[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Michigan State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":713},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,48,78,114,151,181,210,232,265,292,325,348,370,389,418,441,478,501,534,561,584,603,624,656,688],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100633441","adapting-cbt-for-pediatric-functional-abdominal-pain-in-primary-care-100633441",false,"NCT07526727","ADAPTing CBT for Pediatric Functional Abdominal Pain in Primary Care","Pilot Testing a Cognitive Behavioral Program Addressing Pediatric Functional Abdominal Pain in Primary Care Settings","ADAPT-PCP","Inclusion Criteria:\n\n* FAPD diagnosis\n* Ages 9-14 years\n* Functional disability score of 7 or greater\n\nExclusion Criteria:\n\n* \\\u003C9 years or \\>14 years\n* Known developmental disability, sensory, or cognitive impairments that limit youths' ability to engage with behavioral programming\n* Unmanaged psychiatric illness (e.g., psychosis, active suicidal ideation, severe depression as indicated in electronic medical records)\n* Symptoms directly attributable to a physical health concern (e.g., cancer, cystic fibrosis, inflammatory bowel disease).\n* Lack of English proficiency","ALL","9 Years","14 Years",{"count":22,"type":23},15,"ESTIMATED","INTERVENTIONAL",[26],"NA","Many youth experience ongoing stomach pain that does not have a clear medical cause. These conditions, called functional abdominal pain disorders, are common and can last for years. They often interfere with school attendance, daily activities, and social life, and are frequently linked with anxiety. Families may go through many medical tests and appointments without finding relief. The investigator's research shows that teaching these children coping skills, like relaxation, problem solving, and managing anxious thoughts, can reduce pain and improve functioning. The Aim to Decrease Anxiety and Pain Treatment (ADAPT) is a brief program, using cognitive behavioral strategies and mindfulness, the investigators developed that helps children. ADAPT has been shown to work well in specialty clinics, but most children with stomach pain are first seen in primary care, where this type of support is not usually available. The purpose of this project is to test ADAPT in pediatric primary care and test whether it can be delivered successfully. The goal is to improve access to care, reduce symptoms, and better support children.",[29],"Abdominal Pain",[31,32,33,34,35],"functional abdominal pain disorders","pediatrics","cognitive behavioral","mindfulness","primary care","NOT_YET_RECRUITING","2026-06-25",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":23},"2026-08",{"date":44,"type":23},"2026-12",{"name":46,"class":47},"Michigan State University","OTHER",{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},"100589215","how-simplified-language-affects-comprehension-and-learning-in-young-children-with-down-syndrome-100589215","NCT06951516","How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome","How Single-Word and Telegraphic Simplification Affects Language Processing and Word Learning in Young Children With Down Syndrome","Inclusion Criteria:\n\n* Down syndrome\n\nEnglish as primary language\n\n2-7 years old\n\nExclusion Criteria:\n\n* Acquired brain injury\n\nCerebral palsy\n\nUncorrected vision or hearing impairment","2 Years","7 Years",{"count":58,"type":23},30,[26],"The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS). The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with DS (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplification affects language processing. 2) Determine how single-word and telegraphic simplification affects word learning. 3) Evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. Aim 1 will test the hypothesis that children with DS will process grammatical utterances faster and more accurately than telegraphic or single-word utterances. Aim 2 will test the hypothesis that overall, children will demonstrate better word learning in the grammatical compared to the single-word and telegraphic conditions. Aim 3 will test the hypothesis that receptive language and nonverbal cognitive abilities will be significant moderators, such that children with stronger linguistic and cognitive skills will show the greatest benefit from grammatical input but children with lower linguistic and cognitive scores will perform similarly across conditions.",[62],"Down Syndrome",[64,65,66,67],"Down syndrome","language development","language processing","language input","RECRUITING","2026-06-11",{"date":71,"type":40},"2026-06-12",{"date":73,"type":40},"2025-01-01",{"date":75,"type":23},"2027-05-31",{"name":46,"class":47},1,{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":12,"sex":18,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":24,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":113,"locationsCount":77},"100493651","how-simplified-language-affects-comprehension-and-learning-in-young-autistic-children-100493651","NCT05707923","How Simplified Language Affects Comprehension and Learning in Young Autistic Children","How Single-Word and Telegraphic Simplification Affects Language Processing and Word Learning in Young Children With Autism Spectrum Disorder","PALS","Inclusion Criteria:\n\n* Existing or suspected autism spectrum disorder, confirmed through ADOS-2\n* English as primary language\n* 1-4 years old\n\nExclusion Criteria:\n\n* Known genetic condition (e.g., Down syndrome, fragile X)\n* Cerebral palsy\n* Acquired brain injury\n* Uncorrected vision or hearing impairment","1 Year","4 Years",{"count":89,"type":23},104,[26],"The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with ASD. The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with ASD (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplification affects language processing. 2) Determine how single-word and telegraphic simplification affects word learning. 3) Evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. Aim 1 will test the hypothesis that children with ASD will process full, grammatical utterances faster and more accurately than single-word or telegraphic utterances. Aim 2 will test the hypothesis that full, grammatical utterances will support word learning better than telegraphic or single-word utterances. Aim 3 will test the hypothesis that language and cognitive skills significantly moderate the effects of linguistic simplification on language processing and word learning in young children with ASD.",[93],"Autism Spectrum Disorder",[95,96,97,98,99,100,101,102,103,67,104,105,106,107],"language","autism","intervention","processing","learning","early childhood","treatment","early intervention","telegraphic","looking-while-listening","eye tracking","comprehension","neurodevelopmental disorders",{"date":109,"type":40},"2026-06-15",{"date":111,"type":40},"2023-06-01",{"date":75,"type":23},{"name":46,"class":47},{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":12,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":124,"phases":4,"briefSummary":125,"conditions":126,"keywords":135,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},"100201862","clinical-microbial-species--antibiotic-resistance-id-in-ed-patients-presenting-with-infection---is-rapid-id-possible--accurate-100201862","NCT01904188","Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?","Clinical Microbial Species and Antibiotic Resistance Identification in Patients Presenting to the Emergency Department With Three of Four Systemic Inflammatory Response Syndrome (SIRS) Criteria - is Rapid Identification Possible and Accurate?","Inclusion Criteria:\n\nAdult patients with 3 of 4 systemic inflammatory response syndrome (SIRS) characteristics (1. tachycardia, 2. fever or hypothermia, 3. tachypnea, 4. leukocytosis), who have blood cultures drawn and\u002For urine collected for the evaluation of suspected sepsis, and\u002For other bodily fluids collected for culture and sensitivity analysis.\n\nPatients with other sources of infection with less than 3 of 4 SIRS criteria including sputum, wound drainage, CSF, nasal or oral secretions.\n\nExclusion Criteria:\n\nPediatric patients","18 Years",{"count":123,"type":23},2500,"OBSERVATIONAL","The aim of this project is to test the utility of The Gene Z device (as of 2018 Gene Z no longer being used), now using In-Dx and other rapid identification techniques that the investigators have developed in the lab on clinically obtained bodily fluid samples taken from patients with suspected infection or sepsis based on having three of four positive Systemic Inflammatory Response Syndrome markers, or having a known infection for which a specimen is being collected. Specimens will be collected at the University of Michigan Health\u002FSparrow and McLaren Greater Lansing , processed in our lab and stored for analysis at a later date to determine if the microbial pathogens identified by current methods of culture, as well as pathogen susceptibility to antibiotics by culture results, can be identified by the GeneZ technology (no longer in use) or other developed technology accurately, and more timely. It will not affect current patient care nor impact patient care, which will continue in the standard fashion today for sepsis. Results will be compared to standard culture results and antibiotic sensitivities. A secondary aim is related to the antibiotic resistance of the organism causing the infection in an attempt to determine if there are specific characteristics of the organism that allow it to be resistant to certain antibiotics. This requires analysis of the genetic material of the organism in our laboratory. Because there are also human cells in the specimens collected, with separate permission we will evaluate the human genome of the patient with the infection to determine characteristics and conditions that may predict a complicated versus uncomplicated disease course.",[127,128,129,130,131,132,133,134],"Sepsis","Systemic Inflammatory Response Syndrome","Infection Mixed","Infection, Bacterial","Infection, Fungal","Infection, Coronavirus","Antibiotic Resistance Genes","Human Genome Analysis",[136,137,138,139,128,140,141],"microbial identification","antibiotic resistance","In-Dx and other methods as developed","sepsis","antibiotic resistance genes","human genome analysis","2026-06-04",{"date":144,"type":40},"2026-06-08",{"date":146,"type":4},"2015-06",{"date":148,"type":23},"2032-07",{"name":46,"class":47},2,{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":18,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":24,"phases":162,"briefSummary":164,"conditions":165,"keywords":167,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":77},"100628274","phase-2-smart-diets-for-masld-100628274","NCT07459504","SMART Diets for MASLD","A Sequential Multiple Assignment Randomized Trial of Diet Treatments for Hepatic Steatosis and Cardiometabolic Risk in Youth","Inclusion Criteria:\n\n* Children 11 to 17-years-old at the time of consenting\n* Hepatic Steatosis by MRI greater than or equal to 8% on baseline MRI\n* At least 1 of the following cardiometabolic risk factors: BMI greater than or equal to 85th percentile for age\u002Fsex or WC greater than 95th percentile, Abnormal cholesterol or triglyceride levels, Blood pressure BP greater than or equal to 95th percentile OR greater than or equal to 130\u002F80 and\u002For signs of insulin resistance (Acanthosis Nigricans OR HOMA-IR of greater 2.0 and greater 2.6 in prepubertal and pubertal children, respectively, Fasting Insulin Level of 10 pIU\u002FmL in prepubertal children and of 17 pIU\u002FmL and 13 pIU\u002FmL in pubertal girls and boys, respectively, OR Prediabetes)\n* ALT greater than or equal to 40 U\u002FL\n* Currently consumes greater than or equal to 2 eight-ounce sugar drinks (or juice) per week.\n* Patients of childbearing potential agrees to use adequate one or more effective methods of contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation.\n* Patients who are taking medications that can affect insulin (e.g., metformin, corticosteroids), most be on a stable dosage for at least 3 months prior to enrollment of the trial.\n* Written informed consent from parent or legal guardian, assent from child.\n\nExclusion Criteria:\n\n* Patients with Diagnosed Type 2 or Type 1 Diabetes Mellitus (T2DM) or HbA1c of \\>6.5 mg\u002FdL at baseline\n* Patients diagnosed with or suspected to have a chronic liver disease other than MASLD by screening labs or evaluation (i.e autoimmune, viral). Screening labs are defined as: Hepatitis B surface antigen, Hepatitis C virus total antibody, IgG, ceruloplasmin, and alpha 1 antitrypsin phenotype.\n* Patients unable to complete MRI or Labs required for the study.\n* Current participation in another clinical trial\n* Current participation in a weight loss program or obesity treatment program or clinic\n* Cancer or history of cancer within 5 years\n* Severe illness that required hospitalization in the last 60 days\n* Use of medications known to cause liver steatosis (TPN, amiodarone, chronic oral steroids, etc.)\n* Patients with implanted metal devices that are not compatible with magnetic resonance imaging (MRI).\n* Intellectual disability or major psychiatric disorder limiting informed assent\n* Clinical evidence of cirrhosis or advanced liver disease by any one of the following abnormal labs: (Hemoglobin less than 10 g\u002FdL, White blood cell less than 3,500 cells\u002Fmm, Neutrophil count less than 1,500 cells\u002Fmm3 of blood, Platelets less than 130,000 cells\u002Fmm3 of blood, Direct bilirubin greater than 1.0 mg\u002FdL)\n* Elevated total bilirubin except if known to have Gilbert's syndrome and direct bilirubin in normal range.\n* Albumin less than 3.2 g\u002FdL\n* A history of international normalized ratio (INR) greater than 1.4\n* AST or ALT greater than 250 IU\u002FdL.\n* Compensated or decompensated cirrhosis with evidence of portal hypertension.\n* Patients is pregnant or breastfeeding.\n* Patients who have been enrolled in a recent clinical trial and had the last dose of investigational product within 30 days or 5 half-lives of the study drug, whichever is longer.","11 Years","17 Years",{"count":161,"type":23},102,[163],"PHASE2","This phase 2 trial is a single-site sequential, multiple assignment, randomized trial (SMART) to test and construct a high-quality adaptive intervention of essential amino acids (EAA) and\u002For Low Sugar Diet for children with metabolic dysfunction associated steatotic liver disease (MASLD) and increased cardiometabolic risk. The basis for the trial includes high-quality pilot data in both EAA for hepatic steatosis and a low sugar diet for hepatic steatosis. In the trial, children aged 11-17 years old will be eligible to participate if their BMI is greater than or equal to 95th% at baseline and hepatic steatosis is greater than or equal to 8% at baseline by Magnetic Resonance Imaging Proton Density Fat Fraction (MRI-PDFF) because this is the most common age group diagnosed with metabolic-dysfunction associated steatotic liver disease.",[166],"Metabolic-dysfunction Associated Steatotic Liver Disease",[168,169,170,171,172],"MASLD","Adolescents","Liver","Sugar","Amino acid supplement","2026-05-28",{"date":175,"type":40},"2026-06-01",{"date":177,"type":23},"2026-06",{"date":179,"type":23},"2030-12-26",{"name":46,"class":47},{"id":182,"slug":183,"hasResults":12,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":188,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":24,"phases":191,"briefSummary":192,"conditions":193,"keywords":196,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":77},"100605582","empowering-vietnamese-americans-100605582","NCT07164391","Empowering Vietnamese Americans","Empowering Vietnamese Americans: A Culture-Centric Digital Storytelling Intervention to Boost HPV Vaccination","Inclusion Criteria: An individual is eligible if they:\n\n* Self-identify as a Vietnamese American or immigrant woman aged 18 years or older\n* Are the primary caregiver of at least one unvaccinated child aged 11-14 years\n* Can speak and read English or Vietnamese\n* Agree to receive text messages and\u002For emails related to project activities during the study period\n\nExclusion Criteria:\n\n* inability\u002Funwillingness to provide consent.",true,{"count":190,"type":23},60,[26],"The goal of this clinical trial is to learn whether short videos can help Vietnamese American mothers decide to vaccinate their children against HPV (human papillomavirus). The study will explore: (1) whether different interventions influence mothers' intentions and decisions regarding HPV vaccination for their children; (2) how mothers perceive and engage with the videos; and (3) how many children receive the HPV vaccine after their mothers watch the videos.\n\nParticipants will be randomly assigned to one of two groups: (a) watch four short digital stories about the HPV vaccine created by Vietnamese mothers; or (b) watch four short videos on general teen health topics such as mental health and social media use. Participants will complete brief surveys and their child's HPV vaccination status will be checked two months after the intervention.",[194,195],"HPV Vaccination","Cancer Prevention",[197,198,199,200,201],"HPV","cancer prevention","Vietnamese American","youth","digital storytelling","2026-05-18",{"date":204,"type":40},"2026-05-20",{"date":206,"type":40},"2025-10-01",{"date":208,"type":23},"2027-11-30",{"name":46,"class":47},{"id":211,"slug":212,"hasResults":12,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":188,"sex":18,"minAge":158,"maxAge":20,"enrollmentInfo":217,"targetDuration":4,"studyType":24,"phases":219,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":77},"100514926","playing-game-to-learn-about-childrens-vaccine-project-100514926","NCT05984849","Playing Game to Learn About Children's Vaccine Project","A Pilot Randomized Controlled Study to Examine Feasibility and Preliminary Effectiveness of a Game-based Intervention in Promoting HPV Vaccination Among Vulnerable Youth to Prevent Cancers","Inclusion Criteria:\n\n* Child sample: (1) 11-14 years old, (2) speaks and reads English, (3) has never received any doses of the HPV vaccine, (4) is not currently enrolled in another project that involves HPV-related education, and (5) agrees and provides assent to participate in research activities.\n* Parent sample: (1) parent or legal guardian of the participating child, (2) speak and read English, (3) own a smartphone, (4) agree to receive email and text messages, (5) is not currently enrolled in another project that involves HPV-related education, and (6) agree and provide consent to participate in research activities.\n\nExclusion Criteria: Individuals who do not meet inclusion criteria or refuse to provide consent\u002Fassent.",{"count":218,"type":23},180,[26],"This proposed study aims to conduct timely research that promotes vaccine confidence and vaccination of one strongly recommended vaccine with suboptimal uptake rates: Human papillomavirus (HPV) in vulnerable and underserved youth aged 11-14.",[197,222],"Vaccine-Preventable Diseases",[224,225],"adolescent","game intervention",{"date":204,"type":40},{"date":228,"type":40},"2025-10-27",{"date":230,"type":23},"2027-08-31",{"name":46,"class":47},{"id":233,"slug":234,"hasResults":12,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":12,"sex":18,"minAge":239,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":24,"phases":242,"briefSummary":243,"conditions":244,"keywords":247,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":77},"100640930","speech-amplification-devices-for-parkinson-disease-talker--and-technology-driven-enhancements-100640930","NCT07599696","Speech Amplification Devices for Parkinson Disease: Talker- and Technology-Driven Enhancements","Speech Amplification Devices for Parkinson and Related Diseases: Talker- and Technology-Driven Enhancements","Inclusion Criteria:\n\n* Dominant speakers of North American English\n* Have received a neurologist's diagnosis of Parkinson disease or parkinsonism (e.g., PSP\u002FMSA\u002FPSP)\n* Present with changes in their speech\u002Fvoice\n\nExclusion Criteria:\n\n* History of any other speech, language, or neurological concern other than Parkinson\u002Fparkinsonism.\n* Uncorrected hearing loss that exceeds a threshold of 40 dB HL in more than one ear (as per baseline screening audiometry) and\u002For use of a cochlear implant.","50 Years",{"count":241,"type":23},100,[26],"The proposed research aims to investigate the use of speech amplification devices as a potential treatment option for people with Parkinson's disease and related disorders who exhibit hypophonia, a voice disorder that affects over half of those with Parkinson's disease. By characterizing the acoustic and perceptual effects of speech amplification and identifying ways to optimize outcomes through talker- and device-specific enhancements, this project seeks to develop personalized, evidence-based treatment options for hypophonia. The current proposal will move this effort forward by systematically eliciting and modifying speech amplification device output that leverage both behavioral and technological approaches.",[245,246],"Parkinson Disease","Atypical Parkinsonism",[248,249,250,251,252,253,254,255,256,257],"speech","Parkinson's disease","atypical parkinsonism","speech acoustics","speech-language pathology","hypophonia","voice","voice disorders","speech disorders","dysarthria","2026-05-14",{"date":204,"type":40},{"date":261,"type":40},"2024-03-01",{"date":263,"type":23},"2028-05-31",{"name":46,"class":47},{"id":266,"slug":267,"hasResults":12,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":188,"sex":273,"minAge":121,"maxAge":4,"enrollmentInfo":274,"targetDuration":4,"studyType":24,"phases":276,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":287,"startDateStruct":288,"completionDateStruct":289,"leadSponsor":291,"locationsCount":77},"100493100","the-rose-scale-up-study-informing-a-decision-about-rose-as-universal-ppd-prevention-100493100","NCT05700760","The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention","The ROSE Scale-up Study: Informing a Decision About ROSE as Universal Postpartum Depression Prevention","ROSES-II","Inclusion Criteria:\n\n1. Is aged 18 or older\n2. Is receiving prenatal services within the U.S\n3. Is between 12-32 weeks pregnant\n4. Speaks and understand English well enough to understand questionnaires when they are read aloud\n5. Has access to a telephone through owning one, a relative\u002Ffriend, or an agency\n6. Is willing and able to provide the name and contact information of at least two locator persons\n\nExclusion Criteria:\n\n1. Has a current major depressive episode\n2. Has current or past diagnosis of a bipolar disorder or a psychotic disorder","FEMALE",{"count":275,"type":23},2320,[26],"The Reach Out, Stand Strong, Essentials for New Mothers (ROSE) program is an evidence-based intervention that prevents half of cases of postpartum depression and was one of two interventions recommended by the US Preventive Services Task Force in 2019. All effectiveness trials of ROSE and of the other recommended PPD prevention intervention included only low-income women a single risk factor that doubles incidence of PPD. Thus, the existing evidence base for PPD prevention consists primarily of women at increased risk for PPD. Based on data from the PIs' current implementation study of ROSE, many healthcare and community agencies in this implementation trial (78%) find it is more feasible for them to provide or offer ROSE to every woman as part of their standard workflow, than it is to create a screening and referral process for at risk women. In addition to being more feasible for agencies, universal prevention may also be advantageous because the cost of a screening false negative (resulting in a preventable case of PPD; $32,000) far exceeds the cost of ROSE delivery ($50-$300\u002Fwoman). Effectiveness of ROSE among low-income women at risk for PPD is known (ROSE prevents \\~50% of PPD cases). To inform a recommendation about using ROSE as universal vs. selective or indicated prevention, we need to determine the effectiveness of ROSE among general populations of women, including women screening negative for PPD risk. Thus, this project will assess ROSE effectiveness across PPD risk levels and across prevention approaches in a sample of 2,320 women from a large regional health system (based in Detroit, MI). Each proposed aim gathers a piece of information missing that is needed to guide decision-making about ROSE as universal prevention. We will assess ROSE as universal, selective, and indicated prevention in terms of: (1) ROSE effectiveness relative to a control for each prevention approach in preventing PPD and improving functioning; (2) cost outcome, (3) equity and (4) scalability of each prevention approach; and (5) mechanisms of ROSE effects across PPD risk levels. We will integrate results to advise about ROSE as universal prevention. This definitive PPD prevention trial will show how best to get an evidence-based program to those who need it in settings where they receive perinatal care by addressing a pragmatic and novel question (should ROSE be universal prevention?) and by examining equity and cost-outcome of universal vs. other prevention approaches.",[279],"Postpartum Depression",[281,282,283,284,285,286],"postpartum depression","antenatal depression","depression","prevention","depression prevention","pregnancy",{"date":202,"type":40},{"date":111,"type":40},{"date":290,"type":23},"2027-12-31",{"name":46,"class":47},{"id":293,"slug":294,"hasResults":12,"nctId":295,"briefTitle":296,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":188,"sex":18,"minAge":298,"maxAge":121,"enrollmentInfo":299,"targetDuration":4,"studyType":24,"phases":300,"briefSummary":301,"conditions":302,"keywords":311,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":77},"100613449","pursuit-a-technologically-augmented-school-based-program-to-improve-child-coping-and-prevent-substance-use-100613449","NCT07266740","PURSUIT: A Technologically Augmented School-based Program to Improve Child Coping and Prevent Substance Use.","Inclusion Criteria:\n\n* Aged eight to 18 years\n* Enrolled in a Michigan elementary, middle, or high school\n\nExclusion Criteria:\n\n* Age under 8\n* Age over 18 years\n* Non-enrollment in A Michigan school.","8 Years",{"count":241,"type":23},[26],"The study investigators aim to test an online support platform for Michigan youth aged 8-18 years enrolled in elementary, middle, or high school and their parent\u002Fcaregiver. The online support platform will be hosted on the Computerized Intervention Authoring System (CIAS) 3.0 and will provide evidence-based cognitive behavioral coping skills for physical (pain) and mental (stress, mood) health symptoms, with additional substance use prevention content for youth aged 12 and older. Evaluations will occur at baseline and then a post assessment approximately 8 weeks later.",[303,304,305,306,307,308,309,310],"Pediatric Pain","Anxiety","Mood","Stress","Feasibility Studies","Acceptability","Health Promotion","Online Mental Health Program",[312,313,314,306,315,304,305,316],"Cognitive-behavioral","School","Pediatrics","Pain","Substance use","2026-05-05",{"date":319,"type":40},"2026-05-07",{"date":321,"type":23},"2026-05-01",{"date":323,"type":23},"2026-10",{"name":46,"class":47},{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":188,"sex":18,"minAge":332,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":124,"phases":4,"briefSummary":336,"conditions":337,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":345,"leadSponsor":347,"locationsCount":77},"100560535","the-development-of-stuttering-in-young-children-100560535","NCT06578416","The Development of Stuttering in Young Children","Developmental Trajectories to Stuttering Persistence and Recovery","Inclusion Criteria for controls:\n\n* English as first\u002Fprimary language\n* No history of neurological disease\n* Normal or corrected visual acuity\n* No medications expected to affect performance\n* No intellectual impairment, autism spectrum disorder, ADHD\n* Age-appropriate scores on speech and language assessment battery\n* Pass hearing screening at 20 dB at 500, 1000, 2000, and 4000, bilaterally\n\nInclusion Criteria for children who stutter:\n\n* English as first\u002Fprimary language\n* No history of neurological disease\n* Normal or corrected visual acuity\n* No medications expected to affect performance\n* No intellectual impairment or ASD Scores on speech and language assessments indicating stuttering, phonological (speech sound), or language disorders\n* Pass hearing screening at 20 dB at 500, 1000, 2000, and 4000, bilaterally","3 Years","6 Years",{"count":335,"type":23},120,"The goal of this longitudinal research is to learn why some children \"grow out\" of stuttering, while others persist. Children who do and do not stutter aged 3-6 years are eligible to participate in our study. During the study, children's speech and language abilities will be assessed with standardized assessments, and they complete several child-friendly experiments. During these experiments, brain activity will be recorded using specialized caps while children describe pictures, children will speak in two virtual-reality scenarios, and produce speech while keeping to a beat.",[338,339,340],"Stuttering","Stuttering, Childhood","Stuttering, Developmental","2026-04-13",{"date":343,"type":40},"2026-04-16",{"date":111,"type":40},{"date":346,"type":23},"2027-06",{"name":46,"class":47},{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":56,"enrollmentInfo":355,"targetDuration":4,"studyType":24,"phases":357,"briefSummary":358,"conditions":359,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":77},"100630279","reducing-lead-dust-exposure-in-older-housing-100630279","NCT07485608","Reducing Lead Dust Exposure in Older Housing","Reducing Lead Dust Exposure and Childhood Blood Lead Levels in Older Housing in Michigan","Inclusion Criteria:\n\n* child under seven years of age with BLL \\>5 µg\u002FdL,\n* child must reside in housing built before 1978, and\n* child must sleep at home during participation in the two month-long study.\n\nExclusion Criteria:\n\n* anything in child's health history that could affect the study results, or\n* any circumstance that could interfere with guardian's\u002Fparent's ability to consent and\u002For participate in the study.",{"count":356,"type":23},40,[26],"The objective of this study is to assess the effectiveness of portable air filtration (PAF) for mitigating lead dust exposures and reducing childhood blood lead levels in older housing.",[360,361],"Exposure to Toxic Dust","Elevated Blood Lead Levels","2026-03-17",{"date":364,"type":40},"2026-03-20",{"date":366,"type":40},"2022-12-01",{"date":368,"type":23},"2026-11-30",{"name":46,"class":47},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":188,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":377,"targetDuration":4,"studyType":24,"phases":379,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":388,"locationsCount":77},"100616153","culturally-targeted-health-communication-and-receptivity-to-the-human-papillomavirus-vaccine-among-parents-in-flint-mi-100616153","NCT07301905","Culturally Targeted Health Communication and Receptivity to the Human Papillomavirus Vaccine Among Parents in Flint, MI","Culturally Targeted Messaging and Parental Receptivity to the Human Papillomavirus Vaccine","Inclusion Criteria:\n\n* Identify as Black\u002FAfrican American or White\u002FCaucasian\n* Have at least one daughter who is between 8-17 years of age, who is not currently pregnant, and who has not received any doses of the HPV vaccine\n\nExclusion Criteria:\n\n* N\u002FA",{"count":378,"type":23},265,[26],"The goal of this clinical trial is to learn if culturally targeted messaging about the human papillomavirus (HPV) increases receptivity to the HPV vaccine among African American parents of vaccine-eligible daughters. The main question it aims to answer is:\n\n• Does culturally targeted messaging increase African American parents' intentions to vaccinate their daughter against HPV?\n\nResearch will compare culturally targeted messaging to general, educational messaging and no messaging.\n\nParticipants will:\n\n* View culturally targeted messages, education-only messages, or no messages about the HPV vaccine\n* Report their intentions to vaccinate their daughter against HPV\n* Report whether they have initiated HPV vaccination for their daughter six months later",[194],"2026-03-11",{"date":384,"type":40},"2026-03-13",{"date":386,"type":40},"2024-11-17",{"date":177,"type":23},{"name":46,"class":47},{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":395,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":273,"minAge":121,"maxAge":4,"enrollmentInfo":397,"targetDuration":4,"studyType":24,"phases":399,"briefSummary":400,"conditions":401,"keywords":405,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":417,"locationsCount":4},"100609338","michigan-healthy-mom-mi-mom-pregnancy-improvement-web-application-trial-100609338","NCT07213284","Michigan Healthy Mom (MI-MOM) Pregnancy Improvement Web Application Trial","Site Randomized Trial to Evaluate Behavioral Intervention Via Web-Based Application (MI MOM- Michigan Healthy Moms Application) to Improve Pregnancy Outcomes","MI-MOM App","Inclusion Criteria:\n\n* Pregnant at 20 weeks gestation or less\n* 18 years of age or older\n* Access to smartphone with text messaging and internet access\n* Speaks English\n* Enrolled in Medicaid for health insurance\n\nExclusion Criteria:\n\n* Younger than 18 years old\n* Not pregnant or pregnant with more than 20 weeks gestation\n* No access to a smartphone with text messaging and internet access\n* Not English speaking\n* Not enrolled in Medicaid for health insurance",{"count":398,"type":23},500,[26],"The purpose of this research study is to see if using the MI MOM App improves pregnancy and postpartum health. There are two study groups, where one group is \"treatment as usual\" and the other is the \"MI MOM App\" group. Both groups will be asked to answer questions about their pregnancy health. Researchers will also retrieve vital records and Medicaid claims information related to pregnancy for both groups. Those in the \"MI MOM App\" group will receive mobile web app content and text messages with informational links and links to videos and micro-interventions. They will also identify up to three close friends or family members who will be invited to receive text messages. Those in the \"MI MOM App\" will also have the option to contact a community health worker as needed.",[402,403,404],"Pregnancy","Pregnancy, Complications","Pregnancy Outcomes",[402,406,407,408,409],"App","Behavioral Intervention","Web-based Application","Postpartum","2026-03-10",{"date":412,"type":40},"2026-03-12",{"date":414,"type":23},"2026-04-01",{"date":416,"type":23},"2031-12-31",{"name":46,"class":47},{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":424,"eligibilityCriteria":425,"healthyVolunteers":188,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":426,"targetDuration":4,"studyType":24,"phases":428,"briefSummary":429,"conditions":430,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":77},"100465208","app-for-pregnancy-smoking-cessation-with-peer-support-100465208","NCT05337722","App for Pregnancy Smoking Cessation With Peer Support","A Smartphone Intervention for Pregnancy Smoking Cessation With Peer Support","SFT","Inclusion Criteria:\n\n* age\\>=18\n* pregnant\n* user of regular cigarettes\n* availability of Android phone with broadband data\n\nExclusion Criteria:\n\n\\-",{"count":427,"type":23},790,[26],"The objectives of this project are to develop, implement, and test the feasibility and effectiveness of an artificial intelligence adaptive mobile pregnancy tobacco cessation app-based intervention using deep tailoring and a self-nominated support person, and to build mHealth research capacity in Romania. The central hypothesis is that the intervention will show evidence of feasibility and effectiveness in increasing positive support, pregnancy cessation, and postnatal abstinence. The intervention is grounded in Self-Determination Theory (SDT) and Motivational Interviewing (MI), a counselling style that is effective in assisting people to quit smoking. The app will be novel in its use of the unique functionality of smartphones, use of reinforcement learning (RL) and deep tailoring to continuously adapt the intervention, the emphasis on increasing positive support, and the use of the app by both smoker and support person. The long-term goal of the research program is to use mHealth for smoking cessation leveraging the unique functionality of smartphones and to continue building mHealth research capacity and developing research networks in Central and Eastern Europe (CEE) and other LMICs.\n\nAim 1 (R21 phase). Develop and test the feasibility and acceptability of the SFT2.0 app-based mobile smoking cessation intervention with a support person during pregnancy and postpartum in Romania. Through a user-centered and iterative design the investigators will enhance the SFT1.0 app, deepen the tailoring, incorporate RL, expand the app for use by any support person, and test the intervention including the app and MI video counseling in a series of usability studies and a 12-week open trial (n=20).\n\nAim 2 (R33 phase). Test the SFT2.0 app-based smoking cessation intervention in a hybrid effectiveness and implementation randomized controlled trial. The investigators will randomize 375 pregnant smokers and their support persons to i) a fixed arm, including the SFT2.0 app for both, and fixed pre- and postnatal MI counseling; ii) an RL-adaptive arm, with the app continuously optimizing as-needed MI counseling; or iii) control group.\n\nAim 3 (R21 and R33 phases). Develop mHealth research capacity by enhancing individual and institutional research capabilities in Romania and expanding the existing international research network.",[431,432],"Smoking Cessation","Tobacco Smoking","2026-01-14",{"date":435,"type":40},"2026-01-16",{"date":437,"type":40},"2023-01-11",{"date":439,"type":23},"2026-08-31",{"name":46,"class":47},{"id":442,"slug":443,"hasResults":12,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":447,"eligibilityCriteria":448,"healthyVolunteers":12,"sex":18,"minAge":449,"maxAge":450,"enrollmentInfo":451,"targetDuration":4,"studyType":24,"phases":453,"briefSummary":454,"conditions":455,"keywords":457,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":477},"100533936","transforming-care-for-individuals-with-childhood-onset-systemic-lupus-erythematosus-100533936","NCT06232304","Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus","Transforming Behavioral Healthcare to Improve the Quality of Life for Individuals With Childhood-onset Lupus","cSLE","Inclusion Criteria:\n\n* 1\\) be diagnosed with cSLE, meeting the revised American College of Rheumatology Classification Criteria for SLE by age 18 years\n* 2\\) be between the ages of 12 and 22 years\n* 3\\) in recognition of the heterogeneity of cSLE symptoms, have elevations in fatigue (i.e., T scores ≥60; or at least moderate symptoms, on the PROMIS measure) OR depressive symptoms (≥5 on the PHQ-9, T Score ≥ 60 on the BDI or CDI II ), OR pain (i.e., average pain ≥3 out of 10 on the Pain VAS)\n* 4\\) have English language proficiency (their primary caregiver can have English or Spanish language proficiency for the child to enroll)\n* 5\\) those under age 18 years (US), or 16 years (Canada) must have a consenting caregiver\n\nExclusion Criteria:\n\n* 1\\) other chronic medical conditions (e.g., juvenile arthritis)\n* 2\\) a documented developmental delay, severe cognitive impairment, or thought disorder\n* 3\\) an untreated major psychiatric illness (e.g., bipolar disorder, psychosis, severe depression (PHQ9 score ≥21, BDI\u002FCDI II \\> 90) or active suicidal ideation (SI), based on the Pediatric Health Questionnaire (PHQ-9) items plus clinical interview; see Measures section)","12 Years","22 Years",{"count":452,"type":23},175,[26],"This study aims to investigate the feasibility and effectiveness of a cognitive behavioral coping skills program, Treatment and Education Approach for Childhood-onset Lupus (TEACH), for youth with cSLE when integrated into medical care. This TEACH program aims to teach participants skills in order to cope with fatigue, pain, and depressive symptoms--symptoms that commonly affect adolescents and young adults with lupus.",[456],"Systemic Lupus Erythematosus of Childhood (Disorder)",[458,283,459,460,461,462,463,464,33,465,447,466,467,468],"lupus","depressive symptoms","fatigue","pain","SLE","rheumatic disease","rheumatology","Childhood-onset Systemic Lupus Erythematosus","Implementation","Coping skills","Mindfulness","2025-10-28",{"date":471,"type":40},"2025-10-30",{"date":473,"type":40},"2024-09-12",{"date":475,"type":23},"2027-09-30",{"name":46,"class":47},7,{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":12,"sex":273,"minAge":485,"maxAge":486,"enrollmentInfo":487,"targetDuration":4,"studyType":24,"phases":489,"briefSummary":490,"conditions":491,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":496,"completionDateStruct":498,"leadSponsor":500,"locationsCount":77},"100519353","am-vs-pm-exercise-training-100519353","NCT06042439","AM vs PM Exercise Training","Effects of AM vs. PM Exercise Training on Blood Pressure and Vascular Health in Postmenopausal Females With Hypertension","Inclusion Criteria:\n\n* Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg\n* 55-80 years old\n* Post-menopausal female\n* Able to walk without assistance\n\nExclusion Criteria:\n\n* Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week\n* Overt pulmonary disease\u002Fcondition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension\n* Cardiometabolic disease\u002Fcondition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months\n* Cancer within last 5 years\n* Body mass index \\>39 kg\u002Fm2\n* Current smoking or vape\n* Evening shift work\n* uncontrolled thyroid disorder\n* 2 or more falls in the last year\n* Anemia within 3 months of enrollment\n* Parkinson's disease\n* Dementia\n* Unstable angina\n* Acute pulmonary embolus or infarction\n* Acute myocarditis or pericarditis\n* Acute aortic dissection","55 Years","80 Years",{"count":488,"type":23},79,[26],"The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise training performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.",[492],"Hypertension","2025-09-24",{"date":495,"type":40},"2025-09-25",{"date":497,"type":40},"2024-06-11",{"date":499,"type":23},"2027-07-01",{"name":46,"class":47},{"id":502,"slug":503,"hasResults":12,"nctId":504,"briefTitle":505,"officialTitle":506,"acronym":4,"eligibilityCriteria":507,"healthyVolunteers":188,"sex":18,"minAge":332,"maxAge":508,"enrollmentInfo":509,"targetDuration":4,"studyType":24,"phases":511,"briefSummary":513,"conditions":514,"keywords":520,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":77},"100562000","phase-2-food-body-mind-intervention-16-weeks-100562000","NCT06597474","Food-Body-Mind Intervention (16 Weeks)","Food-Body-Mind Intervention: Promote Whole Child Health","Inclusion Criteria:\n\n1. Parental consent and child (if the child is 5 years) verbal assent received\n2. Children are 3-5 years old attending a Head Start program and caregivers are the primary adult caregivers for the children\n3. Caregivers are willing to use Facebook or the private program website for participation\n4. Participants have at least weekly internet access using a smartphone, a tablet, or a computer\n\nExclusion Criteria:\n\n1. preschoolers who have a motor disability or impairment (e.g., cerebral palsy, spinal cord injury, lost or damaged limb, motor skills disorder, muscular dystrophy, spina bifida) preventing them from participating in any physical activity;\n2. preschoolers who have a diagnosed medical condition (e.g., phenylketonuria, pediatric malabsorption syndrome, pollen food allergy syndrome) requiring a restrict diet and precluding them from any dietary changes particularly fruit\u002Fvegetable intake; and\n3. preschoolers who have diagnosed disorders (e.g., autism spectrum disorder level 3) causing severe difficulty (e.g., nonverbal, cannot initiate social interaction) with communication and interaction with other people.\n\nThere will be no exclusion criterion for primary adult caregivers, as the primary focus is preschoolers and caregivers serve as a support role.","5 Years",{"count":510,"type":23},800,[163,512],"PHASE3","This novel, timely, and theory-driven Food-Body-Mind intervention addresses the national emergency of mental health crises in early childhood. By targeting Head Start racially\u002Fethnically diverse preschoolers from low-income backgrounds in both urban and rural areas, this intervention is expected to contribute toward reducing health disparities and promoting health equity, a major priority of the NIH and Healthy People 2030. If effective, it can be scalable to Head Start programs across urban and rural settings nationally with long-term sustainability benefits.",[515,516,517,518,519],"Mental Health Wellness","Emotional Problem","Behavioral Problem of Child","Social Skills","Obesity, Childhood",[468,521,522,523,524,525],"Mindful eating","Yoga","Deep breathing","Family","Prevention","2025-09-22",{"date":528,"type":40},"2025-09-26",{"date":530,"type":40},"2024-08-14",{"date":532,"type":23},"2028-07-31",{"name":46,"class":47},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":540,"eligibilityCriteria":541,"healthyVolunteers":188,"sex":18,"minAge":121,"maxAge":542,"enrollmentInfo":543,"targetDuration":4,"studyType":24,"phases":545,"briefSummary":546,"conditions":547,"keywords":549,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":555,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":77},"100546625","engaging-college-students-in-developing-and-testing-a-video-based-intervention-for-hpv-vaccination-promotion-100546625","NCT06397378","Engaging College Students in Developing and Testing a Video-based Intervention for HPV Vaccination Promotion","Development and Pilot Testing a Video-based Intervention to Promote HPV Vaccination Among College Students","HPV videos","Inclusion Criteria: college students aged 18-26 never receive HPV vaccines able to understand English.\n\nExclusion Criteria: not able to understand English younger than 18 or older than 26 years old have received HPV vaccines.","26 Years",{"count":544,"type":23},123,[26],"HPV vaccines offer hope against HPV-associated cancers for males and females; however, the rate of vaccination has not reached projected public health goals. This study will engage key stakeholders in the research process to co-design and pilot testing a video-based intervention addressing low HPV vaccination rates among college students The intervention and its approach have the potential to reduce health disparities in HPV-associated cancers in young adults via low-cost technology and timely intervention.",[548],"N\u002FA - Healthy Subjects",[550,551,552,553],"video intervention","HPV vaccination rate","HPV infection","college students","2025-09-20",{"date":495,"type":40},{"date":557,"type":40},"2024-08-16",{"date":559,"type":23},"2026-06-30",{"name":46,"class":47},{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":567,"eligibilityCriteria":568,"healthyVolunteers":12,"sex":273,"minAge":121,"maxAge":569,"enrollmentInfo":570,"targetDuration":4,"studyType":24,"phases":571,"briefSummary":573,"conditions":574,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":583,"locationsCount":77},"100486691","phase-1-treating-chronic-cervicogenic-head-and-neck-pain-100486691","NCT05617365","Treating Chronic Cervicogenic Head and Neck Pain","Treating Chronic Cervicogenic Head and Neck Pain With Osteopathic Manipulation and Exercise Therapy","CGH","Inclusion Criteria: Females diagnosed with chronic cervicogenic headache.\n\nExclusion Criteria:\n\n* Have you been involved in a rear-end motor vehicle accident within the past 3 years?\n* Have you had spinal surgery performed on your neck?\n* Do you have a pinched nerve in the neck that produces pain radiating down your arm.\n* Have you been diagnosed with diseases such as rheumatoid arthritis, lupus, or ankylosing spondylitis.\n* Do you have ongoing central nervous system pathology such as hemiparesis, cervical radiculopathy, spondylolisthesis grade III or IV, central nervous system causes of balance \\& coordination deficits, orthostatic hypotension, vestibular disorders, pregnancy, recent spinal fractures, moderate to severe traumatic brain injury.","65 Years",{"count":58,"type":23},[572,163],"PHASE1","The primary aim is to test the combined effectiveness of OMT and targeted head exercise (THE) to achieve a significant decrease in headache measures of frequency, intensity, and duration in a Treatment group when compared to a Control group whose members receive only standard medical care. A parallel, 2-arm, longitudinal, randomized controlled trial (RCT) will focus upon female patients (18 to 75 years of age) who have been diagnosed with chronic cervicogenic headache (CeH) based upon a differential diagnosis that includes classification according to the International Headache Society Classification IHSD 3rd Edition, reproduction of referred headache resulting from manual pressure over the upper cervical regions, and objective MRI findings. It is estimated that a sample size of 30 will provide sufficient statistical power (79%) to detect an intervention effect that corresponds to a clinically meaningful recovery (60%).\n\nCeH is classified as a secondary headache disorder because the headache pain is a consequence of injury to, or disease of, the bony and\u002For soft tissues of the upper cervical spine. It has been reported that some patients diagnosed with CeH demonstrate atrophy and\u002For fatty infiltration (FI) of the RCPm muscles on MRI. FI and\u002For a reduction in the cross-sectional area (CSA) of active muscle would not be expected to be the direct cause of chronic headache, but either or both could prevent muscles from generating normal physiologic levels of force. It has been shown that there is a functional connection between the pain sensitive dura mater and RCPm muscles and it is known that mechanical stretching of the dura mater results in referred headache.\n\nWhile FI and\u002For a reduction in the CSA of active muscle would not be expected to be the direct cause of chronic headache, it is known that muscle pathology will result in functional deficits. It is proposed that pathology in RCPm muscles will compromise the normal functional relationship between the RCPm and the dura mater and result in referred head and neck pain. It is predicted that at the end of the study, the Treatment group will show a significant decrease in headache measures that will be accompanied by a significant increase in CSA and a significant decrease in FI on MRI, and restoration of a normal head posture that will not be seen in the Control group.\n\nThe proposed study is unique in that we are proposing both a mechanism and a source for some instances of CeH. By testing the effectiveness of specific interventions to address a specific pathology within a specific headache population, and by restricting the study cohort to female subjects presenting with CeH, this study will increase the ability to detect a significant change in the outcomes by increasing the power of the statistical analysis.",[575,576],"Cervicogenic Headache","Neck Pain, Posterior","2025-09-13",{"date":579,"type":40},"2025-09-18",{"date":581,"type":40},"2022-09-01",{"date":175,"type":23},{"name":46,"class":47},{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":188,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":590,"targetDuration":4,"studyType":24,"phases":592,"briefSummary":593,"conditions":594,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":77},"100541076","phase-1-the-impact-of-light-exposure-on-cognitive-function-in-classrooms-100541076","NCT06325150","The Impact of Light Exposure on Cognitive Function in Classrooms","Inclusion criteria for wearing light glasses:\n\n* Current Michigan State University (MSU) Undergraduate Student\n* Are 18 years or older\n* Healthy subject without light sensitivity\n* Average bedtime 9:30 pm - 2:00 am, 6 out of 7 days a week\n* Willingness to measure and report fatigue levels\n* Willingness to participate in cognitive testing\n* Willingness to wear light-enriched glasses in the classroom\n\nInclusion criteria for the control group (will not wear light glasses):\n\n* Current Michigan State University (MSU) Undergraduate Student\n* Are 18 years or older\n* Average bedtime 9:30 pm - 2:00 am, 6 out of 7 days a week\n* Willingness to measure and report fatigue levels\n* Willingness to participate in cognitive testing\n\nInclusion criteria for the control group (will not wear light glasses):\n\n* Current Michigan State University (MSU) Undergraduate Student\n* Are 18 years or older\n* Average bedtime 9:30 pm - 2:00 am, 6 out of 7 days a week\n* Willingness to measure and report fatigue levels\n* Willingness to participate in cognitive testing\n\nExclusion criteria for wearing light glasses:\n\n* Are younger than 18 years of age\n* Participation in shift work (evening\u002Fnight shifts, early morning shifts, rotating shifts, etc.)\n* Pregnant women\n* Previous diagnosis of diabetes\n* Use of medication that would cause sensitivity to light (e.g., antidepressants, antibiotics,prescribed sleep medication, prescribed pain meds)\n* Epilepsy or a history of seizures\n* Photophobia - sensitivity or eye discomfort to bright light\n* Eye Diseases that limit the ability of light to be processed (e.g., untreated cataracts,severe glaucoma, macular degeneration, blindness, pupil dilation problems, or retinadamage)\n* Previous eye surgery\n* Previous head injuries (e.g., concussions)\n* Current chronic, severe headaches\u002Fmigraines\n* Clinical insomniacs or those with diagnosed sleep disorders",{"count":591,"type":23},300,[572],"Humans are constantly exposed to a variety of light types, created naturally or through artificial means. Light exposure captured by the eyes impacts many physiological functions in humans, including but not limited to cognitive output, fatigue levels, and mood regulation. The level of impact on cognitive learning from different types of light on undergraduate adult students remains unclear.",[595],"Healthy","2025-09-12",{"date":579,"type":40},{"date":599,"type":23},"2026-05-16",{"date":601,"type":23},"2028-02-01",{"name":46,"class":47},{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":188,"sex":273,"minAge":121,"maxAge":610,"enrollmentInfo":611,"targetDuration":4,"studyType":24,"phases":612,"briefSummary":613,"conditions":614,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":618,"startDateStruct":619,"completionDateStruct":621,"leadSponsor":623,"locationsCount":77},"100402569","impact-of-room-light-on-uterine-contractions-and-labor-progression-in-pregnancy-100402569","NCT04521972","Impact of Room Light on Uterine Contractions and Labor Progression in Pregnancy","Impact of Light on Labor Progression","Inclusion criteria:\n\n* Are pregnant\n* Are 18-42 years old\n* Medically cleared for participation by Medical Investigator\n* Willingness to allow the study access to information in the participant's medical record\n* Willingness to be notified of incidental findings from study procedures\n* Willingness to measure and report on lighting conditions during specified time periods\n* Willingness to use a uterine contraction home monitor system, and report results\n* Willingness to adapt lighting during studies in home and\u002For hospital\n* Willingness to wear blue-filter glasses if requested\n* Willingness to report use of melatonin (for sleep)\n* Willingness to stop melatonin use if requested\n\nExclusion criteria\n\n* Pre-pregnancy BMI \\>36kg\u002Fm2\n* HIV or AIDS (self-reported)\n* Severe anemia (hemoglobin \\\u003C8g\u002FdL and\u002For hematocrit \\\u003C24%)\n* History or current psychotic disorder or diagnosis of a current major depressive episode or bipolar disorder\n* Current use of one or more of the following medications: metformin, systemic steroids, antipsychotic agents (e.g., Abilify, Haldol, Risperdal, Seroquel, Zyprexa), anti-seizure medications or mood stabilizers that would be expected to have a significant impact on body weight (e.g., Depakote, Lamictal, Lithium, Neurontin, Tegretol, Topamax, Keppra), medications for ADHD including amphetamines and methylphenidate\n* Continued use of weight loss medication including OTC and dietary supplements for weight loss (e.g., Adipex, Suprenza, Tenuate, Xenical, Alli, conjugated linoleic acid, Hoodia, Green tea extract, Guar gum, HydroxyCut, Sensa, Corti-slim, Chromium, chitosan, Bitter orange) Other Exclusion Criteria\n* Recent history of or currently smoking, drinking alcohol or abusing drugs (prescription or recreational)\n* Plans to move out of the study area within the next year or plans to be out of the study area for more than 8 weeks in the next 12 months\n* Planned termination of pregnancy","42 Years",{"count":241,"type":23},[26],"Today it remains a challenge to successfully both halt and induce labor progression. Induction of labor is a common obstetric intervention that 1 in 4 women will experience. The goal of induction of labor is to achieve a vaginal birth, however in almost 40% of first-time mothers it fails. Failed labor inductions require a caesarean delivery, which is associated with a vast range of adverse effects for both the mother and her baby. In this application we propose that a simple manipulation of room light will increase the success of vaginal birth through the use of optimal room light settings (halting labor=lights ON, promoting labor=reduced room light\u002Fred room light).\n\nA sparse literature has shown that the hormone melatonin might be an important hormone to consider during late pregnancy and labor. Pineal melatonin release is only released in darkness at night, where nocturnal light such as room light, suppress pineal melatonin release, reducing uterine contractions (Olcese et al 2013, https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F22556015\u002F, Rahman et al 2019, https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fpmc\u002Farticles\u002FPMC6453747\u002F). Melatonin receptor become upregulated in the pregnant myometrium (uterine smooth muscle), and a small study in women having preterm birth, showed a high expression of melatonin receptor, at a gestational week where women not having preterm uterine contractions, had low levels of melatonin receptor, suggesting that premature increase in myometrium melatonin receptor might in some women be associated with preterm labor and birth (Olcese et al 2013, https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F22556015\u002F).\n\nThis study will address how room light impacts melatonin release and uterine contractions in healthy pregnant women.",[615,616,617],"Pregnancy Related","Labor; Poor","Uterine Contractions Weak",{"date":579,"type":40},{"date":620,"type":40},"2025-09-01",{"date":622,"type":23},"2029-09-01",{"name":46,"class":47},{"id":625,"slug":626,"hasResults":12,"nctId":627,"briefTitle":628,"officialTitle":629,"acronym":630,"eligibilityCriteria":631,"healthyVolunteers":12,"sex":18,"minAge":121,"maxAge":632,"enrollmentInfo":633,"targetDuration":4,"studyType":24,"phases":634,"briefSummary":635,"conditions":636,"keywords":641,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":648,"lastUpdatePostDateStruct":649,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":655,"locationsCount":77},"100556739","phase-2-low-amplitude-pulse-seizure-therapy-versus-standard-ultra-brief-right-unilateral-electroconvulsive-therapy-100556739","NCT06529029","Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy","Efficacy of Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy in Remission of Suicidal Ideation","LAP-ST vs ECT","Inclusion Criteria:\n\n1. Patients in whom ECT is clinically indicated: The referrals to ECT by the primary psychiatrist (before a consult by the ECT consultant) will serve to both increase the feasibility of the study and address any ethical concerns that the patient would not undergo ECT without having a valid full indication for the procedure as well as increase the external validity and generalizability of the study.\n2. Male or female patients 18 to 90 years of age\n3. Current DSM-5 criteria for MDE with any SI of major depressive, bipolar, or schizoaffective disorders\n4. Montgomery-Asberg depression rating scale (MADRS) with 2 or more on SI item\n5. Use of effective method of birth control for women of child-bearing capacity\n6. Patient is medically stable\n7. No anticipated need to alter psychotropic medications for the duration of the study (except for urgent\u002Femergent situations)\n8. Ability of patient to fully participate in the informed consent process\n\nExclusion Criteria:\n\n1. Unstable or serious medical condition that substantially increases risks of ECT or cognitive impairment\n2. Female patients who are pregnant or plan to be pregnant during the study or are breast-feeding\n3. History of neurological disorder if deemed by the treating ECT physician or PI to pose a significant risk with ECT, or if there is any metal in the head or history of known structural brain lesion or skull defect that is deemed to affect cognition or safe ECT treatment\n4. Implanted devices that make ECT unsafe\n5. Clinical presentation of delirium or dementia\n6. Active substance use disorders within 1 week of randomization\n7. ECT in the past 1 month or prior failure to respond to an adequate course of ECT as deemed by the ECT physician treating the patient or the PI","90 Years",{"count":58,"type":23},[163,512],"This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse - Seizure Therapy (RUL LAP-ST) treatment has more magnitude and rate of remission of SI as conventional pulse amplitude Right Unilateral Electroconvulsive Therapy (RUL ECT) (based on our prior secondary analysis). Our central hypothesis is that RUL LAP-ST has significantly less cognitive\u002Fmemory side effects (no memory side effects were noted in our prior studies for 500mA and 600mA) and thus is more favorable in terms of side effects compared to RUL conventional pulse amplitude ECT, while maintaining better anti-suicidal effect.",[637,638,639,640],"Suicidal Ideation","Major Depressive Disorder","Schizo Affective Disorder","Bipolar Disorder",[637,642,643,638,639,640,644,645,646,647],"Suicide","Depression","Low Amplitude Seizure Therapy","Electroconvulsive Therapy","Neuromodulation","Brain Stimulation","2025-09-10",{"date":650,"type":40},"2025-09-16",{"date":652,"type":40},"2024-07-03",{"date":654,"type":23},"2026-11-01",{"name":46,"class":47},{"id":657,"slug":658,"hasResults":12,"nctId":659,"briefTitle":660,"officialTitle":661,"acronym":4,"eligibilityCriteria":662,"healthyVolunteers":188,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":663,"targetDuration":4,"studyType":24,"phases":665,"briefSummary":666,"conditions":667,"keywords":672,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":687,"locationsCount":77},"100566994","support-for-bereaved-cancer-caregivers-100566994","NCT06662409","Support for Bereaved Cancer Caregivers","Support for Bereaved Friend and Family Caregivers of Cancer Patients","Inclusion Criteria:\n\n* 18 years old or older; Able and willing to provide reflexology\n* Able to speak and understand English\n* Have access to a telephone\n* Able to hear normal conversation\n* Cognitively oriented to time, place, and person (determined via recruiter)\n\nExclusion Criteria:\n\n* Unwilling to perform return demonstration with 90% accuracy",{"count":664,"type":23},70,[26],"Friend and family caregivers of recently deceased cancer patients experience acute bereavement following the death. Post death bereavement is an intense period of mourning that includes an unfolding of the grief process and is characterized by strong emotions and demands on cognitive resources to those who have put aside their own needs to support the dying patient with cancer. This research will test the feasibility and acceptability of a nature-based healing meditation (NBHM) intervention to support cancer caregivers' during the bereavement process.",[668,669,670,671],"Bereavement","Cancer","Caregiver","Grief",[673,674,675,676,677,678,679,283,680],"nature-based intervention","meditation","bereavement support","grief","directed attention","quality of life","anxiety","cancer caregiver","2025-09-04",{"date":683,"type":40},"2025-09-11",{"date":685,"type":40},"2025-06-01",{"date":42,"type":23},{"name":46,"class":47},{"id":689,"slug":690,"hasResults":12,"nctId":691,"briefTitle":692,"officialTitle":693,"acronym":4,"eligibilityCriteria":694,"healthyVolunteers":188,"sex":18,"minAge":121,"maxAge":4,"enrollmentInfo":695,"targetDuration":4,"studyType":24,"phases":697,"briefSummary":698,"conditions":699,"keywords":702,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":705,"lastUpdatePostDateStruct":706,"startDateStruct":708,"completionDateStruct":710,"leadSponsor":712,"locationsCount":77},"100594869","multilevel-community-centered-intervention-to-reduce-pregnancy-related-and-associated-morbidity-and-mortality-pramm-disparities-100594869","NCT07025057","Multilevel Community-Centered Intervention to Reduce Pregnancy Related and Associated Morbidity and Mortality (PRAMM) Disparities","Multilevel Community-centered Intervention to Reduce Pregnancy Related and Associated Morbidity and Mortality (PRAMM) Disparities in Non-Hispanic Black and Hispanic Medicaid-insured Individuals","Inclusion Criteria:\n\n* Providing care to pregnant and postpartum women in Wayne, Kent, and Genesee Counties in MI\n\nExclusion Criteria:\n\n* None",{"count":696,"type":23},480,[26],"The goal of the study involving human subjects is to train providers to address patient-provider interactions. The study will survey providers to assess pre-post knowledge, understanding, and behavior changes.",[700,701],"Provider Confidence","Provider Behavior",[703,704],"Maternal mortality","Maternal morbidity","2025-06-09",{"date":707,"type":40},"2025-06-17",{"date":709,"type":40},"2025-02-03",{"date":711,"type":23},"2030-08-15",{"name":46,"class":47},""]