[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":299},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,50,82,120,144,172,202,227,250,270],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100624011","epigenetic-enhancement-of-cognitive-training-in-aging-mood-disorder-populations-100624011",false,"NCT07404085","Epigenetic Enhancement of Cognitive Training in Aging Mood Disorder Populations","Epigenetic Priming to Enhance Cognitive Training Gains and Neuroplasticity in Middle-age and Older Adults With Past Depression or Bipolar Disorder (EPIC)","EPIC","Inclusion Criteria:\n\n* Confirmed ICD-10 diagnosis of BD or recurrent UD in partial, or full remission (Hamilton Depression Rating Scale-17 items and Young Mania Rating Scale scores ≤14)\n* Subjective cognitive complaints (self-reported: COBRA ≥12) or objectively-verified cognitive impairment (measured using Screening for Cognitive Impairment in Psychiatry SCIP: total score or at least two subscores ≥ 0.5 SD below expected norms)\n* Fluency in Danish language\n\nExclusion Criteria:\n\n* Diagnosis of schizophrenia\n* Neurological disorders (including dementia)\n* Dyslexia\n* Severe Physical illness\n* Kidney disease\n* Cardiovascular disease\n* Diabetes\n* Alcohol or substance abuse\n* Previous severe head trauma\n* History of epilepsy\n* Pregnancy or breastfeeding\n* BMI \\>30\n* Bodyweight \\\u003C 45kg\n* Daily use of benzodiazepines \\> 22.5 mg. oxazepam or \\> 7.5 mg. diazepam per day\n* Serum lithium levels \\> 0.8 mmol\u002FL\n* Received electroconvulsive therapy \\\u003C 2 months prior to participation\n* Hypertension (\\>140 systolic or \\> 90 diastolic mm Hg)","ALL","40 Years","75 Years",{"count":21,"type":22},160,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi) sodium butyrate on cognition in symptomatically stable patients with mood disorders (depression or bipolar disorder).\n\nThe investigators hypothesize that the VR-based cognitive remediation training (VR-CRT) combined with HDACi butyrate vs. a VR-based control treatment combined with placebo will improve global cognition (primary outcome measure) over three weeks.\n\nSecondly, the investigators hypothesize that VR-CRT with placebo will improve cognition relative to the VR control treatment with placebo, although to a lesser extent than VR-CRT with HDACi butyrate.\n\nThirdly, the investigators hypothesize that the HDACi butyrate with VR control treatment will not produce cognitive improvements relative to placebo with VR control treatment.\n\nFinally, the investigators hypothesize that the combined treatment (VR-CRT + HDACi butyrate) will enhance neuroplasticity (exploratory outcome) vs. VR control with placebo, as indicated by increase in hippocampal volume and\u002For memory-related activity shown with structural and functional MRI.",[28,29,30],"Bipolar Disorder (BD)","Depression - Major Depressive Disorder","Cognitive Impairment",[32,33,34,35,36],"Cognition","Cognitive impairment","Mood disorders","Cognitive decline","Neuroplasticity","RECRUITING","2026-02-04",{"date":40,"type":41},"2026-02-11","ACTUAL",{"date":43,"type":41},"2025-11-14",{"date":45,"type":22},"2028-07-01",{"name":47,"class":48},"Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":49},"100516483","a-randomized-clinical-trial-comparing-active-versus-sham-t-pemf-headband-treatment-for-depression-100516483","NCT06005103","A Randomized Clinical Trial Comparing Active Versus Sham T-PEMF Headband Treatment for Depression","Active Versus Sham Transcranial Pulsed Electromagnetic Field Headband Treatment for Major Depression: a Study Protocol for a Double-blinded Randomized Trial","Inclusion Criteria:\n\n* Meeting the diagnostic criteria for moderate to severe depressive episode without psychotic symptoms according to the International Classification of Diseases and Related Health Problems 10th Revision (ICD-10)(The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research 1993).\n* Female participants: Females in the fertile age must deliver a negative pregnancy test, or previously have been sterilized.\n* Female fertile participants: They must use safe contraceptive methods to be included in the study, and during the whole study.\n* Has given written, informed consent to the trial.\n\nExclusion Criteria:\n\n* Inability to speak or understand the Danish language.\n* A current high risk of suicide (a score of 2 or more on the HAM-D-17 item 3).\n* A co-morbid substance dependence.\n* Bipolar affective disorder.\n* Psychotic illness.\n* Dementia.\n* Other diagnoses of organic brain disease.\n* The participant has any kind of implant, e.g. pacemakers or cochlear implants.\n* Female participants: Pregnancy","18 Years","65 Years",{"count":60,"type":22},117,[25],"An 8-week, two-armed, randomized-controlled trial that examines the antidepressant effect of treatment with transcranial pulsed electromagnetic fields (T-PEMF) in patients diagnosed with moderate to severe depression using using a new device, the MoodHeadBand (MHB).\n\nThe participants will use an active or placebo MHB for 30 minutes daily for 8 weeks.\n\nAdditionally, the following research questions will be answered:\n\n1\\. If there is a positive effect on the patients' emotional and non-emotional cognition after 8 weeks of active treatment compared to the sham group and if possible early changes in the emotional cognition can predict the treatment response after 8 weeks of treatment.\n\n1\\. If the T-PEMF treatment provides improvement in restorative sleep after 8 weeks of treatment",[64,65,66,67],"Moderate Depression","Severe Depressive Episode Without Psychotic Symptoms","Recurrent Depressive Disorder, Current Episode Moderate","Recurrent Depressive Disorder, Current Episode Severe Without Psychotic Symptoms",[69,70,71,72,32,73],"Randomized Controlled Trial","Depression","Transcranial Pulsed Electro-Magnetic Fields (T-PEMF)","Psychiatry","Sleep","2025-08-19",{"date":76,"type":41},"2025-08-26",{"date":78,"type":41},"2024-06-17",{"date":80,"type":22},"2026-08-30",{"name":47,"class":48},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":104,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},"100540305","a-transdiagnostic-mentalization-based-intervention-for-parents-with-mental-disorders-100540305","NCT06315114","A Transdiagnostic Mentalization-based Intervention for Parents With Mental Disorders","A Transdiagnostic Mentalization-based Intervention (LIGHTHOUSE Parenting Program) Versus Care as Usual for Parents With Mental Disorders in Adult Mental Health Service: a Randomised Clinical Trial","LIGHTHOUSE","Inclusion Criteria exclusive to the Outpatient Clinic\n\n* Age \\>18 years\n* Seeking treatment for one of the following non-psychotic disorders according to ICD-10: obsessive-compulsive disorder and anxiety disorders (F40-42), posttraumatic stress disorder (DF43), personality disorders (F60-61), or one of the previous disorders and a drug-or alcohol related disorder (F10-19) (i.e. 'dual diagnosis disorder')\n\nInclusion Criteria exclusive to the trial:\n\n* Parent of at least one child aged 0-17 years of age at baseline\n* Fluent i.e., sufficient Danish language skills\n* Parent is living with child or is in regular contact (min. 5 days monthly)\n* Written informed consent\n\nExclusion Criteria exclusive to the Outpatient Clinic:\n\n* Possibility of a learning disability (IQ\\\u003C75)\n* A diagnosis of schizotypal personality disorder or antisocial personality disorder\n* Presence of a comorbid psychiatric disorder that requires specialist treatment elsewhere\n* Concurrent psychotherapeutic treatment outside the clinic\n\nExclusion Criteria exclusive to the trial:\n\n* Acute suicidal risk or state of crises\n* Lack of informed consent\n* Acute child endangerment\n* Participation in another parenting focused intervention simultaniously",{"count":91,"type":22},170,[25],"The aim of this randomised clinical trial is to evaluate the short and longterm effects of a transdiagnostic mentalization-based intervention (Lighthouse MBT Parenting Program) compared to care as usal (CAU) for parents with a mental disorder in adult mental health service.",[95,96,97,98,99,100,101,102,103],"Mental Disorder","Behavior Disorders","Diagnosis, Psychiatric","Diagnosis Dual","Severe Mental Disorder","Mental Illness","Psychiatric Disorder","Psychiatric Disease","Psychiatric Illness",[105,106,107,108,109,110],"Mental disorder","Parent","Child","Preventive intervention","Prevention","Intergenerational transmission","2025-05-09",{"date":113,"type":41},"2025-05-14",{"date":115,"type":41},"2024-03-11",{"date":117,"type":22},"2028-04-01",{"name":47,"class":48},2,{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":49},"100574163","patient-engagement-in-ptsd-treatment-pep-100574163","NCT06755710","Patient Engagement in PTSD Treatment (PEP)","Patient Engagement in PTSD Treatment (PEP) - Advancing PTSD Treatment Outcomes","PEP","In- and exclusion criteria of the randomised controlled trial for Psychotherapeutic Unit\n\nInclusion Criteria:\n\n* Adults (18 years or older)\n* PTSD pursuant to the ICD-10 research criteria\n* Signed informed consent\n* patients referred to \"Main Level\" treatment\n\nExclusion Criteria:\n\n* Severe psychotic disorder (defined as patients with an ICD-10 diagnosis F2x and F30.1-F31.9). Participants are excluded only if the psychotic experiences are assessed to be part of an independent psychotic disorder and not part of a severe PTSD and\u002For depression.\n* Dependence syndrome of drugs or alcohol: Active dependence and use (F1x.24-F1x.26).\n\nIn- and exclusion criteria of the randomised controlled trial for Competencecenter of Transcultural Psychiatry:\n\nInclusion criteria:\n\n* Adult (18 years or older)\n* Refugees or persons who have been family reunified with a refugee\n* PTSD pursuant to the ICD-10 research criteria\n* Psychological trauma experienced outside Denmark in the anamnesis. Trauma is imprisonment or detention with torture (according to the United Nations' definition of torture) or acts of cruel, inhuman and degrading treatment or punishment. Trauma can also be organised violence, long-term political persecution and harassment, or war and civil war experiences.\n* Signed informed consent\n\nExclusion criteria:\n\n* Severe psychotic disorder (defined as patients with an ICD-10 diagnosis F2x and F30.1-F31.9). Participants are excluded only if the psychotic experiences are assessed to be part of an independent psychotic disorder and not part of a severe PTSD and\u002For depression.\n* Dependence syndrome of drugs or alcohol: Active dependence and use (F1x.24-F1x.26).",{"count":129,"type":22},427,[25],"The goal of this clinical study is to improve the outcome of outpatient PTSD treatment at two clinics treating majority ethnic Danes and refugees with PTSD respectively. The study will consist of two similar randomized controlled trials.\n\nThe main questions the study aims to answer are:\n\n* Does an added motivation enhancement module as a precursor for PTSD treatment reduce dropout and increase treatment outcome?\n* Does an added Shared Decision-Making session which facilitate individualized treatment yield a superior outcome compared to PTSD treatment and PTSD treatment supplemented by motivation enhancement?\n\nParticipants are recruited at two different clinics, Psychotherapeutic Unit (PU) and Competence Centre for Transcultural Psychiatry (CTP). At PU the participants are randomized to one of two arms, and at CTP to one of three arms. One arm is the control group where participants will receive treatment as usual (TAU), one arm is the first intervention group where the participants will receive an Introductory PTSD module consisting of four sessions focusing on enhancing motivation for PTSD treatment, before continuing in TAU. The last arm is the second intervention group, which will only take place at CTP. Here the patient will receive the Introductory PTSD module followed by a session of Shared Decision Making, where the participant together with the MD decides which of four standardized treatment courses they will receive.\n\nThe treatment for all patients will last between 8-13 months.",[133,134,135],"PTSD","Depression Disorders","Patient Engagement","2025-04-08",{"date":138,"type":41},"2025-04-09",{"date":140,"type":41},"2025-01-02",{"date":142,"type":22},"2028-08-31",{"name":47,"class":48},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":17,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},"100453064","teens-multi-site-trial-100453064","NCT05179655","TEENS Multi-site Trial","Inclusion Criteria:\n\n* ≥ 5 non-suicidal self-injury episodes in the past year and ≥ 1 non-suicidal self-injury episodes in the past month assessed by the Deliberate Self-Harm Inventory, Youth version (DSHI-Y).\n* Age-appropriate literacy assessed by referring clinicians and the self-injury team, i.e. age between 13 and 17.\n* Having at least one parent committing to participate in the parent program.\n* Informed consent from parents\u002Flegal caretakers and assent from participants above 15 years of age.\n\nExclusion Criteria:\n\n* Imminent suicidal risk assessed by clinicians during routine screening procedure (that can be rated as no risk, elevated risk, or imminent risk) in need of admission or other life saving strategies.\n* Lack of informed consent from parents\u002Flegal caretakers.\n* Lack of informed assent from the participant above 15 years of age.","13 Years","17 Years",{"count":153,"type":22},356,[25],"Emotion Regulation Individual Therapy for Adolescents, also called ERITA, is a youth friendly online therapy aiming to provide skills and train emotion regulation.\n\nThe aim of the TEENS Multi-site Trial is to investigate the effect of ERITA, including an app, as add-on to treatment as usual in young patients referred to Mental Health Services. We expect 356 families to participate from three designated Regions in Denmark.",[157],"Self-Injurious Behavior",[159,160,161,162],"Internet-based intervention","Online therapy","Emotion regulation","ERITA","2025-03-07",{"date":165,"type":41},"2025-03-10",{"date":167,"type":41},"2022-02-01",{"date":169,"type":22},"2026-12-31",{"name":47,"class":48},4,{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":179,"maxAge":151,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":183,"conditions":184,"keywords":188,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":49},"100540097","the-via-family-20---a-family-based-intervention-for-families-with-parental-mental-illness-100540097","NCT06312410","The VIA Family 2.0 - a Family Based Intervention for Families with Parental Mental Illness","The VIA Family 2.0 Study: a Randomized Clinical Trial Evaluating Family-based Interventions for Children Born to Parents with Mental Disorders","Inclusion Criteria:\n\n* At least one of the parents must be living in Capital Region or in Region North, Denmark, and at least one biological child under age 18 must be living with one of the parents. Only biological children of the parent with at mental health problem can be included.\n* The parent with the mental health problems has at some point been diagnosed in the secondary sector and has within the last three years been treated in the primary sector (GP or private psychiatric clinic) or in the secondary sector (hospital psychiatry).\n* Patients with substance abuse can only be included if substance abuse is a secondary diagnosis to another mental illness disorder being treated within the secondary sector during the last three years.\n* All adult participants must give informed consent. Both parents will need to consent in case of shared custody, but do not have to participate if they are reluctant to do so.\n\nExclusion Criteria:\n\n* Not fulfilling inclusion criteria\n* Not giving informed consent\n* Living at Læsø or at Bornholm, Denmark\n* Children placed in care outside of the home fulltime in institution of professional family care (the family is not excluded if the children placed in part time in care outside home or fulltime family care within the family)\n* No risk factors found after baseline assessment (as described in the stepped care model) at baseline - these families can be re-referred if their situation changes.\n* Ongoing intensive family treatment in the municipality (for example staying at an institution for parental evaluation by the authorities)?","0 Years",{"count":181,"type":22},1452,[25],"VIA Family 2.0 - a Family Based Intervention for families with parental mental illness\n\nBackground: Children born to parents with mental illness have consistently been shown to have increased risks for a range of negative life outcomes including increased frequencies of mental disorders, somatic disorders, poorer cognitive functioning, social, emotional and behavioral problems and lower quality of life. Further these children are often overlooked by both society and mental health services, although they represent a potential for prevention and early intervention.\n\nA collaboration between researchers and clinicians from two regions, the Capital Region and the North Region Denmark has been established as the Research Center for Family Based Interventions. The research center is an umbrella for a series of research activities, all focusing on children and adolescents in families with parental mental illness.\n\nMethod: A large randomized, controlled trial (RCT) for families with parental mental illness will be conducted in order to evaluate the effect of a two-year multidisciplinary, holistic team intervention (the VIA Family 2.0 team intervention) against treatment as usual (TAU). Inclusion criteria will be biological children 0-17 of parents with any mental disorder treated in the secondary sector at any time of their life and receiving treatment in primary or secondary sector within the previous three years. A total of 870 children or approx. 600 families will be included from two sites. Primary outcomes will be changes in child well being, parental stress, family functioning and quality of the home environment, .\n\nTime plan: The RCT will start including families from March 1st, 2024 to Dec 2025 (or later if needed). All families will be assessed at baseline and at end of treatment, i.e. after 24 months and after 36 months. Baseline data will inform the intervention team about each family's needs, problems, and motivation. TAU will be similar in the two regions, which means three family meetings and option for children to participate in peer groups.\n\nChallenges: final funding is being applied for. Recruitment of families can be challenging but we have decades of experience in conducting research in the field. Since both the target group, their potential problems and the intervention is complex, primary outcome is difficult to determine.",[107,185,95,186,187],"Parents","Child of Impaired Parents","Preventive Health Services",[189,190,191,192,193],"family based intervention","early intervention","familial high risk","COPMI - children of parents with mental illness","parental mental illness","2024-10-23",{"date":196,"type":41},"2024-10-26",{"date":198,"type":41},"2024-03-18",{"date":200,"type":22},"2028-12-31",{"name":47,"class":48},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":17,"minAge":210,"maxAge":151,"enrollmentInfo":211,"targetDuration":4,"studyType":213,"phases":4,"briefSummary":214,"conditions":215,"keywords":217,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":49},"100512739","effectiveness-of-family-based-intervention-for-youn-persons-with-eating-disorders-100512739","NCT05956366","Effectiveness of Family-based Intervention for Youn Persons With Eating Disorders","Effectiveness of Family-based Intervention in a Child and Adolescent Mental Health Service for Children and Adolescents With Eating Disorders","VIBUS-wp1","Inclusion Criteria:\n\n* begin treatment for eating disorder\n\nExclusion Criteria:\n\n* lack of informed consent","7 Years",{"count":212,"type":22},1000,"OBSERVATIONAL","This research project aims to characterize a naturalistic cohort of children and adolescents with eating disorders in terms of biological, psychological and psychopathological features. Further, the project will examine the effectiveness of treatment, the determinants of treatment outcome and the course of treatment response for children and adolescents with eating disorders (ED), treated in a generic specialist child and adolescent mental health service. The first choice of treatment is outpatient family-based treatment (FBT), which has documented effect for anorexia nervosa and bulimia nervosa. However, a subgroup of young persons with eating disorders does not respond sufficiently to this treatment, and evidence concerning effective treatment for children and adolescents with atypical eating disorders is still lacking. Further, treatment effectiveness for children and adolescents in a Danish naturalistic setting has never been examined.",[216],"Eating Disorders",[218],"eating disorders, adolescents","2024-04-02",{"date":221,"type":41},"2024-04-03",{"date":223,"type":41},"2018-04-01",{"date":225,"type":22},"2037-12-31",{"name":47,"class":48},{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":49},"100504716","rufus---group-rumination-focused-cbt-for-negative-symptoms-100504716","NCT05851950","RUFUS - Group Rumination-focused CBT for Negative Symptoms","RUFUS - a Randomized Mixed Methods Pilot Clinical Trial Investigating the Relevance and Feasibility of Rumination-focused Cognitive Behavioral Therapy in the Treatment of Patients With Emergent Psychosis Spectrum Disorder","RUFUS","Inclusion Criteria:\n\n1. Diagnosed with a psychosis spectrum disorder (ICD-10 F2x)\n2. At least 8 months left of their OPUS treatment\n3. The presence of rumination behavior as assessed by a score of minimum 30 on the Perseverative Thinking Questionnaire (PTQ)\n4. Danish-speaking\n\nExclusion Criteria:\n\n1. Substance abuse or positive symptoms that make participation in therapy difficult\n2. Severe suicidal thoughts\u002Fbehavior\n3. Lacks capacity to consent\n4. Mild, moderate, or severe intellectual disability (IQ ˂ 70)\n5. Planned adjustment of antidepressant and\u002For antipsychotic treatment (noted in the patient's medical record)","37 Years",{"count":237,"type":22},60,[25],"Abstract - --\n\nIntroduction:\n\nPsychosis spectrum disorders are characterized by both positive and negative symptoms, but whereas there is good effect of treatment on positive symptoms, there is still a scarcity of effective interventions aimed at reducing negative symptoms. Rumination has been proposed as an important and fundamental factor in the development and maintenance of symptoms across psychiatric diagnoses, and there is a need to develop effective interventions targeting rumination behaviors and negative symptoms in patients with psychotic disorders. The aim of the current study is to investigate the feasibility and acceptability of group rumination-focused cognitive behavioral therapy (RFCBT) in the treatment of young people with psychosis spectrum disorders as well as investigating potential indications of treatment efficacy.\n\nMethods and analysis: The study is a mixed-method clinical randomized controlled pilot trial with a target sample of 60 patients, who are randomized to either receive 13 weeks of group CFCBT or 13 weeks of treatment as usual (TAU). All patients are examined at the start of the project and at the 13-week follow-up. The researcher will compare changes in outcomes from baseline to posttreatment between group CFCBT and TAU. In addition, qualitative analyzes are carried out to explore feasibility and acceptability and to uncover the patients' experience of receiving the intervention.",[241],"Psychotic Disorders","2023-10-20",{"date":244,"type":41},"2023-10-23",{"date":246,"type":41},"2023-08-01",{"date":248,"type":22},"2026-07-01",{"name":47,"class":48},{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":23,"phases":259,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":269,"locationsCount":49},"100380194","effects-of-smartphone-based-treatment-for-bipolar-disorder---the-smart-bipolar-100380194","NCT04230421","Effects of Smartphone-based Treatment for Bipolar Disorder - the Smart Bipolar","Effects of Smartphone-based Treatment for Bipolar Disorder - the Smart Bipolar RCT","Inclusion Criteria:\n\n* All patients in CAG Bipolar, i.e., with a main diagnosis of bipolar disorder in the five large centers, in the Mental Health Services, Capital Region of Denmark (Psychiatric Center Copenhagen, Psychiatric Center Hilleroed, Psychiatric Center Amager, Psychiatric Center Glostrup and Psychiatric Center Ballerup)\n\nExclusion Criteria:\n\n* None",{"count":258,"type":22},200,[25],"The Smart Bipolar RCT is a pragmatic RCT aiming to investigate effects of smartphone-based add on treatment in large scale clinical practice (N= 200 patients).",[262],"Bipolar Disorder","2023-06-06",{"date":265,"type":41},"2023-06-07",{"date":267,"type":41},"2021-03-01",{"date":248,"type":22},{"name":47,"class":48},{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":277,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":278,"targetDuration":4,"studyType":213,"phases":4,"briefSummary":279,"conditions":280,"keywords":285,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":49},"100302971","prospective-longitudinal-all-comer-inclusion-study-in-eating-disorders-100302971","NCT03224091","PROspective Longitudinal All-comer Inclusion Study in Eating Disorders","PROLED","Inclusion Criteria:\n\n* Eating Disorder (ICD-10)\n\nExclusion Criteria:\n\n* Forced care\u002Fnon-voluntary",true,{"count":212,"type":22},"The PROLED study is a prospective and longitudinal study of patients with Eating Disorders. Annual interviews and collection of biological samples are done, as well as during changes in disease course e.g. during hospitalization. Included are qualitative interviews, psychometric tests, questionnaires which are used to collect data on psychopathology. There is also collection of blood, urine and faeces.",[281,282,283,284],"Anorexia Nervosa","Bulimia Nervosa","Binge-Eating Disorder","Eating Disorder NOS",[286,287,288,289,290],"Eating disorders","psychopathology","pathophysiology","prospective","longitudinal","2022-04-06",{"date":293,"type":41},"2022-04-07",{"date":295,"type":41},"2016-01-25",{"date":297,"type":22},"2030-04-01",{"name":47,"class":48},""]