[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"National Cancer Institute, Egypt\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":570},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,44,67,86,122,146,165,195,217,240,269,288,309,327,352,379,405,425,450,469,494,521,544],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100053741","ultrasound-guided-parasternalrectus-sheath-block-vs-erector-spinae-plane-block-for-pain-control-in-cardiac-surgery-100053741",false,"NCT07692659","Ultrasound-Guided Parasternal\u002FRectus Sheath Block vs Erector Spinae Plane Block for Pain Control in Cardiac Surgery","Comparison of Ultrasound Guided Bilateral Parasternal Block With Bilateral Rectus Sheath Block Versus Ultrasound Guided Bilateral Erector Spinae Plane Block in Controlling Intra and Post-operative Pain After Cardiac Surgeries","Inclusion Criteria:\n\n* Both sexes,\n* ASA III-IV patients\n* body mass index between 20- 35 kg\u002Fm2\n* adult patients above 18 years old will be included in the study\n\nExclusion Criteria:\n\n* Patients with global hypokinesia\n* ejection fraction \\\u003C 40%\n* low platelet count\n* coagulation impairment\n* deformity in the vertebral column\n* severe renal and hepatic impairment\n* any known allergy to the drugs used","ALL","18 Years","80 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The researchers are working to improve recovery after heart surgery by reducing reliance on opioids. Newer regional anesthesia techniques can provide strong pain relief with fewer risks, but the choice of method depends on each patient's condition, medications, and surgical plan",[27,28,29],"Analgesia","Perioperative Analgesia","Regional Block Technique",[31],"Parasternal block; Rectus sheath block; ESPB; Analgesia","NOT_YET_RECRUITING","2026-07-09",{"date":35,"type":36},"2026-07-13","ACTUAL",{"date":38,"type":21},"2026-07",{"date":40,"type":21},"2027-06",{"name":42,"class":43},"National Cancer Institute, Egypt","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},"100504702","efficacy-of-dexmedetomidine-vs-magnesium-sulphate-with-bupivacaine-in-erector-spinae-block-for-thoracotomy-pain-100504702","NCT05851768","Efficacy of Dexmedetomidine VS Magnesium Sulphate With Bupivacaine in Erector Spinae Block for Thoracotomy Pain","Analgesic Efficacy of Adding Dexmedetomidine VS Magnesium Sulphate as Adjuvants With Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Post Thoracotomy Pain","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Male and female sexes.\n* ASA I-II.,III\n* Cancer patients undergoing thoracotomy incisions\n* Body mass index (BMI) from 18.5 to 30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Patient refusal\n* Known allergy to any of the used drugs\n* Low platelet count, any coagulation defect","65 Years",{"count":53,"type":21},60,[24],"Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.",[27],"RECRUITING","2026-06-27",{"date":60,"type":36},"2026-06-30",{"date":62,"type":36},"2023-05-15",{"date":64,"type":21},"2026-12-27",{"name":42,"class":43},1,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":51,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":80,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":66},"100467060","efficacy-of-serratus-anterior-plane-block-with-dexmedetomidine-during-breast-surgery-100467060","NCT05361837","Efficacy of Serratus Anterior Plane Block With Dexmedetomidine During Breast Surgery","Efficacy of Single Level Versus Bilevel Serratus Anterior Plane Block With Dexmedetomidine During Breast Cancer Surgery","Inclusion Criteria:\n\n* patients scheduled for modified radical mastectomy,\n* Age 18-65 years,\n* ASA I-II\n\nExclusion Criteria:\n\n* patient refusal,\n* coagulation defects,\n* abnormal kidney or liver functions,\n* local infection at site of injection.","FEMALE",{"count":76,"type":21},172,[24],"This study aims to compare single level serratus block versus bilevel serratus block with and without dexmedetomidine in cancer patients undergoing modified radical mastectomy for breast cancer regarding pain control and possible side effects.",[27],{"date":60,"type":36},{"date":82,"type":36},"2022-05-10",{"date":84,"type":21},"2026-11-25",{"name":42,"class":43},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":66},"100644988","super-voltage-prf-of-stellate-ganglion-versus-super-voltage-prf-of-t2-t3-sympathetic-ganglia-in-managing-pmps-100644988","NCT07675096","Super-voltage PRF of Stellate Ganglion Versus Super-voltage PRF of T2 T3 Sympathetic Ganglia in Managing PMPS.","Super-voltage Pulsed Radiofrequency of Stellate Ganglion Versus Super-voltage Pulsed Radiofrequency of T2 T3 Sympathetic Ganglia in Managing Postmastectomy Pain Syndrome.","PMPS PRF","Inclusion Criteria:\n\n* Female patients aged 18-60 years.\n* Patient of class II according to the American society of Anesthesiologists (ASA) physical status classification system.\n* History of unilateral mastectomy for breast cancer.\n* Persistent pain \\>3 months postoperatively.\n* VAS score ≥4 despite pharmacological management.\n* Patients with neuropathic pain who has a score ≥4 by (DN4) questionnaire.\n* Patients on more than 1 antineuropathic drug.\n\nExclusion Criteria:\n\n* Coagulopathy or anticoagulant therapy.\n* Local infection at injection site.\n* History of psychiatric illness or cognitive dysfunction.\n* Previous intervention in the same region (e.g., prior stellate ganglion block or thoracic radiofrequency ablation).\n* Allergy to local anesthetics or contrast agents.","60 Years",{"count":96,"type":21},75,[24],"The aim of this study is to compare the effectiveness of super-voltage pulsed radiofrequency of stellate ganglion and super-voltage pulsed radiofrequency of T2-T3 sympathetic ganglia in the treatment of postmastectomy pain syndrome.",[100,101],"Post Mastectomy Pain Syndrome","Chronic Pain Following Surgical Procedure for Cancer",[103,104,105,106,107,108,109,110,111,112,113,114],"Analgesics","Opioids","gabapentin","post mastectomy pain syndrome","chronic pain","Radiofrequency","stellate ganglion block","sympathectomy","T2","T3","SV-PRF","super-voltage pulsed radiofrequency","2026-06-23",{"date":60,"type":36},{"date":118,"type":21},"2026-07-01",{"date":120,"type":21},"2027-08-30",{"name":42,"class":43},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":51,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":66},"100642606","bilevel-erector-spinae-plane-block-versus-pectoserratus-block-for-analgesia-in-modified-radical-mastectomy-100642606","NCT07650305","Bilevel Erector Spinae Plane Block Versus Pectoserratus Block for Analgesia in Modified Radical Mastectomy","Bilevel Erector Spinae Plane Block Versus Pecto-serratus Block for Analgesia in Modified Radical Mastectomy in Cancer Surgery","Inclusion Criteria:\n\n1. Breast cancer female patients.\n2. ASA class II and III.\n3. Age ≥ 18 and ≤ 65 Years.\n4. Body mass index (BMI): \\> 20 kg\u002Fm2 and \\\u003C 35 kg\u002Fm2.\n5. Type of surgery; elective breast cancer surgery modified radical mastectomy combined with axillary dissection.\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. Age \\\u003C18 years or \\>65 years.\n3. BMI \\\u003C20 kg\u002Fm2 and \\>35 kg\u002Fm2.\n4. Major medical conditions.\n5. Pregnancy or lactation.",{"count":53,"type":21},[24],"Breast cancer remains the most frequently diagnosed cancer and a major cause of cancer-related mortality among women worldwide. Modified radical mastectomy (MRM), a common surgical procedure for breast cancer, is associated with significant postoperative pain, which may delay recovery and contribute to the development of chronic postmastectomy pain syndrome (PMPS). To address this, regional anesthesia techniques have been increasingly incorporated into multimodal analgesia strategies to reduce opioid consumption and enhance patient outcomes. Interfascial plane blocks, in particular, offer safe and effective analgesia under ultrasound guidance. The erector spinae plane block (ESPB), first described in 2016, involves injection of local anesthetic deep to the erector spinae muscle and may spread to the paravertebral space, providing both somatic and visceral analgesia. A bilevel approach may enhance dermatomal coverage. Meanwhile, the pectoserratus plane block (PSPB), which combines PECS II and serratus anterior blocks, targets nerves of the anterior and lateral chest wall and has shown efficacy in breast surgery",[133],"Breast Cancer",[135,136,137],"erector spinae plane block","pectoserratus block","ultrasound","2026-06-10",{"date":140,"type":36},"2026-06-16",{"date":142,"type":36},"2026-05-01",{"date":144,"type":21},"2026-08-02",{"name":42,"class":43},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":51,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":66},"100600290","shoulder-denervation-for-post-mastectomy-irradiation-shoulder-pain-100600290","NCT07095569","Shoulder Denervation for Post Mastectomy Irradiation Shoulder Pain","Shoulder Denervation as Management of Post Mastectomy Irradiation Shoulder Pain: Randomized Control Trial","Inclusion Criteria:\n\n1. Age (18-65) Years.\n2. ASA physical status (II- III).\n3. Patients with post mastectomy irradiation shoulder pain.\n4. Body mass index (BMI): (20-40) kg\u002Fm2.\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. Known sensitivity or contraindication to drugs used in the study.\n3. Pregnancy.\n4. Recent myocardial infarction.\n5. Hemodynamically unstable.\n6. Local and systemic sepsis.\n7. Psychiatric illness.",{"count":53,"type":21},[24],"Breast cancer is the second most common cancer world-wide following lung cancer. It afflicts about 1.7 million patients annually, of which 60% mandate surgery of the breast and\u002For the axilla, and nearly 20-50% of them may develop post mastectomy pain syndrome .\n\nAfter breast cancer surgery, between 6% and 86% of people may develop tight bands of fibrous tissue under their skin, known as axillary web syndrome. These bands can cause pain in the shoulder area by trying to raise or extend the arm. Shoulder pain is a common side effect of breast cancer surgery and treatment.\n\nVarious medical and interventional procedures have been tried for treating postmastectomy shoulder pain, with varying efficacy . Among the interventional procedures that may have a role for treatment.\n\nInnervation of the glenohumeral joint (GHJ) can be divided into anterior and posterior innervation from articular branches of the suprascapular nerve (SN):C5 \\&6 (posterior-lateral), axillary nerve (AN):C5 \\&6 (anterior-lateral, inferior, and posteriorlateral), and lateral pectoral nerve (LPN): C5 \\&6 (anterior superior)",[133],"2026-05-08",{"date":159,"type":36},"2026-05-13",{"date":161,"type":36},"2025-08-01",{"date":163,"type":21},"2026-08-01",{"name":42,"class":43},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":22,"phases":174,"briefSummary":176,"conditions":177,"keywords":180,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":66},"100620708","phase-2-cyclophosphamide-and-etoposide-as-a-metronomic-therapy-in-advanced-head-and-neck-squamous-cell-cancer-100620708","NCT07361133","Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer","Cyclophosphamide and Etoposide as a Promising Metronomic Therapy in Advanced Head and Neck Squamous Cell Carcinoma","Inclusion Criteria:\n\n* Adult participants, age = or \\> 18 years\n* Participants with recurrent head and neck squamous cell carcinoma after failure on first line chemotherapy.\n* Participants with advanced progressed, resistant, metastatic head and neck squamous cell carcinoma.\n\nExclusion Criteria:\n\n* Adjuvant and Neoadjuvant head and neck squamous cell carcinoma patients.",{"count":173,"type":21},120,[175],"PHASE2","The goal of this clinical trial is to learn if drugs as cyclophosphamide (C) and etoposide (E) work to treat advanced head and neck cancer in adults. It will also learn about the safety of both drugs. The main questions it aims to answer are:\n\nDo drugs C and E work to treat advanced head and neck cancer, after failure on first line chemotherapy? What medical problems do participants have when taking drugs C and E? Researchers will compare drugs C and E in combination to a placebo (a look-alike substance that contains no drug) to see if these 2 drugs works to treat advanced head and neck cancer.\n\nParticipants will:\n\nTake drug C every 3 weeks and drug E every 4 weeks or a placebo every week for 6 months.\n\nVisit the clinic once every 3 weeks for checkups and tests. Keep a diary of their symptoms.",[178,179],"Squamous Cell Carcinoma","Advanced Head and Neck Cancer",[181,182,183,184,185,186],"Cyclophosphamide","Etoposide","Head and neck squamous cell carcinoma","Metastatic","Advanced","Recurrent","2026-04-13",{"date":189,"type":36},"2026-04-16",{"date":191,"type":21},"2026-04",{"date":193,"type":21},"2026-09",{"name":42,"class":43},{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":214,"leadSponsor":216,"locationsCount":66},"100625592","interscalene-block-versus-anterior-suprascapular-block-for-post-thoracotomy-shoulder-pain-100625592","NCT07424638","Interscalene Block Versus Anterior Suprascapular Block for Post-Thoracotomy Shoulder Pain","Interscalene Block Versus Anterior Suprascapular Block for Post-Thoracotomy Shoulder Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years and ≤ 65 years old.\n* American Society of Anesthesiologists (ASA) physical status II-III.\n* Body mass index 18-35 kg\u002Fm2.\n* Patients who have a confirmed diagnosis of lung cancer and are scheduled for elective open-lung surgery.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics.\n* Known psychiatric or neurologic disorders.\n* Alcohol or narcotics abuse.\n* Contraindications to thoracic epidural or suprascapular block, or interscalene block, e.g., coagulopathy or local infection.\n* Pre-existing shoulder symptoms.\n* History of previous thoracotomy.\n* Severe restrictive or obstructive pulmonary disease.\n* Pre-existing contralateral diaphragmatic paralysis.",{"count":96,"type":21},[24],"This study aims to compare the frequency of occurrence of ipsilateral shoulder pain in patients undergoing thoracotomy with ultrasound-guided interscalene block, anterior suprascapular block as adjunct to epidural and epidural block only.",[206,207,208,209],"Interscalene Block","Anterior Suprascapular Block","Thoracotomy","Shoulder Pain","2026-02-21",{"date":212,"type":36},"2026-02-24",{"date":210,"type":36},{"date":215,"type":21},"2026-07-30",{"name":42,"class":43},{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":94,"enrollmentInfo":224,"targetDuration":4,"studyType":22,"phases":226,"briefSummary":227,"conditions":228,"keywords":229,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":66},"100622963","rhomboid-intercostal-sub-serratus-plane-blocks-and-erector-spinae-plane-block-in-mastectomy-surgeries-100622963","NCT07390448","Rhomboid Intercostal Sub-serratus Plane Blocks and Erector Spinae Plane Block in Mastectomy Surgeries","A Comparative Study Between Ultrasound Guided Combined Rhomboid Intercostal and Sub- Serratus Plane Blocks and Erector Spinae Plane Block as Perioperative Analgesia in Mastectomy Surgeries in Cancer Breast Patients","Inclusion Criteria:\n\n1. Breast cancer female patients.\n2. ASA class II and III.\n3. Age ≥ 18 and ≤ 60 Years.\n4. Body mass index (BMI): \\> 20 kg\u002Fm2 and \\\u003C 35 kg\u002Fm2.\n5. Type of surgery; elective breast cancer surgery (either modified radical mastectomy or conservative breast surgery) combined with axillary dissection.\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. Age \\\u003C18 years or \\>65 years.\n3. BMI \\\u003C20 kg\u002Fm2 and \\>35 kg\u002Fm2.\n4. Major medical conditions.\n5. Pregnancy or lactation.",{"count":225,"type":21},40,[24],"Acute post-mastectomy pain can cause adverse impacts on the patients as delayed discharge from post-operative recovery area, impairs pulmonary and immune functions, increases risk of ileus, thromboembolism, myocardial infarction and may lead to increased length of hospital stay. It is also an important factor leading to the development of chronic post mastectomy pain syndrome (PMPS) in almost half of the patients.\n\nVarious regional anesthetic techniques have been described for postoperative pain relief after mastectomy, for example, thoracic epidural anesthesia, intercostal nerve block, paravertebral block, serratus anterior plane block, and pectoral nerve I and II blocks. All of them offer satisfactory pain relief after mastectomy.\n\nErector spinae plane block is a novel para-spinal regional anesthesia technique, , promises to provide effective visceral as well as somatic analgesia after carcinoma of the breast surgeries.\n\nThe ultrasound-guided rhomboid intercostal block sub-serratus plane block (RISS) is a novel analgesic technique The RISS block anesthetizes the lateral cutaneous branches of the thoracic intercostal nerves and can be used in multiple clinical settings for chest wall and upper abdominal analgesia",[133],[135,230,231],"Rhomboid Intercostal and Sub-serratus Plane Blocks","ultra sound","2026-02-07",{"date":234,"type":36},"2026-02-10",{"date":236,"type":36},"2026-01-01",{"date":238,"type":21},"2026-04-01",{"name":42,"class":43},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":255,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":66},"100618877","ultrasound-guided-external-oblique-intercostal-plane-block-versus-erector-spinae-block-for-post-hepatectomy-pain-100618877","NCT07337330","Ultrasound Guided External Oblique Intercostal Plane Block Versus Erector Spinae Block for Post Hepatectomy Pain","Comparative Study Between Ultrasound Guided External Oblique Intercostal Plane Block and Erector Spinae Block for Postoperative Analgesia in Hepatectomy Incision in Cancer Patients","Inclusion Criteria:\n\n* Cancer patients undergoing hepatectomy under general anaesthesia\n* Aged 18 years or older\n* ASA II \\& III\n* BMI \\>20kg\u002Fm2 and \\\u003C35kg\u002Fm2\n\nExclusion Criteria:\n\n* History of psychiatric disorders or history of major depression.\n* Major medical conditions (heart failure , chronic kidney disease ,patient on dialysis)",{"count":248,"type":21},52,[24],"Management of acute post-operative pain has received keen attention in recent years with considerable concurrent advancement in the field.\n\nThe importance of effective pain relief has long been realised, and acute pain services (APS) are operational in majority of the hospitals in the developed world for decades.\n\nPostoperative pain following abdominal surgery if severe enough may cause several side effects as \"splinting, hypoventilation, atelectasis, immobility, hypercoagulability, thromboembolic events, vasoconstriction, tachycardia, increased systemic vascular resistance, dysrhythmias and cardiac ischemia in susceptible patients, insomnia, anxiety, feeling of helplessness\".\n\nUltrasound-guided fascial plane blocks have been rapidly incorporated into regional anaesthesia practice in recent years as an alternative to neuraxial techniques and involve injection into a tissue plane to provide analgesia in various anatomic areas.\n\nExternal oblique intercostal plane block (EOIPB) is a novel block, which has been described as an important modification of the fascial plane blocks that can consistently involve the upper lateral abdominal walls.\n\nThe erector spinae plane (ESP) block is a new regional aesthetic technique that can be used to provide analgesia for a variety of surgical procedures or to manage acute or chronic pain. The technique is relatively easy to perform on patients.\n\nThe ESPB involves injection of local anaesthetic in the erector spinae fascial plane, superficial to the tip of the transverse process of the vertebra and deep to the erector spinae muscle.",[252,253,254],"Pain; Cancer","Hepatectomy","Nerve Block",[256,257,258,259,260],"hepatectomy","erector spinae block","external oblique intercostal plane block","liver cancer","ultrasound guided","2026-01-29",{"date":263,"type":36},"2026-02-02",{"date":265,"type":21},"2026-01-15",{"date":267,"type":21},"2026-09-15",{"name":42,"class":43},{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":276,"targetDuration":4,"studyType":22,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":287,"locationsCount":66},"100622336","effect-of-adding-ultrasound-guided-ipack-block-to-adductor-canal-block-for-postoperative-pain-in-knee-tumor-excision-100622336","NCT07382297","Effect of Adding Ultrasound Guided IPACK Block to Adductor Canal Block for Postoperative Pain in Knee Tumor Excision","Analgesic Efficacy of Adding Ultra Sound Guided IPACK Block to Adductor Canal Block for Postoperative Pain Management After Excision of Tumors Around Knee: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* American Society of Anesthesiologists (ASA) physical status II-IV.\n* Patients undergoing excision of tumors around the knee under spinal anesthesia\n\nExclusion Criteria:\n\n* Patient refusal.\n* Neuromuscular disorders\n* Allergy to local anesthetics\n* Previous history of knee surgery\n* Patients with a prior knee infection\n* Contraindications to spinal anesthesia as coagulopathies and severe aortic stenosis.",{"count":277,"type":21},70,[24],"the aim of this study is to determine the analgesic effect of iPACK in combination to ACB after the excision of tumors around the Knee regarding the following:\n\n* Time to the 1st rescue analgesia.\n* Postoperative morphine consumption.\n* Postoperative visual analogue scale (VAS). This study will include patients, aged 18 to 65 years, belonging to the American Society of Anesthesiologists (ASA) physical status II to IV , undergoing excision of tumors around the knee under spinal anesthesia.\n\nPatients will be randomly allocated Group iPACK plus Adductor canal block (ACB) : patients will receive ACB plus iPACK block.\n\n• Control group : patients will not receive any block but will take morphine 3mg bolus at VAS more than 4 and regular NSAIDS and paracetamol iv.",[281],"Cancer Pain","2026-01-25",{"date":263,"type":36},{"date":285,"type":36},"2025-08-15",{"date":60,"type":21},{"name":42,"class":43},{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":296,"briefSummary":297,"conditions":298,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":306,"leadSponsor":308,"locationsCount":66},"100621204","costotransverse-foramen-block-versus-thoracic-paravertebral-block-in-thoracotomy-for-lung-cancer-100621204","NCT07367581","Costotransverse Foramen Block Versus Thoracic Paravertebral Block in Thoracotomy for Lung Cancer","Costotransverse Foramen Block Versus Thoracic Paravertebral Block in Thoracotomy for Lung Cancer: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years and ≤ 65 years old.\n* American Society of Anesthesiologists (ASA) physical status II-III.\n* Body mass index 18-35 kg\u002Fm2.\n* Patients scheduled for thoracotomies for lung cancer.\n\nExclusion Criteria:\n\n* Patient refusal.\n* History of sensitivity to local anesthetics.\n* History of psychological disorders.\n* Contraindication to regional anesthesia, e.g., local sepsis, pre-existing peripheral neuropathies, and coagulopathy.\n* Severe respiratory, cardiac, hepatic, or renal disease.\n* Morbid obesity.\n* Uncooperative patients.\n* Patients on chronic pain therapy.",{"count":277,"type":21},[24],"This study aims to compare the costotransverse foramen block (CTFB) with thoracic paravertebral block (TPVB) in patients undergoing thoracotomy for lung cancer.",[299,300,208,301],"Costotransverse Foramen Block","Thoracic Paravertebral Block","Lung Cancer","2026-01-24",{"date":304,"type":36},"2026-01-27",{"date":302,"type":36},{"date":307,"type":21},"2026-06-01",{"name":42,"class":43},{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":51,"enrollmentInfo":316,"targetDuration":4,"studyType":22,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":323,"startDateStruct":324,"completionDateStruct":325,"leadSponsor":326,"locationsCount":66},"100621203","costotransverse-foramen-block-with-erector-spinae-plane-block-in-modified-radical-mastectomy-100621203","NCT07367568","Costotransverse Foramen Block With Erector Spinae Plane Block in Modified Radical Mastectomy","Comparison of Costotransverse Foramen Block With Erector Spinae Plane Block in Modified Radical Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult females \\> 18 years and ≤ 65 years old.\n* American Society of Anesthesiologists (ASA) physical status П-III.\n* Body mass index (BMI) 18-35 kg\u002Fm2.\n* Scheduled for modified radical mastectomy.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetic agents.\n* Active infection at the injection site (e.g., cellulitis, abscess).\n* Coagulopathy or ongoing anticoagulant\u002Fantiplatelet therapy \\[International Normalized Ratio (INR) \\> 1.5 or platelet count \\\u003C 100,000\u002FµL\\].\n* Severe respiratory, cardiac, hepatic, or renal disease.\n* Morbid obesity.\n* Severe cognitive impairment or uncooperative behavior that could interfere with block placement.",{"count":317,"type":21},110,[24],"This study aims to compare the costotransverse foramen block with erector spinae plane block in modified radical mastectomy.",[299,321,322],"Erector Spinae Plane Block","Modified Radical Mastectomy",{"date":304,"type":36},{"date":302,"type":36},{"date":307,"type":21},{"name":42,"class":43},{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":4,"eligibilityCriteria":333,"healthyVolunteers":334,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":335,"targetDuration":4,"studyType":22,"phases":337,"briefSummary":338,"conditions":339,"keywords":341,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":66},"100618400","the-analgesic-efficacy-of-ultrasound-guided-transversalis-fascia-plane-block-in-inguinal-lymph-node-dissection-100618400","NCT07331129","The Analgesic Efficacy of Ultrasound Guided Transversalis Fascia Plane Block in Inguinal Lymph Node Dissection","Evaluation of Peri-operative Analgesic Efficacy of Ultrasound Guided Transversalis Fascia Plane Block in Cancer Patients Undergoing Inguinal Lymph Node Dissection: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n1. American society of anesthesiologists (ASA) class I and II.\n2. Age ≥ 18 and ≤ 65 Years.\n3. Cancer patients for inguinal lymph node dissection.\n4. Body mass index (BMI): \\> 20 kg\u002Fm2 and \\\u003C 40 kg\u002Fm2.\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. Local infection at the puncture site.\n3. Coagulopathies with platelets count below 50,000 or an INR\\>1.6.\n4. Unstable cardiovascular disease.\n5. History of psychiatric and cognitive disorders.\n6. Patients allergic to medication used.",true,{"count":336,"type":21},90,[24],"Pain accompanying Inguinal lymph node dissection triggers a complex stress response leading to impairment of pulmonary, immunological and metabolic function. Opioids are the current gold standard drug for postoperative pain relief, however exposure to large doses lead to multiple side effects of varying significance such as nausea, vomiting, dizziness, constipation, respiratory depression, hypoventilation and sleep disordered breathing. Therefore, strategies other than opioids are recommended without sacrificing proper and effective analgesia, especially in cancer patients who are more susceptible to tolerance and addiction.\n\nTransversalis Fascia Plane Block is used in patients undergoing various surgeries like iliac crest bone harvesting, appendicectomy, cecostomy and inguinal hernia repair, often in combination with TAP block. The initial description of TFPB was with patients in the supine position, with a linear array or curvilinear probe placed between the iliac crest and the costal margin. The external oblique, internal oblique and transversus abdominis muscles and the transversus aponeurosis are identified. The entry of the needle has to be in-plane, from the anterior aspect, and after traversing through the deep surface of the transversus abdominis muscle, local anesthetic is injected to separate the transversalis fascia from the transversus muscle. Studies have demonstrated that this intervention blocks the proximal branches of T12 and L1 and to a lesser extent T11 in the plane between the transversus abdominis muscle and the transversalis fascia. Since its initial description, ultrasound (US)-guided TFPB has been explored in many randomized controlled trials for patients undergoing iliac crest bone harvesting, lower segment caesarean section (LSCS), inguinal hernia repair and hip surgeries.",[340],"Inguinal Lymph Nodes Enlarged",[342,137,343],"transversalis fascia plane block","inguinal lymph node dissection","2025-12-28",{"date":346,"type":36},"2026-01-09",{"date":348,"type":36},"2025-12-22",{"date":350,"type":21},"2026-06-29",{"name":42,"class":43},{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":94,"enrollmentInfo":359,"targetDuration":4,"studyType":22,"phases":361,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":378,"locationsCount":66},"100614228","intrathecal-dexmedetomidine-fentanyl-combination-versus-fentanyl-alone-as-adjuvant-to-bupivacaine-in-spinal-anesthesia-for-above-knee-amputation-in-sarcomas-of-lower-extremity-100614228","NCT07276867","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity: A Randomized, Comparative Study","Inclusion Criteria:\n\n* Age from 18 to 60 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status of II-III.\n* Height between 150-185 cm.\n* Body mass index between 18-35 kg\u002Fm².\n* Scheduled for above-knee amputation due to lower limb sarcomas.\n\nExclusion Criteria:\n\n* Allergy to any of the investigated drugs.\n* History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors.\n* Contraindications to spinal anesthesia.\n* Pregnancy or lactation.\n* Presence of psychiatric illness or chronic pain conditions.",{"count":360,"type":21},58,[24],"The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.",[364,365,366,367,368,369,370,371],"Intrathecal","Dexmedetomidine","Fentanyl","Bupivacaine","Spinal Anesthesia","Above Knee Amputation","Sarcomas","Lower Extremity","2025-11-30",{"date":374,"type":36},"2025-12-11",{"date":376,"type":36},"2025-10-20",{"date":238,"type":21},{"name":42,"class":43},{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":11,"sex":16,"minAge":386,"maxAge":387,"enrollmentInfo":388,"targetDuration":4,"studyType":22,"phases":390,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":66},"100601404","nalbuphine-versus-tramadol-on-post-operative-analgesia-in-abdominal-surgery-on-pediatric-cancer-patient-100601404","NCT07110051","Nalbuphine Versus Tramadol on Post Operative Analgesia in Abdominal Surgery on Pediatric Cancer Patient","Comparative Study Between Nalbuphine Versus Tramadol on Post Operative Analgesia in Abdominal Surgery on Pediatric Cancer Patient","Inclusion Criteria:\n\n* Participants will be children aged 3-12 years\n* American society of anesthesia (ASA) classification I-III.\n* scheduled for elective Abdominal surgery under general anesthesia\n\nExclusion Criteria:\n\n* child guardian refusal.\n* Allergy from Tramal or nalbuphine\n* Patient with previous chronic pain on opioids","3 Years","12 Years",{"count":389,"type":21},128,[24],"In current study the investigators aim to compare between nalbuphine versus tramadol for post-operative pain control in abdominal surgeries in pediatric.",[393,394,395,396],"Tramadol","Nalbuphine","Abdominal Surgeries","Pediatric Cancer","2025-08-06",{"date":399,"type":36},"2025-08-11",{"date":401,"type":36},"2025-01-15",{"date":403,"type":21},"2025-10-15",{"name":42,"class":43},{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":16,"minAge":411,"maxAge":17,"enrollmentInfo":412,"targetDuration":4,"studyType":22,"phases":413,"briefSummary":414,"conditions":415,"keywords":417,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":423,"leadSponsor":424,"locationsCount":66},"100597319","supra-inguinal-fascia-iliaca-block-versus-ultrasound-guided-caudal-analgesia-for-pediatrics-undergoing-anterior-and-lateral-thigh-surgeries-a-randomized-controlled-trial-100597319","NCT07056946","Supra Inguinal Fascia Iliaca Block Versus Ultrasound-guided Caudal Analgesia for Pediatrics Undergoing Anterior and Lateral Thigh Surgeries: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 1-12 years\n* scheduled for anterior and lateral thigh Surgeries\n* American Society of Anesthesiologists (ASA) physical status II or III\n\nExclusion Criteria:\n\n* Refusal of parental consent\n* Allergy to any local anesthetics","1 Year",{"count":277,"type":21},[24],"patients will then be randomized in the two groups.\n\n1. Group C: in this group children will receive US-guided caudal analgesia (CA) after GA. The caudal block will be performed\n2. Group B: in this group children will receive lower limb peripheral nerve blocks in the form of US-guided fascia iliaca Block.",[416],"Cancer Bone",[418],"Supra inguinal fascia iliaca Block ,Caudal Analgesia,Pediatrics","2025-07-14",{"date":421,"type":36},"2025-07-15",{"date":161,"type":21},{"date":118,"type":21},{"name":42,"class":43},{"id":426,"slug":427,"hasResults":11,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":51,"enrollmentInfo":431,"targetDuration":4,"studyType":22,"phases":433,"briefSummary":434,"conditions":435,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":66},"100584093","ultrasound-guided-multilevel-erectorspinae-plane-block-versus-thoracic-epidural-analgesia-for-prevention-of-post-mastectomy-pain-syndrome-for-breast-cancer-patients-100584093","NCT06884852","Ultrasound-guided Multilevel Erectorspinae Plane Block Versus Thoracic Epidural Analgesia for Prevention of Post Mastectomy Pain Syndrome for Breast Cancer Patients","Inclusion Criteria:\n\n* Female patients age ≥ 18 years and ≤ 65 Years.\n* Type of surgery; Modified Radical Mastectomy (MRM)\n* Physical status ASA II, III.\n* Body mass index (BMI): \\> 20 kg\u002Fm2 and \\\u003C 35 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Allergy or a contraindication to the drug used in the study, e.g. local anesthetics, opioids.\n* History of psychological disorders.\n* History of chronic pain.\n* Contraindication to regional anesthesia e.g. sepsis, peripheral neuropathies and coagulopathy.\n* Advanced chronic renal disease, which is defined as a chronic kidney disease (CKD) in which there is a severe reduction in glomerular filtration rate (GFR \\\u003C 30 ml\u002Fmin) and includes stages 4 and 5 of the CKD classification.\n* Decompensated cirrhosis, which is defined as an acute deterioration in liver function in a patient with cirrhosis and is characterized by jaundice, ascites, hepatic encephalopathy, hepatorenal syndrome, or variceal hemorrhage.\n* Severe heart disease which is defined as NYHA class iii (moderate symptoms with less than normal activity, marked limitation of function status) or NYHA class IV (severe symptoms with features of heart failure with minimal activity or at rest and severe limitation of functional status)\n* Severe lung disease which includes oxygen saturation of blood less than 92%, RR more than 20, FEV1\u002FFVC ratio less than 60%.\n* Pregnancy.",{"count":432,"type":21},44,[24],"The aim of this study is to compare the analgesic efficacy of multilevel erector spinae plane block (ESPB) vs thoracic epidural in modified radical mastectomy (MRM) regarding duration of analgesia, postoperative opioid consumption, effect on intraoperative fentanyl consumption, postoperative numerical pain rating scale and quality of life for the next 6 months.",[436,437,438,439,440,441],"Ultrasound","Multilevel Erector Spinae Plane Block","Thoracic Epidural Analgesia","Post Mastectomy","Pain Syndrome","Breast Cancer Patients","2025-05-18",{"date":444,"type":36},"2025-05-21",{"date":446,"type":36},"2025-03-20",{"date":448,"type":21},"2026-03-01",{"name":42,"class":43},{"id":451,"slug":452,"hasResults":11,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":94,"enrollmentInfo":457,"targetDuration":4,"studyType":22,"phases":458,"briefSummary":459,"conditions":460,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":66},"100584355","compare-analgesia-between-mtp-block-and-espb-in-mrm-100584355","NCT06888258","Compare Analgesia Between MTP Block And ESPB in MRM","Comparative Study Between Ultrasound Guided Mid-point Transverse Process to Pleura Block And Erector Spinae Plane Block For Perioperative Analgesia In Modified Radical Mastectomy In Breast Cancer Patients","Inclusion Criteria:\n\n* ASA I-II.\n* Undergoing modified radical mastectomy surgery.\n* Body mass index (BMI) from 18.5 to 30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Patient refusal.\n* Known allergy to local anesthetics.\n* Bleeding disorders; platelets count \\\u003C50,000 , prothrombin concentration \\\u003C 60% or any coagulopathy disorder.\n* Use of any anti-coagulants.\n* Inability to provide informed consent.\n* ASA III-IV.\n* Neurological disorders.\n* Patient with psychiatric disorders",{"count":336,"type":21},[24],"This study is conducted to compare the analgesic efficacy between ultrasound guided Erector Spinae Plane block Vs midpoint transverse process to Pleura block in modified radical mastectomy surgeries",[133],"2025-03-22",{"date":463,"type":36},"2025-03-26",{"date":465,"type":36},"2024-10-01",{"date":467,"type":21},"2026-02-01",{"name":42,"class":43},{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":476,"targetDuration":4,"studyType":22,"phases":477,"briefSummary":478,"conditions":479,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":493,"locationsCount":66},"100584488","bilateral-ultrasound-guided-intramuscular-quadratus-lumborum-plane-block-versus-bilateral-lateral-quadratus-lumborum-plane-block-in-controlling-postoperative-pain-in-cancer-patients-undergoing-open-nephrectomy-100584488","NCT06889987","Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Postoperative Pain in Cancer Patients Undergoing Open Nephrectomy","Efficacy of Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block (Ql4) Versus Bilateral Lateral Quadratus Lumborum Plane Block (Ql1) in Controlling Post-Operative Pain in Cancer Patient Undergoing Open Nephrectomy: A Randomized Control Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status II-III.\n* Body mass index (BMI): (20- 40) kg\u002Fm2.\n* Type of surgery: midline incision for unilateral open nephrectomy.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Age \\\u003C18 years or \\>65 years\n* BMI \\\u003C20 kg\u002Fm2 and \\> 40 kg\u002Fm2\n* Known sensitivity or contraindication to drugs used in the study\n* Contraindication to regional anesthesia, e.g. local infection at the introduction site, pre-existing peripheral neuropathies and coagulopathy.\n* Physical status ASA IV\n* Patients on chronic analgesic therapy (daily morphine ≥30 mg or equivalent dose of other opioids or tramadol or any medication for neuropathic pain)\n* Patients with a history of drug abuse\n* Patients with neuropsychiatric diseases; patients with a history of chronic pain syndromes that may enhance sensitivity to pain, for example, fibromyalgia\n* All patients who are going to have severe intra- or post-operative bleeding or will require postoperative mechanical ventilation are also excluded from the study.",{"count":336,"type":21},[24],"This study aims to evaluate the efficacy of bilateral ultrasound-guided intramuscular quadratus lumborum plane block (QL4) versus bilateral lateral quadratus lumborum plane block (QL1) in controlling postoperative pain in cancer patients undergoing open nephrectomy.",[480,436,481,482,483,484,485],"Bilateral","Intramuscular Quadratus Lumborum Plane Block","Lateral Quadratus Lumborum Plane Block","Postoperative Pain","Cancer Patients","Open Nephrectomy","2025-03-16",{"date":488,"type":36},"2025-03-21",{"date":490,"type":36},"2024-12-10",{"date":492,"type":21},"2025-12-06",{"name":42,"class":43},{"id":495,"slug":496,"hasResults":11,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":501,"targetDuration":4,"studyType":22,"phases":503,"briefSummary":504,"conditions":505,"keywords":507,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":66},"100554591","dexamethasone-versus-mg-added-to-bupivacaine-used-in-espb-for-perioperative-pain-control-in-patients-undergoing-unilateral-nephrectomy-100554591","NCT06501079","Dexamethasone Versus Mg Added to Bupivacaine Used in ESPB for Perioperative Pain Control in Patients Undergoing Unilateral Nephrectomy","The Efficacy of Dexamethasone Versus Magnesium Sulphate Added to Bupivacaine Used in Erector Spinae Plane Block for Perioperative Pain Control in Patients Undergoing Unilateral Nephrectomy","Inclusion Criteria:\n\n* Adult (18 - 65)\n* Patients undergoing unilateral nephrectomy\n* ASA II \u002F III\n\nExclusion Criteria:\n\n* Patient refusal\n* Age less than 18 years\n* Allergy to any of the studied medications\n* Mid line incision\n* Bilateral nephrectomy\n* Distorted anatomy of the back (e.g. kyphoscoliosis)\n* Known neurologic disorders, psychiatric disorder or chronic pain\n* Local infection\n* Hemodynamic instability",{"count":502,"type":21},78,[24],"Aim of the study:\n\nThe current study aims to compare the effect of adding dexamethasone versus magnesium sulfate to bupivacaine in ultrasound-guided erector spinae plane block on the severity of postoperative pain.\n\nPrimary Objectives:\n\n\\- To compare the effect of ESPB without additives to the effect of adding dexamethasone and to the impact of adding magnesium sulfate in the form of post-operative morphine consumption",[506],"Renal Neoplasm",[508,509,367,321,510,511,512],"Dexamethasone","Magnesium Sulphate","perioperative","pain control","unilateral nephrectomy","2024-07-11",{"date":515,"type":36},"2024-07-15",{"date":517,"type":36},"2024-05-01",{"date":519,"type":21},"2024-12-01",{"name":42,"class":43},{"id":522,"slug":523,"hasResults":11,"nctId":524,"briefTitle":525,"officialTitle":526,"acronym":4,"eligibilityCriteria":527,"healthyVolunteers":334,"sex":74,"minAge":17,"maxAge":94,"enrollmentInfo":528,"targetDuration":4,"studyType":22,"phases":530,"briefSummary":531,"conditions":532,"keywords":534,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":66},"100518933","preoperative-erector-spinae-plane-block-versus-paravertebral-plane-block-in-decreasing-post-mastectomy-pain-syndrome-100518933","NCT06036979","Preoperative Erector Spinae Plane Block Versus Paravertebral Plane Block in Decreasing Post Mastectomy Pain Syndrome","A Comparative Study Between Preoperative Erector Spinae Plane Block Versus Preoperative Paravertebral Plane Block in Decreasing Post Mastectomy Pain Syndrome. A Randomized Controlled Study.","Inclusion Criteria:\n\n* Age ≥ 18 years and ≤ 60 years old.\n* Female patients ASA ΙΙ, ΙΙΙ.\n* Female patients scheduled for unilateral breast surgeries.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Patients have sepsis\n* Patients known to have allergy against local anesthetics.\n* Patients with prior surgery in areas above or below the clavicle or in the axillary region.\n* Patients with opioid dependence, alcohol or drug abuse.\n* Patient with coagulopathy.\n* Patients with psychiatric illness that prevent them from proper pain perception and assessment.\n* ASA 4 or higher.",{"count":529,"type":21},51,[24],"Breast cancer is considered the commonest malignancy affecting women with an incidence exceeding one million cases per year. Although it has a favorable prognosis with improved lines of treatment, some complications may still disturb the patient's life quality. One of these complications is post-mastectomy pain syndrome (PMPS) .Regional Anaesthesia (RA) is considered one of the most effective methods in reducing acute pain after breast surgeries, these include pectoral nerves block (PECS), serratus anterior plane block (SAPB), paravertebral plane block (PVPB) and erector spinae plane block (ESPB) . Our study is aiming for comparing the effect of preoperative PVPB versus preoperative ESPB in the prevention of PMPS in patients undergoing unilateral breast surgeries.",[533],"Chronic Postoperative Pain",[535],"PVPB, ESPB, prevention of PMPS","2024-06-27",{"date":538,"type":36},"2024-06-28",{"date":540,"type":21},"2024-07-01",{"date":542,"type":21},"2025-02-01",{"name":42,"class":43},{"id":545,"slug":546,"hasResults":11,"nctId":547,"briefTitle":548,"officialTitle":549,"acronym":4,"eligibilityCriteria":550,"healthyVolunteers":11,"sex":74,"minAge":17,"maxAge":551,"enrollmentInfo":552,"targetDuration":4,"studyType":22,"phases":554,"briefSummary":555,"conditions":556,"keywords":559,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":66},"100527175","metastases-directed-therapy-for-oligometastatic-breast-cancer-100527175","NCT06144346","Metastases Directed Therapy for Oligometastatic Breast Cancer","Role of Metastases Directed Radiotherapy in Addition to Standard of Care Systemic Treatment in the Management of Extracranial Oligometastatic Breast Cancer","Inclusion Criteria:\n\n* Female patients aged 18 to 70 years.\n* Pathological evidence of breast cancer, any grade, any T stage.\n* Radiological (at least) evidence of metastatic activity with maximum number of 5 extracranial lesions.\n* Performance status ≤ 2\n* No pre-existing conditions that may prohibit radiotherapy.\n\nExclusion Criteria:\n\n•.Pregnant and lactating women.\n\n* Prior radiotherapy to affected site(s) in less than a year.\n* Active Connective tissue diseases (e.g Rheumatoid Arthritis).\n* Progression to widespread metastatic disease\n* Cases with brain metastasis","70 Years",{"count":553,"type":21},150,[24],"This is a phase III randomized study evaluating the benefit from adding metastases directed therapy and locoregional treatment of the primary in breast cancer patients diagnosed with de novo oligometastatic disease patients will be randomized to receive the standard of care (SOC) treatment vs. systemic treatment + Stereotactic Ablative Radiation Therapy. Responders will be randomized to either undergo loco-regional management of the primary tumor or not",[133,557,558],"Metastatic Cancer","Metastatic Breast Cancer",[560,561],"stereotactic radiation","oligometastatic breast cancer","2023-11-20",{"date":564,"type":36},"2023-11-22",{"date":566,"type":36},"2023-09-20",{"date":568,"type":21},"2028-09-20",{"name":42,"class":43},""]