[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Mst.Sumyara Khatun\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":119},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,70,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100616597","melatonin--metformin-on-clinical--biochemical-parameters-in-insulin-resistant-pcos-compared-to-metformin-100616597",false,"NCT07307677","Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin","Effect of Melatonin and Metformin Combination Therapy on Clinical and Biochemical Parameters inInsulin Resistant Polycystic Ovary Syndrome Compared to Metformin Alone","Inclusion Criteria:\n\n* Diagnosed case of PCOS according to Rotterdam criteria\n* Women of age 18-35 years\n* Insulin resistance (HOMA-IR \\>2.6)\n\nExclusion Criteria:\n\n* BMI: ≤ 18.5 and ≥ 30 kg\u002Fm2\n* Uncontrolled endocrine disorders (Diabetis melitus, Hypothyroidism, Hyperprolactinemia)\n* Known case of any medical disease (Renal, hepatic or cardiac disease)\n* Any medication which would affect insulin resistance (Metformin, Myo- inositol, Pioglitazone) in last three months.\n* Hypersensitivity to melatonin.","FEMALE","18 Years","35 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Women with polycystic ovary syndrome with HOMA-IR \\>2.6 fulfilling inclusion and exclusion criteria will be randomly allocated into two groups:experimental group: A (Melatonin 3mg and Metformin 500mg) and control group: B (Metformin 500mg). Each group will be contained 30 selected patients.\n\nGroup B:Tab. Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks.\n\nOutcome variables will be measured after three months, will be meticulously recorded for analysis and comparison.",[27],"PCOS(Insulin Resistant)",[29],"Melatonin in PCOS","RECRUITING","2026-01-05",{"date":33,"type":34},"2026-01-07","ACTUAL",{"date":36,"type":34},"2025-03-11",{"date":38,"type":21},"2026-08-10",{"name":40,"class":41},"Mst.Sumyara Khatun","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},"100613412","effect-of-levocarnitine-plus-myoinositol-versus-myoinositol-alone-on-hormonal-and-insulin-resistance-in-pcos-women-100613412","NCT07266259","Effect of Levocarnitine Plus Myoinositol Versus Myoinositol Alone on Hormonal and Insulin Resistance in PCOS Women","Effects of Levocarnitine and Myoinositol in Comparison to Myoinositol Alone on Hormonal and Insulin Resistance Parameters in Subfertile Women With Insulin Resistant Polycystic Ovary Syndrome","Inclusion Criteria:\n\n* Age:18-40 years old.\n* Diagnosed cases of PCOS patients(both old \\& new cases) according to International evidence-based guideline criteria 2023\n* Primary or secondary subfertility.\n* Insulin resistance (HOMA-IR \\>2.6)\n\nExclusion Criteria:\n\n* Hypothyroidism\n* Diabetes mellitus\n* Hormonal (Myo-inositol,D-chiro-inositol) or insulin sensitizing drugs like Metformin,Pioglitazone etc. treatment in the last three months\n* Known hypersensitivity to Myo-inositol and Levo-carnitine\n* Pregnancy","40 Years",{"count":52,"type":21},72,[24],"The goal of this clinical trial is to learn if combination of levocarnitine and myoinositol works better than myoinositol alone on insulin resistance and hormonal parameters in subfertile women with insulin resistant polycystic ovary syndrome . It will also learn about the safety of drug levocarnitine and myoinositol. The main questions it aims to answer are:\n\nDoes combined action of levocarnitine and myoinositol improve insulin resistance and hormonal parameters in comparison to myoinositol alone in subfertile women with insulin resistant polycystic ovary syndrome ? What medical problems do participants have when taking drug levocarnitine and myoinositol? Researchers will compare the drug combination of levocarnitine and myoinositol to myoinositol alone to see if combination therapy works better?\n\nParticipants will:\n\nTake drug levocarnitine and myoinositol or a myoinositol alone twice daily for 3 months Visit the clinic once after 3 months for checkups and tests Keep a diary of their symptoms and the number of times.",[56],"Polycystic Ovary Syndrome (PCOS)",[58,59,60],"levocarnitine myoinositol","insulin resistance hormonal parameters","polycystic ovary syndrome","2025-12-13",{"date":63,"type":34},"2025-12-19",{"date":65,"type":34},"2025-09-19",{"date":67,"type":21},"2027-03-01",{"name":40,"class":41},2,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":42},"100612617","cabergoline--letrozole-versus-letrozole-in-ovulation-induction-in-pcos-100612617","NCT07255911","Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOS","Cabergoline and Letrozole Compared to Letrozole Alone for Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome","PCOS OID","Inclusion Criteria:\n\n1. PCOS patients diagnosed according to Rotterdam criteria.\n2. Age: 18-35 years.\n3. Primary or secondary subfertility.\n4. Selected for ovulation induction.\n\nExclusion Criteria:\n\n1. Women suffered from PCOS like symptom ex. Late onset congenital adrenal hyperplasia, Cushing syndrome.\n2. Serum prolactin (more than 50 ng\u002Fml) (Kyritsi et al., 2018).\n3. Male factor infertility.\n4. Women with other infertility factors (endometriosis, PID,uterine \\& tubal causes of infertility).\n5. Uncontrolled Medical disease (DM, HTN, kidney disease, liver disease).\n6. History of hypersensitivity to cabergoline \\& letrozole.\n7. Thyroid dysfunction ( serum TSH ≥5mIU\u002FL)\n8. BMI:\\\u003C 18.5 kg\u002Fm2 and ≥30 kg\u002Fm2.\n9. Patients on metformin therapy.\n10. Patient on antiemetic like Domperidone metoclopramide, antipsychotic drug like haloperidol and risperidone, tricyclic antidepressant like amitriptyline, clomipramine, antihypertensive like verapamil, methyldopa, reserpine.",{"count":52,"type":21},[24],"Does combined Cabergoline and letrozole increase ovulation rate What medical problems do participants have when taking drug Cabergoline and Letrozole ? Researchers will compare drug combination of Cabergoline and letrozole to letrozole alone to see combined cabergoline and letrozole works better as ovulation induction.\n\nParticipants will:\n\nexperimental group will receive Cabergoline and Letrozole comparator group will receive letrozole alone TVS Monitoring will be done for 3 cycle for ovarian response",[82],"PCOS",[84],"ovulation induction by Cabergoline","2025-12-09",{"date":87,"type":34},"2025-12-16",{"date":89,"type":34},"2025-02-07",{"date":91,"type":21},"2026-06-30",{"name":40,"class":41},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":118,"locationsCount":42},"100612356","effect-of-pentoxifylline--coq10-vs-coq10-alone-on-sperm-motility-in-subfertile-men-with-asthenozoospermia-100612356","NCT07252518","Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With Asthenozoospermia","Effect of Pentoxifylline Plus Coenzyme Q10 Combination Therapy Compared to Coenzyme Q10 Alone on Sperm Motility in Sub-fertile Male With Asthenozoospermia","Inclusion Criteria:\n\n* Sub fertile men with asthenozoospermia(Total motility20% to less than 42%) according to WHO semen analysis,2021.\n* Age 20-50 years.\n\nExclusion Criteria:\n\n* Severe oligoasthenoteratozoospermia\n* Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.\n* Antioxidants supplmentation in the last 3 months\n* Drug, alcohol or substance abuse, psycho-sexual abnormalities.\n* Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage Severe oligoasthenoteratozoospermia\n* Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.\n* Antioxidants supplmentation in the last 3 months\n* Drug, alcohol or substance abuse, psycho-sexual abnormalities.\n* Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage","MALE","20 Years","50 Years",{"count":104,"type":21},56,[24],"The goal of this clinical trial is to learn if drug Pentoxifylline plus Coenzyme Q10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Pentoxifylline plus Coenzyme Q10. The main questions it aims to answer are:\n\nDoes drug Pentoxifylline plus Coenzyme Q10 increase the motility of sperm in participants? What medical problems do participants have when taking drug Pentoxifylline plus Coenzyme Q10 ? Researchers will compare drug Pentoxifylline plus Coenzyme Q10 combination to Coenzyme Q10 alone to see if drug Pentoxifylline plus Coenzyme Q10 combination works better.\n\nParticipants will:\n\nExperimental Group:Pentoxifylline 400mg twice dailyand Coenzyme Q10 100mg twice daily for 3 months.\n\nComparator Group: Coenzyme Q10 100mg twice daily for 3 months Visit the clinic after three months of treatment for checkups and tests",[108],"Asthenozoospermia",[108,110,111],"Pentoxifylline","Coenzyme Q10","2025-11-24",{"date":114,"type":34},"2025-11-26",{"date":116,"type":34},"2025-10-01",{"date":67,"type":21},{"name":40,"class":41},""]