[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Meir Medical Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":506},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,39,57,78,104,135,156,177,199,219,238,263,281,298,314,332,348,365,381,398,414,432,448,467,486],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100645092","feasibility-of-point-of-care-ultrasound-training-and-remote-quality-assurance-for-community-physicians-in-conflict-affected-syria-100645092",false,"NCT07677553","Feasibility of Point-of-Care Ultrasound Training and Remote Quality Assurance for Community Physicians in Conflict-Affected Syria","Inclusion Criteria:Nine physicians from five community clinics serving villages in a region of Syria that cannot be further specified for security reasons participated in the program. Participants represented several medical specialties and were selected in collaboration with IFA based on their involvement in frontline community care and their anticipated ability to integrate POCUS into clinical practice.\n\n\\-\n\nExclusion Criteria:None\n\n\\-","ALL","18 Years","99 Years",{"count":20,"type":21},9,"ESTIMATED","OBSERVATIONAL","Background: POCUS can extend diagnostic capabilities where conventional imaging is unavailable, yet evidence on its implementation in active conflict zones remains scarce. We describe the feasibility of a POCUS training, device deployment, and remote quality assurance program for community physicians working in village clinics in Syria.\n\nMethods: Nine physicians from five community clinics participated in a two-day in-person POCUS training course adapted to a conflict-affected, resource-constrained setting. The curriculum focused on cardiac, lung, FAST, and soft-tissue applications. At course completion, each clinic received a handheld Butterfly ultrasound device. Participants subsequently uploaded examinations to a cloud-based platform for remote expert review and feedback. Outcomes included immediate post-course satisfaction, perceived confidence, and early post-course POCUS use over follow-up.",[25],"Training","RECRUITING","2026-06-24",{"date":29,"type":30},"2026-07-01","ACTUAL",{"date":32,"type":30},"2026-01-01",{"date":34,"type":21},"2026-08-31",{"name":36,"class":37},"Meir Medical Center","OTHER",1,{"id":40,"slug":41,"hasResults":12,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":45,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":47,"conditions":48,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":50,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":38},"100644852","continuous-erector-spinae-block-versus-thoracic-epidural-analgesia-for-the-prevention-of-chronic-pain-following-thoracotomy-a-retrospective-study-100644852","NCT07677540","Continuous Erector Spinae Block Versus Thoracic Epidural Analgesia for the Prevention of Chronic Pain Following Thoracotomy: a Retrospective Study","Inclusion Criteria:\n\n1\\. Ages 18-65 years 2. Presenting for elective thoracic surgery under general anesthesia. 3. Undergoing either ESP or TEA prior to surgery.\n\n\\-\n\nExclusion Criteria:Patients were excluded if they met any of the following criteria:\n\n1\\. Any CNS and\u002For psychiatric disease. 2. Patients who are unable to complete the pain survey for any reason. 3. Patients who had baseline chronic pain around the surgical incision.\n\n\\-",{"count":46,"type":21},34,"Post-thoracotomy pain syndrome (PTPS) is a prevalent complication that significantly impacts patients' quality of life, with reported incidence ranging from 25% to 90%. This study evaluated the effectiveness of continuous erector spinae plane (ESP) block compared to thoracic epidural analgesia (TEA), the current gold standard, in preventing PTPS. Our goal was to compare the incidence of PTPS between patients who received ESP block and those who underwent TEA. Additional goals included assessing postoperative pain levels, analgesic consumption, and complications related to the anesthesia techniques.",[49],"Thoracic Surgery",{"date":51,"type":30},"2026-06-30",{"date":53,"type":30},"2023-09-12",{"date":55,"type":21},"2026-07-31",{"name":36,"class":37},{"id":58,"slug":59,"hasResults":12,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":38},"100643339","investigation-of-chemical-stability-and-sterility-of-morphine-in-intrathecal-pumps-for-long-term-pain-management-100643339","NCT07641608","Investigation of Chemical Stability and Sterility of Morphine in Intrathecal Pumps for Long-Term Pain Management","Morphine in Intrathecal Pumps for Long-Term Pain Management","Inclusion Criteria: • Adult patients (age ≥ 18 years), Diagnosed with chronic pain and currently treated with an implantable intrathecal pump.\n\n* Receiving intrathecal Morphine (Rafa Laboratories, 20 mg\u002Fml; registration no. 106-25-28981-00).\n* Scheduled for a routine pump refill procedure at an interval of 3 to 6 months.\n\nExclusion Criteria:• Patients receiving polyanalgesic mixtures (admixtures of morphine with other drugs) in the intrathecal pump.\n\n* Evidence of active systemic infection or localized infection at the pump implantation site.\n* History of recent pump malfunction or refills occurring outside the standard 3 to 6-month window.\n* Inability to provide informed consent.\n* Pregnant patients.",{"count":65,"type":21},5,"Intrathecal drug delivery systems (IDDS) are effective for managing chronic pain by delivering medications directly into the cerebrospinal fluid. Morphine, a primary opioid used in these systems, must remain chemically stable and sterile over prolonged periods to ensure patient safety and therapeutic efficacy . Previous studies have evaluated morphine stability in vitro under simulated conditions , indicating minimal degradation in saline over time . However, there is limited real-world data regarding the residual morphine in pump reservoirs after extended use . This study seeks to bridge this gap by analyzing morphine aspirated from intrathecal pumps during routine refills in a clinical setting, while comparing it to in vitro samples taken in the clinic .. Objectives Primary Objective: To determine the chemical stability of morphine in intrathecal pump reservoirs over a 3 to 6-month period of clinical use.\n\nSecondary Objective: To assess the sterility of residual morphine and evaluate any microbial contamination.",[68],"Rate of Positive Culture From Morphine Aspirate","NOT_YET_RECRUITING","2026-06-07",{"date":72,"type":30},"2026-06-11",{"date":74,"type":21},"2027-01-01",{"date":76,"type":21},"2028-01-01",{"name":36,"class":37},{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":84,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":88,"studyType":22,"phases":4,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":38},"100634611","doppler-flow-in-tubal-ectopic-pregnancy-in-diagnosis-as-a-predictor-of-treatment-success---conservative-and-mtx-treatment-100634611","NCT07541937","Doppler Flow in Tubal Ectopic Pregnancy in Diagnosis as a Predictor of Treatment Success - Conservative and MTX Treatment","Inclusion criteria:\n\n* Tubal ectopic pregnancy\n* Hemodynamically stable, with no suspicion of rupture,\n* Eligible for MTX or conservative therapy.\n\nExclusion criteria:\n\n* Intrauterine pregnancy\n* Hemodynamic instability\n* Suspected tubal rupture\n* Other ectopic pregnancy: CSP, Ovarian, heterotopic pregnancy","FEMALE","45 Years",{"count":87,"type":21},60,"2 Months","The study \"Doppler Flow in Tubal Ectopic Pregnancy as a Predictor of Treatment Success: Conservative and MTX Therapy\" aims to evaluate the role of Doppler ultrasound parameters (RI, PI, and PSV) in predicting treatment success for tubal ectopic pregnancies. Ectopic pregnancies, affecting \\~2% of all pregnancies (98% in fallopian tubes), pose significant risks, including rupture and maternal mortality. Diagnosis is typically achieved via transvaginal ultrasound, with Doppler imaging enhancing accuracy by detecting characteristic vascular patterns.\n\nManagement options include conservative monitoring, methotrexate (MTX) therapy, or surgery, based on clinical stability, β-hCG levels, and ultrasound findings. While β-hCG levels are a known predictor of MTX treatment failure, there is no consensus on an optimal threshold. Prior research suggests increased vascularization on Doppler ultrasound may correlate with higher MTX success rates.\n\nThis prospective study will involve 60 women aged 18-45 with stable, unruptured tubal ectopic pregnancies. It will assess Doppler parameters and other clinical factors as predictors of treatment success. Findings aim to address gaps in the literature and improve management strategies for tubal ectopic pregnancies.",[91],"Ectopic Pregnancy",[93,94,95],"ectopic pregnancy conservative management","Ectopic pregnancy MTX therapy","Doppler flow parameters in ectopic pregnancy","2026-04-14",{"date":98,"type":30},"2026-04-21",{"date":100,"type":30},"2024-06-01",{"date":102,"type":21},"2027-06-01",{"name":36,"class":37},{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":84,"minAge":17,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":117,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":38},"100561521","membrane-stripping-for-cervical-ripening-100561521","NCT06591247","Membrane Stripping for Cervical Ripening","Evaluation of Stripping for Cervical Ripening - A Randomized Controlled Study","Stripping","Inclusion Criteria:\n\n* Patients aged 18 and above\n* Patients with a cervical dilation of at least 1 cm\n* Full-term pregnancy\n* Cephalic presentation\n* No contraindication to vaginal delivery\n\nExclusion Criteria:\n\n* Patients with rupture of membranes\n* Patients who do not require cervical ripening and proceed directly to the delivery room for induction with oxytocin\n* Patients for whom the use of a double-balloon catheter\u002FPGE2 is contraindicated\n* Twin pregnancies\n* Pregnancies with macrosomic fetuses where vaginal delivery is contraindicated\n* Patients with maternal or fetal pathologies that do not allow for vaginal delivery due to concerns about fetal or maternal distress",true,"50 Years",{"count":115,"type":21},400,"INTERVENTIONAL",[118],"NA","The goal of this interventional study is to evaluate the effectiveness of membrane stripping in cervical ripening compared to double balloon catheter induction.\n\nThe study population consists of women undergoing labor induction.\n\nThe main questions it aims to answer are:\n\n1. Is membrane stripping as effective as double balloon catheter induction in cervical ripening?\n2. What is the influence of membrane stripping on the time required for cervical ripening, delivery duration, and maternal and fetal outcomes compared to balloon induction.",[121,122,123,124,125,126],"Labor, Induced","Cervical Ripening","Balloon Induction","Membrane Stripping","Pregnancy Related","Induction of Birth","2026-04-10",{"date":129,"type":30},"2026-04-15",{"date":131,"type":30},"2024-08-07",{"date":133,"type":21},"2027-12-31",{"name":36,"class":37},{"id":136,"slug":137,"hasResults":12,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":142,"targetDuration":144,"studyType":22,"phases":4,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100631519","comparison-of-the-direct-anterior-approach-daa-and-the-direct-lateral-approach-dla-in-patients-treated-with-partial-hip-replacement-for-femoral-neck-fracture-based-on-postoperative-functional-status-100631519","NCT07501741","Comparison of the Direct Anterior Approach (DAA) and the Direct Lateral Approach (DLA) in Patients Treated With Partial Hip Replacement for Femoral Neck Fracture Based on Postoperative Functional Status","Impact of Surgical Approach on Post-Fracture Function: A Prospective Hemiarthroplasty Study","Inclusion Criteria:\n\nAdults aged 18 years or older Patients undergoing hemiarthroplasty (partial hip replacement) during the study period at Meir Medical Center Ability to provide informed consent for participation in the study\n\nExclusion Criteria:\n\nRevision surgery performed during the index hospitalization Inability to complete postoperative follow-up Inability to provide informed consent (e.g., dementia or presence of a legal guardian) Pre-injury mobility status of bedbound or wheelchair-bound Polytrauma patients Prior fixation or arthroplasty of the contralateral hip within the previous year",{"count":143,"type":21},100,"1 Year","The goal of this clinical trial is to learn whether the surgical approach used for hemiarthroplasty can improve clinical and functional outcomes in adults with displaced femoral neck fractures.\n\nThe main questions it aims to answer are:\n\n* Does the direct anterior approach (DAA) result in superior postoperative functional recovery compared with the direct lateral approach (DLA)?\n* Are mortality, complications, hospital utilization, and readmission rates different between the two surgical approaches? Researchers will compare hemiarthroplasty performed using the direct anterior approach to hemiarthroplasty performed using the direct lateral approach to determine whether surgical approach influences postoperative function, complications, and survival.\n\nParticipants will:\n\n* Undergo hemiarthroplasty for displaced femoral neck fracture using a randomly assigned surgical approach (DAA or DLA)\n* Complete a baseline functional assessment using the Activities of Daily Living (ADL) questionnaire before surgery\n* Have perioperative data collected during hospitalization, including laboratory values, operative details, blood loss, transfusions, analgesic use, complications, length of stay, and in-hospital mortality\n* Attend follow-up clinic visits at 6 weeks and 3 months after surgery\n* Complete postoperative functional assessment using the Harris Hip Score at both follow-up visits\n* Have demographic data, complications, readmissions, and mortality monitored through review of electronic medical records",[147],"Femoral Neck Fractures","2026-03-24",{"date":150,"type":30},"2026-03-30",{"date":152,"type":21},"2026-05-01",{"date":154,"type":21},"2028-05",{"name":36,"class":37},{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":12,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":4},"100617196","characteristics-of-patients-intubated-for-airway-protection-in-the-intensive-care-unit-and-timing-of-tracheostomy-100617196","NCT07315477","Characteristics of Patients Intubated for Airway Protection in the Intensive Care Unit and Timing of Tracheostomy","Characteristics of Patients Intubated for Airway Protection in the Intensive Care Unit and Timing of Tracheostomy: a Retrospective Study","Inclusion Criteria: All patients aged 18-99 who were admitted to the intensive care unit from January 2012 to November 2025 and ventilated for airway protection for any reason.\n\n\\-\n\nExclusion Criteria:Patients who did not meet the above criteria or patients for whom data was missing.\n\n\\-",{"count":164,"type":21},200,"Every year, approximately 10-15 patients are admitted to the general intensive care unit at our institution who have been intubated for airway protection for various reasons, the main ones being soft tissue infection of the head\u002Fneck, anaphylaxis with airway edema, oral and maxillofacial\u002FENT surgery with airway threat, and head\u002Fneck injury with airway threat. Some patients are successfully extubated after the acute condition that caused the need for ventilation in the first place has passed, and some require tracheostomy for reasons related to the primary disease (unresolved edema, continued infectious process, need for additional invasive interventions, etc.) or for reasons related to difficulty in respiratory weaning (poor awakening, muscle weakness, development of respiratory infection, etc.).\n\nWe would like to examine whether it is possible to characterize certain parameters in the above patient population that are associated with a higher likelihood of requiring tracheostomy during hospitalization (such as age Adult). In these cases, we may consider performing the tracheostomy earlier.",[167,168],"Airway Clearance Impairment","Intubating Conditions","2025-12-23",{"date":171,"type":30},"2026-01-02",{"date":173,"type":21},"2026-02-01",{"date":175,"type":21},"2029-02-01",{"name":36,"class":37},{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100612692","validation-of-the-icvs-model-in-patients-admitted-to-the-intensive-care-unit-100612692","NCT07256886","Validation of the iCVS Model in Patients Admitted to the Intensive Care Unit","Validation of the iCVS Model in Patients Admitted to the Intensive Care Unit: a Retrospective Study","Inclusion Criteria: The relevant experiment population are all patients over age 18 admitted to the ICU in Meir -\n\nExclusion Criteria: Missing data\n\n\\-",{"count":185,"type":21},1150,"One of the significant challenges in the care of critically ill patients in the intensive care unit is the assessment of hemodynamically unstable patients (shock states). The treating team uses data such as heart rate, arterial blood pressure, physical examination findings, etc. to assess the patient's cardiac output, peripheral vascular resistance, filling pressures and volumes, and vascular tone. These assessments are essential to assess the cause of shock (cardiac cause, hypovolemia, sepsis, etc.), but in many situations they are not easy to perform and require extensive knowledge and experience. Assessing the hemodynamic status of a critically ill patient based on dynamic mechanical models may be a good option for more accurate assessment of complex patients. Such a model is, for example, the iCVS model: it is a relatively simple, mechanical-dynamic model that can be used to understand complex cardiovascular conditions. This model requires only age and weight as initial data, and as dynamic data the model requires only an arterial blood pressure (AR) curve and a central venous pressure (CVP) curve. The model is based on the shape of the above curves for the purpose of analyzing the cardiovascular status of the patient. The model is suitable for both adults and children, although most of the work to date has been among pediatric intensive care patients.",[188],"Shock",[190],"shock","2025-11-20",{"date":193,"type":30},"2025-12-01",{"date":195,"type":21},"2026-04-01",{"date":197,"type":21},"2030-04-30",{"name":36,"class":37},{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":213,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":4},"100612690","influence-of-chest-x-ray-vs-chest-ct-scan-on-the-management-of-icu-patients-with-respiratory-failure-100612690","NCT07256860","Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure","Influence of Chest X-ray vs. Chest CT Scan on the Management of ICU Patients With Respiratory Failure: A Retrospective Study.","Inclusion Criteria: All patients who underwent CT scans as part of their hospitalization in the intensive care unit for acute respiratory failure\u002Fhypoxemia, from January 2020 to January 2023.\n\n\\-\n\nExclusion Criteria: Missing data.\n\n\\-",{"count":207,"type":21},50,"Patients admitted to the intensive care unit (ICU) often require CT imaging. Performing this test on a critically ill patient involves risks, such as those associated with transferring a ventilated and unstable patient (respiratory or hemodynamic instability during transfer, unplanned extubation, unplanned removal of central catheters, drains, etc.), and those associated with intravenous contrast injection (renal impairment, anaphylactic reaction). Additionally, multiple CT scans may create a burden on the radiology department and medical staff, cause CT scans to be postponed for other patients, and increase hospitalization costs (1).\n\nIn a study conducted in 2014, approximately 533 CT scans were performed for 359 patients admitted to the ICU at 2 different medical centers. In this study, they examined the extent to which CT scanning affected patient care management by comparing the medical diagnosis given to the patient before and after the scan.\n\nThe diagnostic yield of the scan was 40% complete agreement between the diagnosis before and after the CT scan, about 6% partial agreement, and about 54% inconsistency. The CT scan resulted in new findings in the patient's diagnosis in 23% of cases, and in 54% of patients, the CT scan resulted in a change in the patient's treatment plan.\n\nAmong the patients who underwent a CT scan, about 23% experienced side effects or adverse events as a result of the scan, of which 6% were defined as life-threatening. The more critically ill the patient was, the greater the risk of these events (1).\n\nIn another study, which looked at a subgroup of septic patients in intensive care, there was no agreement between CT findings and the patients' treatment outcomes, and there was no significant effect of the CT scan on the patient's treatment plan (2).\n\nIn our previous work on all patients who underwent CT scans in the unit, we found that, in general, the rate of impact of CT scans on the patient's treatment plan was low compared to other studies, although in the group of patients hospitalized due to sepsis, the rate was similar - about a third of the patients. Among the patients hospitalized with multisystem trauma, about 31% of the patients had new traumatic findings on CT scans, but in only half of these patients did the test lead to a change in the treatment plan. It appears from this work that the group in which it was possible to retrospectively find the largest number of CT scans that could have been omitted was the group of patients with respiratory failure. The purpose of performing CT scans in these patients was mainly to look for pulmonary infiltrates, pleural effusions, or pulmonary embolism. With the exception of pulmonary embolism, a condition that is relatively rare compared to other diagnoses in patients with acute respiratory failure, the other diagnoses could also be confirmed by physical examination, ultrasound examination, or chest x-ray (these patients usually undergo a chest x-ray as part of the investigation of acute respiratory failure anyway), and this may be the reason why the CT scan did not add relevant information to change the treatment plan in these patients. However, we did not specifically examine in this study whether the chest x-ray showed all the findings seen on the chest CT scan, and whether the CT scan added new findings, and especially whether these new findings would have changed the treatment plan (such as pulmonary embolism). In this study, we would like to focus on this group of patients.",[210],"Respiratory Failure",[212],"chest x ray",{"date":193,"type":30},{"date":215,"type":21},"2025-11-21",{"date":217,"type":21},"2026-11-30",{"name":36,"class":37},{"id":220,"slug":221,"hasResults":12,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":226,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":235,"leadSponsor":237,"locationsCount":38},"100607042","impact-of-blood-cultures-drawn-from-arterial-lines-on-the-incidence-of-contamination-detection-of-bacteremia-and-blood-culture-volume-100607042","NCT07183410","Impact of Blood Cultures Drawn From Arterial Lines on the Incidence of Contamination, Detection of Bacteremia, and Blood Culture Volume","Impact of Blood Cultures Drawn From Arterial Lines on the Incidence of Contamination, Detection of Bacteremia, and Blood Culture Volume: an Observational Study","Inclusion Criteria:All patients aged 18-99 years who had blood cultures taken as part of their routine care in the intensive care unit for any reason, from January 2024 to January 2027.\n\n\\-\n\nExclusion Criteria:Missing data or patients who did not fullfil the above criteria.\n\n\\-",{"count":227,"type":21},1500,"Taking blood cultures is an important and very common procedure in intensive care units due to the high incidence of sepsis and the need for rapid and accurate identification of bacteremia. However, despite the importance of taking a sufficient volume of blood for the purpose of identifying bacterial growth in the blood, the average blood volume in blood cultures at our institution ranges from 3.5-4 ml per bottle (where the desired volume is 10 ml). Taking an insufficient amount of blood reduces the ability of the bacteriological laboratory to detect bacterial growth and thus may lead to a delay or missed diagnosis of bacteremia, identification of the pathogen, and adjustment of appropriate treatment according to sensitivities.\n\nIn intensive care units, most patients are monitored using an arterial catheter, which allows for frequent blood tests without the need to puncture the patient. Following recently published studies that showed that there is no significant difference in the incidence of contamination when taking blood cultures from an arterial catheter compared to a peripheral vein puncture, and in order to improve our ability to identify bacteremia, it was decided to implement a new protocol in the General Intensive Care Unit that includes taking blood cultures from an arterial catheter. According to the new protocol, it was decided that when taking blood cultures from a patient with an arterial catheter, one pair of cultures should be taken from the arterial catheter and another pair from a peripheral vein puncture.\n\nIn this study, we would like to examine the contamination rate of blood cultures, the identification of true bacteremia, and the collection of appropriate blood volume and number of blood specimens taken in patients hospitalized in the General Intensive Care Unit at our institution, while analyzing differences between the period before the implementation of the new protocol and the period after the implementation, and differences between cultures taken from an arterial catheter and from a peripheral vein puncture.",[230],"Bacteremia","2025-09-14",{"date":233,"type":30},"2025-09-19",{"date":32,"type":21},{"date":236,"type":21},"2028-06-01",{"name":36,"class":37},{"id":239,"slug":240,"hasResults":12,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":112,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":248,"conditions":249,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":262},"100507037","prospective-validation-of-the-ohi-index-100507037","NCT05882175","Prospective Validation of the OHI Index","A Prospective Study to Validate the Prognostic Power of the Optimized HLH Inflammatory (OHI) Index","HLH","Inclusion Criteria:\n\n* Patients with hematologic malignancies\n* At least 18 years old\n\nExclusion Criteria:\n\n* Prior recent treatment (chemotherapy\u002F other cytoreductive therapies in the last month)",{"count":247,"type":21},300,"Hemophagocytic lymphohistiocytosis (HLH) associated with hematologic malignancies (HM-HLH) is a syndrome with an abysmal prognosis (10-30% 5 years overall survival). The investigators have recently established an improved diagnostic and prognostic index for HM-HLH, termed the Optimized HLH Inflammatory (OHI) index. The OHI index is comprised of the combined elevation of soluble CD25 (sCD25) \\> 3,900 U\u002FmL and ferritin \\>1,000 ng\u002FmL . However, the true incidence and outcomes of HLH\u002FOHI+ in an unselected cohort are unknown, and so is the mechanism of HM-HLH.",[244,250,251,252,253],"Hemophagocytic Lymphohistiocytoses","Hemophagocytic Syndrome","Hematologic Malignancy","Hematologic Neoplasms","2025-05-08",{"date":256,"type":30},"2025-05-13",{"date":258,"type":30},"2021-03-03",{"date":260,"type":21},"2030-03-03",{"name":36,"class":37},2,{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":269,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":270,"conditions":271,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":38},"100577970","increased-body-temperature-post-tracheostomy-a-retrospective-study-100577970","NCT06805214","Increased Body Temperature Post Tracheostomy: a Retrospective Study","Inclusion Criteria: Patients admitted to the ICU from 1.2020 to 1.2025 who underwent tracheostomy during ICU admission -\n\nExclusion Criteria: Patients who did not fullfil the above criteria\n\n\\-",{"count":115,"type":21},"Tracheostomy is one of the most common procedures in intensive care units. Post-tracheostomy increased body temperature within 24 hours is common. However, frequently sepsis workup is performed along with initiation of broad spectrum antibiotic therapy. We will investigate the incidence of post tracheostomy fever and whether retrospectively the increased temperature indicated development of sepsis or not. The study is retrospective and will be based on data collection.",[272],"Tracheostomy Complication","2025-05-07",{"date":275,"type":30},"2025-05-11",{"date":277,"type":30},"2025-05-01",{"date":279,"type":21},"2028-03-01",{"name":36,"class":37},{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":288,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":290,"conditions":291,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":293,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":297,"locationsCount":38},"100567233","28-day-mortality-prediction-for-critically-ill-patients-in-the-intensive-care-unit-physician-nurse-vs-score-100567233","NCT06665529","28-day Mortality Prediction for Critically Ill Patients in the Intensive Care Unit: Physician-nurse vs. Score","28-day Mortality Prediction for Critically Ill Patients in the Intensive Care Unit: Physician-nurse vs. Score. A Prospective Observational Study","Inclusion Criteria:\n\n* All patients admitted to the ICU between 1.1.2025 and 1.1.2027.\n\nExclusion Criteria:\n\n* Patients who were hospitalized in the ICU for less than 72 hours.",{"count":289,"type":21},2000,"There are several scores for predicting mortality within 28 days in the intensive care unit, including APACHE 2, MPM 2 and MODS. These models for predicting mortality can help intensive care physicians to identify patients at high risk of mortality, thus helping them in the decision regarding their admission to the ICU and the management of their care during hospitalization. However, it is not entirely clear whether these models can predict mortality better than an experienced ICU physician or nurse.\n\nThe purpose of the study is to compare the ability of a senior ICU physician and nurse to predict mortality within 28 days in intensive care patients and between the predictive ability of three models for mortality prediction, as well as to investigate what were the parameters that particularly influenced the mortality prediction of the medical and nursing staff.\n\nThe study will be performed as a prospective observational study and will include approximately 2000 patients. For each patient admitted to intensive care, the risk of mortality will be calculated according to APACHE 2, MPM 2 and MODS. In addition, an independent evaluation by 3 specialist ICU physicians and an experienced ICU nurse will be carried out. The medical and nursing staff's reasons for the risk provided by them will be presented.",[292],"Mortality Prediction",{"date":256,"type":30},{"date":295,"type":30},"2025-02-01",{"date":74,"type":21},{"name":36,"class":37},{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":305,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":307,"conditions":308,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":310,"startDateStruct":311,"completionDateStruct":312,"leadSponsor":313,"locationsCount":38},"100563954","incidental-discovery-of-pulmonary-emboli-via-ct-scan-impact-of-detections-on-patient-care-and-resulting-complications-100563954","NCT06622876","Incidental Discovery of Pulmonary Emboli Via CT Scan: Impact of Detections on Patient Care and Resulting Complications","Incidental Discovery of Pulmonary Emboli Via CT Scan: Impact of Detections on Patient Care and Resulting Complications. A Retrospective Study","Inclusion Criteria: All patients who were admitted to the ICU between 8\u002F2020 and 8\u002F2024 and underwent chest CT during ICU stay -\n\nExclusion Criteria: Missing information\n\n\\-",{"count":306,"type":21},1000,"In recent years, with an increase in the frequency of CT examinations, there has also been an increase in the random discovery of pulmonary emboli, often small, as part of examinations performed for other indications. Most of the literature so far deals with the discovery of such findings mainly in oncological patients, and there is relatively little information regarding the frequency of such random discovery in other patient populations. Specifically in the intensive care patient population, we have not yet found any study that examined the detection rates of these findings. Also, there is no consensus regarding how these random findings should be treated from a therapeutic point of view (whether to start treatment with full anticoagulation, and if so, for what period of time).\n\nRandom pulmonary embolism is often discovered as part of a CT scan done to assess acute lung disease or lung cancer staging. In a study done in oncology patients, 385 chest CT examinations were examined, with a random discovery of pulmonary emboli at a rate of 2.6% . A larger analysis of 8 studies involving 8491 cancer patients found a slightly higher incidence of 3.6%.\n\nWe would like to check the rate of pulmonary emboli that were randomly discovered in chest CT examinations performed in the intensive care unit for other indications, and the consequences of discoveries - ie starting anti-coagulant treatment and whether there were any complications for starting such treatment (bleeding).",[309],"Pulmonary Embolism",{"date":256,"type":30},{"date":295,"type":30},{"date":74,"type":21},{"name":36,"class":37},{"id":315,"slug":316,"hasResults":12,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":321,"targetDuration":4,"studyType":116,"phases":322,"briefSummary":323,"conditions":324,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":326,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":38},"100558938","reaching-a-caloric-goal-using-a-gastric-sonar-versus-aspiration-of-gastric-contents-in-critically-ill-patients-receiving-nasogastric-enteral-nutrition-100558938","NCT06557629","Reaching a Caloric Goal Using a Gastric Sonar Versus Aspiration of Gastric Contents in Critically Ill Patients Receiving Nasogastric Enteral Nutrition","Reaching a Caloric Goal Using a Gastric Sonar Versus Aspiration of Gastric Contents in Critically Ill Patients Receiving Nasogastric Enteral Nutrition - Randomized Controlled Trial","Inclusion Criteria: Adult intensive care patients who recieve enteral nutrition via nasogastric tube -\n\nExclusion Criteria: 1. Pregnant patient 2. History of bariatric or other gastric surgery 3. Post-operative patients with sub-costal incision 4. Diaphragmatic hernia 5. Patients who recieve parenteral nutrition 6. Technically difficult US exam\n\n\\-",{"count":207,"type":21},[118],"Enteral nutrition intolerance, manifested in delayed gastric emptying and high gastric residual, is a common problem in critically ill patients in intensive care, with adverse consequences on patients' outcomes. A decrease in the levels of the ghrelin hormone in these patients may contribute to this problem. The gastric residual test (GRV) is used to assess enteral absorption and gastric motility, but the traditional methods can lead to inaccuracy and waste of resources. In recent years, the use of ultrasound (PoCUS) to assess GRV has developed, but its effect on the rate of reaching the caloric goal has not yet been evaluated.",[325],"Enteral Nutrition Intolerance in Critically Ill Patients",{"date":256,"type":30},{"date":328,"type":30},"2024-10-01",{"date":330,"type":21},"2027-10-01",{"name":36,"class":37},{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":344,"startDateStruct":345,"completionDateStruct":346,"leadSponsor":347,"locationsCount":38},"100563136","early-vs-late-tracheostomy-in-patients-with-guillain--barre-syndrome-100563136","NCT06612242","Early vs. Late Tracheostomy in Patients With Guillain -Barre Syndrome","Early vs. Late Tracheostomy in Patients With Guillain -Barre Syndrome: Comparison of Clinical Outcomes- a Retrospective Study","Inclusion Criteria: All patients aged 18--99 who were admitted to the general intensive care unit from January 2012 to September 2024 with a diagnosis of Guillain-Barre syndrome who required mechanical ventilation and underwent tracheostomy during ICU stay.\n\n\\-\n\nExclusion Criteria: Missing recoreded data\n\n\\-",{"count":5,"type":21},"Tracheostomy is one of the most common procedures in the intensive care unit in patients who need prolonged invasive mechanical ventilation. There is controversy in the literature regarding the ideal timing for performing tracheostomy in critically ill patients. Early tracheostomy may be associated with a decrease in ventilation days and hospitalization. We would like to investigate whether in ventilated patients with Guillain Barre syndrome, early tracheostomy will be associated with decreased ventilation days, decreased mortality and shorter hospital and ICU length of stay.",[342,343],"Guillain Barre Syndrome","Mechanical Ventilation",{"date":256,"type":30},{"date":295,"type":30},{"date":74,"type":21},{"name":36,"class":37},{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":355,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":356,"conditions":357,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":359,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":38},"100542932","venous-thrombosis-after-removal-of-central-venous-catheter-100542932","NCT06349291","Venous Thrombosis After Removal of Central Venous Catheter","Venous Thrombosis After Removal of Central Venous Catheter-prospective Observational Study","Inclusion Criteria: Patients who were admitted to the intensive care unit and had a central catheter inserted during their stay in the unit for any reason, and whose central catheter was removed during their stay in the general intensive care unit.\n\n\\-\n\nExclusion Criteria:Patients whose insertion or removal of the central catheter did not occur during the hospitalization in the intensive care unit, patients who were treated with full anticoagulation in the intensive care unit.\n\n\\-",{"count":143,"type":21},"Insertion of intravenous catheter is a very common operation in patients in the general intensive care unit. These catheters are used for a variety of purposes - administration of inotropics\u002Fpressors, intravenous nutrition, concentrated electrolytes and performing dialysis.There are several known complications of central venous catheter insertion, such as thrombosis and pulmonary embolism. In a literature review, there are no clear data regarding the rate of intravenous thrombosis in patients after removal of a central venous catheter. These findings are often discovered randomly, when the patient undergoes imaging for a different indication. There is no recommendation for an active search for intravenous thrombi at the catheter insertion sites in these patients, and it is not entirely clear whether it is mandatory to administer anticoagulant treatment in these patients if thrombi are randomly discovered at the catheter insertion sites.\n\nIn this study, we aim to check the proportion of patients who developed thrombosis at the central catheter insertion sites after its removal, to check whether there are catheter insertion sites that are at a higher risk of developing thrombosis than other sites, and to check whether there are predictive characteristics for the development of this type of thrombosis.",[358],"Thrombosis, Venous",{"date":256,"type":30},{"date":361,"type":30},"2024-11-01",{"date":363,"type":21},"2025-08-01",{"name":36,"class":37},{"id":366,"slug":367,"hasResults":12,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":372,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":373,"conditions":374,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":376,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":380,"locationsCount":38},"100543850","routine-use-of-rush-protocol-in-the-intensive-care-unit-100543850","NCT06361225","Routine Use of RUSH Protocol in the Intensive Care Unit","Routine Use of RUSH Protocol in the Intensive Care Unit- Does it Influence Patient Management? Prospective Observational Study","Inclusion Criteria:\n\n* Patients who were admitted to the intensive care unit for any reason and were evaluated daily using the RUSH protocol.\n\nExclusion Criteria:Patients who were not evaluated using the RUSH protocol or for whom data were missing.\n\n\\-",{"count":207,"type":21},"The RUSH protocol has been used for several years for the rapid evaluation of a patient admitted to the emergency room with shock. Traditionally, its use was especially common in trauma victims, but later its use was extended to patients admitted to the emergency room with shock from any reason. The protocol includes rapid assessment with the guideness of ultrasound of heart contraction, assessment for pleural effusions, assessment of intra-abdominal blood (FAST), diagnosis of venous thrombosis (DVT), and rulling out hydronephrosis. It can also add a pupil size assessment and an evaluation of the gallbladder and bile ducts, as well as the size of the bladder. In intensive care, we use this protocol (or part of it) for the evaluation of a patient who is deteriorating in the ICU for an unknown reason . In some patients we use this protocol as a routine part of the physical examination as part of the daily patient evaluation.\n\nWe would like to investigate whether the routine use of the RUSH protocol as part of the daily patient evaluation in the general intensive care unit will lead to any change in the patient's management.",[375],"RUSH Protocol",{"date":275,"type":30},{"date":378,"type":30},"2024-12-01",{"date":363,"type":21},{"name":36,"class":37},{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":388,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":389,"conditions":390,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":392,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":38},"100531973","vitamin-c-administration-and-triglycerides-level-in-critical-care-patients-100531973","NCT06206759","Vitamin C Administration and Triglycerides Level in Critical Care Patients","Vitamin C Administration and Triglycerides Level in Critical Care Patients: a Retrospective Study","Inclusion Criteria: patients aged 18-99 who were admitted to the general intensive care unit from January 2017 to December 2023, and who were treated with intravenous vitamin C. The control group will include patients with the same characteristics who were not treated with vitamin C.\n\nExclusion criteria: patients who did not meet the above conditions or for whom data were missing.\n\n\\-\n\n\\-",{"count":289,"type":21},"Vitamin C (ascorbic acid) is a water-soluble vitamin with antioxidant properties. Previous studies showed that the administration of vitamin C was associated with decreased triglyceride (TG) levels in ambulatory patients, especially in patients with type 2 diabetes. The decrease in TG level was more significant the younger the patient's age (less than 52.8 years), the longer the administration of vitamin C lasted (over 12 weeks) and the higher the daily dose was (over 1 gram per day) (2). However, we did not find any studies that examined the relationship between administration of vitamin C and lowering of TG level in critical patients in intensive care. High TG levels are often found in these patients, secondary to sepsis, administration of propofol by continuous infusion, administration of TPN, pancreatitis, liver failure and chronic dyslipidemia, diabetes and chronic renal failure. High TG levels in these patients may cause pancreatitis secondary to elevated TG, and we take several actions to lower TG levels in the unit when they exceed 500 mg per dL in order to avoid these complications. The actions taken include starting treatment with fibrates and\u002For statins, giving high-dose insulin, stopping the propofol drip and changing it to another hypnotic drug (usually midazolam), and giving fat-free TPN instead of fat-containing TPN. There are of course disadvantages to these interventions, such as drug interactions, longer clearance time and higher incidence of delirium when giving midazolam compared to propofol, hypoglycemia when giving a continuous insulin drip in high doses and giving a lower amount of calories to a patient who will receive TPN without lipids.\n\nThere are many studies that examined the administration of vitamin C to patients in intensive care, especially patients with sepsis, with varied but inconclusive results. A recently published meta-analysis found a reduction in mortality among critical intensive care patients treated with intravenous vitamin C, especially in the subgroup of critically ill patients with a high risk of in-hospital mortality. The drug was found to be safe for use among patients in intensive care. In these patients in the various studies, vitamin C treatment was given intravenously in different doses, with most patients receiving a dose of 6 grams per day for 3-5 days. In light of a trend about five years ago that showed an improvement in survival among septic patients in intensive care who were treated with intravenous vitamin C as monotherapy, or in combination with steroids and\u002For intravenous thiamine, also in the intensive care unit at our institution (as well as in other hospitals) we started giving this treatment, at the recommended dose of 6 grams per day for 3-5 days. Over time, new studies did not find clear benefits for this treatment, so we gradually stopped giving it. However, if indeed vitamin C can contribute to a significant decrease in TG levels in patients in intensive care, there may be a point in administering it to a group of patients with high TG levels, in order to reduce complications associated with a high TG level and\u002For treatment to reduce it.",[391],"Hypertriglyceridemia",{"date":275,"type":30},{"date":394,"type":30},"2024-05-01",{"date":396,"type":21},"2027-02-01",{"name":36,"class":37},{"id":399,"slug":400,"hasResults":12,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":405,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":407,"conditions":408,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":410,"startDateStruct":411,"completionDateStruct":412,"leadSponsor":413,"locationsCount":38},"100527947","eltroxin-administration-to-patients-with-extremely-low-t4-values-in-the-intensive-care-unit-100527947","NCT06154382","Eltroxin Administration to Patients With Extremely Low T4 Values in the Intensive Care Unit","Eltroxin Administration to Patients With Extremely Low T4 Values in the Intensive Care Unit: Comparison Between Groups and Therapeutic Outcomes","Inclusion Criteria: All patients aged 18--99 who were admitted to the general intensive care unit from January 2016 to November 22, 2023 for any reason, and who during their hospitalization in the intensive care unit had lower than normal T4 levels measured. It is about 350 patients. Of these, we will specifically examine the group of patients for whom an extremely low level of T4 was measured (less than 50% of the lower limit of the norm).\n\n\\-\n\nExclusion Criteria: Patients who were known to have a chronic thyroid dysfunction prior to their hospitalization in the unit, patients who were regularly treated with eltroxin prior to their hospitalization\n\n\\-",{"count":406,"type":21},350,"Nonthyroidal illness (formerly called sick euthyroid syndrome) is a common condition in patients hospitalized in the intensive care unit, and it is caused by changes in the levels of thyroid hormones in the blood . These changes are correlated to the severity of the critical illness, morbidity and mortality. This condition is characterized by low serum T3 levels, high rT3 levels, normal or low T4 levels, and normal or low TSH levels. Previous studies have shown a relationship between NTIS (nonthyroidal illness) and poor therapeutic outcomes in patients admitted with sepsis, multi trauma, ARDS, acute respiratory failure, septic shock and mechanically ventilated patients in intensive care .\n\nIn general, the recommendation is not to routinely take blood tests to evaluate thyroid function in critical patients in the intensive care unit, unless they were previously known to have a thyroid disease or there is a clinical suspicion that such a disorder developed during hospitalization in the intensive care unit. Also, studies so far have not shown an advantage for eltroxin administration to intensive care patients with low T3 and\u002For T4 levels when the laboratory tests indicate NTIS. However, there is a specific group of patients, with NTIS and extremely low T4 levels (less than 50% of the lower limit of the normal range) who have a particularly high mortality rate in intensive care (over 85%) and in whom it has not been investigated whether the administration of eltroxin will improve the therapeutic outcomes ( , i.e. was such a low T4 level in them considered a marker for the severity of their general critical illness, or is it another disorder in itself, the treatment of which would benefit the patient) . We would like to examine whether the administration of eltroxin in this specific group of patients, which has not been studied so far, will be beneficial in improving the therapeutic outcomes",[409],"Thyroid; Functional Disturbance",{"date":275,"type":30},{"date":100,"type":30},{"date":173,"type":21},{"name":36,"class":37},{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":421,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":423,"conditions":424,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":426,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":38},"100510260","empiric-antibiotic-treatment-for-septic-patients-in-the-intensive-care-unit-100510260","NCT05924126","Empiric Antibiotic Treatment for Septic Patients in the Intensive Care Unit","Empiric Antibiotic Treatment for Septic Patients in the Intensive Care Unit: Appropriateness and Therapeutic Outcomes","Inclusion Criteria:\n\n* All patients admitted to the general ICU due to sepsis or septic shock between 1\u002F1\u002F20 and 31\u002F12\u002F20\n\nExclusion Criteria: Patients who were admitted due to other non-infectious etiologies\n\n\\-",{"count":422,"type":21},155,"Sepsis is one of the most common causes of ICU admission. About 5-15% of patients admitted to the hospital with an infection will have sepsis, and about 30-40% of them will have septic shock. About 34% of septic patients and about 53% of patients with septic shock will die within 28 days of admission. Broad-spectrum empiric antibiotic treatment (depending on the source of infection and patient risk factors) is one of the cornerstones of sepsis management. According to the recommendations of the surviving sepsis campaign, empiric antibiotic treatment should be given within one hour of the patient's arrival for patients with sepsis or septic shock. Administration of inappropriate antibiotics in the first 24 hours of admission was found in 34% of septic patients in various studies, and administration of inappropriate antibiotics (or when administered in delay) was found to be associated with increased morbidity and mortality.\n\nIn this study, we will assess the proportion of patients who were admitted to the ICU due to sepsis or septic shock and received empiric antibiotic treatment which, in retrospect, according to the growth in the cultures later on, was inappropriate. We will also assess the therapeutic results in these patients - mainly significant morbidity and mortality within 28 days, and compare them to the group of patients who received appropriate antibiotic therapy. We would also like to assess what were the possible reasons for inappropriate empiric antibiotic treatment, in order to draw conclusions to reduce the rate of these cases.",[425],"Septic Patients Admitted to the ICU",{"date":254,"type":30},{"date":428,"type":30},"2024-01-01",{"date":430,"type":21},"2025-09",{"name":36,"class":37},{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":438,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":439,"conditions":440,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":442,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":38},"100501341","patients-who-were-not-admitted-to-the-intensive-care-unit-characteristics-and-clinical-outcomes-retrospective-study-100501341","NCT05807997","Patients Who Were Not Admitted to the Intensive Care Unit: Characteristics and Clinical Outcomes. Retrospective Study","Inclusion Criteria:All patients aged 18--99 who were presented to the general intensive care unit from January 2018 to the end of December 2023 and were not admitted.\n\n\\-\n\nExclusion Criteria:None\n\n\\-",{"count":306,"type":21},"There is extensive medical literature supporting the contribution of intensive care physicians to improvement of clinical outcomes in patients treated in an intensive care unit (1-3). There are many reasons for this contribution, including adherence to evidence-based medical protocols, as well as collaboration between different medical specialties in patient care (4-7). Over the years, several criteria have been formulated for the admission of patients to intensive care (8) according to their medical condition, but there are other factors that influence the decision whether to admit patients to intensive care, not necessarily medical ones, such as the availability of beds in the unit and the availability of medical and nursing staff.\n\nThere are several studies that examined the characteristics and clinical outcomes of patients who were not admitted to the intensive care unit, for medical or paramedical reasons (9). We would like to retrospectively examine all patients in the last 5 years who were presented for admission to general intensive care from various departments in our institution but were not admitted, to characterize the reasons why they were not admitted, the clinical characteristics of the patients and their clinical outcomes.\n\nObjectives:\n\nMain objective:\n\nTo characterize the clinical outcomes of the patients who were presented for admission to general intensive care but were not admitted in the last 5 years.\n\nSecondary objectives:\n\nTo characterize the reasons why the patients were not admitted - medical and paramedical, and to examine the clinical characteristics of these patients (age, sex, background diseases and current disease.).\n\nDesign and methods:\n\nStudy design:\n\nThis is a retrospective study based on data collection.\n\nMethods and materials:\n\nCollecting information from computer systems regarding the patients who were presented by the various departments at the Meir Hospital in Kfar Saba for admission to the general intensive care unit and were not admitted, starting from the beginning of January 2018 until the beginning of January 2023. These are about 1000 patients. After the end of data collection in the study, the data will be typed anonymously into a dedicated Excel file. The patients will be identified according to the patient number in the study and the case number, without specifying identifying details.\n\nInclusion criteria:\n\nAll patients aged 18--99 who were presented to the general intensive care unit from January 2018 to the end of December 2023 and were not admitted.\n\nData collection:\n\nThe research will be conducted in the format of observational data collection from the patient files and from computerized systems (Camelion system and iMDsoft software).\n\nThe data collected in the study will be exposed to the research team only as long as the actual data collection is carried out. After the end of data collection in the study, the data will be typed anonymously into a dedicated Excel file. The patients will be identified according to the patient number in the study and the case number, without specifying identifying details.\n\nThe data to be collected: age, sex, underlying diseases, regular medications, duration of hospitalization, need for ventilation, number of days of ventilation, mortality within 28 days, APACHE-2 score, SOFA score, lactate level, need for pressors, need for dialysis or other RRT, The reasons for not being admitted to the intensive care unit.\n\nSize of the research group: about 1000 patients - this is the estimated number of patients in the time period detailed above.\n\nThe method of processing the results: all the demographic and in-hospital indicators will be tested statistically by a certified statistician depending on the type of data.",[441],"Refusal of ICU Admission",{"date":275,"type":30},{"date":444,"type":30},"2024-08-01",{"date":446,"type":21},"2025-07-01",{"name":36,"class":37},{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":12,"sex":16,"minAge":455,"maxAge":18,"enrollmentInfo":456,"targetDuration":4,"studyType":116,"phases":458,"briefSummary":459,"conditions":460,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":462,"startDateStruct":463,"completionDateStruct":464,"leadSponsor":466,"locationsCount":38},"100499522","preoperative-point-of-care-ultrasound-guided-fluid-optimization-and-intravenous-ondansetron-to-prevent-general-anesthesia-induced-hypotension-100499522","NCT05784350","Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesia-Induced Hypotension","Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesia-Induced Hypotension: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age \\> 18\n2. Elective, non-cardiac, non-obstetric surgery under general anesthesia\n3. American Society of Anesthesiologists physical status classification I - III\n\nExclusion Criteria:\n\n1. MAP below 60 mmhg prior to the induction of general anesthesia.\n2. Patients treated with angiotensin converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB) on the day of surgery.\n3. Patients with heart failure with ejection fraction (EF) \\\u003C 40%.\n4. Patients with documented acute or chronic renal failure.\n5. Patients with hepatic failure.\n6. Patients with neuraxial (spinal\u002Fepidural) anesthesia performed before induction of general anesthesia.\n7. Patients with suspected difficult airway.\n8. Patients with documented allergy to Ondansetron or prolonged QT-syndrome.\n\n   \\-","19 Years",{"count":457,"type":21},150,[118],"Hypotension is a common side-effect of general anesthesia induction and is related to adverse outcomes including significantly increasing risk of one-year mortality. Even short durations of intraoperative hypotension have been associated with acute kidney injury (AKI) and myocardial injury.Half of all the patients were fluid-responsive, pointing to volume status as a significant risk factor. Ultrasound measurements of inferior vena cava (IVC) diameter with respiration, including the maximal diameter of the IVC (dIVCmax) at the end of expiration during spontaneous respiration and the collapsibility index (CI), have been recommended as rapid and noninvasive methods for estimating volume status.\n\nIn attempt to prevent hypotension after spinal anesthesia induction, Ondansetron, a serotonin receptor antagonist, has been used effectively .\n\nResearch Question Can preoperative IVC-US guided fluid optimization and intravenous ondansetron reduce the incidence of general anesthesia-induced hypotension in adult patients undergoing elective non-cardiac non-obstetric surgery?",[461],"Intra-operative Hypotension",{"date":254,"type":30},{"date":363,"type":21},{"date":465,"type":21},"2028-05-01",{"name":36,"class":37},{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":474,"enrollmentInfo":475,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":477,"conditions":478,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":480,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":38},"100457088","automated-system-for-monitoring-urine-output-in-intensive-care-patients-100457088","NCT05232045","Automated System for Monitoring Urine Output in Intensive Care Patients","Automated System for Monitoring Urine Output in Intensive Care Patients: What Are the Advantages? Before-after Intervention Study","Inclusion Criteria: Patients aged 18-100, who were admitted to the General Intensive Care Unit in Meir Medical Center from January 2021 to January 2024, and had admission times longer than 48 hours.\n\n\\-\n\nExclusion Criteria: Patients without a urinary catheter, Patients with admission times less than 48 hours.\n\n\\-","100 Years",{"count":476,"type":21},1800,"Acute kidney injury is common among ICU-admitted patients, and is associated with increased morbidity and mortality. Early recognition is essential to prevent complications. In this study we aim to examine whether strict monitoring of urine output may reduce the incidence of acute kidney injury, allow for less positive fluid balance and reduce the clinical symptoms of fluid overload in ICU patients. Currently we monitor urine output using a Urinometer, with manual recording. From June 2022 we will begin routine use of an automated urine monitoring system in the ICU and test its effect on the parameters listed above. We will conduct a before-after retrospective intervention. The group of patients in whom the automated system will be used, from June 2022 to January 2024, will be the study group. The patients admitted to the ICU in the period between January 2021 and June 2022 will be the control group. We will include patients aged 18-100, who were admitted to the General Intensive Care Unit in Meir Medical Center from January 2021 to January 2024, and had admission time longer than 48 hours. Patients without a urinary catheter will not be included. The study will be conducted in the format of observational data collection from hospital files and computerized systems (Metavision system and Chameleon system). We estimate that we will include about 900 patients in the study group and about 900 in the control group. All demographic and inpatient data will be statistically examined by a qualified statistician depending on the type of data.",[479],"Acute Kidney Injury in the ICU",{"date":254,"type":30},{"date":482,"type":21},"2025-12",{"date":484,"type":21},"2026-06",{"name":36,"class":37},{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":112,"sex":84,"minAge":493,"maxAge":494,"enrollmentInfo":495,"targetDuration":4,"studyType":116,"phases":496,"briefSummary":497,"conditions":498,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":505,"locationsCount":262},"100420864","local-tranexamic-acid-during-vaginal-hysteractomy-to-reduce-blood-loss-100420864","NCT04760301","Local Tranexamic Acid During Vaginal Hysteractomy to Reduce Blood Loss","Local Tranexamic Acid During Vaginal Hysterectomy to Reduce Blood Loss","Inclusion Criteria:\n\n* 20-90 years old female patients going through vaginal hysterctomy\n\nExclusion Criteria:\n\n* massive bleeding during operation due to major vessles injury\n* known coagulopathies\n* sensitivity to tranexamic acid\n* medical need in tranexamic acid administration during operation due to bleeding","20 Years","90 Years",{"count":87,"type":21},[118],"Assessing the efficiency of Prophylactic use of local tranexamic acid during vaginal hysterectomy to reduce blood loss during operation",[499],"Blood Loss",{"date":501,"type":30},"2025-05-06",{"date":503,"type":30},"2021-02-16",{"date":484,"type":21},{"name":36,"class":37},""]