[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Milwaukee VA Medical Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":85},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,59],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100621170","occupational-exposure-to-whole-body-vibration-among-us-military-veterans-acute-and-chronic-contributions-to-musculoskeletal-disorders-and-spine-area-pain-100621170",false,"NCT07367139","Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain","Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain, and the Role of Water","Inclusion Criteria:\n\n* English speaking; Male\u002FFemale Veterans age 20-45 years; BMI \\\u003C 30; ability to sit upright for 60 mins; ability to drive to Deerfield, IL; ambulatory\n\nExclusion Criteria:\n\n* Previous spinal surgery; conditions\u002Fdiseases associated with altered pain perception including neurological diseases (e.g., multiple sclerosis, trigeminal neuralgia, central sensitization), major psychiatric disorders, diabetes, neoplasm and cardiovascular disorders, chronic widespread pain diagnosis, pregnant women, MRI contraindications.",true,"ALL","20 Years","45 Years",{"count":21,"type":22},112,"ESTIMATED","INTERVENTIONAL",[25],"NA","Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain. Military operational exposure to whole body vibration (WBV) is known to contribute to MSK disorders and pain. Our preliminary studies identified accelerated lumbar and cervical spine degenerative changes in military fighter pilots and helicopter aircrew compared to age- and sex-matched civilian controls. Those changes were likely associated with WBV that military aircrew experience during flight training, primarily affected intervertebral discs (IVDs) and endplates, were associated with neck and back pain symptoms and reduced functional capacity, and are likely to lead to lifelong spine-related issues. Therefore, these aircrew, and other military personnel that experience occupational WBV, are likely to enter the VA Healthcare system with pre-existing degenerative changes and spine-related pain symptoms that can progress over time. Similarly, many Veterans enter civilian occupations that involve WBV such as truck drivers and heavy equipment operators that may also have detrimental effects to the spine and lead to spine-related pain. Development of informed interventions and treatment protocols requires a mechanistic understanding of how the spine is acutely and chronically affected by occupational WBV from both structural and physiological perspectives. Innovation and Impact: Novel multi-parametric application of noninvasive magnetic resonance imaging (MRI) techniques such as arterial spin labeling (ASL), T2\\* decay from ultra short TE, and diffusion MRI can provide early objective indications of endplate degenerative state and IVD hydration and perfusion, and novel application of upright MR imaging allows for gravitational loading of the IVD while observing segmental and region IVD fluid distribution and transport patterns. Specific Aims: The goal of the proposed effort is to characterize the effects of previous military and current civilian occupational WBV on IVD and endplate health and degeneration (Aim 1), and segmental and regional IVD fluid distribution and transport differences (Aim 2). The endplates contain vasculature that permits IVD fluid exchange and may be linked to IVD fluid dynamics. We propose looking for connections between segmental and regional IVD fluid dynamics, degenerative state of the associated endplates, and WBV exposure (acute-controlled and longitudinal-occupational). Finally, we propose evaluating the impact of body hydration state on IVD fluid distribution and transport following acute (30 min) controlled WBV (Aim 3). Cumulatively, these results inform population-specific preventative measures to preserve endplate health for Veterans in occupations that present with WBV and identify potential areas for further research and targeted treatment of MSK disorders and MSK pain. Methodology: This study will explore acute and chronic changes to the structure and physiology of the spine by enrolling Veterans with prior military or current civilian occupation that involves daily WBV. Advanced MRI sequences will identify endplate sclerosis and physiological changes including disc hydration and perfusion. Acute effects of WBV will be assessed using pre\u002Fpost MRI scans with experimental WBV. Path to translation\u002FImplementation: Our existing relationships with VA clinicians, including spine surgeons, physical medicine and rehabilitation, and pain medicine, will ensure VA patient applicability of these findings and will help to translate any outcomes from this research and future studies directly into patient care.",[28,29,30,31],"Spine Health","Spine Injuries and Disorders","Spine Degeneration","Whole Body Vibration",[33,34,31,35,36,37,38,39,40,41,42,43,44,45],"Biomechanics","Magnetic Resonance Imaging (MRI)","Lumbar Spine","Degeneration","Intervertebral Disc","Hydration","Oswestry Disability Index","PainDETECT","Pain Catastrophizing","PROMIS","Brief Pain Inventory","Longitudinal","Endplate","NOT_YET_RECRUITING","2026-01-16",{"date":49,"type":50},"2026-01-26","ACTUAL",{"date":52,"type":22},"2026-07-01",{"date":54,"type":22},"2030-06-30",{"name":56,"class":57},"Milwaukee VA Medical Center","FED",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":17,"minAge":67,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":23,"phases":70,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":4},"100602809","cgm-use-in-non-insulin-patients-with-dm2-100602809","NCT07128342","CGM Use in Non-insulin Patients With DM2","Use of Continuous Glucose Monitoring in Veterans With Uncontrolled Diabetes Managed Without Insulin Therapy","CGM-DWI","Inclusion Criteria:\n\n* Successfully enrolled and ready to begin the VDOP program not on insulin therapy\n* Type 2 diabetes by clinical history\n* HbA1C between 8.0-12.0% inclusive within 3 months of enrollment\n* Assessment by clinician that patient is willing to and able to wear a CGM device\n* Stable diabetes medication regimen during the 3 months prior to entry\n\nExclusion Criteria:\n\n* Patients already or planned on starting insulin therapy, already on CGM, or those who qualify for CGM under VA policy\n* Patients with gestational diabetes or pregnant at time of screening or are planning to become pregnant during the study\n* Patients with end stage renal disease (ESRD) on dialysis\n* Anticipated acute uses of glucocorticoids (oral, injectable, or IV)\n* Acute conditions that impact the HbA1c measurement stability such as GI blood loss, recent (within 3 months of study entry), anticipated red blood cell transfusion or erythropoietin administration\n* Known or suspected significant allergy to use the Dexcom sensors\n* Planning or currently enrolled on different weight program different from MOVE!\n* Participating other clinical trials","18 Years",{"count":69,"type":22},100,[25],"The U.S. Food and Drug Administration (FDA) has approved multiple Continuous Glucose Monitoring (CGM) devices from different manufacturers to be used as an aide in patients with type 1 and type 2 diabetes who require medications, and more recently, as over the counter versions for patients with and or without diabetes who want to better understand how diet and exercise may impact blood sugar levels. However robust evidence supporting that CGM is significantly superior to traditional home fingerstick blood glucose monitoring (FSBGM) in this population is lacking. Thus, Medicare and VHA only authorize use of CGM for patients with diabetes who require daily insulin therapy , unless they meet special criteria such as having hypoglycemia or inability to monitor glucose via traditional FSBGM.\n\nObjectives Primary Study Aim: Among veterans with uncontrolled diabetes not requiring insulin therapy who are participating in an intensive multidisciplinary program to improve diabetes control (VDOP), to assess whether use of a CGM compared to use of traditional FSBGM results in greater change in hemoglobin A1c upon VDOP completion and up to 12 months.\n\nSecondary study aims: To assess whether use of CGM in this population leads to greater improvement in diet, physical activity, and weight loss upon VDOP completion and up to 12 months.\n\nHypothesis\n\nThe use of a CGM by Veterans with T2DM who do not use insulin will help them improve their diabetes self - management (diet, physical activity, weight) and glycemic control more so than those using traditional fingerstick glucose monitoring.\n\nMethods\n\nThis will be a prospective \"open label\" randomized controlled trial where participants will be randomly assigned to CGM (intervention group) or FSBGM (control group) during their participation in VDOP.\n\nRelevance to Veterans and VA mission\n\nMost Veterans with T2DM do not use insulin. It is important for both, these Veterans and the VA, to learn whether this more costly and somewhat burdensome technology supports improvement in diabetes self-management",[73,74,75,76],"Diabetes","Type 2 Diabetes (T2DM)","Obesity Type 2 Diabetes Mellitus","Non Insulin Dependent Diabetes Mellitus","2025-08-12",{"date":79,"type":50},"2025-08-18",{"date":81,"type":22},"2025-11-01",{"date":83,"type":22},"2028-11",{"name":56,"class":57},""]