[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"NHS Lothian\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":184},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,70,92,126,152],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637181","establish-whether-hyperangulated-videolaryngoscopy-havl-can-be-used-to-facilitate-tracheal-intubation-effectively-and-safely-in-unselected-adult-patients-describe-the-population-in-whom-havl-fails-to-facilitate-tracheal-intubation-successfully-identifying-any-contributory-characteristics-100637181",false,"NCT07600502","Establish Whether Hyperangulated Videolaryngoscopy (HAVL) Can be Used to Facilitate Tracheal Intubation Effectively and Safely in Unselected Adult Patients; Describe the Population in Whom HAVL Fails to Facilitate Tracheal Intubation Successfully, Identifying Any Contributory Characteristics.","McGrath X-blade Study","Inclusion Criteria:\n\n* Adult patients undergoing surgical procedures requiring tracheal intubation as part of their routine anaesthetic care\n* Patients undergoing either naso- or oro-tracheal intubation\n* Patients undergoing tracheal intubation with or without administration of neuromuscular blocking agents (e.g. those undergoing surgery where facial nerve or recurrent laryngeal nerve monitoring will be utilised)\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Patients in whom tracheal intubation is not required as part of their routine anaesthetic care\n* Patients in whom tracheal intubation was not planned as part of their routine anaesthetic care, but was required as a rescue technique (e.g. for failed insertion of a supraglottic airway) since appropriate patient consent will not have been obtained · Patients that are physiologically unstable (where clinical care must take priority and\u002For patient is unable to consent for inclusion in the study)",true,"ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","INTERVENTIONAL",[24],"NA","When patients have a general anaesthetic (go to sleep for surgery), the anaesthetist often places a small tube into their windpipe (intubation) to help them breathe. To see exactly where to put the tube, the anaesthetist uses a device called a laryngoscope.\n\nA commonly used laryngoscope is the McGrath videolaryngoscope. It has a small camera and screen to help guide safe placement of the tube. It comes in two different shapes - one shaped in the same way laryngoscopes have been shaped for the last 80 years, and another newer design (McGrath X-blade) that matches the curve of patients' tongues better.\n\nAll different classes of videolaryngoscope have been shown to have benefits to patients; however, the best videolaryngoscope shape has yet to be determined.\n\nThe McGrath X-blade is currently recommended in patients in whom the anaesthetist thinks it might be slightly more difficult to place the tube, but some anaesthetists already prefer to use it in all their patients. This is not a new device or a new technique.\n\nIn this study, the investigators wish to explore if there is any special benefit of using it in all patients, by collecting some information when the device is used.",[27,28,29],"Intubation Skill","Intubation Complications","Intubation With Uncuffed Endotracheal Tube",[31,32,33,34],"videolaryngoscopy","hyperangulated blade","first-pass success","airway management","NOT_YET_RECRUITING","2026-05-13",{"date":38,"type":39},"2026-05-20","ACTUAL",{"date":41,"type":21},"2026-06",{"date":43,"type":21},"2027-09",{"name":45,"class":46},"NHS Lothian","OTHER_GOV",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100621593","sensorised-surgical-gloves-for-neuroendovascular-procedures-100621593","NCT07372638","Sensorised Surgical Gloves for Neuroendovascular Procedures","Sensorised Surgical Gloves for Neuroendovascular Procedures: Preclinical Study in Flow Diverter Placement Using 3D Printed Biorealistic Haptic Simulators","Inclusion Criteria:\n\n\\- Experienced neurointerventionist or doctor in training.\n\nExclusion Criteria:\n\n\\- No training in use of medical ionising radiation.",{"count":56,"type":21},12,[24],"A deeper understanding of the forces required for optimal flow diverter stent deployment could improve procedural safety and shorten the learning curve for new devices. In the past, force sensors have been physically attached to devices in some way. The investigators approach is to incorporate force sensors into the hands of the operator handling the device using sensorised surgical gloves. Participants will be asked to deploy a Flow Diverter (FD) in a biorealistic silicone model while wearing force sensing surgical gloves. The primary objective of the study is to show whether sensorised gloves are capable of meaningful force detection in neurointerventional procedures. The investigators will also explore the potential of developing computer vision technology in neurointervention. The investigators are inviting groups of experts and novices to participate. This will allow the investigators to understand if analysis of glove force outputs can distinguish operator experience.",[60,61],"Endovascular Procedures","Force Sensing Surgical Gloves","2026-05-05",{"date":64,"type":39},"2026-05-06",{"date":66,"type":21},"2026-07",{"date":68,"type":21},"2026-11",{"name":45,"class":46},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":47},"100324329","igel-laryngeal-mask-airway-device-effectiveness-in-irradiated-necks-100324329","NCT03502590","IGEL Laryngeal Mask Airway Device Effectiveness in Irradiated Necks","Effectiveness of Airway Control Using the IGEL Laryngeal Mask Airway Device in Patients With Previous Radiotherapy to the Neck","Inclusion Criteria:\n\n* 18 years or older\n* Attending for an elective procedure requiring general anaesthesia\n* Prior radiotherapy to the neck\n\nExclusion Criteria:\n\n* General anaesthesia is not the primary airway plan\n* Previously known difficult intubation\n* Patient refusal",{"count":78,"type":21},62,[24],"It is known that patients with head and neck cancer who have had radiation therapy to the structures of the neck are at a greater risk of difficult mask ventilation and tracheal intubation than the majority of patients undergoing general anaesthesia.\n\nFailure to maintain oxygenation can lead to catastrophic consequences for any patient undergoing general anaesthesia, such as severe hypoxic brain injury and death.\n\nAs such, the current guidelines from the Difficult Airway Society promote the use of a second generation laryngeal mask airway to maintain oxygenation in the event of failed mask ventilation or tracheal intubation, a rescue technique that has in most patient groups a very high chance of success. Unfortunately these guidelines are by necessity generic guidance and do not take into account the clinical performance of these devices in specific patient groups. While there is evidence of the effectiveness of the IGEL device as the primary method of airway maintenance in many studies there are none that describe its clinical performance in a group of patients in whom the rate of failed mask ventilation and tracheal intubation are significantly higher than the general population of patients. It is therefore of great interest to have an idea of the likelihood of success of rescue ventilation with this device in a group of high risk patients.",[82],"Laryngeal Masks","RECRUITING","2026-02-16",{"date":86,"type":39},"2026-02-19",{"date":88,"type":39},"2018-07-01",{"date":90,"type":21},"2027-09-01",{"name":45,"class":46},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":47},"100461604","total-versus-robotic-assisted-unicompartmental-knee-replacement-100461604","NCT05290818","Total Versus Robotic Assisted Unicompartmental Knee Replacement","Total Versus Robotic Assisted Unicompartmental Knee Replacement (TRAKER) for Medial Compartment Osteoarthritis: Randomised Controlled Trial","TRAKER","Inclusion Criteria:\n\n* Listed for elective primary TKA for end stage medial compartment osteoarthritis\n* Intact anterior cruciate ligament\n* Full thickness and good quality lateral cartilage\n* Correctable intra-articular varus deformity and intact medial collateral ligament\n* American Society of Anesthesiologists (ASA) grades 1 and 2\n* Male or female, age 50 - 75 at the time of listing for surgery\n* Suitable candidate for a cruciate retaining TKA (Triathlon prosthesis) and a UKA\n\nExclusion Criteria:\n\n* Varus deformity of \\> 20 degrees\n* Fixed flexion of \\>10 degrees\n* Patient is unable to comply with the study protocol (incl. refusal for CT scan) or functional assessments\n* Female participants who are pregnant, lactating or planning pregnancy during the course of the study\n* Requires patella resurfacing or lateral compartment has significant OA\n* Inability to understand the patient information for the study, provide written informed consent or answer study questionnaires for cognitive or language reasons\n* Inflammatory disorder e.g. rheumatoid arthritis\n* Symptomatic foot, hip or spine pathology\n* Prior surgery (other than arthroscopy) or septic arthritis of the knee\n* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study,","50 Years","75 Years",{"count":103,"type":21},159,[24],"The purpose of this research is to compare the functional outcomes of patients with end stage medial compartment OA of the knee undergoing a conventional mTKA to those undergoing rUKA and to assess the associated cost economics of such technology.",[107,108,109],"Osteo Arthritis Knee","Arthritis Knee","Arthropathy of Knee",[111,112,113,114,115,116,117],"Arthroplasty","Robotic","Knee","Total","Partial","Outcome","MAKO","2026-02-04",{"date":120,"type":39},"2026-02-06",{"date":122,"type":39},"2024-08-26",{"date":124,"type":21},"2027-12-31",{"name":45,"class":46},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":135,"phases":4,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":151},"100558916","single-cell-sequencing-analysis-of-radiation-pneumonitis-signals-in-patients-treated-for-cancer-with-radiotherapy-100558916","NCT06557343","Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy","SPITFIRE","Inclusion Criteria:\n\n* Age over 18 years\n* Patient has received thoracic radiotherapy and has clinical or radiological features in fitting with a diagnosis of Radiation Pneumonitis (onset one to four months post-RT with breathlessness, especially exertional, cough, chest discomfort, which is persistent over weeks, a chest x-ray \\[CXR\\] may demonstrate patchy or widespread opacification although can be normal.)\n* Must be ambulant, oxygen independent with SpO2 \\>92% on air and haemodynamically stable to be considered safe for a bronchoscopy.\n* Willing to undergo and likely able to tolerate bronchoscopy, ie. Can lie flat without compromising ventilation, and able to consent to the ELFMAN Protocol and SPITFIRE trial.\n\nExclusion Criteria:\n\n* Contraindication to bronchoscopy, ie. Previously not tolerated, unable to lie flat, Sp02 \\\u003C92% on air\n* Patient requires admission or oxygen dependant\n* Test positive for Covid-19 within the preceding six weeks to enrolment",{"count":134,"type":21},5,"OBSERVATIONAL","Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel technique which allows for identification of which cells are present and what they are doing. This hopes to better understand radiation pneumonitis, a dose-limiting toxicity in cancer treatment which can be highly morbid and even fatal.",[138],"Radiation Pneumonitis",[140,141,142],"radiation pneumonitis","cancer","single cell sequencing","2026-01-08",{"date":145,"type":39},"2026-01-09",{"date":147,"type":39},"2024-10-25",{"date":149,"type":21},"2026-12",{"name":45,"class":46},3,{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":160,"minAge":4,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":164,"conditions":165,"keywords":169,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":47},"100525078","the-precision-study-3-fractions-of-prostate-sbrt-and-raypilot-hypocath-image-guidance-100525078","NCT06117059","The PRECISION Study: 3 Fractions of Prostate SBRT and RayPilot HypoCath Image Guidance","The PRECISION Study: A Phase II Study of 3 Fractions of Prostate SBRT With RayPilot System and HypoCath Image Guidance for Men With NCCN Low or Intermediate Risk Prostate Cancer","PRECISION","Inclusion Criteria:\n\n* low and favorable intermediate NCCN Criteria patients\n* Prostate volume under 80cc\n* IPSS under 20\n* Q-max above 10cc per second and urinary residual less than 150mls\n* No TURP\n* No hip replacements\n* No previous radiotherapy to the pelvis\n* No active second malignancy except skin SCC or BCC for the last 2 years\n* No history of inflammatory bowel disease\n* No co-morbid illness that would make compliance to treatment difficult\n* Able to give informed consent\n\nExclusion Criteria:\n\n* T3a or above\n* Gleason 4+3=7\n* PSA\\>20ng\u002Fml","MALE",{"count":162,"type":21},100,[24],"The investigators want to investigate whether it is possible to reduce the number of curative radiotherapy doses from 5 to only 3 for men with localized early prostate cancer. The aim of the study is to ensure that the side effects of the 3-dose treatment are the same or potentially lower than those already published when using the 5-dose treatment as used in the UK PACE-B trial (NCT01584258). The name of this type of radiotherapy is Stereotactic Body Radiotherapy (SBRT) or participants may see it referred to as Stereotactic Ablative Radiotherapy (SABR). The study is a two-stage single arm Phase II study open to those Centres that use the RayPilot HypoCath tumour tracking system (Micropos Medical). This commercially available system was not available at the time of the original PACE-B study. The system acts like a Global Positioning Device (GPS) to continuously track the prostate position during radiotherapy. If the prostate moves more than 2mm (about 0.08 in) from its intended position during the treatment, then the radiotherapy team are alerted, and the treatment halted until the prostate moves back into the correct position. The ability to understand exactly where the prostate is throughout the treatment ensures the intended dose hits the cancer and does not accidentally increase the dose to the nearby bladder and rectum. The system is a modification of a standard urinary catheter which sits within the bladder with the GPS placed within the wall of the catheter as it passes through the prostate. The investigators are not testing the system as it is commercially available but using it to improve the accuracy of radiotherapy delivery, reducing the number of days of treatment, minimizing side effects and helping ease the burden on busy radiotherapy Departments.",[166,167,168],"Localized Prostate Cancer","Low Risk Prostate Cancer","Intermediate Risk Prostate Cancer",[170,171,172,173,174,175,176],"SBRT","SABR","PROSTATE CANCER","RayPilot","HypoCath","Continuous tracking","3 fractions",{"date":178,"type":39},"2026-01-12",{"date":180,"type":39},"2024-11-01",{"date":182,"type":21},"2027-11-01",{"name":45,"class":46},""]