[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ministry of Health, Kuwait\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":99},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100613212","the-effect-of-balance-focused-exercise-programme-in-enhancing-the-solus-muscle-activation-during-gait-initiation-for-people-with-parkinson-disease-100613212",false,"NCT07263646","The Effect of Balance-focused Exercise Programme in Enhancing the Solus-muscle Activation During Gait Initiation for People With Parkinson Disease","Inclusion Criteria:\n\n* participants diagnosed by their neurologist with Parkinson's disease (moderate to severe stage)\n* stable on anti-Parkinson's drugs\n* able to walk independently without a frame or walking stick.\n* Able to walk for more than 10 mins unaided\n* without cognitive disability (Able to follow simple instructions and communicate, orally),\n* have good vision (with or without corrective aids)\n\nExclusion Criteria:\n\n* are pregnant\n* cardiac problems exacerbated by exercise\n* currently complaining of joint or muscle problems that affect walking ability\n* known to have neurological conditions (other than Parkinson) that affect walking ability\n* uncorrected hearing or vision problems\n* history of severe motion sickness\n* history of vestibular or balance problems\n* an active skin condition that could be irritated by contact with sticky tape.","ALL","18 Years",{"count":18,"type":19},80,"ESTIMATED","INTERVENTIONAL",[22],"NA","Gait initiation (GI) is a crucial component of walking that requires a balanced muscle activity and postural stability. GI could be challenging for people with neurological condition such as people with Parkinson (PWP), where GI is usually impaired. The purpose of this study is determining effectiveness of comprehensive, balanced-focused exercise programme in controlling the activation of Solus-muscle in people with Parkinson disease. We hypothesise that balance-focus exercise programe could improve Solus-muscle activation during GI.\n\nstudy type: this is a parallel group prospective (10 weeks) randomised single-blinded controlled trial conduct in Kuwait.\n\nParticipant: People with Parkinson, who met the inclusion criteria.",[25,26,27],"Parkinson Disease","Gait Disorders","Gait Balance",[29,30,31,32],"gait initiation","Parkinson disease","rehabilitation","balance-focus exercise","NOT_YET_RECRUITING","2025-12-03",{"date":36,"type":37},"2025-12-10","ACTUAL",{"date":39,"type":19},"2026-01-22",{"date":41,"type":19},"2028-12-22",{"name":43,"class":44},"Ministry of Health, Kuwait","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":20,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":45},"100488603","effects-of-fall-prevention-program-on-the-number-of-falls-among-elderly-following-total-knee-replacement-100488603","NCT05642260","Effects of Fall Prevention Program on the Number of Falls Among Elderly Following Total Knee Replacement","The Short- and Long-term Effects of Fall Prevention Program on the Number of Falls Among Elderly Following Total Knee Replacement: a Pragmatic Single-blinded Randomized Controlled Trial.","Inclusion Criteria:\n\n* Female gender.\n* Aged 60 years and older.\n* Diagnosed with primary osteoarthritis of the knee.\n* Underwent unilateral TKR.\n\nExclusion Criteria:\n\n* revision TKR surgery\n* history of systemic inflammatory conditions (i.e., rheumatoid arthritis, Lupus erythematosus),\n* neurological disorders (i.e., multiple sclerosis, Parkinson's disease, stroke)\n* lower limb surgery\u002Ftrauma in the past 12 months\n* have cognitive and\u002For vision impairments\n* post-surgical complications (e.g., infection, intraoperative fracture)\n* any health condition that may preclude them from undertaking physiotherapy.","FEMALE","60 Years",{"count":56,"type":19},90,[22],"the aim of the proposed research is to investigate the short and long-term effects of integrating a comprehensive fall prevention programme into conventional physiotherapy on the number of falls, balance, and functional ability among elderly following TKR. the investigator hypothesize that conventional physiotherapy integrated with a fall prevention program is more effective than conventional physiotherapy alone in improving balance and functional ability and preventing the occurrence of falls among elderly following TKR.\n\nStudy type: The proposed study is a parallel group prospective (24 weeks) randomised single-blinded pragmatic controlled trial.\n\nParticipants: Older adults operated for TKR at Al-Razi orthopedic hospital, who met the inclusion criteria.",[60,61,62],"Fall","Osteo Arthritis Knee","Total Knee Replacement",[64,65,66,67,31],"fall","older people","fall prevention","TKR","RECRUITING","2025-12-02",{"date":71,"type":37},"2025-12-09",{"date":73,"type":37},"2023-01-08",{"date":75,"type":19},"2026-09-08",{"name":43,"class":44},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":54,"enrollmentInfo":84,"targetDuration":4,"studyType":20,"phases":86,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100500392","phase-1-the-effect-of-platelet-rich-plasma-for-the-treatment-of-osteochondral-lesions-of-the-talus-100500392","NCT05795660","The Effect of Platelet Rich Plasma for the Treatment of Osteochondral Lesions of the Talus","The Effect of Platelet Rich Plasma for the Treatment of Osteochondral Lesions of the Talus: Randomized Controlled Trial","Inclusion criteria:\n\n* Diagnosis of OCL, which will be confirmed with radiographs and magnetic resonance imaging.\n* aged \\> or = 18 years \\\u003C 60 year\n* complain of ankle pain.\n\nExclusion Criteria:\n\n* posterior OCL\n* pregnancy\n* ankle infection\n* teroid injection within 6 months\n* surgery of the involved joint with 6 months\n* received glucosamine and\u002For chondroitin sulfate, or anticoagulant\n* Systematic inflammatory condition\n* substantial venous or lymphatic stasis in the legs\n* Pathologies that my confound pain and functional assessment in the ankle (plantar fasciitis, Achilles tendonitis, sprains, and degenerative joint disease of the foot.\n* Allergy to any of the component of the PRP injection, disabling degenerative joint disease.",{"count":85,"type":19},24,[87],"PHASE1","Osteochondral lesion of the talus (OCL) results from the detachment of the talar cartilage which could also be associated with subchondral bone fragmentation due to trauma. OCL can be managed conservatively by immobilization and weight bearing restriction or surgically to stimulate the regeneration and the formation of fibrous cartilage including reparative or replacement approaches. OCL surgical intervention includes bone marrow stimulation or autologous osteochondral transplantation while the cartilage regeneration was found unsatisfactory with these interventions. However, introducing platelet rich plasma (PRP) as an adjacent intervention could enhance the cartilage regeneration in OCL due to the release of growth factors and bioactive components, which could in turn reduce the need for replacement interventions and improve the regeneration of the cartilage.\n\nThe literature was reviewed, and four randomized controlled trials have been found exploring the effect of PRP in OCL where both ankle function and pain were examined. The results of the previous studies have proved the effectiveness of PRP in managing OCL as an adjunct to microfracture surgery in improving ankle function and reducing pain which was superior to the surgical intervention alone and also superior to the injection of PRP alone. Despite the promising results, the previous studies were limited to several factors. There was a lack of blinding which could risk the results to expectation bias, and the follow up period was short in according to the MCMS, which is needed to monitor the long-term effect of the PRP and to document any potential adverse effects or relapse in the function. Additionally, all the previous studies performed blind injection. Additionally, the previous studies have not controlled the administration of analgesic which could risk the results of the pain effect.\n\nThe proposed study aims to examine the effect of PRP in the management of OCL using randomized double-blind control trial design to eliminate any expectation bias. Patients will be followed up for 12 months, and the PRP will be administered intra-operatively. Moreover, PRP concentration will be standardized. Analgesic will be controlled and documented as a confounded factor. Additionally, the quality of the repaired tissue and the regeneration of the hyaline cartilage will be examined using MRI at the end of the follow-up. Therefore, the study aims to examine the effectiveness of PRP in OCL using randomized controlled trial design.",[90],"Osteochondral Lesions of the Talus","2023-03-31",{"date":93,"type":37},"2023-04-03",{"date":95,"type":19},"2023-04-01",{"date":97,"type":19},"2026-12-01",{"name":43,"class":44},""]