[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Necmettin Erbakan University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":680},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,36,0,25,[9,48,89,114,142,164,191,220,232,257,286,319,342,374,400,423,454,478,505,532,557,578,609,638,661],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":44,"locationsCount":47},"100054328","pelvic-floor-muscle-training-and-dynamic-neuromuscular-stabilization-exercises-in-pediatric-patients-100054328",false,"NCT07267364","Pelvic Floor Muscle Training and Dynamic Neuromuscular Stabilization Exercises in Pediatric Patients","Effects of Adding Dynamic Neuromuscular Stabilization to Pelvic Floor Muscle Training on Voiding Dysfunction in Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Having been diagnosed with voiding dysfunction according to ICCS diagnostic criteria in a urology outpatient clinic,\n* Being 5-18 years old,\n* The child and their parent\u002Fguardian agree to participate in the study voluntarily and provide signed consent.\n\nExclusion Criteria:\n\n* Organic pathologies such as urethral obstruction, ectopic ureter, spinal dysraphism, and diabetes\n* Diagnosis of VUR or neurogenic bladder\n* Cognitive and mental impairment\n* Having spina bifida\n* Being under 5 years of age\n* Receiving treatment such as PTC training or electrical stimulation",true,"ALL","5 Years","18 Years",{"count":22,"type":23},48,"ESTIMATED","INTERVENTIONAL",[26],"NA","Dysfunctional voiding (DY) is one of the most common conditions in children. Various treatments are available. Participants will be randomly assigned to either PFMT (Group I) or PFMT+DNS (Group II). PFMT is the gold standard and routinely administered in hospitals for children diagnosed with dysfunctional voiding who are referred by a urologist. The PFMT group serves as the control group, and treatment will be scheduled for a total of 10 weeks, three days a week. During PFMT, children receive instruction about the pelvic floor using video visuals and increase awareness of their pelvic floor muscles. They are then instructed on how to contract and relax their muscles to control urination. DNS training is an exercise model that begins with spinal stabilization and addresses muscle synergies. Patients included in the study will be evaluated twice, at the beginning and at the end of the treatment: Voiding Disorders Symptom Score (VODS), Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0), Pediatric Incontinence Questionnaire (PIN-Q), Bladder Bowel Dysfunction Scale (BDS), Bristol gaita scale, and Children's Body Image Scale.",[29,30],"Urology","Pediatric Disorder",[32,33,34,35],"Voiding dysfunction","pelvic floor muscle training","neuromuscular stabilization","quality of life","RECRUITING","2026-07-10",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2025-11-11",{"date":37,"type":23},{"name":45,"class":46},"Necmettin Erbakan University","OTHER",2,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":68,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":47},"100053458","selective-median-lobe-surgery-outcomes-study-100053458","NCT07699718","Selective Median Lobe Surgery Outcomes Study","UNVEIL-BPO Median Lobe Study: An International Multicenter Evaluation of Selective Median Lobe Resection and Enucleation","UNVEIL-BPO","Inclusion Criteria:\n\n* Male patients aged 45 years or older.\n\n  * Moderate-to-severe lower urinary tract symptoms due to benign prostatic obstruction or urinary retention requiring transurethral surgery.\n  * Preoperative findings suggesting median lobe-dominant or median lobe-related obstruction.\n  * Planned selective median lobe-only TURP, HoLEP, or anatomical endoscopic enucleation as part of routine clinical care.\n  * Available baseline International Prostate Symptom Score, uroflowmetry and\u002For postvoid residual volume, prostate volume, intravesical prostatic protrusion measurement, and cystoscopic assessment.\n  * Ability to provide written informed consent and comply with the follow-up schedule.\n\nExclusion Criteria:\n\n* Previous prostate surgery for benign prostatic hyperplasia.\n* Known urethral stricture requiring treatment before or during the index procedure.\n* Known neurogenic lower urinary tract dysfunction.\n* Active prostate cancer or bladder cancer requiring treatment that may confound urinary outcomes.\n* Planned complete TURP, complete HoLEP\u002FAEEP, or lateral lobe-dominant surgery.\n* Severe kissing lateral lobe obstruction considered to require complete surgery rather than selective median lobe surgery.\n* Inability to provide valid baseline or follow-up outcome data.","MALE","45 Years",{"count":59,"type":23},420,"OBSERVATIONAL","This prospective multicenter observational cohort study will evaluate clinical outcomes after selective median lobe transurethral surgery for benign prostatic obstruction. Eligible men with lower urinary tract symptoms or urinary retention who are scheduled for selective median lobe-only TURP, HoLEP, or anatomical endoscopic enucleation as part of routine clinical care will be enrolled and followed after surgery.\n\nThe study will collect preoperative clinical data, symptom scores, uroflowmetry, postvoid residual volume, prostate volume, intravesical prostatic protrusion measurements, cystoscopic anatomical findings, intraoperative variables, and postoperative outcomes. The primary outcome is composite clinical failure at 12 months.\n\nThe main aim is to identify practical preoperative urology-based anatomical and functional predictors of clinical failure after selective median lobe surgery and to develop an exploratory prediction model that may help improve patient selection in future practice.",[63,64,65,66,67],"Benign Prostatic Hyperplasia","Lower Urinary Tract Symptoms (LUTS) in Men With Benign Prostatic Hyperplasia (BPH)","Benign Prostatic Obstruction","Urinary Retention","Median Lobe Prostatic Enlargement",[69,70,71,72,73,74,75,76,77,78,79,80],"Median lobe","Intravesical prostatic protrusion","Selective median lobe surgery","Selective median lobe enucleation","Selective median lobe resection","TURP","HoLEP","Anatomical endoscopic enucleation of the prostate","Uroflowmetry","Postvoid residual","Clinical failure","Ejaculation preservation","NOT_YET_RECRUITING","2026-07-09",{"date":39,"type":40},{"date":85,"type":23},"2026-09-01",{"date":87,"type":23},"2030-12-01",{"name":45,"class":46},{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":24,"phases":98,"briefSummary":99,"conditions":100,"keywords":103,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":4},"100643982","the-impact-of-a-web-based-empowerment-program-on-intolerance-of-uncertainty-and-maintenance-burden-100643982","NCT07668427","The Impact of a Web-based Empowerment Program on Intolerance of Uncertainty and Maintenance Burden.","The Effect of a Web-Based Empowerment Program Based on the Theory of Illness Applied to Caregivers of Prostate Cancer Patients on Intolerance of Uncertainty and Caregiver Burden: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Over 18 years of age,\n* Able to speak Turkish,\n* Literate,\n* No hearing or vision problems,\n* No neurological and\u002For psychiatric disorders,\n* Physical and cognitive health levels suitable for answering the forms used in the study,\n* Having a patient diagnosed with prostate cancer,\n* Being the primary caregiver responsible for meeting the patient's care needs (home care, supervision, hospital check-ups, etc.) within the family,\n* Having a patient scheduled for hormone therapy and radiotherapy,\n* Not having undergone prostatectomy,\n* Having an electronic device such as a smartphone or computer with internet access, either themselves or a family member,\n* Caregivers of prostate cancer who volunteer to participate in the study will be included.\n\nExclusion Criteria:\n\n* Caregivers whose patients are receiving chemotherapy will be excluded.",{"count":97,"type":23},62,[26],"The aim of this study is to examine the relationship between uncertainty intolerance and caregiver burden in a web-based empowerment program based on uncertainty theory in disease, applied to caregivers of prostate cancer patients.",[101,102],"Intolerance of Uncertainty","Caregiving Burden",[104,105],"Intolerance of uncertainty","caregiving burden","2026-06-19",{"date":108,"type":40},"2026-06-25",{"date":110,"type":23},"2026-07-01",{"date":112,"type":23},"2027-05-17",{"name":45,"class":46},{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":24,"phases":125,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":141},"100641446","use-of-hand-extension-rubber-during-intravenous-catheter-placement-100641446","NCT07659015","Use of Hand Extension Rubber During Intravenous Catheter Placement","The Effect of Hand Extension Rubber Used in Patients With Peripheral Intravenous Catheter Insertion on Pain, Anxiety and Satisfaction: A Randomized Controlled Trial","PIC","Inclusion Criteria:\n\n* Volunteers willing to participate in the study\n* Patients aged 18-65\n* Patients who are alert and able to communicate verbally in Turkish\n* Patients assigned to the green zone during triage\n* Patients suitable for PICC placement in the left cephalic and basilic veins\n* Patients who are right-handed\n* Patients with a VAS pain score of 0 prior to the PIC procedure\n\nExclusion Criteria:\n\n* Patients with acute or chronic pain\n* Patients with conditions that cause limited mobility, such as muscle disorders or grip dysfunction\n* Patients with peripheral neuropathy, arteriovenous fistula, or bilateral mastectomy\n* Patients with a psychiatric diagnosis (as self-reported)\n* Patients with communication impairments (hearing, speech, and vision)\n* Patients with a history of negative PIC procedure experiences\n\nTerminating Criteria:\n\n* Participants wishing to withdraw from the study at any stage after giving their consent\n* Failure of the PIC procedure\n* Failure to use the hand extension band until the end of the procedure\n* Occurrence of complications related to the PIC procedure during the procedure","65 Years",{"count":124,"type":23},114,[26],"The study aims to investigate the effect of a hand extension rubber used in patients with peripheral intravenous catheters on pain, anxiety, and satisfaction.",[128,129,130],"Pain","Anxiety","Satisfaction",[132,133,120,128,129,130],"Nursing","Peripheral intravenous catheter","2026-06-15",{"date":136,"type":40},"2026-06-22",{"date":134,"type":23},{"date":139,"type":23},"2026-08-01",{"name":45,"class":46},1,{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":24,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":141},"100573953","the-effect-of-eye-mask-and-earplugs-on-sleep-quality-and-delirium-in-coronary-artery-bypass-graft-patients-a-randomized-controlled-study-100573953","NCT06752980","The Effect of Eye Mask and Earplugs on Sleep Quality and Delirium in Coronary Artery Bypass Graft Patients: A Randomized Controlled Study","Inclusion Criteria:\n\n-Patients who voluntarily agree to participate in the study\n\n* Those who have undergone coronary artery bypass graft surgery\n* Those between the ages of 18-79\n* Those who are cooperative and oriented\n* Those who are literate\n* Those who speak Turkish\n* Those whose initial delirium scale score (Nu-DECS) is less than 2\n* Those whose Glasgow coma scale score is \\>13 will be included in the study.\n\nExclusion Criteria:\n\n* • Patients diagnosed with sleep disorders,\n\n  * Those using sleeping pills,\n  * Those who have a habit of using an eye patch while sleeping,\n  * Those who were not transferred to the clinic on the first day after surgery and whose treatment continues in the intensive care unit,\n  * Those who develop complications and\u002For need to be re-operated,\n  * Those who need treatment other than routine treatment,\n  * Patients with hearing or vision problems will be excluded.","79 Years",{"count":150,"type":23},128,[26],"Coronary artery bypass grafting is the most commonly performed surgical procedure among cardiovascular diseases. Nursing care for patients undergoing cardiac surgery involves a process that includes preoperative preparation and subsequent close monitoring of neurological, cardiac, respiratory, vascular status, kidney function, and pain. Sleep disturbances are observed after cardiac surgery. Sleep plays a critical role in the body's maintenance, repair, and renewal processes. Improved sleep can reduce patient agitation and decrease the risk of delirium. The presence of delirium leads to increased care requirements and prolonged hospital stays, which in turn raises hospital costs. Enhancing sleep quality and preventing delirium after surgery have positive effects on clinical patient outcomes. This study is designed to determine the effects of using eye masks and\u002For earplugs on sleep quality and delirium in patients undergoing coronary artery bypass grafting during nighttime sleep. This research is a randomized controlled clinical trial.",[154],"Cardiovascular Surgical Procedures",[156],"Cardiovascular surgical procedures, Delirium, Sleep",{"date":158,"type":40},"2026-06-17",{"date":160,"type":23},"2026-09-07",{"date":162,"type":23},"2026-11-01",{"name":45,"class":46},{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":24,"phases":173,"briefSummary":174,"conditions":175,"keywords":179,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":4},"100640022","mobile-application-developed-based-on-the-thompson-thompson-bioethical-decision-making-100640022","NCT07601776","Mobile Application Developed Based on the Thompson &Thompson Bioethical Decision-Making","The Effect of a Mobile Application Developed Based on the Thompson &Thompson Bioethical Decision-Making Model on Nursing Students' Ethical Decision-Making and Ethical Sensitivity: A Randomized Controlled Study","Inclusion Criteria:\n\n* Being a 4th-year nursing student.\n* Having taken and successfully passed the Professional Ethics course.\n* Having a mobile device and internet access.\n* Willing to volunteer to participate in the research.\n\nExclusion Criteria:\n\n* Difficulty understanding and speaking Turkish\n* Having a Cumulative Grade Point Average (CGPA) below 2.00\n\nExclusion criteria from the study:\n\n* Experiencing problems with internet access\n* Completing data collection forms incompletely\u002Fincorrectly\n* Not attending any of the case study or case analysis sessions\n* Wishing to withdraw from the study",{"count":172,"type":23},90,[26],"Aim: The aim of this study is to examine the effect of a mobile application, developed based on the Thompson \\& Thompson bioethical decision-making model, on the ethical decision-making and ethical sensitivity of nursing students. Method: This randomized controlled trial, planned with pre-, post-, and followup tests, will be conducted at Necmettin Erbakan University Faculty of Nursing during the 2026-2027 academic year. The study population will consist of 4th-year students enrolled in the Necmettin Erbakan University Faculty of Nursing during the 2026-2027 academic year. The sample size was statistically calculated using the G Power 3.1.9.7 software package. The total sample size was calculated as 82. To prevent data loss, the sample size was increased by 10%, resulting in a sample size of 90 students. Students in the intervention group will use the mobile application. Students in the control group will conduct face-toface case analysis. The research data will be collected using the \"Introductory Information Form\", \"Ethical Dilemma Test in Nursing\" and \"Adapted Ethical Sensitivity Scale for Nursing Students\". The data will be analyzed using the IBM SPSS 22 software package. Conclusion: As a result of the research, it is predicted that the mobile application developed based on the Thompson \\& Thompson bioethical decision-making model will have a positive effect on the ethical decision-making and sensitivity levels of nursing students.",[176,177,178],"Mobile Applications","Ethical Sensitivity","Ethical Decision-making",[180,181,182],"Nursing students","Nursing fundamentals","Ethics","2026-05-18",{"date":185,"type":40},"2026-05-22",{"date":187,"type":23},"2027-01-11",{"date":189,"type":23},"2027-06-11",{"name":45,"class":46},{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":199,"minAge":57,"maxAge":122,"enrollmentInfo":200,"targetDuration":4,"studyType":24,"phases":202,"briefSummary":203,"conditions":204,"keywords":206,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":141},"100629654","effect-of-manuel-therapy-on-tension-type-headache-in-menopausal-and-premenopasual-women-100629654","NCT07477483","Effect of Manuel Therapy on Tension Type Headache in Menopausal and Premenopasual Women","Comparison of the Effect of Manuel Therapy on Tension Type Headache in Menopausal and Premenopasual Women","TTH-MT","Inclusion Criteria:\n\n* Female participants aged between 45 and 65 years.\n* Diagnosis of tension-type headache.\n* Premenopausal or menopausal status.\n* HIT-6 score of 49 or higher.\n* Willingness to participate in the study.\n\nExclusion Criteria:\n\n* Use of hormone therapy.\n* History of cervical surgery.\n* History of neurological disease.\n* Pregnancy.\n* Inability to understand questionnaire forms.\n* Failure to attend treatment sessions.","FEMALE",{"count":201,"type":23},50,[26],"This study aims to investigate the effectiveness of manual therapy in women with tension-type headache and to compare treatment outcomes between menopausal and premenopausal women. Hormonal changes occurring during menopause may influence pain perception and headache characteristics.\n\nParticipants diagnosed with tension-type headache will receive manual therapy interventions. Headache intensity, headache-related disability, pressure pain threshold, cervical range of motion, sleep quality, and quality of life will be evaluated before and after treatment using validated assessment tools. The results are expected to contribute to physiotherapy approaches in women experiencing tension-type headache during different hormonal periods.",[205],"Tension Type Headache",[207,205,208,209,210,211],"Manuel Therapy","Women","Menopause","Premenopause","Physiotherapy","2026-05-16",{"date":214,"type":40},"2026-05-20",{"date":216,"type":40},"2025-10-01",{"date":218,"type":23},"2026-05",{"name":45,"class":46},{"id":221,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":222,"targetDuration":4,"studyType":24,"phases":223,"briefSummary":27,"conditions":224,"keywords":225,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":230,"leadSponsor":231,"locationsCount":47},"100613497",{"count":22,"type":23},[26],[29,30],[32,33,34,35],"2026-04-30",{"date":228,"type":40},"2026-05-04",{"date":42,"type":40},{"date":226,"type":23},{"name":45,"class":46},{"id":233,"slug":234,"hasResults":12,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":12,"sex":199,"minAge":20,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":24,"phases":243,"briefSummary":244,"conditions":245,"keywords":248,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":141},"100631752","surgical-glove-compression-to-prevent-paclitaxel-neuropathy-100631752","NCT07504770","Surgical Glove Compression to Prevent Paclitaxel Neuropathy","Comparison of Surgical Glove Compressions as a Prophylactic Method to Prevent Paclitaxel-induced Peripheral Neuropathy: Randomized Controlled Trial","Surgical Glove","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years\n* Diagnosed with Stage II-III breast cancer\n* No distant metastasis\n* Planned to receive adjuvant or neoadjuvant paclitaxel for at least 12 weeks\n* Willing and able to provide informed consent\n* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 Karnofsky ≥ 60%)\n\nExclusion Criteria:\n\n* Recurrent breast cancer\n* Prior treatment associated with neuropathy (e.g., taxanes, platinum-based chemotherapy, anti-tubulin or proteasome inhibitors)","80 Years",{"count":242,"type":23},84,[26],"This study aims to evaluate the effect of surgical glove compression as a prophylactic method to prevent paclitaxel-induced peripheral neuropathy. Participants will be randomly assigned to two groups: one receiving standard care, and the other receiving prophylactic surgical glove compression. The study will compare the development, severity of neuropathy in the hands and fingers, and its impact on quality of life.",[246,247,238],"Paclitaxel-Induced Peripheral Neuropathy","Breast Cancer",[238,246,247],"2026-04-14",{"date":251,"type":40},"2026-04-17",{"date":253,"type":23},"2026-03-26",{"date":255,"type":23},"2027-03-26",{"name":45,"class":46},{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":265,"enrollmentInfo":266,"targetDuration":4,"studyType":24,"phases":268,"briefSummary":269,"conditions":270,"keywords":273,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":141},"100631907","home-based-exercise-after-cervical-epidural-steroid-injection-for-cervical-radiculopathy-100631907","NCT07506785","Home-Based Exercise After Cervical Epidural Steroid Injection for Cervical Radiculopathy","Effect of a Home-Based Exercise Program After Cervical Interlaminar Epidural Steroid Injection on Clinical Outcomes in Patients With Chronic Cervical Radiculopathy: A Randomized Controlled Trial","CESI-HEP","Inclusion Criteria:\n\n* Age between 18 and 70 years.\n* Chronic cervical radicular pain lasting ≥3 months, characterized by neck pain with accompanying arm pain consistent with a cervical nerve root distribution.\n* Average pain intensity ≥4\u002F10 on the Numeric Rating Scale (NRS) over the preceding 7 days at baseline.\n* Diagnosis of chronic cervical radiculopathy due to cervical disc herniation, confirmed by clinical examination and cervical MRI findings at the corresponding level.\n* Insufficient response to conservative treatment, including physical therapy, medication, and\u002For exercise therapy.\n* Ability to provide written informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Patients were excluded if any of the following were present:\n* Clinical signs of cervical myelopathy or progressive neurological deficit.\n* Suspicion of serious spinal pathology (e.g., infection, malignancy).\n* Contraindications to epidural steroid injection, including uncontrolled coagulopathy, anticoagulant therapy not appropriately managed, or local\u002Fsystemic infection.\n* Pregnancy.\n* Prior cervical spine surgery or cervical epidural steroid injection within the prespecified washout period.\n* Severe musculoskeletal or neurological comorbidities that could interfere with safe participation in the exercise program.\n* Discordance between clinical symptoms and imaging findings.","70 Years",{"count":267,"type":23},60,[26],"Cervical radiculopathy is a common cause of neck and arm pain resulting from compression or inflammation of a cervical nerve root. Cervical epidural steroid injection is frequently used to reduce pain and improve function in patients who do not respond to conservative treatment. However, long-term functional recovery may require additional rehabilitation strategies. This randomized controlled trial aims to investigate whether adding a standardized home-based exercise program after cervical interlaminar epidural steroid injection improves pain, disability, sleep quality, and quality of life in patients with chronic cervical radiculopathy. Participants will be randomly assigned to receive either injection alone or injection followed by an eight-week home-based exercise program.",[271,272],"Cervical Radiculopathy","Home Based Rehabilitation",[274,275,276,277],"Cervical Epidural Steroid Injection","Neck Pain","cervical radiculopathy","Home based exercise","2026-03-28",{"date":280,"type":40},"2026-04-02",{"date":282,"type":40},"2026-02-01",{"date":284,"type":23},"2026-06",{"name":45,"class":46},{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":12,"sex":56,"minAge":294,"maxAge":4,"enrollmentInfo":295,"targetDuration":297,"studyType":60,"phases":4,"briefSummary":298,"conditions":299,"keywords":303,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":141},"100611609","minimally-invasive-prostate-interventions-registry-mist-study-100611609","NCT07242807","Minimally Invasive Prostate Interventions Registry (MIST Study)","Evaluation of Clinical and Functional Outcomes After Minimally Invasive Prostate Interventions: A Multicenter Prospective REDCap Registry (MIST Study)","MIST","Inclusion Criteria:\n\n* Male patients aged ≥40 years\n* Diagnosis of benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS) or benign prostatic obstruction (BPO)\n* Undergoing a minimally invasive prostate intervention (Rezum, UroLift, Aquablation, PAE, iTind, TPLA, TUNA, TUMT) as part of standard clinical care\n* Ability and willingness to attend scheduled follow-up visits\n* Prospective participants able to provide written informed consent\n* Retrospective cases eligible if data are fully de-identified and inclusion is approved by local ethics\u002FIRB authorities\n\nExclusion Criteria:\n\n* Active urinary tract infection at the time of treatment\n* ASA physical status ≥5\n* Prior pelvic radiotherapy resulting in severe bladder dysfunction\n* Severe cognitive impairment or inability to participate in follow-up\n* Missing essential baseline data (for retrospective entries)\n* Patients receiving experimental or investigational prostate devices or therapies outside routine clinical care","40 Years",{"count":296,"type":23},2000,"72 Months","This study is a multicenter prospective patient registry designed to evaluate clinical, functional, and safety outcomes after minimally invasive prostate interventions (MIST) performed for benign prostatic obstruction (BPO) secondary to benign prostatic hyperplasia (BPH). The interventions included in this registry represent standard-of-care treatment options and may include Rezum water vapor therapy, UroLift prostatic urethral lift, Aquablation, prostatic artery embolization (PAE), iTind, transperineal laser ablation (TPLA), transurethral needle ablation (TUNA), and transurethral microwave therapy (TUMT).\n\nThe registry collects standardized data using a secure REDCap platform from participating international centers. Data elements include demographic characteristics, comorbidities, medication use, laboratory parameters, prostate volume assessments, uroflowmetry, post-void residual measurements, patient-reported symptom scores, sexual function assessments, intraoperative details, complications (classified using Clavien-Dindo), and postoperative recovery parameters. Follow-up visits occur at 1, 3, 6, 12, 24, and 36 months, with an optional extended follow-up at 72 months to assess long-term durability and reintervention-free survival.\n\nThe primary aim of the study is to evaluate improvements in urinary symptoms (IPSS), quality of life, maximum urinary flow rate (Qmax), and post-void residual volume (PVR) following MIST procedures. Secondary objectives include assessing perioperative safety, catheterization duration, predictors of treatment success or failure, need for reintervention, and long-term preservation of continence and sexual function.\n\nThis registry is observational and does not assign or modify any treatment. All procedures are performed based on local clinical practice and physician judgment. Prospective participants provide informed consent. Data collected will be used to generate real-world evidence to guide patient selection, optimize procedural outcomes, and compare clinical performance across different minimally invasive prostate interventions.",[300,301,302],"Benign Prostatic Hyperplasia (BPH)","Minimal Invasive Surgery","LUTS",[292,304,305,306,307,308,309,310,63,311],"Minimally Invasive Surgical Therapy","Rezum","UroLift","Aquablation","Prostatic Artery Embolization","iTind","TPLA","Lower Urinary Tract Symptoms",{"date":313,"type":40},"2026-03-31",{"date":315,"type":23},"2026-03-25",{"date":317,"type":23},"2031-12-30",{"name":45,"class":46},{"id":320,"slug":321,"hasResults":12,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":17,"sex":18,"minAge":327,"maxAge":4,"enrollmentInfo":328,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":330,"conditions":331,"keywords":333,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":141},"100631990","validation-of-the-turkish-version-of-the-oral-assessment-sheet-100631990","NCT07507864","Validation Of The Turkish Version Of The Oral Assessment Sheet","Turkish Validity And Reliability Study Of The Oral Assessment Sheet (OAS)","OAS-TR","Inclusion Criteria:\n\n* Age 60 years or older\n* Ability to understand Turkish\n* Voluntary participation and provision of written informed consent\n* Ability to undergo oral examination and assessment\n* Adequate cognitive and psychological status\n\nExclusion Criteria:\n\n* Individuals who refuse to participate in the study\n* Individuals who withdraw from the study during the research process\n* Individuals with severe cognitive impairment preventing completion of the assessment\n* Individuals with conditions preventing oral examination","60 Years",{"count":329,"type":23},99,"The aim of this observational study is to evaluate the validity and reliability of the Turkish version of the Oral Assessment Sheet (OAS). The OAS is a clinical assessment tool developed to evaluate oral health conditions such as lips, tongue, mucosa, saliva, swallowing, and voice.\n\nThis study will investigate whether the Turkish version of the OAS is a valid and reliable tool for assessing oral health status in clinical practice. Participants will undergo oral assessment using the Turkish version of the OAS. Statistical analyses will be performed to determine the validity and reliability of the scale.\n\nThe results of this study are expected to provide a standardized oral assessment tool that can be used in Turkish clinical settings.",[332],"Oral Health",[334],"Oral Assessment Sheet OAS","2026-03-27",{"date":280,"type":40},{"date":338,"type":40},"2026-02-26",{"date":340,"type":23},"2026-07",{"name":45,"class":46},{"id":343,"slug":344,"hasResults":12,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":348,"eligibilityCriteria":349,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":350,"targetDuration":352,"studyType":60,"phases":4,"briefSummary":353,"conditions":354,"keywords":358,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":141},"100629868","homocysteine-and-early-diastolic-dysfunction-in-newly-diagnosed-hypertension-100629868","NCT07480265","Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension","Relationship Between Elevated Homocysteine Levels and Early Diastolic Dysfunction in Newly Diagnosed Hypertensive Patients","HHT-EDD","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Newly diagnosed essential hypertension within the previous 6 months\n* Ability and willingness to provide informed consent\n* Availability for clinical evaluation, laboratory testing, ambulatory blood pressure monitoring, electrocardiography, and transthoracic echocardiography\n\nExclusion Criteria:\n\n* Resistant hypertension\n* Secondary hypertension\n* Acute coronary syndrome within the previous 6 months\n* Major surgery within the previous 6 months\n* Known heart failure\n* Pulmonary hypertension\n* Congenital heart disease\n* Atrial fibrillation or atrial flutter\n* Moderate or severe valvular heart disease\n* Chronic kidney disease\n* Anemia\n* Current folate, vitamin B12, or vitamin B6 supplementation or treatment\n* Inadequate echocardiographic image quality for strain analysis\n* Known systemic conditions that may significantly affect plasma homocysteine levels",{"count":351,"type":23},500,"2 Years","This prospective single-center observational study aims to evaluate the relationship between elevated plasma homocysteine levels and early echocardiographic abnormalities in patients with newly diagnosed essential hypertension. Adult patients diagnosed with essential hypertension within the previous 6 months will undergo clinical assessment, ambulatory blood pressure monitoring, electrocardiography, laboratory testing, and comprehensive transthoracic echocardiography including diastolic function assessment and strain analysis when image quality is adequate. Participants will be classified according to plasma homocysteine level using, and patients with elevated and normal homocysteine levels will be compared with respect to diastolic dysfunction and left ventricular and left atrial global longitudinal strain parameters. Clinical, laboratory, and echocardiographic data will also be used to develop a machine-learning based model for prediction of H-type hypertension.",[355,356,357],"Hypertension (HTN)","Hyperhomocysteinemia","Diastolic Dysfunction",[359,360,361,362,363,364,365],"H-type hypertension","Homocysteine","Echocardiography","Diastolic dysfunction","Left ventricular global longitudinal strain","Left atrial global longitudinal strain","Machine learning","2026-03-20",{"date":368,"type":40},"2026-03-24",{"date":370,"type":40},"2025-06-02",{"date":372,"type":23},"2028-03",{"name":45,"class":46},{"id":375,"slug":376,"hasResults":12,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":12,"sex":18,"minAge":122,"maxAge":4,"enrollmentInfo":381,"targetDuration":383,"studyType":60,"phases":4,"briefSummary":384,"conditions":385,"keywords":389,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":141},"100627894","preoperative-cardiac-power-output-and-p-possum-score-100627894","NCT07454564","Preoperative Cardiac Power Output and P-POSSUM Score","Investigation of the Relationship Between Preoperative Cardiac Power Output and P-POSSUM Score","Inclusion Criteria: Being 65 years of age or older,\n\n* Undergoing abdominal surgery in general surgery practice (including elective and emergency procedures),\n* ASA (American Society of Anesthesiologists) class I-III,\n* Adequate recording with transthoracic echocardiography,\n* Having given informed consent.\n\nExclusion Criteria:Advanced heart failure with ejection fraction (EF) \\\u003C30%,\n\n* Severe valvular disease (severe stenosis or insufficiency),\n* Unstable coronary artery disease or recent myocardial infarction (within the last 3 months),\n* Pulmonary hypertension,\n* Severe arrhythmia (uncontrolled atrial fibrillation, ventricular tachycardia, etc.)",{"count":382,"type":23},120,"1 Month","This study aims to investigate the relationship between preoperative Cardiac Power Output (CPO), which reflects the pumping capacity of the heart, and the P-POSSUM score, a widely used surgical risk assessment tool, in patients aged 65 years and older undergoing abdominal surgery. Simple and non-invasive measurements performed in the preoperative period will be used to obtain CPO values and to evaluate whether these measurements are helpful in predicting postoperative morbidity and mortality. No additional procedures beyond routine clinical care will be performed as part of this observational study. The findings of this study may contribute to a more accurate assessment of surgical risk and help improve patient safety in the perioperative period.",[386,387,388],"Surgical Risk Assessment","Postoperative Mortality","Postoperative Morbidity",[390,391],"p-possum score","cardiac power output","2026-03-18",{"date":394,"type":40},"2026-03-23",{"date":396,"type":40},"2026-03-10",{"date":398,"type":23},"2026-11-30",{"name":45,"class":46},{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":122,"enrollmentInfo":407,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":409,"conditions":410,"keywords":412,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":141},"100630477","preoperative-carotid-doppler-ultrasound-parameters-for-prediction-of-post-induction-hypotension-in-elective-non-cardiac-surgery-100630477","NCT07488182","Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery","The Value of Preoperative Carotid Doppler Ultrasonography Parameters in Predicting Post-Induction Hypotension in Patients Undergoing Elective Non-Cardiac Surgery","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n\nAmerican Society of Anesthesiologists (ASA) physical status I-II\n\nScheduled for elective non-cardiac surgery under general anesthesia\n\nPlanned endotracheal intubation\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nRefusal to participate in the study\n\nPlanned emergency surgery\n\nPlanned cardiac surgery\n\nPresence of carotid artery stenosis greater than 50%\n\nModerate to severe valvular heart disease\n\nPresence of atrial fibrillation or significant arrhythmia\n\nAdvanced heart failure\n\nPreoperative hypotension or hemodynamic instability\n\nInability to obtain reliable ultrasonographic measurements\n\n\\-",{"count":408,"type":23},110,"This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for post-induction hypotension in adult patients undergoing elective non-cardiac surgery under general anesthesia. Hemodynamic instability during anesthesia induction is a common and clinically important problem associated with adverse perioperative outcomes. Carotid Doppler ultrasonography provides a rapid and non-invasive method for assessing hemodynamic status at the bedside. In this study, carotid Doppler measurements will be performed in the preoperative period and their association with post-induction hypotension will be analyzed. The results of this study may help identify patients at risk for hypotension and improve perioperative hemodynamic management.",[411,388],"Post Induction Hypotension",[413,414,415],"Doppler Ultrasound","Velocity Time Integral","Anesthesia","2026-03-17",{"date":394,"type":40},{"date":419,"type":23},"2026-09",{"date":421,"type":23},"2027-09",{"name":45,"class":46},{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":431,"targetDuration":433,"studyType":60,"phases":4,"briefSummary":434,"conditions":435,"keywords":439,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":4},"100623392","intraoperative-bladder-injury-assessment-in-turbt-using-bicep-100623392","NCT07396038","INTRAOPERATIVE BLADDER INJURY ASSESSMENT IN TURBT USING BICEP","Evaluation of Intraoperative Bladder Injuries During Transurethral Resection of Bladder Tumors Using the BICEP Classification (BICEP on TURBT)","BICEP in TURBT","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients undergoing transurethral resection of bladder tumor\n* Procedures performed for primary resection, re-resection, diagnostic, or staging purposes\n\nExclusion Criteria:\n\n* Patients with incomplete intraoperative data regarding bladder injury assessment\n* Patients who decline participation, if informed consent is required",{"count":432,"type":23},1000,"12 Months","Transurethral resection of bladder tumor (TURBT) is the cornerstone procedure in the diagnosis and treatment of bladder cancer but is associated with a spectrum of intraoperative bladder injuries ranging from minor mucosal tears to major perforations. Currently, there is no standardized intraoperative classification system specifically designed to grade and report these injuries during TURBT.\n\nThis study aims to apply the Bladder Injury Classification System for Endoscopic Procedures (BICEP) to TURBT in order to systematically classify intraoperative bladder injuries, evaluate their management, and explore their association with perioperative and early postoperative outcomes.",[436,437,438],"Bladder (Urothelial, Transitional Cell) Cancer","TURBT","Bladder Injury",[440,441,442,443,444,445],"Transurethral resection of bladder tumor","Bladder perforation","Bladder cancer surgery","Bladder injury classification","Ureteral orifice injury","Endoscopic bladder surgery complications","2026-02-05",{"date":448,"type":40},"2026-02-09",{"date":450,"type":23},"2026-02-15",{"date":452,"type":23},"2027-03-30",{"name":45,"class":46},{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":461,"enrollmentInfo":462,"targetDuration":463,"studyType":60,"phases":4,"briefSummary":464,"conditions":465,"keywords":467,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":141},"100620914","large-granular-lymphocytes-in-mnsclc-treated-with-nivolumab-100620914","NCT07363811","Large Granular Lymphocytes in mNSCLC Treated With Nivolumab","Large Granular Lymphocytes as a Prognostic Factor in Metastatic Non-small Cell Lung Cancer Treated With Nivolumab","Inclusion Criteria:\n\n* Histological and staging diagnosis of metastatic non-small cell lung cancer\n* ECOG performance score between 0 and 2\n* No contraindications for nivolumab\n\nExclusion Criteria:\n\n* Patients diagnosed with mNSCLC who received nivolumab as adjuvant or perioperative therapy\n* Those with a second primary malignancy undergoing active treatment\n* Those who have not signed the informed consent form\n* Those with additional hematological malignancies such as leukemia, lymphoma, or myelodysplastic syndrome\n* Those who have undergone palliative or curative radiotherapy within the last three months\n* Those with active viral\u002Fbacterial infections before nivolumab treatment\n* Patients who have used steroids in the last three months","90 Years",{"count":201,"type":23},"24 Months","Large granular lymphocytes (LGLs), which constitute 10-15% of peripheral blood mononuclear cells, are large lymphocytes with a round nucleus, large cytoplasm, and azurophilic granules in the cytoplasm.\n\nMost normal LGLs in peripheral blood are natural killer (NK) cells, but some are T lymphocytes. These cells cannot be measured by a standard complete blood count (CBC) test. These cells, which can be detected by peripheral smear, are expressed numerically and as a percentage relative to other cells. The aim of this study is to determine the relationship between the percentage of LGLs at baseline and at three months and the response and clinical parameters in participants with metastatic non-small cell lung cancer treated with nivolumab in second-line therapy.",[466],"Metastatic NSCLC - Non-Small Cell Lung Cancer",[468,469],"Large granular lymphocyte","Nivolumab","2026-01-23",{"date":472,"type":40},"2026-01-26",{"date":474,"type":40},"2025-07-01",{"date":476,"type":23},"2027-06-01",{"name":45,"class":46},{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":484,"eligibilityCriteria":485,"healthyVolunteers":17,"sex":199,"minAge":20,"maxAge":486,"enrollmentInfo":487,"targetDuration":4,"studyType":24,"phases":489,"briefSummary":490,"conditions":491,"keywords":497,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":141},"100620796","mat-pilates-on-body-awareness-and-physical-activity-levels-in-sedentary-emerging-adulthood-women-100620796","NCT07362277","Mat Pilates on Body Awareness and Physical Activity Levels in Sedentary Emerging Adulthood Women","The Effect of Mat Pilates on Body Composition and Physical Activity Levels in Sedentary Women Emerging Adulthood","mat pilates","Inclusion Criteria:\n\n* Possess the ability to read and understand Turkish, be between the ages of 18 and 29,\n* I have a sedentary lifestyle, possess the cognitive ability to understand and interpret survey questions, and for sedentary participants, not have engaged in regular exercise for 2 months, have a Physical Activity Score (IPAQ) -short form of less than 600 Metabolic Equivalent of Task (MET) minutes per week, and body weight below 130 kg.\n\nExclusion Criteria:\n\n* Participants with chronic, neurological, orthopedic, rheumatic systemic and\u002For lung disease, those who exercise\u002Fsport, have a history of malignancy, are pregnant, have a history of fracture in the last year,\n* I have chronic kidney or liver disease, have cardiovascular disease, and have peripheral vestibular disorder were excluded.","29 Years",{"count":488,"type":23},54,[26],"This study investigating the effects of mat pilates on body awareness and physical activity levels in sedentary women transitioning to adulthood, 27 control groups and 27 mat pilates exercise groups will be included. The groups will be compared at the end of an 8-week exercise program. Participants' socio-demographic characteristics, body awareness (using the Body Awareness Questionnaire), and physical activity level (using the Tegner Physical Activity Questionnaire and the International Physical Activity Questionnaire short-form scales) will be assessed.",[492,493,494,495,496],"Exercise Therapy","Awareness","Sedentary Behavior","Woman's Role","Exercise",[492,493,494,495,496],"2026-01-22",{"date":470,"type":40},{"date":501,"type":40},"2025-12-05",{"date":503,"type":23},"2026-02-20",{"name":45,"class":46},{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":514,"conditions":515,"keywords":519,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":529,"leadSponsor":531,"locationsCount":141},"100618267","turkish-adaptation-and-validation-of-the-burnt-hand-outcome-tool-bhot-100618267","NCT07329400","Turkish Adaptation and Validation of the Burnt Hand Outcome Tool (BHOT)","Turkish Adaptation of the Burnt Hand Outcome Tool (BHOT): A Validity and Reliability Study in Adult Patients With Hand Burns","Inclusion Criteria:\n\n* Age 18 years or older\n* History of second-degree or higher burn injury in one or both hands\n* Ability to read and understand Turkish\n* Willingness to participate and provision of written informed consent\n\nExclusion Criteria:\n\n* History of trauma, surgery, or rheumatologic disease affecting hand function prior to the burn injury\n* Age under 18 years\n* Cognitive impairment or psychiatric disorder preventing completion of the questionnaires\n* Refusal to participate or withdrawal from the study at any time",{"count":513,"type":23},100,"The goal of this observational study is to evaluate the validity and reliability of the Turkish adaptation of the Burnt Hand Outcome Tool (BHOT) in adults with a history of hand burns. The participant population will include adults aged 18 years and older who have experienced unilateral or bilateral hand burns and can read and understand Turkish.The main questions this study aims to answer are:\n\nDoes the Turkish version of the BHOT demonstrate high internal consistency, test-retest reliability, and construct validity? How strongly are BHOT scores associated with objective hand function measures such as grip strength and sensory evaluation? Participants will not be assigned to comparison groups, as this is a methodological validation study.\n\nParticipants will: Complete a sociodemographic information form. Complete the Turkish version of the BHOT and the QuickDASH questionnaire. Undergo objective assessments including hand grip strength using a dynamometer and sensory evaluation using Semmes-Weinstein monofilaments. Participate in repeated assessments at baseline, 1 month, 3 months and 6 months for reliability analyses.",[516,517,518],"Hand Burn","Hand Injuries","Burn Injuries",[520,521,522,523,518],"Hand Burns","Burnt Hand Outcome Tool (BHOT)","Validation Study","Reproducibility of Results","2026-01-11",{"date":526,"type":40},"2026-01-13",{"date":528,"type":40},"2025-11-17",{"date":530,"type":23},"2026-11",{"name":45,"class":46},{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":536,"acronym":4,"eligibilityCriteria":537,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":122,"enrollmentInfo":538,"targetDuration":4,"studyType":24,"phases":539,"briefSummary":540,"conditions":541,"keywords":545,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":556,"locationsCount":141},"100618127","the-effect-of-watson-human-care-theory-and-acceptance-and-commitment-therapy-based-counseling-program-applied-to-parents-of-pediatric-palliative-care-patients-on-value-based-life-and-care-burden-100618127","NCT07327580","The Effect of Watson Human Care Theory and Acceptance and Commitment Therapy-Based Counseling Program Applied to Parents of Pediatric Palliative Care Patients on Value-Based Life and Care Burden","Inclusion Criteria:\n\n* Being the parent of a patient in need of pediatric palliative care at the hospital where the study will be conducted during the dates of the study,\n* Being between the ages of 18-65,\n* Agreeing to participate in the study,\n* Having the ability to read, write and understand Turkish,\n* The patient with pediatric palliative care has been provided care for at least 1 month.\n\nExclusion Criteria:\n\n* Having previously received similar therapy or psychoeducation or being involved in ongoing training,\n* Having received a psychiatric diagnosis,\n* Having communication problems such as hearing and vision,\n* Being a foreign national,\n* Not being the biological mother or father of the patient in need of pediatric palliative care.",{"count":97,"type":23},[26],"This study aims to examine the effect of Watson Human Care Theory and Acceptance and Commitment Therapy-based counseling program applied to parents of pediatric palliative care patients on value-oriented living and care burden.",[542,543,544],"Pediatric Palliative Care","Caregiver Burden","Acceptance and Commitment Therapy",[546,547,548],"pediatric palliative care","caregiver burden","acceptance and commitment therapy","2025-12-26",{"date":551,"type":40},"2026-01-08",{"date":553,"type":23},"2026-02",{"date":555,"type":23},"2026-10",{"name":45,"class":46},{"id":558,"slug":559,"hasResults":12,"nctId":560,"briefTitle":561,"officialTitle":562,"acronym":4,"eligibilityCriteria":563,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":122,"enrollmentInfo":564,"targetDuration":4,"studyType":24,"phases":565,"briefSummary":566,"conditions":567,"keywords":569,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":573,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":577,"locationsCount":141},"100618133","changes-in-periodontal-pocket-depth-after-periodontal-treatment-100618133","NCT07327658","Changes in Periodontal Pocket Depth After Periodontal Treatment","Investigation of the Changes in Periodontal Pocket Depth Following Periodontal Treatment in Patients With Periodontitis","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Not being pregnant or breastfeeding\n* Smoking less than 10 cigarettes a day\n* Having a clinical record of periodontitis (stages 3 and 4 according to the 2017 classification)\n\nExclusion Criteria:\n\n* Individuals with uncontrolled systemic disease\n* Patients diagnosed with diabetes\n* Individuals under 18 years of age\n* Individuals who smoke 10 or more cigarettes a day\n* Patients who do not attend regular follow-up appointments and do not have sufficient clinical records",{"count":201,"type":23},[26],"This study is a prospective, observational clinical research conducted at the Department of Periodontology, Faculty of Dentistry, Necmettin Erbakan University. The study aims to evaluate periodontal records routinely obtained before treatment and throughout the treatment process from individuals who visited the clinic and were planned for non-surgical periodontal treatment. Within the scope of the research, the effectiveness of periodontal treatments will be evaluated solely through non-invasive clinical periodontal parameters. No additional invasive procedures will be performed during the study; only records obtained during routine periodontal examinations and treatments at the clinic will be used.",[568],"Periodontitis",[568,570,571],"Periodontal Therapy","Periodontal Pocket","2025-12-25",{"date":551,"type":40},{"date":575,"type":40},"2025-09-26",{"date":108,"type":23},{"name":45,"class":46},{"id":579,"slug":580,"hasResults":12,"nctId":581,"briefTitle":582,"officialTitle":583,"acronym":584,"eligibilityCriteria":585,"healthyVolunteers":17,"sex":199,"minAge":20,"maxAge":586,"enrollmentInfo":587,"targetDuration":4,"studyType":24,"phases":589,"briefSummary":590,"conditions":591,"keywords":595,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":602,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":4},"100605332","developing-an-immersive-virtual-reality-platform-100605332","NCT07161141","Developing an Immersive Virtual Reality Platform","Developing an Immersive Virtual Reality Platform to Support Birth Preparedness and Mental Wellbeing in Pregnant Women","VR Support","Inclusion Criteria:\n\n* The pregnant women between the ages of 18-49\n* Primiparous\n* At least 20 weeks of gestation\n* Single pregnancy\n* Without any visual and hearing problems andcan communicate verbally are included to this study.\n\nExclusion Criteria:\n\n* Pregnant women with multiple pregnancies were multiparous\n* Risky pregnancy, and did not accept participation in the study will excluded from the study.\n* Individuals with a history of any psychiatric disorder (eg, mood disorder or anxiety disorder) will excluded from this study.","49 Years",{"count":588,"type":23},68,[26],"This study is a two-stage, mixed-method, pre-test post-test design aimed at developing and testing an immersive VR intervention for new mothers. This research is 2-arm a 4-week prospective randomized clinical trial",[592,593,594],"Pregnancy","Mental Health (Depression)","Childbirth Preparation Program",[596,597,598,599,600],"Virtual reality","immersive","childbirth","mental health","pregnancy","2025-09-15",{"date":603,"type":40},"2025-09-16",{"date":605,"type":23},"2026-01-01",{"date":607,"type":23},"2026-12-30",{"name":45,"class":46},{"id":610,"slug":611,"hasResults":12,"nctId":612,"briefTitle":613,"officialTitle":614,"acronym":615,"eligibilityCriteria":616,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":617,"enrollmentInfo":618,"targetDuration":4,"studyType":24,"phases":620,"briefSummary":621,"conditions":622,"keywords":625,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":637,"locationsCount":141},"100602102","effect-of-emotional-freedom-technique-on-nursing-students-exam-anxiety-100602102","NCT07119138","Effect of Emotional Freedom Technique on Nursing Students Exam Anxiety","The Effect of Emotional Freedom Technique on State Exam Anxiety Levels of Nursing Students: A Randomized Controlled Trial","EFT","Inclusion Criteria:\n\n* Volunteers to participate in the study • Qualified to take the final exam of the Surgical Diseases Nursing course\n\nExclusion Criteria:\n\n* Refusing to participate in the study\n* Receiving psychiatric treatment\u002Freceiving psychological support\n* Failing the Surgical Diseases Nursing course application\n\nRemoval criteria\n\n* A student who did not take the course exam due to illness, delay, or similar reasons\n* Someone who wishes to withdraw from the study during the implementation phase after having agreed to participate.","35 Years",{"count":619,"type":23},82,[26],"Aim: This study was conducted to evaluate the effect of Emotional Freedom Technique (EFT) on the state exam anxiety levels of nursing students.\n\nBackground: Exam anxiety is a common problem among nursing students. EFT has emerged as a complementary method to reduce exam anxiety. However, experimental studies on this subject are limited in the literature.\n\nDesign: Randomized controlled trial design.\n\nMethods: This study was carried out with second-year students enrolled in the Surgical Nursing course at the Faculty of Nursing of a state university. Participants were assigned to intervention and control groups using simple random sampling. One hour before the exam, all students were present in the exam hall. While the intervention group received EFT, the control group was given free time. Data were collected using the State Test Anxiety Scale (STAS) and the Subjective Units of Distress Scale (SUD). Descriptive statistics, normality tests (Shapiro-Wilk\u002FKolmogorov-Smirnov), independent and paired samples t-test, Mann-Whitney U test, Wilcoxon test, and two-way mixed ANOVA were used for data analysis. The significance level was set at p\\\u003C0.05.\n\nOutcomes: There were no significant differences between the groups in the pre-test STAS total and subscale scores or SUD scores. However, post-test results revealed statistically significant differences between the intervention and control groups in all measurements (p\\\u003C0.05), with effect sizes ranging from medium to large. The time and group-time interaction effects for STAS total and subscale scores and SUD scores were also significant (p\\\u003C0.05), and the effect size of the change over time was determined to be large (η² \\> 0.14).\n\nConclusion: This study demonstrated that EFT is effective in reducing exam anxiety among nursing students. EFT should be considered a complementary intervention in managing exam anxiety. It is recommended that EFT be integrated into the support services provided to students prior to examinations.",[623,624],"Pre-Exam Anxiety","Emotional Freedom Technique",[623,626,627,628,629],"Nursing student","Mind-Body Therapies","Surgical nursing","Randomised controlled trial","2025-08-05",{"date":632,"type":40},"2025-08-12",{"date":634,"type":40},"2025-06-30",{"date":636,"type":23},"2025-08-30",{"name":45,"class":46},{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":644,"eligibilityCriteria":645,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":461,"enrollmentInfo":646,"targetDuration":433,"studyType":60,"phases":4,"briefSummary":647,"conditions":648,"keywords":650,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":660,"locationsCount":141},"100601273","adar1-expression-level-in-rectal-cancer-100601273","NCT07108348","ADAR1 Expression Level in Rectal Cancer","The Effect of ADAR1 Expression Level on Total Neoadjuvant Treatment Response in Locally Advanced Rectal Cancer","ADAR1TNT","Inclusion Criteria:\n\n* Histological and staging diagnosis of local\u002Flocally advanced rectal cancer\n* ECOG performance score between 0 and 2\n* No contraindications for chemotherapy (CT) and\u002For radiotherapy (RT)\n\nExclusion Criteria:\n\n* Those diagnosed with metastatic rectal cancer\n* Those suspected of having rectal cancer or patients with a diagnosis of a second primary cancer\n* Those who have not signed the informed consent form\n* Those with contraindications for chemotherapy (CT) and\u002For radiation therapy (RT)",{"count":201,"type":23},"Total neoadjuvant therapy (TNT) is currently the standard treatment for locally\u002Flocally advanced rectal cancer due to better response and fewer distant metastases. In TNT, sequential chemotherapy (CT) and chemoradiotherapy (CRT) are planned and depending on the treatment response, either surgery is performed or a watch and wait approach is applied. Depending on tumor localization and patient performance status, CT is planned as induction or consolidation. Most of the time, mFOLFOX6 and CAPOX are preferred as CT regimen. In proximal rectal cancer, surgery can be performed without CRT and only after CT. In locally\u002Flocally advanced rectal cancer, the aim is to avoid surgery as much as possible or to perform sphincter-sparing surgery if possible. Colonoscopy and pelvic MR at the time of diagnosis are the most important steps in staging, treatment selection and decision making. These two diagnostic methods should be repeated especially for watch and wait decision and for response evaluation after TNT.\n\nADAR 1 (Adenosine deaminase acting on RNA1) is an RNA editing enzyme that catalyzes the deamination of adenosine to inosine (A-to-I), a dynamic modification that can lead to a diverse transcriptome in a combinatorial manner. A defect in ADAR1-mediated RNA modification results in abnormal regulation of substrates that can affect phenotypic changes in cancer. This phenomenon of over-regulation is seen in many cancers such as colon, liver, lung, breast and esophageal cancers and in many cases promotes tumor progression. In studies, increased ADAR1 expression has been associated with lower survival and worse prognosis, especially in metastatic colon and gastric cancer. ADAR1 is also predicted to increase proliferation through both the AKT pathway and the mTOR pathway and therefore may be targeted in the near future.\n\nADAR1 expression is monitored by RNA-based real time PCR. In order to demonstrate increased expression, biopsies should be taken from the malignant tissue and the intact tissue of the patient and the biopsy should be stored under -80 C conditions immediately after biopsy to prevent RNA degradation. The tissue will not come into contact with nitrogen or formaldehyde.\n\nIn this study, sufficient biopsies from cancerous and intact tissue will be taken from patients with suspected rectal cancer, confirmed by pelvic MRI and consent for participation in the study, and fresh tissue will be stored at -80 C in the genetics laboratory. After the TNT plan is made by the investigators and the treatment is completed, both pelvic MRI and control rectoscopy will be performed for preoperative evaluation. Again, biopsies will be taken from diseased and healthy tissue and ADAR1 expression will be evaluated. The study is planned to include 50 participants and a period of one year is foreseen for tissue procurement\u002Fstorage.\n\nThe investigators' aim in this study will be to determine whether ADAR1 expression level changes after TNT, whether this predicts clinical and pathological response, whether responses change according to the selected CT, whether there is a difference between CT induction-consolidation\u002FRT short or long course, and the relationship between tumor DNA mismatch repair enzyme status and ADAR1 level. The investigators primary endpoint will be the effect of the change in ADAR1 expression level on the response after TNT (ORR). Secondary endpoints will be quality of life, recurrence-free survival (RFS) and overall survival (OS).",[649],"Rectum Cancer, Adenocarcinoma",[651,652,653],"ADAR1","rectum cancer","TNT","2025-08-04",{"date":656,"type":40},"2025-08-07",{"date":658,"type":40},"2025-06-01",{"date":85,"type":23},{"name":45,"class":46},{"id":662,"slug":663,"hasResults":12,"nctId":664,"briefTitle":665,"officialTitle":666,"acronym":4,"eligibilityCriteria":667,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":122,"enrollmentInfo":668,"targetDuration":4,"studyType":24,"phases":670,"briefSummary":671,"conditions":672,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":673,"lastUpdatePostDateStruct":674,"startDateStruct":676,"completionDateStruct":678,"leadSponsor":679,"locationsCount":4},"100588908","effects-of-shotblocker-and-manual-pressure-on-pain-and-satisfaction-100588908","NCT06947525","Effects of Shotblocker and Manual Pressure on Pain and Satisfaction","Effects of Shotblocker and Manual Pressure on Pain and Satisfaction During Peripheral Venous Catheter Placement: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Admission to the urology clinic,\n* No verbal, perceptual and visual communication problems,\n* Between the ages of 18 and 65,\n* Literate,\n* Volunteer to participate in the study,\n* Not using medication that will create a chronic analgesic effect,\n* Not having chronic or acute pain,\n* No intervention has been performed on the vein where the PIC is placed in the last month,\n* No scar tissue or infection in the areas where the PIC will be placed,\n* Not having a disease that will cause problems in feeling pain (such as neuropathy)\n\nExclusion Criteria:\n\n* The individual wants to leave the study,\n* Feels unwell during the PIC placement (such as dizziness, palpitations),\n* Uses sedatives or alcohol,",{"count":669,"type":23},81,[26],"This study aims to determine the effects of shotblocker and manual pressure applied during peripheral venous catheter placement on pain and satisfaction. 81 patients hospitalized in the Urology clinic will be included in the study. Patients will be assigned to three groups as shotblocker (n=27), manual pressure (n=27) and control group (n=27) by block randomization method.\n\nResearch Hypotheses\n\n* H1-1: The mean pain scores of the intervention group to which shotblocker was applied during peripheral intravenous catheterization are different from the control group.\n* H1-2: The mean pain scores of the intervention group to which manual pressure was applied during peripheral intravenous catheterization are different from the control group.\n* H1-3: The mean satisfaction scores of the intervention group to which shotblocker was applied during peripheral intravenous catheterization are different from the control group.\n* H1-4: The mean satisfaction scores of the intervention group to which manual pressure was applied during peripheral intravenous catheterization are different from the control group.",[128,130],"2025-04-20",{"date":675,"type":40},"2025-04-27",{"date":677,"type":23},"2025-04-28",{"date":634,"type":23},{"name":45,"class":46},""]