[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Minneapolis Veterans Affairs Medical Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":103},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100634585","reaching-rural-veterans-applying-mind-body-skills-for-pain-using-a-whole-health-telehealth-intervention---uh3-100634585",false,"NCT07541599","Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention - UH3","Reaching Rural Veterans: Applying Mind-Body Skills for Pain Using a Whole Health Telehealth Intervention","RAMP","Inclusion Criteria:\n\n* 18 years of age or older\n* rural-dwelling based on U.S. Health Services Research Administration Criteria\n* chronic pain based on two qualifying pain diagnoses in their electronic health record (EHR) within the same diagnostic category, at least 90 days apart, during the previous 2 years\n* self-reported pain on at least most days in the past 3 months\n* Brief Pain Inventory Interference subscale score ≥ 4\u002F10\n* access to a device with internet\n* willingness to engage in intervention-specific procedures (e.g., meet remotely online for sessions)\n* an email address listed in the EHR.\n\nExclusion Criteria:\n\n* severe, poorly controlled psychiatric or substance use disorder (identified by chart review)\n* active member of advisory panel for the study\n* enrollment in another research study for pain\n* enrollment in a similar study\n* enrollment in a similar facilitated, multi-week, multi-modal complementary and integrative health program.","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of the RAMP mind-body program is to provide Veterans with information and tools that can help them manage their pain. The program explores the important connection between our bodies and minds, and how to use this special connection to manage pain more effectively.",[27],"Chronic Pain",[29,30,31,32,33],"chronic pain","complementary therapies","models, biopsychosocial","rural","Veteran","RECRUITING","2026-05-11",{"date":37,"type":38},"2026-05-15","ACTUAL",{"date":40,"type":38},"2026-04-01",{"date":42,"type":21},"2028-12",{"name":44,"class":45},"Minneapolis Veterans Affairs Medical Center","FED",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100618490","remote-stimulation-and-training-to-advance-recovery-from-tbi-in-seniors-100618490","NCT07332299","Remote Stimulation and Training to Advance Recovery From TBI in Seniors","ReSTART","Inclusion Criteria:\n\n1. Veterans age 65 and older.\n2. History of mild TBI (as defined by the DOD\u002FVA criteria used in conjunction with the OSU TBI-ID) sustained at least 3 months prior to enrollment.\n3. Self-reported or medically documented attention and\u002For concentration difficulties.\n4. Stable dose of all prescription and non-prescription medications that may impact cognition or brain chemistry (except for PRN medication) for at least 3 weeks prior to the baseline session (Visit 1), in the medical opinion of the principal investigator.\n5. Capable and willing to provide voluntary informed consent, in the medical opinion of the principal investigator.\n\nExclusion Criteria:\n\n1. Presence of a medical, psychiatric, physical or non-physical disease, disorder, condition, injury, disability or pre-existent history such that study participation, in the opinion of the principal investigator: (a) may pose a significant risk to the participant, (b) raises the possibility that the participant is unlikely to successfully complete all the requirements of the study according to the study protocol, or (c) might adversely impact the integrity of the data or the validity of the study results. Specific conditions include (but are not limited to) a history of brain tumor near the stimulation site, brain surgery, stroke with current sequalae, epilepsy, multiple sclerosis, Huntington's Disease, ALS, ataxia, aphasia, Alzheimer's Disease, and dementia.\n2. Moderate to severe cognitive impairment with MoCA score (assessed upon enrollment) less than 15.\n3. Prior treatment with ECT or neuromodulation in the last 12 months.\n4. Current severe alcohol or substance use disorder with evidence of withdrawal or tolerance within the past 6 months, based on psychiatric history and\u002For a review of available medical records.\n5. Psychosis or mania within 30 days of enrollment, as determined by the principal investigator, based on psychiatric history and\u002For a review of available medical records.\n6. Contraindications for tDCS (e.g., metallic cranial plates\u002Fscrews or implanted device, eczema or skin lesions on scalp near electrode site, etc.).\n7. No or limited internet connection in their home.","65 Years",{"count":56,"type":21},40,[24],"The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI).\n\nThe main questions are:\n\n* Does transcranial direct current stimulation (tDCS) make cognitive training more effective for improving attention, memory, and decision-making?\n* Is this type of home-based program feasible and acceptable for older adults with TBI?\n\nResearchers will compare two groups: one group will receive active tDCS during cognitive training, and the other group will receive sham (placebo) tDCS during cognitive training.\n\nParticipants will:\n\n* Complete computer-based cognitive training exercises (BrainHQ) to practice attention, memory, and decision-making.\n* Receive either active or sham tDCS during training sessions.\n* Complete assessments before and after the program to measure changes in thinking and daily functioning.",[60,61],"Traumatic Brain Injury","Aging Related Cognitive Decline",[63,64,65,60],"Aging","Cognitive Training","Transcranial Direct Current Stimulation","2026-01-08",{"date":68,"type":38},"2026-01-12",{"date":70,"type":21},"2026-01-15",{"date":72,"type":21},"2027-09",{"name":44,"class":45},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":46},"100533636","phase-2-ketamine-treatment-for-ptsd-and-mdd-in-tbi-100533636","NCT06228391","Ketamine Treatment for PTSD and MDD in TBI","Examining the Efficacy and Safety of Subanesthetic Ketamine on Depression and Post-traumatic Stress Among Veterans With Mild and Moderate Traumatic Brain Injury","Inclusion Criteria:\n\n* Willingness\u002Fable to sign informed consent.\n* Able to read and write in English.\n* Male or female Veterans aged 18-55 years old.\n* Remote history of TBI mild-moderate that is ≥12 weeks post-injury (chronic period) that met at minimum the 2021 VA\u002FDoD Clinical Practice Guideline for the Management and Rehabilitation of Post-Acute Mild Traumatic Brain Injury (i.e., new onset or worsening of at least one of the following clinical signs immediately following the event: loss or decreased of consciousness, period of posttraumatic amnesia, period of being dazed and confused, and neurologic deficits).\n* Lifetime history of treatment resistance to at least one adequate trial of an antidepressant as determined by the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (MGH-ATRQ).\n* FDA-approved antidepressant, trazodone, atypical neuroleptic, prazosin, or clonidine with stable treatment, as determined by the study clinician, for at least 4 weeks prior to randomization. Following randomization, changes to doses may be allowable at the investigator's discretion\n\nExclusion Criteria:\n\n* Ketamine treatment within the last 6 months\n\n  * Lifetime history of psychosis-related disorder, current episode of mania\u002Fhypomania\u002Fmixed assessed by the Mini-International Neuropsychiatric Interview (MINI 7.0 for DSM-5).\n  * History of penetrating head wounds or severe traumatic brain injury (Glasgow Coma Scale \\<9; loss of consciousness \\>24hr; post-traumatic amnesia\\>7 days).\n  * Severe substance and\u002For alcohol use disorder (DSM-5-TR) within six months of initial assessment; presence of illicit drugs (except cannabis) by positive urine toxicology at screening.\n  * Intellectual disability or pervasive developmental disorder; dementia of any type.\n  * Any disorder that, based on the Principal Investigator\\'s judgement, would increase risk (e.g., unstable cardiac conditions) or protocol adherence (e.g., severe personality disorder).\n  * For women: pregnancy (confirmed by lab test), initiation of female hormonal treatments within 3 months of screening, or inability\u002F unwillingness to use a medically accepted contraceptive method during the study. Women who are surgically sterile or have been post-menopausal for at least 1 year will not be excluded\n  * At screening, resting blood pressure (sitting or supine) lower than 90\u002F60 or higher than 150\u002F90, or resting heart rate lower than 45\u002Fmin or higher than 100\u002Fmin.\n  * Imminent risk of suicidal\u002Fhomicidal ideation and\u002For behavior with intent and\u002For plan.\n  * Concurrent participation in a cognitive rehabilitation program, however patient will have a TBI clinician involved in directed services.\n  * Subjects on a prohibited medication: monoamine oxidase inhibitors, memantine, long acting benzodiazepines (i.e., Chlordiazepoxide, Diazepam, Flurazepam)","75 Years",{"count":56,"type":21},[84],"PHASE2","The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI). The main questions it aims to answer are:\n\n* Efficacy of ketamine to reduce symptoms of depression and\u002For PTSD\n* Safety of ketamine to treat depression and\u002For PTSD in TBI Participants will be randomly assigned to receive either ketamine or midazolam (active placebo) twice a week for 3 weeks. During participation, subjects will be interviewed, have lab tests, and complete rating scales, and questionnaires.",[87,88,60],"PTSD, Post Traumatic Stress Disorder","Major Depressive Disorder",[33,90,91,92,93],"Ketamine","PTSD","Depression","TBI","NOT_YET_RECRUITING","2024-01-26",{"date":97,"type":38},"2024-01-29",{"date":99,"type":21},"2024-03",{"date":101,"type":21},"2027-03",{"name":44,"class":45},""]