[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"National Hospital of Obstetrics and Gynecology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":75},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100621582","cerclage-plus-progesterone-vs-progesterone-alone-in-twin-short-cervix-100621582",false,"NCT07372495","Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix","Cervical Cerclage Plus Vaginal Progesterone Versus Vaginal Progesterone Alone in Twin Pregnancies With a Short Cervix for Prevention of Preterm Birth: a Randomized Controlled Trial","VNTWINC","Inclusion Criteria:\n\n* Maternal age ≥ 18\n* Twin pregnancy\n* Asymptomatic short cervix (CL≤30mm) at routine ultrasound investigation\n* Gestational age at 16+0- 24+0 weeks\n\nExclusion Criteria:\n\nA potential paticipant who meets any of the following criteria will be excluded from participation in this trial:\n\n* Women with twin pregnancy in which one or both fetuses are diagnosed with a major structural or congenital abnormality that is likely to influence the composite adverse neonatal outcome.\n* Women with a monochorionic monoamniotic twin pregnancy\n* A monochorionic twin pregnancy with twin-to-twin transfusion syndrome before or at the time of inclusion.\n* Patients have indications for vaginal cerclage: Recurrent late miscarriage (from 14 weeks) or preterm birth occurring two or more times.\n* Women with dilatation of the cervix diagnosed by ultrasound or physical exam\n* Women with overt symptoms of preterm labor at the time of measurement of the short cervix (regular contractions, PPROM, recurrent blood loss).\n* Women with the presence of fever ≥ 38 degrees Celsius.\n* Women with a placenta previa, vasa previa.\n* Uterine malformations: unicornuate uterus, bicornuate uterus, uterine septum, fibroid…\n* Severe maternal conditions (heart failure, chronic kidney disease, systemic lupus erythematosus …)","FEMALE","18 Years",{"count":20,"type":21},260,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm). Participants will be randomly allocated to either the intervention group (cerclage plus progesterone) or the control group (progesterone alone).",[27],"Preterm",[29,30,31],"Twin pregnancy","cervical cerclage","Progesterone","RECRUITING","2026-04-23",{"date":35,"type":36},"2026-04-24","ACTUAL",{"date":38,"type":21},"2026-04-10",{"date":40,"type":21},"2029-05-30",{"name":42,"class":43},"National Hospital of Obstetrics and Gynecology","OTHER",6,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100621110","pge2-followed-by-oxytocin-vs-oxytocin-in-term-prom-poxy-prom-100621110","NCT07366359","PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)","Comparison of the Effectiveness of Labor Induction Using Dinoprostone Followed by Oxytocin Versus Oxytocin Alone in Term Pregnancies With Premature Rupture of Membranes and an Unfavorable Cervix - A Randomized Clinical Trial","POXY-PROM","Inclusion Criteria\n\n* Maternal age ≥ 18 years\n* Gestational age from 37 to 42 weeks, determined by last menstrual period or by a first- or second-trimester ultrasound\n* Live singleton fetus\n* Prelabor rupture of membranes (PROM) confirmed by at least one of the following:\n\n  * Amniotic fluid visibly draining from the cervical os during sterile speculum examination\n  * Pool of fluid in the posterior fornix\n* Cephalic presentation\n* Bishop score ≤ 6\n* No spontaneous uterine contractions\n* No contraindications for vaginal delivery\n\nExclusion Criteria:\n\n* Active labor\n* Previous uterine surgery (e.g., cesarean section)\n* Chorioamnionitis or non-reassuring fetal status\n* Major fetal anomalies\n* Contraindications to prostaglandin or vaginal delivery\n* Refusal to participate",{"count":54,"type":21},450,[24],"This study is being done to learn more about the best way to start labor for pregnant women whose water breaks at term before labor begins, a condition called term prelabor rupture of membranes (term PROM). When this happens and the cervix is not ready for labor, it is unclear which induction method works best and is safest for mother and baby.\n\nThe purpose of this study is to compare two common ways to induce labor in women with term PROM and an unfavorable cervix (Bishop score ≤ 6). One group will receive a vaginal dinoprostone insert (Propess) for 6 hours to soften the cervix, followed by oxytocin if labor does not start. The other group will receive immediate oxytocin through a vein.\n\nPregnant women aged 18 years or older with a single baby in head-down position at 37-42 weeks, whose water has broken and whose cervix is not yet favorable, may be able to join this study. All care will be provided at the National Hospital of Obstetrics and Gynecology in Hanoi, Vietnam, where both medicines are already used in routine practice.\n\nThe main outcome is how many women have a vaginal birth. The study will also look at how long it takes from induction to birth, complications for mothers and babies, and women's experiences of labor. The results may help doctors choose the safest and most effective way to induce labor for women with term PROM in the future.",[58,59,60],"Premature Rupture of Fetal Membranes","Labor, Induced","Cervical Ripening",[58,62,63,64,60,65],"Labor Induction","Dinoprostone","Oxytocin","Vaginal Delivery","2026-02-18",{"date":68,"type":36},"2026-02-20",{"date":70,"type":36},"2026-02-10",{"date":72,"type":21},"2028-01",{"name":42,"class":43},1,""]