[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"National Institute of Mental Health, Czech Republic\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":108},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100635771","unified-protocol-for-emotional-disorders-hitop-pro-trial-100635771",false,"NCT07557017","Unified Protocol for Emotional Disorders: HiTOP-PRO Trial","Investigating the Impact of the Unified Protocol on HiTOP Dimensions and Temperamental Traits in Patients With Emotional Disorders","UP-HITOP","Inclusion Criteria: Adults aged 18-65 years.\n\nSeeking outpatient treatment at NÚDZ for emotional disorder symptoms.\n\nMeets diagnostic eligibility on ADIS-5 for at least one of the following (ICD-10 categories consistent with the protocol): F32, F33, F34, F40, F41, F42, F43, F45, F60, F61.\n\nAble to understand and complete study questionnaires and procedures (Czech language).\n\nWilling and able to participate in psychotherapy and complete assessments at baseline and post-treatment (14 weeks).\n\nIf taking psychotropic medication: dose stable for ≥6 weeks prior to enrolment and expected to remain stable during the acute study period where clinically feasible.\n\nProvides written informed consent.\n\nExclusion Criteria: Current or lifetime psychotic disorder or current manic\u002Fhypomanic episode.\n\nHigh acute suicide risk requiring a higher level of care (e.g., imminent risk, recent serious attempt) or current severe self-harm risk incompatible with outpatient psychotherapy study procedures.\n\nPrimary substance use disorder requiring specialised treatment or acute intoxication\u002Fwithdrawal.\n\nSevere cognitive impairment or neurodevelopmental\u002Fneurological condition that prevents valid consent or completion of study procedures.\n\nConcurrent psychological treatment that would conflict with study participation (e.g., starting a new structured psychotherapy during the 14-week study period), unless it constitutes the assigned TAU.\n\nImmediate need for intensive treatment (e.g., inpatient admission) at the time of screening.\n\nInability to commit to the study schedule or complete required assessments.","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomised, parallel-group clinical trial evaluates the effects of the Unified Protocol (UP), a transdiagnostic cognitive-behavioural psychotherapy, on dimensional symptom outcomes aligned with the Hierarchical Taxonomy of Psychopathology (HiTOP) and on related temperamental\u002Fpersonality traits in adults with emotional disorders. Participants are randomly assigned (1:1:1) to UP, treatment as usual (TAU), or a waitlist (WL). Outcomes are assessed at baseline and after approximately 14 weeks. A planned follow-up assessment approximately 3 months after treatment completion is collected in the UP arm only.",[27],"Emotional Disorder",[29,30,31,32,33,34,35],"emotional disorders","unified protocol","HiTOP","Hierarchical Taxonomy Of Psychopathology","transdiagnostic therapy","personality traits","temperamental traits","RECRUITING","2026-04-22",{"date":39,"type":40},"2026-04-29","ACTUAL",{"date":42,"type":40},"2025-10-08",{"date":44,"type":21},"2028-07-31",{"name":46,"class":47},"National Institute of Mental Health, Czech Republic","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":48},"100611788","virtual-reality-exposure-therapy-for-obsessive-compulsive-disorder-a-randomized-controlled-trial-in-inpatients-100611788","NCT07245134","Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients","Virtual Reality Exposure Therapy in Patients With Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients","OCD-VRET1","Inclusion Criteria:\n\n* Diagnosis of OCD (F42) using currently valid DSM-V and ICD-11\n* Fluent in Czech\n\nExclusion Criteria:\n\n* Any other psychiatric, neurological and serious somatic illness\n* Substance abuse\n* Psychotropic medication (e.g. benzodiazepines) except antidepressants, antipsychotic medication and hypnotics.\n* Contradictions to using a virtual reality (e.g., epilepsy, balance problems)\n* Pregnancy\n* Cardiostimulator and mental implants","17 Years","55 Years",{"count":60,"type":21},62,[24],"The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD). Participants are randomly assigned to one of the following interventions: a) exposure condition - the group with a standard CBT program enriched with exposure therapy in VR (VRET), b) control condition 1 - the group with a standard CBT program enriched with VR cognitive training aimed at cognitive flexibility or c) control condition 2 - standard CBT program without any additional VR intervention. The treatment effect will be evaluated using pre\u002Fpost assessments, as well as monitoring adherence to exposure and response prevention assignments.",[64,65,66,67],"Obsessive-Compulsive Disorder","Virtual Reality Exposure Therapy","Virtual Reality Cognitive Training","Cognitive Behavior Therapy",[69,70,71,72],"obsessive-compulsive disorder","VR exposure therapy","cognitive flexibility","Inpatient clinic","2025-11-20",{"date":75,"type":40},"2025-11-24",{"date":77,"type":40},"2022-11-15",{"date":79,"type":21},"2026-12-30",{"name":46,"class":47},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":48},"100608795","virtual-reality-exposure-therapy-for-obsessive-compulsive-disorder-outpatients-trial-100608795","NCT07206199","Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: Outpatients Trial","Virtual Reality Exposure Therapy in Patients With Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Outpatients","OCD-VRET2",{"count":89,"type":21},30,[24],"The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD). This study focuses on patients receiving treatment in outpatient psychiatry or clinical psychology settings, utilizing a within-subject design for comparison. Patients first complete informed consent and baseline questionnaires and are placed on a waiting list for five weeks. After this period, they are reassigned to the active (experimental) group, which will receive five sessions of exposure therapy in virtual reality over a subsequent five-week period. The treatment effect will be evaluated using pre\u002Fpost assessments, as well as monitoring adherence to exposure and response prevention assignments.",[93],"Obsessive-compulsive Disorder",[95,96,97,98,99],"Obsessive-compulsive disorder","virtual reality","Virtual reality exposure therapy","within-subject design","Outpatients","2025-09-25",{"date":102,"type":40},"2025-10-03",{"date":104,"type":40},"2024-03-20",{"date":106,"type":21},"2027-03-31",{"name":46,"class":47},""]