibilityCriteria":518,"healthyVolunteers":519,"sex":18,"minAge":520,"maxAge":521,"enrollmentInfo":522,"targetDuration":4,"studyType":24,"phases":524,"briefSummary":525,"conditions":526,"keywords":528,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":536,"leadSponsor":538,"locationsCount":75},"100626263","family-steps-family-check-up-100626263","NCT07433361","Family STEPS: Family Check-Up+","CHAMPP4KIDS: Family STEPS: Tailored, Stepped Prevention Strategy Using the Family Check-Up+","FamilySTEPS","Inclusion Criteria:\n\n* Custodial caregiver of child is aged 2 to 6 years at time of screening.\n* Families with sufficient knowledge of English needed for assessment measures.\n* Caregivers capable of giving informed, written consent.\n* Definition of 'at-risk' as measured by (a) or (b)as outlined below:\n\nparental mental health problems, as indexed by a score of ≥ 13 on the K6 distress scale or; (b) Meeting pre-determined criteria for higher risk, for example, a family may be eligible for FCU if any one or more of the following are present based on the Family Needs Assessment : i) child behaviour or school-related concerns; ii) parenting difficulty or low parenting confidence; iii) Substance use causing family-level problems; or iv) three or more social or material stressors affecting parenting\n\nExclusion Criteria:\n\n* Families with in sufficient knowledge of English, Families with caregivers incapable of giving informed written consent",true,"2 Years","6 Years",{"count":523,"type":23},300,[26],"Interventions that promote safe, stable, and nurturing relationships between caregivers and children are key to improving healthy family relationships, reducing child socioemotional and behaviour problems, and preventing child maltreatment. Although a broad range of parenting programs are currently implemented in communities across Ontario, most programs are inadequately evaluated, or else not evaluated at all using a pilot pragmatic Hybrid Type II individually randomized controlled trial conducted within routine service settings. The trial will enroll 300 families in Ontario, Canada. The evaluation is informed by the RE-AIM framework, with a primary emphasis on Reach and Implementation and secondary examination of Effectiveness, consistent with the objectives of a Hybrid Type II design.",[527],"Child Behavior Problem",[529,530,531],"child behavior problem","parenting","parental capacity","2026-02-19",{"date":534,"type":40},"2026-02-25",{"date":361,"type":23},{"date":537,"type":23},"2029-12-31",{"name":46,"class":47},{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":545,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":18,"minAge":419,"maxAge":4,"enrollmentInfo":547,"targetDuration":4,"studyType":24,"phases":549,"briefSummary":551,"conditions":552,"keywords":554,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":563,"leadSponsor":565,"locationsCount":75},"100624322","phase-2-partner4exercise-randomized-controlled-trial-100624322","NCT07408128","Partner4Exercise Randomized Controlled Trial","Evaluating a Virtual Peer-support Exercise Intervention for Older Adults With Cancer: The Partner4Exercise Randomized Controlled Trial","P4E RCT","Inclusion Criteria:\n\n* 1\\) English speaking;\n* 2\\) older adults (\\>60 years);\n* 3\\) living beyond a cancer diagnosis (any type or stage of cancer at any stage of treatment);\n* 4\\) living in Canada;\n* 5\\) have been medically cleared for exercise; and\n* 6\\) have consistent access to an internet-connected device.\n\nExclusion Criteria:\n\n* 1\\) self-report any chronic condition, cognitive impairment, or injury that prevents participation in independent moderate intensity exercise,\n* 2\\) do not pass medical clearance via the GAQ46, or\n* 3\\) had recent (in the last 4 weeks) or have planned surgery of any kind (including reconstructive surgery) in the next 6 months",{"count":548,"type":23},183,[550,58],"PHASE2","Background:\n\nAs Canada's population ages, the number of older adults facing cancer is on the rise. By 2030, 23% of Canadians will be over 65, and two in five will be diagnosed with cancer in their lifetime. This situation is compounded by many older adults experiencing functional decline and social isolation, impacting their quality of life (QOL). While regular exercise can mitigate these effects, older adults with cancer often struggle to meet exercise guidelines, leading to decreased physical and mental well-being.\n\nObjectives:\n\nOur study aims to evaluate the effectiveness of a novel, virtually delivered peer-based exercise intervention designed specifically for older adults with cancer.\n\nMethods:\n\nWe will conduct a randomized trial with three groups involving older adults (65 years and older) who have a previous cancer diagnosis. Participants will be divided into three groups: one group will receive peer support along with tailored guidance from qualified exercise professionals (PartnerMatchPLUS), another group will receive peer support only (PartnerMatch), and the third group will receive usual care with no intervention. Over 10 weeks, participants will engage in a structured exercise program supported by peer matching, a peer support guide, educational materials about exercise guidelines, and a Fitbit to track their activity levels. We will assess outcomes at four time points: baseline, post intervention, post tapering, and at a six-month follow-up. Key outcomes include measured and self-reported exercise volume, social support levels, QOL, frailty, and physical activity enjoyment. In addition to these measures, we will conduct one-on-one virtual interviews to explore participants' experiences and the mechanisms that make peer support effective.\n\nImpact:\n\nIf successful, this intervention could serve as a scalable model to encourage physical activity, promote social interaction, and ultimately enhance the psychosocial well-being of older adults with cancer.",[553],"Cancer",[555,556,557,558],"cancer","peer support","exercise","rehabilitation","2026-02-05",{"date":561,"type":40},"2026-02-13",{"date":223,"type":23},{"date":564,"type":23},"2028-05-30",{"name":46,"class":47},{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":570,"acronym":571,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":18,"minAge":573,"maxAge":574,"enrollmentInfo":575,"targetDuration":4,"studyType":24,"phases":576,"briefSummary":577,"conditions":578,"keywords":582,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":75},"100575506","iamable-implementation-and-evaluation-of-an-app-for-evidence-based-self-management-rehabilitation-strategies-100575506","NCT06773169","IAMABLE: Implementation and Evaluation of an App for Evidence-Based Self-Management Rehabilitation Strategies","IAMABLE","Inclusion Criteria:\n\n* is community-dwelling, has access to a computer or mobile device, has an email address, is able to follow directions in English, self-reports at least one of three types of prevalent chronic conditions associated with disability that frequently require rehabilitation supports (i.e., musculoskeletal, cardiovascular, and neurological conditions), responds \"somewhat easily\" or \"very easily\" to questions on the Modified Computer Proficiency Questionnaire (MCPQ-12).\n\nExclusion Criteria:\n\n* scores \\\u003C 11\u002F15 on the Montreal Cognitive Assessment (MoCA) 5-Minute Test (Version 2.1).","44 Years","75 Years",{"count":269,"type":23},[26],"Background: As the population gets older, a rise in chronic conditions has resulted in increased demand for rehabilitation. We developed a web-based app called IAMABLE (I am able), to share evidence-based rehabilitation strategies with people with chronic conditions. Our project will guide us to test this app's effectiveness and explore the ways that people use it.\n\nGoals, Methods, Approach: This pilot randomized controlled trial will offer people receiving the intervention access and use of the IAMABLE app for 4 months. People in the comparison group will have access to general web-based health information. We will recruit 50 people, 45 to 75 years, with at least one chronic condition; we will advertise in five communities (Hamilton, Kingston, London, Halifax, Winnipeg) to evaluate feasibility of the study design.\n\nPatients, therapists and app experts will be an expert group to study how the app encourages people to start and continue to use it. We will use patient-reported measures to determine if the people in the IAMABLE group experience better function; quality of life, mobility, participation, self management, pain, health service use, and falls are secondary outcomes. We will measure outcomes at baseline, 4 and 8 months.\n\nResearch Team: Our team is led by researchers with experience in rehabilitation and chronic disease management, including testing technology innovations. Patient advisors will support the project, along with co-investigators with expertise in statistics, technology, and rehabilitation research.\n\nExpected Outcomes: This research has the potential to prove how a web-based app can deliver occupational therapy and physiotherapy to support health and well being for people with chronic conditions. After this study, we plan a larger trial that will focus on effectiveness and address sustained use. IAMABLE will become a resource for people with chronic illnesses to support their independent self-management with rehabilitation strategies.",[579,580,581],"Neurological Conditions","Musculoskeletal Diseases or Conditions","Cardiovascular Diseases",[558,583,584,384,585],"chronic conditions","self-management","web-based application",{"date":587,"type":40},"2026-02-06",{"date":589,"type":40},"2025-09-25",{"date":591,"type":23},"2027-03-31",{"name":46,"class":47},{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":519,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":601,"targetDuration":4,"studyType":24,"phases":603,"briefSummary":604,"conditions":605,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":607,"lastUpdatePostDateStruct":608,"startDateStruct":610,"completionDateStruct":612,"leadSponsor":614,"locationsCount":134},"100545425","phase-2-a-trial-of-a-next-generation-covid-19-vaccine-delivered-by-inhaled-aerosol-100545425","NCT06381739","A Trial of a Next Generation COVID-19 Vaccine Delivered by Inhaled Aerosol","A Phase 2 Trial to Evaluate Safety and Immunogenicity of a Next-generation COVID-19 Vaccine Delivered by Inhaled Aerosol to Humans","AeroVax","Inclusion criteria:\n\n1. Adults who are 18-65 years old on the day of randomization (day 1)\n2. Able to read, write and communicate using the English or French language.\n3. Received at least 3 doses of an mRNA COVID vaccine.\n4. Individuals of childbearing potential must have a negative pregnancy test prior to vaccination and be willing to practice effective contraception for 8 weeks post-vaccination.\n5. Able to understand and comply with protocol requirements and instructions; able to report adverse events; able to attend scheduled study visits and complete required investigations.\n6. For participants in the BAL sub-study, Complete Blood Count (CBC) and chemistry (creatinine) within normal limits.\n7. For participants in the BAL sub-study, forced expiratory volume in 1 second (FEV1) \\> the lower limit of normal (LLN), and FEV1\u002FFVC (forced expiratory volume in 1 second\u002Fforced vital capacity) ratio above the LLN.\n8. Agree not to enroll in any other intervention studies for the duration of the study where the intervention could be reasonably expected to be associated with adverse events overlapping with the inhaled vaccine or the immune responses being measured.\n\nExclusion criteria:\n\n1. Failure to provide informed consent.\n2. Women who are pregnant or breastfeeding.\n3. Have received any recombinant adenoviral-vectored COVID-19 vaccine (AstraZeneca \\[Vaxzeria\\] or Johnson \\& Johnson (Janssen Jcovden).\n4. COVID infection (positive PCR or antigen (Ag) test, self-reported or lab documented) within the last 90 days.\n5. Last dose of a COVID vaccine administered less than 90 days prior to study entry.\n6. Administration of any vaccine within 2 weeks of study entry.\n7. Active pulmonary disease diagnosed by a physician including asthma, chronic bronchitis, interstitial lung disease, pulmonary hypertension, lung cancer, cystic fibrosis, or bronchiectasis. Current use of daily inhaled steroids for any condition.\n8. Persons with HIV and a detectable HIV viral load (\\>20 copies\u002FmL), self-reported or confirmed.\n9. Administration of monoclonal antibodies for treatment of COVID-19 infection within 3 months.\n10. Moderately or severely immunocompromised (e.g. transplant recipients\u002FCAR-T cell therapy, currently on chemotherapy for cancer or on potent immunosuppressant therapies e.g. rituximab or high dose steroids \\[\\>30 mg of prednisone equivalent daily\\], or moderate or severe primary immunodeficiency syndrome).\n11. History of severe reaction to previous COVID vaccination (e.g. hives, difficulty breathing, high fever, seizures, myocarditis, pericarditis)).\n12. Potential contraindication to COVID vaccination (e.g. venous or arterial thrombosis with thrombocytopenia after vaccination, history of cerebral venous thrombosis with thrombocytopenia, history of heparin induced thrombocytopenia, history of myocarditis or pericarditis).\n13. Known allergy to vaccine components or previous receipt of any experimental adenovirus-vector vaccine by the aerosol route.\n14. Enrolment in any clinical trial of experimental treatment for COVID infection within 90 days.\n15. For participants in the BAL sub-study, any health-related condition for which study bronchoscopy is contraindicated.\n16. For participants in the BAL sub-study, current use of anticoagulants.",{"count":602,"type":23},350,[550],"The goal of this clinical trial is to study the safety of a new inhaled vaccine to prevent COVID infection and learn about the immune responses that are made in the lungs and the blood after vaccination. Participants will be randomized (like the toss of a coin) to receive the experimental vaccine or a placebo (a look-alike solution that contains no vaccine).\n\nTo be in the study participants will have to have already had three doses of a messenger ribonucleic acid (mRNA) COVID vaccine and be generally healthy. Participants are given a single dose of the vaccine by breathing in a fine mist that goes directly into the lungs.\n\nDuring follow-up participants will:\n\n* visit the clinic for checkups and blood tests at 2, 4 and 8 weeks after vaccination\n* report their symptoms for 24 weeks after getting the vaccine.\n\nIn some participants, the researchers will collect cells from the lung 4 weeks after vaccination (a test known as a bronchoscopy).",[606],"COVID-19 Infection","2026-01-22",{"date":609,"type":40},"2026-01-26",{"date":611,"type":40},"2025-03-25",{"date":613,"type":23},"2027-01",{"name":46,"class":47},{"id":616,"slug":617,"hasResults":12,"nctId":618,"briefTitle":619,"officialTitle":620,"acronym":4,"eligibilityCriteria":621,"healthyVolunteers":519,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":622,"targetDuration":4,"studyType":24,"phases":623,"briefSummary":624,"conditions":625,"keywords":629,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":134},"100562692","all-providers-better-communication-skills-program-abcs-100562692","NCT06606470","All Providers Better Communication Skills Program' (ABCs)","All Providers Better Communication Skills Program' (ABCs) Interprofessional Provider Education Randomized Controlled Trial","Inclusion Criteria:\n\nAll individuals that work in a health care provision capacity including health care professionals, care coordinators and administrators are eligible to enroll and participate in the ABCs study.\n\nExclusion Criteria:\n\nIndividuals, including patients, that do not work in a health care provision capacity.",{"count":602,"type":23},[26],"High quality, person-centered communication for those living with serious illness benefits patients, families and clinicians. Evidence shows that clinicians rarely engage patients in these, sometimes challenging, discussions. Current education programs to build health care provider competency in serious illness communication are often inconsistent in defined purpose and use of terms. This education also tends to be oriented to treatments, not a person or do not cover the full range of difficult conversations between diagnosis and delivery of end-of-life care.\n\nThe ABCs program is an education intervention for health care providers that features a blended format of online modules and interactive virtual workshops, relevant to clinicians at all levels of training and practice. This study will examine the effectiveness of this training (over no training) for impacting provider competency and behavior change in serious illness communication. All participants in this study will receive the full ABCs training, but at different times. The overall intended impact of this program is to improve clinician confidence and satisfaction in having conversations with patients and families about serious illness. The ultimate goal of the ABCs program is to increase access to early palliative care by empowering more providers to initiate this care.",[626,627,628],"Education of Primary Care Clinicians","Palliative Care","Communication",[627,630,631,632,633,634],"Education","seriously ill communication","Observed Structured Clinical Examination (OSCE)","Provider Training","Virtual learning","2026-01-14",{"date":637,"type":40},"2026-01-16",{"date":639,"type":40},"2024-09-23",{"date":641,"type":23},"2027-01-30",{"name":46,"class":47},{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":649,"eligibilityCriteria":650,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":651,"targetDuration":4,"studyType":24,"phases":653,"briefSummary":654,"conditions":655,"keywords":657,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":664,"startDateStruct":665,"completionDateStruct":666,"leadSponsor":668,"locationsCount":4},"100620488","conservative-care-versus-decompression-trial-for-degenerative-cervical-myelopathy-pilot-100620488","NCT07358273","Conservative Care Versus Decompression Trial for Degenerative Cervical Myelopathy Pilot","Conservative Care Versus Decompression Trial for Degenerative Cervical Myelopathy Pilot: A Multicenter Randomized Controlled Feasibility Trial","CADET-DCM","Inclusion Criteria:\n\n* 18 years of age or older\n* Show evidence of spinal cord compression between C2 and T1 on MRI or CT myelography conducted within 2 years of enrollment\n* Present with mild DCM defined as a score of 15-17 on the modified Japanese Orthopaedic Association (mJOA) score\n\nExclusion Criteria:\n\n* Clinical suspicion that myelopathic symptoms are exacerbated or caused by another neurologic condition (i.e. amyotrophic lateral sclerosis, multiple sclerosis, syringomyelia, peripheral neuropathy)\n* Demonstrate ossification of the posterior longitudinal ligament (OPLL)\n* Previous cervical spine surgery\n* Report known or suspected tandem symptomatic thoracic or lumbar spinal stenosis\n* Present with an acute traumatic spinal cord injury (i.e., central cord syndrome)\n* Have a prior history of an acute spinal cord injury\n* Have spinal cord compression due to an infectious or oncologic process\n* Inflammatory arthritis\n* Significant active health-related comorbidity (ASA Class IV or higher)\n* English language ability insufficient to complete outcome questionnaires",{"count":652,"type":23},56,[26],"This study is a pilot randomized clinical trial designed to test whether it is feasible to conduct a larger study comparing two standard treatments for mild degenerative cervical myelopathy (DCM).\n\nThe main questions it aims to answer are:\n\n* Can enough participants be recruited and successfully complete follow-up assessments?\n* Will participants adhere to their assigned treatment?\n\nResearchers will compare two groups:\n\n* Surgical group: Participants receive decompressive spine surgery (with or without fusion).\n* Conservative care group: Participants follow a structured program that includes education, fall prevention strategies, and tailored exercises.\n\nParticipants will:\n\n* Complete baseline and follow-up assessments at 6 weeks, 6 months, and 12 months.\n* In the surgical group: undergo surgery within 12 weeks of randomization and receive standard post-operative care.\n* In the conservative care group: follow a 6-week progressive exercise program and continue self-management strategies.\n* Complete a monthly online symptom monitoring questionnaire",[656],"Degenerative Cervical Myelopathy",[658,659,660,661,662],"myelopathy","spinal cord diseases","surgery","conservative care","spine","2026-01-13",{"date":607,"type":40},{"date":486,"type":23},{"date":667,"type":23},"2027-06",{"name":46,"class":47},{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":675,"eligibilityCriteria":676,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":677,"enrollmentInfo":678,"targetDuration":4,"studyType":24,"phases":680,"briefSummary":681,"conditions":682,"keywords":685,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":691,"startDateStruct":692,"completionDateStruct":693,"leadSponsor":695,"locationsCount":75},"100609354","multimodal-intervention-to-support-hospital-to-community-transition-in-bipolar-disorder-100609354","NCT07213492","Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar Disorder","A Bridge to Better Days: A Pilot Study of a Multimodal Intervention to Support the Successful Transition From Hospital to Community Care for People Living With Bipolar Disorder","BTBD","Inclusion Criteria:\n\n* Age: Patient-participants must be between 18 and 35 years old.\n* Diagnosis: Must have been diagnosed with bipolar disorder within the past 24 months.\n* Clinical Features: Must have experienced psychosis and\u002For a lack of insight into their illness at the time of enrollment.\n* Language Proficiency: Must be able to understand and speak English.\n\nExclusion Criteria:\n\n* Severe Psychiatric Conditions: Individuals with a severe psychiatric condition that would prevent them from safely engaging in the intervention.\n* Cognitive or Medical Impairment: Those with significant cognitive impairment or a medical condition that interferes with their ability to participate in psychoeducation or peer-support sessions.\n* Substance Use Disorder: Individuals with an active substance use disorder that may impact adherence to the intervention.\n* Language Barriers: Participants who do not speak English and are unable to engage in study sessions without language support.\n* Concurrent Participation in Similar Programs: Individuals who are already enrolled in another structured psychoeducational or peer-support program that could interfere with study outcomes.","35 Years",{"count":679,"type":23},10,[26],"People with bipolar disorder (BD) are at high risk of relapse following hospital discharge, partly due to a lack of BD-specific expertise and resources within community services required for comprehensive treatment. Although clinical guidelines recommend combining medication and psychosocial support, and research shows that early intervention is associated with improved outcomes, no structured care programs currently exist for individuals in the early stages of BD, contributing to chronic illness progression and preventable hospitalizations. This open-label pilot trial will assess the feasibility, acceptability, and preliminary effectiveness of a structured care pathway to support the transition from hospital to community care. The intervention includes group-based psychoeducation, individual peer support, and personalized support for community healthcare providers to improve illness insight, treatment adherence, and symptom management.",[683,684],"Bipolar Disorder (BD)","Psychosis",[686,687,688,684,689,690],"Bipolar Disorder","Psychoeducation","Insight","Multimodal Intervention","Early-Stage Bipolar Disorder",{"date":635,"type":40},{"date":100,"type":23},{"date":694,"type":23},"2027-05-01",{"name":46,"class":47},{"id":697,"slug":698,"hasResults":12,"nctId":699,"briefTitle":700,"officialTitle":701,"acronym":702,"eligibilityCriteria":703,"healthyVolunteers":12,"sex":18,"minAge":208,"maxAge":704,"enrollmentInfo":705,"targetDuration":4,"studyType":24,"phases":707,"briefSummary":709,"conditions":710,"keywords":711,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":726,"startDateStruct":727,"completionDateStruct":729,"leadSponsor":731,"locationsCount":75},"100581598","phase-4-joule---metabolic-adaptation-to-weight-loss-in-response-to-a-behavioural-lifestyle-program-with-or-without-semaglutide-in-adolescents-with-obesity-100581598","NCT06852391","JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity","JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity - a Randomized Controlled Trial","JOULE-MARS","Inclusion Criteria:\n\n* Youth aged 12-17 years\n* Diagnosed with obesity (BMI ≥2 standard deviations above WHO Reference median)\n* Enrolled in Growing Health Weight Management or Next Step pediatric clinics (ie. have at least one year of the program remaining).\n\nExclusion Criteria:\n\n* Any contraindications for MRI (i.e. claustrophobia, implanted metal, metallic injuries recent tattoo or weight \\>300lb. Ineligible for imaging visit only.\n* Use of atypical anti-psychotics.\n* Use of the following medication classes: (i.e. Beta-blocker medications, Steatogenic medications, Anti-hyperglycemic medications, HIV drugs, Antidepressants, anxiolytic drugs, anti-psychotic drugs, Thyroid drugs, Antiemetic or amphetamine, dextromethorphan and metoclopramide.)\n* Elevated alanine aminotransferase (ALT) \\> 5 x upper range of normal at screening.\n* Use of glucose lowering or any anti-obesity medication in the previous 3 months.\n* Known monogenic, syndromic or hypothalamic causes of obesity.\n* Diagnosis of type 1 or 2 diabetes mellitus.\n* Prior bariatric surgery or liver transplantation.\n* Alcohol intake exceeding 3 drinks per week or reported cannabis use.\n* Recent history of cigarette smoking (previous 3 months) - ineligible for imaging only.\n* History or family history of multiple endocrine neoplasia 2 or medullary thyroid cancer.\n* History of pancreatitis.\n* Presence of untreated endocrine disorder.\n* History of an eating disorder and \u002F or history of suicidal ideation\n* History of a cardiac condition that precludes exercise testing or unable to have exercise testing done in the GHWM pediatric clinic, inability to use a cycle ergometer.\n\nParticipant who does not have a peak power value obtained in the GHWM pediatric clinic\n\nFemale who is pregnant, breast-feeding or intends to become pregnant.\n\nFemale who refuses to use a means of contraception if sexually active.\n\nParticipation in any interventional clinical study within 90 days before screening.","17 Years",{"count":706,"type":23},74,[708],"PHASE4","The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity. Behavioural lifestyle intervention with and without a pharmacological intervention - semaglutide- will be studied. Study participants will be randomized to one of two groups. Group A will follow a behavioral lifestyle program (BLP) alone for 6 months, followed by BLP and treatment with semaglutide for six months. Group B will be enrolled in BLP and semaglutide from baseline to 6 months. The primary research question will assess, in youth aged 12-17 years diagnosed with obesity and enrolled in a weight management program, if the implementation of a BLP together with semaglutide, compared to the implementation of BLP alone for 6 months leads to less adaptive thermogenesis.",[502],[712,713,714,715,716,717,718,719,720,721,722,723,724,725],"Adaptive Thermogenesis","obesity","semaglutide","GLP-1 agonist","weight loss","Energy expenditure","Whole room calorimetry","MRI","MR elastography","Cold exposure","Liver stiffness","Brown adipose tissue","Pediatric","Quality of life",{"date":635,"type":40},{"date":728,"type":40},"2025-06-18",{"date":730,"type":23},"2027-12-31",{"name":46,"class":47},""]