[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ming Zhong\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":81},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,62],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100641064","eit-evaluation-of-the-impact-of-inhaled-nitric-oxide-on-ventilationperfusion-mismatch-in-ards-patients-receiving-noninvasive-respiratory-support-100641064",false,"NCT07617298","EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation\u002FPerfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory Support","EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation\u002FPerfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory Support: A Prospective Physiological Study","Inclusion Criteria:\n\n1. Age ≥ 18 years, gender unlimited;\n2. Non invasive ventilation (NIV) with PEEP or CPAP ≥ 5 cmH2O or nasal high flow oxygen therapy (hfnc) with flow rate ≥ 30 l\u002Fmin met the diagnostic criteria of non intubated ARDS according to the new global definition of ARDS: pao2\u002Ffio2 ≤ 300MMHG or spo2\u002Ffio2 ≤ 315 (SpO2 ≤ 97%);\n3. Patients with spontaneous breathing and clear consciousness can cooperate with instructions and hold breath for ≥ 8s;\n4. Patients with spontaneous breathing and clear consciousness can cooperate with instructions and hold breath for ≥ 8s;\n\nExclusion Criteria:\n\n1. There are signs of worsening respiratory failure requiring immediate intubation: respiratory rate \\> 40 times \u002F min with severe use of auxiliary respiratory muscles or contradictory breathing, or Paco ₂ \\> 50 mmHg and pH \\\u003C 7.25;\n2. Hemodynamic instability or the presence of refractory shock; That is, the vasoactive drugs increased by more than 30% within 6 hours, or the norepinephrine dose exceeded 0.5 μ g \u002Fkg\u002Fmin;\n3. There are contraindications to EIT monitoring, such as thoracic implantable defibrillator \u002F pacemaker, large area of severe skin damage on the chest, serious allergy to electrode patches, etc;\n4. There are contraindications to the use of iNO: such as severe left ventricular dysfunction, active bleeding, etc;\n5. Patients with intracranial hypertension, severe arrhythmia or digestive tract obstruction;\n6. Pneumothorax and massive pleural effusion were not treated;\n7. Chronic kidney disease;\n8. Pregnant or lactating women;\n9. Participating in other studies;\n10. The investigator judged that there were any other circumstances not suitable for participation in this study. -","ALL","18 Years","80 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","This study aimed to quantitatively evaluate the immediate effect of inhaled nitric oxide on the ventilation \u002F perfusion ratio in ARDS patients receiving nasal high flow oxygen therapy or noninvasive ventilation using electrical impedance tomography.",[25],"ARDS (Acute Respiratory Distress Syndrome)",[27,28],"ARDS","inhaled nitric oxide","NOT_YET_RECRUITING","2026-05-24",{"date":32,"type":33},"2026-06-01","ACTUAL",{"date":35,"type":21},"2026-06-30",{"date":37,"type":21},"2027-12-31",{"name":39,"class":40},"Ming Zhong","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":61,"locationsCount":41},"100611127","impact-of-airway-mucus-plugs-on-secondary-pulmonary-fibrosis-in-copd-patients-a-single-center-case-control-study-100611127","NCT07236541","Impact of Airway Mucus Plugs on Secondary Pulmonary Fibrosis in COPD Patients: A Single-Center Case-Control Study","Inclusion Criteria:\n\n* ① Age ≥ 18 years old;\n\n  * Planned radical resection for lung cancer, with postoperative pathological diagnosis of primary lung cancer;\n\n    * During surgery, non tumor lung tissue at a distance of ≥ 5 cm from the tumor edge can be obtained; ④ Case group: Preoperative pulmonary function examination confirmed diagnosis of COPD (FEV ₁\u002FFVC\\\u003C0.70); ⑤ Control group: Preoperative lung function was normal (FEV ₁\u002FFVC ≥ 0.70), with no history of COPD; ⑥ The subjects are able to understand and sign the informed consent form\n\nExclusion Criteria:\n\n* ① Clear presence of other interstitial lung diseases (ILD) or idiopathic pulmonary fibrosis before or during surgery （IPF）、 Fibrosis after pneumoconiosis or tuberculosis;\n\n  * Active pulmonary infections (such as bacterial pneumonia, fungal infections, active tuberculosis);\n\n    * Having received neoadjuvant radiotherapy or chemotherapy, which may affect the morphology or molecular results of distal lung tissue; ④ Combined severe immunodeficiency or long-term systemic immunosuppressive therapy (such as glucocorticoids ≥ 20 mg\u002Fd, More than 4 weeks);\n\n      * Merge with other serious systemic diseases (such as advanced heart failure, end-stage renal disease), affecting study compliance or Survival expectation; ⑥ Pregnant or lactating women; ⑦ Refusing to sign the informed consent form or deemed unsuitable by the researcher to participate in the study.","89 Years",{"count":50,"type":21},20,"Chronic obstructive pulmonary disease (COPD) is frequently accompanied by airway mucus plugs, which are closely associated with airflow obstruction, acute exacerbations, and increased mortality. However, whether mucus plugs contribute to secondary pulmonary fibrosis remains unclear. This single-center, prospective, case-control study aims to investigate the relationship between airway mucus plugs and lung fibrosis in patients with COPD undergoing lung cancer surgery.\n\nDuring surgery, distal non-tumorous lung tissues and airway mucus will be collected for histological and molecular analyses. Mucus plug burden will be quantified using AB-PAS staining, and fibrosis will be assessed using Masson staining. Expression of epithelial-mesenchymal transition (EMT) markers, fibrotic markers, and the mechanosensitive ion channel Piezo1 will also be measured. COPD patients (FEV₁\u002FFVC \\\u003C0.70) will be compared with non-COPD surgical controls.\n\nThe study aims to clarify whether mucus plugs are associated with increased fibrosis and to explore the potential involvement of mechanical-signaling pathways, including Piezo1 activation. Findings may provide new clinical and pathological evidence for mucus-induced fibrotic remodeling in COPD and help identify novel therapeutic targets.",[53],"Lung Fibrosis","RECRUITING","2025-11-14",{"date":57,"type":33},"2025-11-19",{"date":59,"type":33},"2025-10-30",{"date":35,"type":21},{"name":39,"class":40},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":70,"conditions":71,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":41},"100605684","a-real-world-study-of-respiratory-critical-disease-100605684","NCT07165717","A Real World Study of Respiratory Critical Disease.","Inclusion Criteria:\n\n* Patients with underlying diseases associated with high risk of ARDS, including but not limited to: sepsis, pneumonia, multiple trauma, pulmonary contusion, inhalation injury, massive blood transfusion, other high-risk conditions, or other factors causing excessive respiratory drive.\n* Patients meeting the inclusion criteria for a high-risk ARDS population.\n* Patients (or legal representatives) who have provided a signed and dated informed consent form.\n\nExclusion Criteria:\n\n* Age under 18 years.\n* HIV infection.\n* Known immunodeficiency disorders (e.g., leukemia, common variable immunodeficiency, etc.).\n* History of solid organ or bone marrow transplantation.\n* Receiving treatment with G-CSF or GM-CSF.\n* Patients with a decision to withdraw from active treatment.",{"count":69,"type":21},500,"Acute Respiratory Distress Syndrome (ARDS) is a form of acute diffuse lung injury caused by various etiologies, which rapidly progresses to acute respiratory failure. It is characterized by a sudden onset and severe clinical course. Globally, ARDS affects approximately 3 million individuals each year, accounting for about 10% of admissions to intensive care units (ICUs). Due to the lack of specific pharmacological therapies, mechanical ventilation remains the mainstay of treatment. Therefore, identifying and analyzing prognostic factors for ARDS patients is of great significance for improving patient outcomes and reducing the incidence of poor prognosis.",[25,72],"Real World Study","2025-09-02",{"date":75,"type":33},"2025-09-10",{"date":77,"type":33},"2019-03-01",{"date":79,"type":21},"2025-12-31",{"name":39,"class":40},""]