[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"National University of La Rioja\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100641067","phase-2-phase-ii-randomized-double-blind-placebo-controlled-clinical-trial-to-evaluate-the-efficacy-and-safety-of-omega-3-fatty-acids-as-an-adjunct-to-morphine-in-acute-postoperative-pain-100641067",false,"NCT07657468","Phase II, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Omega-3 Fatty Acids as an Adjunct to Morphine in Acute Postoperative Pain","O3MORPH","Inclusion Criteria:\n\n1. Able to provide written informed consent prior to any study procedures;\n2. Able to communicate clearly with the Investigator and staff;\n3. Males and females aged 18 to 65;\n4. American Society of Anesthesiologists (ASA) risk class of I to II;\n5. Patients with an indication for laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients with reduced kidney function (serum creatinine level above 2 mg\u002Fdl).\n* Sensitive to local anesthetics.\n* A history of hepatic insufficiency.\n* Chronic pain.\n* Patients with diabetes.\n* Patients with Body Mass Index (BMI) greater than 35 kg\u002Fm2.\n* Daily intake of analgesics or corticosteroids.\n* Patients with Inflammatory bowel disease.\n* Chronic opioid use.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","This is a single-center, randomized, double-blind, placebo-controlled, parallel-group proof-of-concept study to evaluate the analgesic efficacy and safety of omega-3 fatty acids as an adjunct to morphine for acute postoperative pain following laparoscopic cholecystectomy.\n\nPatients will receive either omega-3 fatty acid supplementation or a placebo before and after surgery. At the end of surgery, a loading dose of morphine of 0.04 mg\u002Fkg body weight will be administered intravenously as a bolus in both groups. The primary endpoint will be the total amount of rescue morphine used during the first 24 postoperative hours.",[28,29],"Pain Postoperative","Analgesia",[31,32,33,34,35,36],"analgesia","post-operation pain","analgesic adjunct","morphine reduction","omega-3 fatty acids","lapararoscopic cholecystectomy","NOT_YET_RECRUITING","2026-06-13",{"date":40,"type":41},"2026-06-18","ACTUAL",{"date":43,"type":22},"2026-06-15",{"date":45,"type":22},"2026-10-31",{"name":47,"class":48},"National University of La Rioja","OTHER",""]