[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Memorial University of Newfoundland\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":100},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100600731","icansleep-smartphone-app-based-insomnia-treatment-for-cancer-survivors-100600731",false,"NCT07101302","iCANSleep: Smartphone App-Based Insomnia Treatment for Cancer Survivors","iCANSleep: A Randomized Controlled Trial of a Smartphone App-Based Insomnia Treatment for Cancer Survivors","iCANSleep","Inclusion Criteria:\n\n* Cancer survivors\n* Over 18 years of age\n* Lives in Canada\n* Understands English or French fluently\n* DSM-5 diagnosis of insomnia\n* ISI score of 8 or higher\n* Good performance status as indicated by a score of 0-2 on the Eastern Cooperative Oncology Group (ECOG) performance status scale\n* Access to internet connection\n* Ownership of smartphone\n* Fluency using mobile applications.\n* Individuals with non-hematological malignancies must show no evidence of cancer or clinically stable\u002Finactive disease for a minimum of 3 months prior to enrollment (for individuals with non-metastatic cancer) or be on a stable treatment regimen for the prior 3 months (for individuals with metastatic cancer) to ensure that insomnia is not a direct, acute response to cancer treatment.\n* Individuals with hematological malignancies must be in remission at the time of recruitment and have completed cancer treatments (e.g., transplant, chemotherapy, immunotherapy, radiotherapy) at least 3 months prior.\n\nExclusion Criteria:\n\n* Presence of a sleep disorder other than insomnia that is not adequately treated (e.g., untreated sleep apnea)\n* Presence of a psychological disorder that is currently untreated or would impair the ability to participate (e.g., bipolar disorder)\n* Major sensory deficit (e.g., blindness)\n* Previous experience receiving CBT-I.\n* The use of medications prescribed for sleep (e.g., hypnotics, sedatives, or antidepressants) will be tracked and adjusted for in the statistical analysis.","ALL","18 Years",{"count":20,"type":21},146,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators will answer the question of whether treating insomnia using the mobile-app-based intervention of Cognitive Behavioural Therapy for Insomnia (CBT-I) for cancer survivors (\"iCANSleep\") can improve symptoms of insomnia in Canadian cancer survivors compared to a waitlist control group. The investigators will recruit 146 people with insomnia who have completed cancer treatment at least 3 months prior to the study.",[27,28],"Insomnia","Cancer",[30,27,31],"Cancer Survivor","Mobile Application","RECRUITING","2026-02-18",{"date":35,"type":36},"2026-02-20","ACTUAL",{"date":38,"type":36},"2025-11-04",{"date":40,"type":21},"2026-11",{"name":42,"class":43},"Memorial University of Newfoundland","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100611791","randomized-control-trial-comparing-the-incidence-of-loop-formation-in-colonoscopy-techniques-100611791","NCT07245173","Randomized Control Trial Comparing the Incidence of Loop Formation in Colonoscopy Techniques","Randomized Control Trial Comparing the Incidence of Loop Formation in Water Infusion Versus Air Insufflation Colonoscopy Techniques","Inclusion Criteria:\n\n* Consenting patients who are undergoing a routine colonoscopy.\n* Ages between 18-80 years old.\n\nExclusion Criteria:\n\n* Refusal to participate\n* Inability to provide informed consent.\n* History of prior colonic surgery.\n* Poor bowel preparation.\n* Known bowel obstruction.\n* Emergency colonoscopy.",true,"80 Years",{"count":55,"type":21},142,[24],"A colonoscopy is a common procedure used to check for problems in the colon, such as disease or other health issues. Although it's widely used, one challenge is that the flexible tube used in the procedure (called a colonoscope) can sometimes form loops inside the colon. When this happens, pushing the tube further doesn't help it move forward-it just makes the loop bigger, which can make the procedure harder to complete. These loops can also cause more pain for the patient, require more sedation (medication to relax or put the patient to sleep), and increase the time it takes to finish the procedure. Because of this, it's important to find ways to reduce loop formation. Two common methods used in colonoscopies are called air insufflation and water infusion.\n\nThis study will compare the two methods-air vs. water-to see which one causes fewer loops. It will be a randomized controlled trial, meaning participants will be randomly assigned to one of the two methods. The study will involve real patients, and the data will be collected by physicians, residents (doctors in training), and medical students. During the colonoscopies, images from a tool that guides the scope will be recorded on video.\n\nExperienced staff doctors and surgical residents (with at least two months of special training in this procedure) will perform the colonoscopies. Each procedure will be supervised by a team member, such as a medical student, resident, or staff doctor. Afterward, two reviewers who don't know which method was used will watch the videos to look for any loops. They will look for specific types of loops, including n, alpha, reverse alpha, reverse splenic, and gamma loops.\n\nThe study will also track how long it takes to reach the end of the colon (called the cecum), how comfortable the patient was (using a standard rating system already used in all colonoscopies), and how much sedation was needed.",[59],"Colon Cancer Screening","NOT_YET_RECRUITING","2025-11-20",{"date":63,"type":36},"2025-11-24",{"date":65,"type":21},"2026-01-01",{"date":67,"type":21},"2027-09-30",{"name":42,"class":43},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},"100575092","morbid-obesity-and-severe-knee-osteoarthritis---which-should-be-treated-first-100575092","NCT06767787","Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?","Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? A Randomized Cross-over Study","Inclusion Criteria:\n\n* BMI \\> or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy\n\nExclusion Criteria:\n\n* a history of revision surgery, surgery for neoplastic disease, significant mental illness, ASA class \\> 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.","65 Years",{"count":55,"type":21},[24],"The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.\n\nParticipants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. Quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.",[81,82,83],"Osteoarthritis of Knee","Arthroplasties, Knee Replacement","Sleeve Gastrectomy",[85,86,87,88,89,90],"knee osteoarthritis","bariatric surgery","laparoscopic sleeve gastrectomy","knee replacement","knee arthroplasty","obesity","2025-01-28",{"date":93,"type":36},"2025-01-30",{"date":95,"type":21},"2025-02",{"date":97,"type":21},"2027-01",{"name":42,"class":43},2,""]