[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mona Lichtblau\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":124},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,72,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100626126","effect-of-acute-hypoxia-on-right-ventricular-function-in-asthma-100626126",false,"NCT07431580","Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.","Effect of Acute Hypoxia on RIght VEntRicular Function. A Single-Center, Double-Blind, Randomized Controlled Cross-Over Trial.","RIVER-Asthma","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed and well controlled asthma bronchiale\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment","ALL","18 Years","80 Years",{"count":21,"type":22},18,"ESTIMATED","INTERVENTIONAL",[25],"NA","More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with asthma responds to this stress is still not well understood.\n\nTherefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with asthma. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability.\n\nIn addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random.\n\nThe aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[28,29,30,31],"Hypoxia, Altitude","Hypoxia","Normobaric Hypoxia","Right Ventricular Function",[33,34,35,36,37,38,39],"right ventricular free wall strain","RVFWS","right ventricular function","tissue oxygenation","breathing difficulty","blood gas","heart rate","RECRUITING","2026-05-26",{"date":43,"type":44},"2026-05-29","ACTUAL",{"date":41,"type":44},{"date":47,"type":22},"2030-01",{"name":49,"class":50},"Mona Lichtblau","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":14,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":71,"locationsCount":51},"100626124","effect-of-acute-hypoxia-on-right-ventricular-function-in-hape-100626124","NCT07431554","Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.","RIVER-HAPE","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed or suspicion of past HAPE\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment",{"count":21,"type":22},[25],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with past HAPE responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with past HAPE. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[63,29,30,31],"Altitude Hypoxia",[33,34,35,36,37,38,39],"2026-04-28",{"date":67,"type":44},"2026-05-01",{"date":69,"type":44},"2026-03-17",{"date":47,"type":22},{"name":49,"class":50},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":14,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":91,"locationsCount":92},"100626125","effect-of-acute-hypoxia-on-right-ventricular-function-in-healthy-adults-100626125","NCT07431567","Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.","RIVER-H","Inclusion Criteria:\n\n* Signed informed consent\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders -Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old -Any diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women -Participation in other study with active treatment",true,{"count":21,"type":22},[25],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the healthy heart, especially the right ventricle, responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity. The present investigation focuses on healthy individuals in order to establish a reference for future comparisons with patients suffering from cardiopulmonary diseases. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Healthy participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[29,30,63,84],"Right Heart Function",[33,34,35,36,37,38,39],"2026-03-13",{"date":69,"type":44},{"date":89,"type":44},"2026-03-11",{"date":47,"type":22},{"name":49,"class":50},2,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":23,"phases":103,"briefSummary":104,"conditions":105,"keywords":109,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":92},"100626077","feasibility-of-integrating-street-racket-into-ambulatory-pulmonary-rehabilitation-100626077","NCT07430943","Feasibility of Integrating Street Racket Into Ambulatory Pulmonary Rehabilitation","Acceptability, Appropriateness and Feasibility of Integrating Street Racket Into Ambulatory Pulmonary Rehabilitation: A Prospective, Single-Arm Feasibility Study","APRacket","Inclusion Criteria:\n\n* Any sex or gender\n* Age \\>18 years\n* Prescribed APR by a physician and currently participating in APR at the USZ\n* Physically and psychologically capable of following instructions and standing\u002Fwalking for up to one hour (short, seated breaks are allowed if needed)\n\nExclusion Criteria:\n\n* Require supplemental oxygen therapy that cannot be delivered via a portable backpack system (e.g., large oxygen cylinders on wheels, which pose a fall risk)\n* Are unable to follow study procedures due to language barriers, psychological conditions, or orthopaedic limitations that prevent them from standing or walking for up to one hour\n* Require walking aids due to impaired balance (e.g., walking sticks, rollator, etc.)",{"count":102,"type":22},12,[25],"This study looks at whether Street Racket is a feasable activity that can be added to pulmonary rehabilitation for people with chronic lung disease. Participants complete short questionnaires at the start and end of the program to rate the feasibility and rate their breathlessness during each session. Attendance is recorded to understand how well the activity is used and whether there are any barriers.",[106,107,108],"Pulmonary Rehabilitation","Physical Activities","Exercise Therapy",[110,111,112,113,114,115],"pulmonary rehabilitation","street racket","exercise therapy","COPD","ILD","pulmonary hypertension","2026-03-09",{"date":118,"type":44},"2026-03-12",{"date":120,"type":44},"2026-03-05",{"date":122,"type":22},"2027-02-28",{"name":49,"class":50},""]