[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Montana State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":214},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,40,73,104,135,164,187],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100637513","improving-patient-engagement-in-mental-health-services-100637513",false,"NCT07618312","Improving Patient Engagement in Mental Health Services","Improving Patient Engagement in Mental Health Services: Adaptation and Implementation of a Behavioral Activation Intervention","Inclusion Criteria:\n\n* Age 18 years or older\n* Spanish-speaking adult who prefers to receive services in Spanish\n\nResident of a rural or frontier community in Montana or New Mexico\n\nPositive screen for depressive symptoms at or above study eligibility threshold on Spanish-language screening measure\n\nAble and willing to participate in telehealth sessions\n\nAble to provide informed consent\n\nExclusion Criteria:\n\n* Active suicidal intent requiring immediate emergency intervention\n\nCurrent psychosis or mania\n\nSevere cognitive impairment that would prevent participation\n\nCurrently receiving intensive psychiatric treatment that would conflict with the intervention\n\nUnable to participate in telehealth sessions\n\nUnable to provide informed consent","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","Hybrid Type II Implementation Trial",[26,27],"Depression Disorder","Engagement","NOT_YET_RECRUITING","2026-05-26",{"date":31,"type":32},"2026-06-01","ACTUAL",{"date":34,"type":20},"2027-03",{"date":36,"type":20},"2030-02",{"name":38,"class":39},"Montana State University","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":17,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},"100628387","nen-nkumbiedahiyedo-plus-we-are-here-now-plus-a-multi-level-intervention-to-reduce-health-disparities-among-american-indian-youth-100628387","NCT07460973","Nen ŨnkUmbi\u002FEdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth","Nen ŨnkUmbi\u002FEdaHiYedo Plus (NE+): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth","NE+","Inclusion Criteria:\n\n* 12 to 18 years old\n* Registered member of a federally recognized tribe or an associate tribal member\n* Resident of the Fort Peck Reservation with a caregiver who agrees for their child to participate in the intervention\n\nExclusion Criteria:\n\n* Not meeting any of the aforementioned inclusion criteria\n* Having a medically identified physical or cognitive impairment that would impede their understanding of and participation in the educational content, activities, and teachings of the intervention",true,"12 Years",{"count":51,"type":20},843,[23],"We Are Here Now - Plus (NE+) is a holistic, culturally centered, and multilevel intervention for American Indian youth to improve sexual health, mental health, and substance use outcomes. The goal of this intervention is to learn if NE+ can decrease substance use during sex, decrease sexual activity, increase condom use, increase positive mental health, increase caregiver(parent)-youth communication, increase communication between school personnel and youth, and increase utilization of clinical services. Researchers will compare one intervention arm to one control arm to see if the aforementioned indicators improve among the intervention arm for youth participants.\n\nYouth participants (ages 12-18) will participate in a 9-month educational program consisting of 18 modules that discuss healthy relationships, puberty \\& physiology (separate girls \\& boys), parenting, pregnancy and sexually transmitted infections (STIs) and Human Immunodeficiency Virus (HIV) prevention, sexual avoidant behaviors with a focus on abstinence, substance use prevention with a focus on abstinence and refusal skills, \\& positive mental health, resources; skills (high school)- self-efficacy, refusal skills, decision making, communication, abstinence; skills (middle school) - health knowledge, self-efficacy, boundaries, communication, abstinence. Youth will also participate in six teachings offered by local cultural leaders that coincide with educational modules, including: kinship networks \\& family; cultural values; 7 sacred roles of tribal members; ceremonies; cultural teachings and responsibilities of women \\& men in tribe \\& ceremonies; Indigenous worldview; skills - knowledge of traditional ways, language \\& cultural people to go to for help; community members roles \\& responsibilities in tribe \\& ceremonies.\n\nCaregiver (parent) participants will participate in three in-person visits\u002Fmeetings to discuss the following: visit 1 - age specific physical, cognitive, emotional, spiritual development; visit 2: prevention of substance use, promoting positive mental health, promotion of healthy relationships; skills -communication with youth; visit 3 - pregnancy and STIs\u002FHIV prevention and abstinence from sex, parental monitoring, tribal resources.\n\nSchool personnel participants will participate in three workshops during teacher in-service training days, including the following information: Workshop 1 - cultural teachings on kinship \\& family networks, cultural values, cultural age \\& community roles; Workshop 2 - sexual risk avoidant behaviors, substance use prevention, positive mental health promotion, pregnancy STIs\u002FHIV prevention, tribal resources; Workshop 3 - culturally respectful communication skills by age \\& youth (boy\u002Fgirl) and age \\& caregiver (male\u002Ffemale); skills - knowledge of cultural ways, substance use prevention, positive mental health promotion, sexual risk avoidant behaviors, culturally respectful communication.",[55,56,57,58],"Healthy","Condom Use","Mental Health","Substance Use (Drugs, Alcohol)",[60,61,62],"Sexual and reproductive health","Mental health","Substance use","RECRUITING","2026-05-09",{"date":66,"type":32},"2026-05-12",{"date":68,"type":32},"2026-03-23",{"date":70,"type":20},"2029-05-01",{"name":38,"class":39},1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":48,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":90,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":72},"100619446","impact-of-haskap-berries-on-recovery-from-high-intensity-resistance-training-100619446","NCT07344727","Impact of Haskap Berries on Recovery From High Intensity Resistance Training","Inclusion Criteria:\n\n* 2+ years of barbell squat experience\n* Currently squatting at least once a week\n\nExclusion Criteria:\n\n* BMI \\\u003C18 or \\> 40 kg\u002Fm\\^2\n* potential allergy to Haskap or placebo ingredients\n* anti-inflammatory, weight loss, anabolic steroids, testosterone, or other drugs that may interfere with the measures of the study or any other medications that may interfere with study measures\n* pregnant or lactating woman\n* diagnosis with type 1 or type 2 diabetes, hypo-\u002Fhyperthyroidism or any other condition that may interfere with study measures\n* smoke cigarettes\n* lower extremity injury within the last year\n* currently following a special diet including vegan, vegetarian, low carbohydrate, or ketogenic.\n* currently consuming any of the following products: tart cherry juice, pomegranate juice, or 1 or more cups of acai or other berries per day.","35 Years",{"count":81,"type":20},30,[23],"The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following:\n\n* Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults?\n* Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults?\n* The data collected in this investigation may also be used to ask additional questions not yet identified. For example, the investigators may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses.\n\nResearches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance.\n\n* Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet\n* Participants will perform an intense resistance workout\n* Participants will have their blood drawn before and after the workout\n* Performance will be analyzed at 24, 48 and 72 hours after the workout",[85,86,87,88,89],"Inflammation","Oxidative Stress","Resistance Exercise","Recovery","Exercise Performance Recovery",[91,92,93,94,95],"exercise performance","resistance exercise","recovery","oxidative stress","inflammation","2026-01-19",{"date":98,"type":32},"2026-01-21",{"date":100,"type":32},"2025-10-21",{"date":102,"type":20},"2026-05",{"name":38,"class":39},{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":48,"sex":16,"minAge":111,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":72},"100597159","rural-autistic-individuals---supporting-expression-100597159","NCT07054866","Rural Autistic Individuals - Supporting Expression","RAISE","Inclusion Criteria:\n\n* 1.1 Confirmed (preferably) or suspected diagnosis of ASD (autism spectrum disorder), or a receptive language impairment (i.e., difficulties with comprehension, Developmental Language Disorder), or both. Additional diagnoses, including ADHD (Attention Deficit and Hyperactivity Disorder), are acceptable. Siblings and cousins of these individuals are also welcome.\n\nOR 1.2 No diagnoses of ASD or DLD for unrelated control typically-developing participants.\n\n2\\. Normal hearing and normal vision (or corrected to normal with glasses or contacts).\n\n3\\. Ages 2+. 4. English as the dominant language of caregivers. 5. Caregivers who self-identify as living in a rural area. 6. The ability to verbally or physically respond is optional.\n\nExclusion Criteria:\n\n* 1\\. Poor hearing. 2. Inborn or acquired brain damage.","2 Years",{"count":113,"type":20},50,[23],"This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and\u002For minimally verbal individuals with Autism Spectrum Disorders (ASD), who are especially disadvantaged by the lack of accessible services in their rural communities. Individuals with other cognitive profiles, including Developmental Language Disorder (DLD), ADHD, Dyslexia, and others are welcome too. The study uses methods of eye tracking and recording of brain activity to understand how hand gestures adapted from signs from American Sign Language, such as \\[cry\\], can promote successful understanding of words like \"cry\". The overarching goal is to help families effectively utilize gestures to support communication with their children.",[117,118,119,120,121,122,123,124,125,126],"Autism Disorder","Language Development Disorders","ADHD","Typical Development","Rural Health","Children","Neuroimaging","Eye Tracking","EEG","fNIRS","2025-07-07",{"date":129,"type":32},"2025-07-10",{"date":131,"type":20},"2025-07",{"date":133,"type":20},"2027-07",{"name":38,"class":39},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":48,"sex":16,"minAge":79,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":21,"phases":146,"briefSummary":147,"conditions":148,"keywords":151,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":72},"100558046","gut-microbiota-dependent-health-impacts-of-haskap-berries-100558046","NCT06546020","Gut Microbiota-dependent Health Impacts of Haskap Berries","PARTNERSHIP: Elucidating Gut Microbiota-dependent Health Impacts of Haskap Berries to Inform Agricultural Production Practices That Will Maximize Bioactive Potential","HIH","Inclusion Criteria for Metabolically Healthy Group:\n\nAll of the following:\n\n* Waist circumference: men ≤ 40, women ≤ 35 inches\n* Systolic blood pressure: ≤ 130 mmHg\n* Diastolic blood pressure: ≤ 85 mmHg\n* Fasting glucose: ≤ 100 mg·dl-1\n* Fasting triglycerides: ≤ 150 mg·dl-1\n* HDL: men \\> 40, women \\> 50 mg·dl-1\n\nInclusion Criteria for Metabolically Unhealthy Group:\n\nRequired:\n\n\\- Waist circumference: men ≥ 40, women ≥ 35 inches\n\nAND ≥ 1 of the following:\n\n* Systolic blood pressure: \\> 130 mmHg\n* Diastolic blood pressure: \\> 85 mmHg\n* Fasting glucose: \\> 100 mg·dl-1\n* Fasting triglycerides: \\> 150 mg·dl-1\n* HDL: men ≤ 40, women ≤ 50 mg·dl-1\n\nExclusion Criteria:\n\n* BMI \\\u003C18 or \\> 40 kg\u002Fm\\^2\n* potential allergy to Haskap or placebo ingredients\n* use of anti-inflammatory, lipid lowering, glucose lowering, blood pressure, or any other medications that may interfere with study measures\n* pregnant or lactating woman\n* diagnosis with type 1 or type 2 diabetes or any other condition that may interfere with study measures\n* smoke cigarettes\n* have taken antibiotics in the past 90 days\n* take supplements including pre\u002Fprobiotics or \"superfoods\" within 30 days of starting the study\n* are planning on starting a weight loss or exercise regiment change\n* follow a specific diet such as low carbohydrate, vegan, and vegetarian\n* consume over 5 servings of fruit\u002Fvegetables per day\n* are unwilling to reduce caffeine intake to one 8 oz serving per day for the durations of the study","65 Years",{"count":145,"type":20},120,[23],"Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases. A critical knowledge gap is that little is known about the interactions between gut microbes and Haskap polyphenols to produce bioactive metabolites linked to downstream health impacts. Additionally, little is known about which Haskap varieties and harvest timing yield the greatest bioactive potential. This study aims to address these gaps by investigating the interaction of bioactive components in Haskap with gut microbiota and the resultant gut and serum metabolites, inflammation, and metabolic health, and then couple this with analysis of berries from different Haskap varieties and harvest times.",[149,85,150],"Metabolic Disease","Microbial Colonization",[152,153,154,155],"Microbial metabolism","Gut microbial composition","Serum metabolome","Polyphenols","2025-04-01",{"date":158,"type":32},"2025-04-02",{"date":160,"type":32},"2025-02-26",{"date":162,"type":20},"2028-05",{"name":38,"class":39},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":48,"sex":16,"minAge":17,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":21,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":72},"100583635","trauma-and-cardiometabolic-health-in-an-american-indian-community-100583635","NCT06878885","Trauma and Cardiometabolic Health in an American Indian Community","IHPIPO'TO'TSP","Inclusion Criteria:\n\n* 18-40 years\n* Identifying as American Indian\n* Living on or near Blackfeet reservation\n\nExclusion Criteria:\n\n* Uncontrolled hypertension","40 Years",{"count":173,"type":20},400,[23],"Volunteers for the study are asked to participate in two laboratory sessions. In the first laboratory session, volunteers are asked to provide a blood sample which will be used to measure factors related to health. Participants also complete questionnaires related to demographic and health-related information and undergo evaluations of their body composition. In the second laboratory visit, participants are asked to have cardiovascular, neuroendocrine, and inflammatory activity measured during a brief period of rest and during a short challenging psychological task. Participants will also complete questionnaires. The study is designed to examine the associations between experiences such as trauma and resiliency with changes in bodily systems during a challenge and current health.",[177,178,57],"Psychological Stress","Cardiometabolic Conditions","2025-03-10",{"date":181,"type":32},"2025-03-17",{"date":183,"type":32},"2024-05-10",{"date":185,"type":20},"2027-06-30",{"name":38,"class":39},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":21,"phases":197,"briefSummary":199,"conditions":200,"keywords":204,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":72},"100252744","phase-3-creatine-for-depressed-male-and-female-methamphetamine-users-100252744","NCT02568878","Creatine for Depressed Male and Female Methamphetamine Users","An Open-Label Pilot Study of Creatine for Depressed Male and Female Methamphetamine Users","Inclusion Criteria:\n\n* Current primary diagnosis of methamphetamine dependence or abuse, with methamphetamine preferred drug of abuse\n* Current diagnosis of major depressive disorder (primary or substance-induced)\n* Current diagnosis of an anxiety disorder (primary or substance-induced)\n* Current Hamilton Depression Rating scale score \\> or = to 16\n* Current Hamilton Anxiety Scale score \\> = to 18\n* If taking a psychotropic medication for depressed or anxious mood, regimen must be stable for \\> = to 4 weeks prior to creatine treatment initiation\n\nExclusion Criteria:\n\n* Persons unable to provide adequate informed consent\n* Persons who are at clinically significant suicidal or homicidal risk\n* Primary substance-related diagnosis other than methamphetamine dependence or abuse\n* Positive pregnancy test (females only)\n* History of renal disease\n* Clinically significant medical or neurological illness identified by history, physical exam and laboratory testing\n* History of hypersensitivity reaction to creatine","59 Years",{"count":196,"type":20},29,[198],"PHASE3","* Assess the antidepressant\u002Fanxiolytic effect of creatine in male and female methamphetamine users\n* Assess creatine's effect on methamphetamine use\n* Assess the safety of creatine in male methamphetamine users with depression",[201,202,203],"Depression","Anxiety","Methamphetamine Dependence",[201,202,205],"Methamphetamine dependence","2015-12-10",{"date":208,"type":20},"2015-12-11",{"date":210,"type":4},"2015-11",{"date":212,"type":20},"2017-05",{"name":38,"class":39},""]