[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Midwest Biomedical Research Foundation\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":71},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100101977","barretts-esophagus-related-neoplasia-bern-project-100101977",false,"NCT00590239","Barrett's Esophagus Related Neoplasia (BERN) Project","Endoscopic Detection of Early Neoplasia in Patients With Barrett's Esophagus","BERN","Inclusion Criteria:\n\n* 18-80 years\n* Patients must be able to provide written informed consent\n* Patients referred for endoscopy for screening\u002Fsurveillance of BE or for endoscopic treatment of BE with early mucosal neoplasia\n\nExclusion Criteria:\n\n* Current use of aspirin, non-steroidal anti-inflammatory agents(NSAIDs),or chronic anticoagulants that cannot be discontinued prior to the procedure.\n* Inability to provide written informed consent\n* Significant thrombocytopenia or coagulopathy\n* Any significant co-morbid condition that would prevent the safe administration of conscious sedation","ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","OBSERVATIONAL","* The use of high resolution endoscopy (HRE), narrow band imaging (NBI) and chromoendoscopy increases the detection rates of Barrett's esophagus (BE) and early neoplasia.\n* Endoscopic mucosal resection (EMR) will improve the accuracy for detection of dysplasia\u002Fearly neoplasia.\n\nSpecific Aim 1 - To create a video-atlas of non-dysplastic and dysplastic\u002Fearly neoplastic lesions in patients with BE. This will be used for training purposes and to assess learning curve associated with these new technologies.\n\nSpecific Aim 2 - To create a standardized classification system for the mucosal and vascular patterns observed in patients with BE.\n\nSpecific Aim 3 - To determine the interobserver agreement using the video-atlas for the mucosal and vascular patterns classification agreed upon.\n\nSpecific Aim 4 - To determine the endoscopic detection rate of esophageal cancer or precancerous lesions removed during endoscopy.\n\nSpecific Aim 5 - To determine the pathologic and clinical outcomes of patients undergoing EMR\u002Fablation; including morbidity, mortality and complications of the procedure.\n\nResults to date (June 2008) : this study is active and open to enrollment. Currently 26 patients have enrolled in this study at the Kansas City VA medical center. In order to participate, patients must be eligible for care at the KCVA hospital.",[25,26,27],"Barrett's Esophagus","Neoplasms","Gastroesophageal Reflux",[25,29,30,31,32],"Neoplasia","Endoscopic mucosal resection","High resolution endoscopy","Chromoendoscopy","RECRUITING","2024-11-20",{"date":36,"type":37},"2024-11-22","ACTUAL",{"date":39,"type":37},"2007-05-15",{"date":41,"type":21},"2026-12-30",{"name":43,"class":44},"Midwest Biomedical Research Foundation","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100100786","progression-of-gastroesophageal-reflux-disease-and-barretts-esophagus-and-the-creation-of-a-barretts-registry-100100786","NCT00574327","Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry","A Prospective Study To Define The Role Of Various Factors In Development And Progression Of Gastroesophageal Reflux Disease (GERD) And Barrett's Esophagus And The Creation Of A Registry.","All patients must be eligible for care that the Kansas City VA Hospital where this study was approved for enrollment.\n\nInclusion Criteria:\n\n* Kansas City VA Patients with confirmed BE with and without dysplasia and patients with reflux disease (patients\u002Fcases); patients with other indicators for endoscopy such as anemia, weight loss, diarrhea, but without GERD and PE (controls).\n\nExclusion Criteria:\n\n* Patients with uncontrolled significant comorbidities such as cardiovascular, pulmonary, renal, hepatic or metabolic diseases.\n* Presence of anticoagulation that would increase risk from biopsies\n* Patients unable to provide history\n* Patients with dyspepsia",true,{"count":55,"type":21},3000,"The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer. The investigators hypothesis is that systematic collection of data on the natural history of GERD and BE patients and risk factors for development of BE in patients with chronic GERD and progression of BE to dysplasia and adenocarcinoma will provide useful information to develop a decision model for risk stratification and risk reduction strategies in these patients.\n\nAs of March 17, 2011, 585 patients have consented at the Kansas City VA Medical Center.",[25,58,59],"Gastroesophageal Reflux Disease","Esophageal Adenocarcinoma",[61,62,25],"Role","Registry","2023-03-15",{"date":65,"type":37},"2023-03-16",{"date":67,"type":4},"2006-01",{"date":69,"type":21},"2029-01",{"name":43,"class":44},""]