[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Muzaffer GENCER\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100641846","direct-versus-video-laryngoscopy-in-patients-with-acromegaly-100641846",false,"NCT07659912","Direct Versus Video Laryngoscopy in Patients With Acromegaly","Determination of the Appropriate Intubation Method in Patients With Acromegaly: Comparison of Direct Laryngoscopy and Video Laryngoscopy","ACRO-VL","Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of acromegaly and scheduled for surgery after evaluation by the institutional pituitary diseases council\n* Diagnosis of nonfunctioning pituitary adenoma and scheduled for surgery after evaluation by the institutional pituitary diseases council\n* Requirement for general anesthesia with endotracheal intubation\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Refusal to participate in the study\n* Presence of extrapituitary malignancy\n* Emergency surgery\n* Previous tracheostomy or major laryngeal\u002Ftracheal surgery\n* Severe limitation of mouth opening preventing standard laryngoscopic evaluation\n* Cervical spine instability or severe restriction of neck extension\n* Patients requiring awake fiberoptic intubation according to preoperative airway assessment\n* Patients for whom participation is considered unsafe by the responsible anesthesiologist","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","Acromegaly is associated with craniofacial skeletal changes and upper airway soft tissue hypertrophy, which may increase the risk of difficult laryngoscopy and tracheal intubation. This prospective observational study aims to evaluate airway and intubation characteristics in patients with acromegaly undergoing surgery under general anesthesia and to compare direct laryngoscopy and video laryngoscopy findings.\n\nAdult patients with acromegaly and patients with nonfunctioning pituitary adenomas scheduled for surgery under general anesthesia will be prospectively enrolled between July 1, 2026, and August 31, 2026. Preoperative airway assessment parameters, hormonal data including growth hormone and insulin-like growth factor-1 levels, Mallampati score, modified Cormack-Lehane grade, intubation-related variables, and peri-intubation complications will be recorded.",[25,26],"Acromegaly","Nonfunctioning Pituitary Adenoma",[25,28,29,30,31,32,33,34,35],"Difficult Intubation","Direct Laryngoscopy","Video Laryngoscopy","Cormack-Lehane Classification","Airway Management","Growth Hormone","Insulin-Like Growth Factor 1","Pituitary Adenoma","NOT_YET_RECRUITING","2026-06-17",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":21},"2026-07-01",{"date":44,"type":21},"2026-08-31",{"name":46,"class":47},"Muzaffer GENCER","OTHER_GOV",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100641476","pleth-variability-index-monitoring-in-pediatric-craniosynostosis-surgery-100641476","NCT07657598","Pleth Variability Index Monitoring in Pediatric Craniosynostosis Surgery","Association of Pleth Variability Index Monitoring With Intraoperative Hemodynamic Control in Pediatric Craniosynostosis Surgery","PVI-CRANIO","Inclusion Criteria:\n\n* Pediatric patients aged 0 to 6 years\n* Patients scheduled to undergo craniosynostosis surgery\n* American Society of Anesthesiologists physical status I, II or III\n* Written informed consent obtained from the parent or legal guardian\n\nExclusion Criteria:\n\n* Patients older than 6 years\n* American Society of Anesthesiologists physical status IV\n* Inappropriate preoperative fasting status\n* History of significant cardiac, pulmonary or renal disease\n* Patients operated at another institution and subsequently transferred to the study center\n* Patients with peripheral circulatory impairment\n* Withdrawal of consent by the parent or legal guardian","6 Years",{"count":58,"type":21},30,"This prospective observational study aims to evaluate the role of pleth variability index (PVI) and perfusion index (PI) monitoring in intraoperative hemodynamic control among pediatric patients undergoing craniosynostosis surgery. Patients aged 0-6 years will be monitored intraoperatively using standard anesthesia monitoring together with PVI and PI measurements. Hemodynamic parameters, including systolic, diastolic and mean arterial pressure, heart rate, central venous pressure, oxygen saturation, body temperature, urine output, blood loss, fluid replacement, blood product requirement, serum lactate level, blood gas parameters and intraoperative complications will be recorded. The study will assess the association between PVI\u002FPI changes and intraoperative hemodynamic status, bleeding and transfusion requirements.",[61],"Craniosynostosis",[63,64,65,66,67,68,69],"Pleth Variability Index","Perfusion Index","Craniosynostosis Surgery","Pediatric Anesthesia","Hemodynamic Monitoring","Intraoperative Hemodynamics","Fluid Management","RECRUITING","2026-06-13",{"date":73,"type":40},"2026-06-18",{"date":75,"type":40},"2024-08-01",{"date":77,"type":21},"2028-02-01",{"name":46,"class":47},1,""]