[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Monell Chemical Senses Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":74},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100610077","phase-2-impact-of-smell-testing-on-health-outcomes-100610077",false,"NCT07222891","Impact of Smell Testing on Health Outcomes","Validating the Impact of Smell Testing on Health Outcomes and Provider Engagement.","Inclusion Criteria:\n\n\\- Can read and understand English and have access to a reliable internet connection and a smart device or computer for the duration of the experimental sessions, unless they are part of community events in which smart devices are provided\n\nExclusion Criteria:\n\n\\- Known intolerance or allergy to any of the odor stimuli used",true,"ALL","7 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Smell dysfunction is frequent yet neglected. The sense of smell plays a crucial role in signaling disease, safety, and overall quality of life. However, the significance of a functional sense of smell in terms of health and well-being is often overlooked until one experiences a loss of smell due to injury or disease. Research demonstrates that individuals are often not self-aware of their smell dysfunction (i.e. they do not spontaneously report smell dysfunction as a symptom), especially if the changes are gradual, as in normal aging. Patients with smell dysfunction experience a marked reduction in quality of life, poor mental health, nutritional health, and brain health as well as increased 5- and 10-year mortality in older adults. This study explores whether or not enabling healthcare providers to offer resources and guidance on coping strategies for smell dysfunction improves health and wellbeing in those who experience it.",[27,28],"Olfactory Dysfunction","Wellbeing",[30,31,32,33,34,35],"Olfactory testing","Smell dysfunction","Psychological health","Randomized clinical trial","Patient-centered care","Access to care","NOT_YET_RECRUITING","2025-10-29",{"date":39,"type":40},"2025-10-30","ACTUAL",{"date":42,"type":21},"2025-11-01",{"date":44,"type":21},"2027-11-30",{"name":46,"class":47},"Monell Chemical Senses Center","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":48},"100587520","using-bitter-taste-receptor-blockers-to-improve-the-palatability-of-pediatric-medicines-100587520","NCT06929455","Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines","Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines: Trained Human Sensory Panels","Inclusion Criteria:\n\n* Between the ages of 18 and 60;\n* Generally healthy by self-report;\n* All races\u002Fethnicities, both men and women;\n* Able to provide informed consent;\n* Able to attend repeated visits to Monell for sensory testing;\n* Willing to follow instructions (e.g., refrain from eating or drinking for at least 1 hour before sessions, willing to remain on site for one hour after tasting an API that the participant has never tasted before). -\n\nExclusion Criteria:\n\n* Under 18 or over 60;\n* Pregnant, nursing, or plans to become pregnant;\n* Unable to provide consent (including limited ability to understand written and spoken English);\n* Tobacco, vape, marijuana, or tetrahydrocannabinol cartridge users. We will accept people who have used tobacco or marijuana products on occasion, but not regular users;\n* Known drug or food allergies of any kind;\n* Diabetes or other metabolic disorder;\n* Liver issues of any kind, including viral hepatitis;\n* Kidney issues of any kind;\n* Other chronic illness, including cardiovascular, neurological, immune disorders, or any other serious acute or chronic condition\n* Dentures or other major dental implants;\n* Condition affecting the oral cavity, including dry mouth, burning mouth syndrome, active sores or blisters, geographic tongue, or other disorders\n* Current infection or cold, flu, or infection with SARS-CoV-2 within the last four weeks;\n* Unable to taste or smell\n* Daily use, or use within the last four weeks, of either prescription or over-the-counter medications (except for birth control)\n* History of tuberculosis (including latent tuberculosis), positive skin or other tuberculosis test at any time in the past, birth in or residence in a country with high tuberculosis rates, known contact with someone who is tuberculosis positive\n* HIV infection","18 Years","60 Years",{"count":59,"type":21},100,[61],"NA","Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better.\n\nParticipants in this research study will be healthy adults between the ages of 18 and 60 years old. Participants will taste samples (liquids or gels) containing active pharmaceutical ingredients (substances in medications that produce desired health effects). After tasting each sample participants will spit out the sample and rinse with water (no samples will be swallowed). Active pharmaceutical ingredients of current interest are: 1) tenofovir alafenamide, used to treat HIV infection and hepatitis B, 2) rifampicin, used to treat tuberculosis, 3) rifapentine, used to treat tuberculosis, and 4) levofloxacin, used to treat various bacterial infections). Other active pharmaceutical ingredients may be added as the study goes forward. Participants will be instructed to taste samples both with and without experimental flavor ingredients added and judge how the samples taste. People who volunteer for the study will be instructed to complete many repeated visits to the Monell Center (University City area of Philadelphia) for tasting sessions. Tasting visits will last between 1 and 2 hours.",[64],"Healthy Adults","RECRUITING","2025-04-14",{"date":68,"type":40},"2025-04-16",{"date":70,"type":40},"2025-03-18",{"date":72,"type":21},"2026-11-01",{"name":46,"class":47},""]