[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"National Institute of Cardiology, Laranjeiras, Brazil\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":117},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,69,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100635848","evaluation-of-the-systemic-microcirculation-as-a-surrogate-for-coronary-microcirculation-in-women-with-anoca-100635848",false,"NCT07558018","Evaluation of the Systemic Microcirculation as a Surrogate for Coronary Microcirculation in Women With ANOCA","Evaluation of the Systemic Microcirculation as a Surrogate for Coronary Microcirculation in Women With ANOCA: Insights Into Pathophysiology and Diagnosis Using Noninvasive, Innovative Techniques (NOCAWT)","NOCAWT","Inclusion Criteria:\n\n* Age 18-65 years\n* Anginal chest pain\n\nExclusion Criteria:\n\n* Malignant neoplasms\n* Autoimmune diseases\n* Acute systemic diseases\n* Pregnancy or lactation\n* Iodine allergy\n* CAD on invasive coronary angiography or coronary computed tomography angiography (CCTA)","FEMALE","18 Years","65 Years",{"count":21,"type":22},60,"ESTIMATED","OBSERVATIONAL","The primary objective of this project is to validate a multi-modal systemic microvascular phenotyping platform-combining Laser Speckle Contrast Imaging (LSCI) and Sublingual Handheld Videomicroscopy (IDF imaging)-as a non-invasive surrogate for coronary microvascular function in women with ANOCA (Angina with Non-Obstructive Coronary Arteries). We aim to demonstrate that systemic microvascular signatures (microvascular reactivity and density) can predict coronary endotypes with high accuracy, potentially reducing the need for invasive diagnostics.",[26],"Angina, Microvascular",[28,29,30],"microcirculation","Laser Speckle Contrast Imaging","Sublingual videomicroscopy","NOT_YET_RECRUITING","2026-05-02",{"date":34,"type":35},"2026-05-05","ACTUAL",{"date":37,"type":22},"2026-08",{"date":39,"type":22},"2029-12",{"name":41,"class":42},"National Institute of Cardiology, Laranjeiras, Brazil","OTHER_GOV",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":67,"locationsCount":68},"100636287","vascular-aging-and-microcirculation-physiological-aspects-of-vascular-aging-in-the-elderly-population-vamp-aging-100636287","NCT07563725","Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)","VAMP-Aging","Inclusion Criteria:\n\n* Absence of symptoms and history of cardiovascular and cerebrovascular diseases.\n* Baseline blood pressure levels within the normal range (\\\u003C 140\u002F90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.\n\nExclusion Criteria:\n\n* Diabetes Mellitus: Fasting blood glucose ≥ 126 mg\u002FdL or use of hypoglycemic agents.\n* Smoking: Active or quit less than 5 years ago.\n* Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.\n* Surgery or trauma in the last 60 days.\n* Renal Dysfunction: Chronic renal failure (estimated by eGFR \\\u003C 60 mL\u002Fmin\u002F1.73m²).\n* Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).",true,"ALL","60 Years","100 Years",{"count":55,"type":22},62,"Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or \"inflammaging\". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.",[58],"Aging Problems",[28,29,60],"vascular aging","2026-04-29",{"date":63,"type":35},"2026-05-04",{"date":65,"type":22},"2026-06",{"date":39,"type":22},{"name":41,"class":42},1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":51,"minAge":18,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":68},"100529089","early-phase-1-effect-of-nitrate-supplementation-on-blood-pressure-and-microvascular-function-of-resistant-hypertensive-patients-100529089","NCT06169241","Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients","Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients","Inclusion Criteria:\n\n* Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.\n\nExclusion Criteria:\n\n* neoplasms\n* heart failure\n* use of medications with nitrate in their formula\n* patients undergoing renal denervation","75 Years",{"count":78,"type":22},50,"INTERVENTIONAL",[81],"EARLY_PHASE1","Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.",[84,85,86,87],"Arterial Hypertension","Resistant Hypertension","Microvascular Function","Nitrate Supplementation",[28,89,90,91],"capillary density","microvascular reactivity","systemic resistant hypertension","RECRUITING","2026-04-07",{"date":95,"type":35},"2026-04-13",{"date":97,"type":35},"2023-11-01",{"date":99,"type":22},"2026-12",{"name":41,"class":42},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":51,"minAge":18,"maxAge":76,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":116,"locationsCount":68},"100495271","the-evolution-of-systemic-microvascular-reactivity-in-heart-transplant-patients-100495271","NCT05729009","The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients","Inclusion Criteria:\n\n* capability to understand the objectives of the research and to fulfill the Term of Consent\n\nExclusion Criteria:\n\n* Pregnancy, acute infection diagnosis, use of circulatory assistance devices",{"count":108,"type":22},31,"The evolution of systemic microvascular reactivity may aid in the comprehension of cardiovascular physiology in heart transplantation patients, and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients.",[111],"Heart Transplantation",{"date":95,"type":35},{"date":114,"type":35},"2022-10-01",{"date":99,"type":22},{"name":41,"class":42},""]