[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Michael Garron Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":75},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100613450","phase-4-comparison-of-oral-antibiotics-for-bone-infections-of-the-leg-and-foot-100613450",false,"NCT07266753","Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot","Oral Beta-lactams Versus Non-beta-lactamS for Treatment of Lower Extremity Osteomyelitis","OSTEO","Inclusion Criteria:\n\n1. Adult (\\> 18 years old)\n2. OM of the lower extremity (below the knee) as determined by the treating healthcare provider (clinically and\u002For radiographically)\n3. Expected duration of treatment at least 28 additional days of antibiotic therapy for the infection episode, from the time of enrolment\n4. Treating health care team has already transitioned or is willing to transition to oral antibiotic therapy for the remainder of the treatment duration\n\nExclusion Criteria:\n\n1. Prior enrolment in the OSTEO trial\n2. Already received more than 14 days of uninterrupted antibiotic treatment for this episode of OM\n3. No beta-lactam or non-beta-lactam option due to any of:\n\n   1. Allergy\n   2. Suspected or confirmed antimicrobial resistance\n   3. Medical contraindications\n   4. Non-modifiable drug-drug interaction risk\n4. Need to receive combination antibiotic therapy with both beta-lactam and non-beta-lactam, with the exception of metronidazole and rifampin\n5. Prior antibiotic treatment for the same infection in the past 6 months\n6. Known pregnancy, planning to become pregnant during the study period, or breastfeeding","ALL","18 Years",{"count":20,"type":21},1418,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot. The hypothesis is that oral beta-lactam antibiotics work as well as oral non-beta-lactam antibiotics to treat these infections. The first step is to assess whether it is possible to perform the trial by determining whether participants can be recruited and followed successfully. If the trial is proven to be possible, it will be expanded to ensure an answer to whether the two antibiotic classes work as well for the treatment of bone infections of the leg and foot.",[27,28,29],"Osteomyelitis of Lower Extremities","Osteomyelitis - Foot","Osteomyelitis of the Foot",[31,32,33,34],"Osteomyelitis","Bone Infection","Lower Extremity","Oral beta-lactams versus non-beta-lactams","RECRUITING","2026-03-23",{"date":38,"type":39},"2026-03-27","ACTUAL",{"date":41,"type":39},"2026-02-26",{"date":43,"type":21},"2033-12-31",{"name":45,"class":46},"Michael Garron Hospital","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":5},"100566842","respiratory-outbreak-mitigation-in-long-term-care-using-point-of-care-testing-100566842","NCT06660433","Respiratory Outbreak Mitigation in Long-Term Care Using Point-of-Care Testing","imProving Respiratory Outbreak Mitigation Through Point-of-care Testing in Long Term Care (PROMPT-LTC): A Cluster Randomized Trial","PROMPT-LTC","Inclusion Criteria:\n\n\\- Long-term care facility engaged with an Ontario Health Team overseen by Sunnybrook Health Science Centre, Michael Garron Hospital or Humber River Health\n\nExclusion Criteria:\n\n* No signed statement of agreement for study participation\n* Pre-existing use of a point-of-care testing platform",{"count":57,"type":21},24,[59],"NA","Outbreaks of seasonal respiratory viruses can spread rapidly in long-term care homes. Timely results for diagnostic tests remains a challenge for respiratory viruses due to the logistics of using a reference laboratory with delays leading to missed opportunities to implement virus-specific control measures to interrupt transmission resulting in larger outbreaks. Use of a point-of-care testing platform is a potential solution that provides faster results, but it is uncertain whether this translates into benefits for long-term care residents. This trial aims to assess whether rapid test results for respiratory pathogens (Influenza, Coronavirus disease of 2019 (COVID-19) and Respiratory Syncytial Virus) can impact the number and size of respiratory virus outbreaks in long-term care homes.",[62],"Outbreaks",[64,65,66],"respiratory virus outbreaks","outbreak mitigation","long-term care home","2025-11-24",{"date":69,"type":39},"2025-12-02",{"date":71,"type":39},"2024-11-11",{"date":73,"type":21},"2026-03-31",{"name":45,"class":46},""]