[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Nashwa Ahmed\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":63},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100622859","phase-4-opioid-free-anesthesia-versus-opioid-based-anesthesia-for-adolescent-idiopathic-scoliosis-100622859",false,"NCT07389096","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis A Prospective Randomized Double-Blind Controlled Trial","Inclusion Criteria:Patients younger than 18 years of age, classified as American Society of Anesthesiologists (ASA) Physical Status I or II, and will be scheduled for surgical correction of adolescent idiopathic scoliosis.\n\n\\-\n\nExclusion Criteria:• Refusal to participate in the study or to allow use of personal data\n\n* Non-idiopathic scoliosis\n* Contraindications to commonly used perioperative medications\n* ASA Physical Status ≥ III\n* Presence of neuromuscular disorders or severe cardiac dysfunction\n* Requirement for postoperative mechanical ventilation\n* Regular use of analgesics or opioids\n* History of allergy to opioids or dexmedetomidine\n* Diagnosed mental disorders\n* Severe hepatic or renal dysfunction\n* Coagulopathy or significant pulmonary disease\n* Preoperative or postoperative neurological deficits\n* Occurrence of serious arrhythmia, hypotension, or bradycardia necessitating discontinuation of dexmedetomidine infusion","ALL","8 Years","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids. This technique employs a combination of antinociceptive agents targeting various pathways within the central and peripheral nervous systems to achieve effective analgesia.\n\nDexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, is a centrally acting non-opioid agent increasingly utilized in clinical practice for its antinociceptive and anxiolytic properties. Only a few prospective randomized controlled trials have specifically examined the postoperative analgesic efficacy of intraoperative dexmedetomidine infusion in patients undergoing spinal surgery, with limited data focusing on this as a primary endpoint. Importantly, no clinical studies have investigated its analgesic impact in patients undergoing spinal surgery under general anesthesia.",[27],"Opioid Free Anesthesia","RECRUITING","2026-01-30",{"date":31,"type":32},"2026-02-05","ACTUAL",{"date":29,"type":21},{"date":35,"type":21},"2027-01-31",{"name":37,"class":38},"Nashwa Ahmed","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":39},"100598954","phase-4-comparative-analysis-of-intraoperative-effect-dexmedetomidine-and-fentanyl-as-an-adjuvant-to-heavy-bupivacaine-in-spinal-anaesthesia-in-lower-limb-orthopedic-surgeries-to-evaluate-the-hemodynamic-stability-and-onset-and-duration-of-motor-block-of-using-intrathecal-dexmedetomidine-and-fentanyl-100598954","NCT07078201","Comparative Analysis of Intraoperative Effect Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Spinal Anaesthesia in Lower Limb Orthopedic Surgeries to Evaluate the Hemodynamic Stability and Onset and Duration of Motor Block of Using Intrathecal Dexmedetomidine and Fentanyl","Comparative Analysis of Intraoperative Effect Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Spinal Anaesthesia in Lower Limb Orthopedic Surgeries.","Inclusion Criteria:\n\n1. The patient aged range from 20 to 60 years\n2. ASA 1 and 2\n3. Patient prepared for elective lower limb orthopaedic surgeries.\n4. Height 150-180 cm.\n5. Weight 50-70 kg. 6- Either sex male or female.\n\nExclusion Criteria:\n\n\\- 1- Patient refusal. 2- Patient had absolute contraindication to spinal anaesthesia. 3-Patients with neurological disorders, pregnancy, local infection at the site of injection.\n\n4- Patients suffering from dysrhythmia or heart block. 5- Patients with ASA 3 or more.","20 Years","60 Years",{"count":50,"type":21},40,[24],"Spinal anesthesia is the most widely employed procedure for lower limb orthopedic operations, as it is very cost-effective and simple to apply. These advantages could be restricted because presently existing local anesthetic drugs had relatively short length of action. (1) Spinal anesthesia with 0.5% heavy bupivacaine (hyperbaric) is a common technique, still there was burden of its short duration of action. To overcome this issue, there was a continuous search for an ideal adjuvant.(2) Adjuvants were mostly added to local anesthetic drugs to increase their effectiveness, speedy onset, increase the period of the block, and reduce the local anesthetics dosage, thus reduction their adverse effects.(3) Such adjuvants had been beneficial in extension of analgesia along with initiation of movement though their related side effects.(4)",[54],"Spinal Anesthesia Duration","2025-12-28",{"date":57,"type":32},"2025-12-30",{"date":59,"type":32},"2025-07-01",{"date":61,"type":21},"2025-12-25",{"name":37,"class":38},""]