[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Neuroscience Research Australia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":145},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,69,97,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100554849","the-natural-history-of-mitochondrial-diseases-100554849",false,"NCT06504433","The Natural History of Mitochondrial Diseases","Inclusion Criteria:\n\n1. A clinical and\u002For genetically confirmed diagnosis of MITO.\n2. Individuals \\> 18 years of age, managed by a specialist neurologist, with confirmed MITO\n3. Control participants will comprise asymptomatic relatives of confirmed MITO patients with no clinical or genetic evidence of MITO; clinically confirmed non-MITO movement disease controls (from other clinics at NeuRA) or age\u002Fgender-matched healthy participants.\n\nExclusion Criteria:\n\n* Those participants who do NOT match the inclusion criteria above\n* Not willing to participate in the AMDC Clinical Registry\n* Not willing to undergo genetic testing\n* Not willing to provide consent",true,"ALL","18 Years",{"count":19,"type":20},500,"ESTIMATED","10 Years","OBSERVATIONAL","The Natural History of Mitochondrial (MITO) Diseases (a longitudinal study observing the natural history of mitochondrial diseases)\n\nThe goal of this observational study (non-randomised retrospective and prospective) is to fully characterise primary MITO disease; that includes both sexes\u002Fgenders, over 18 years of age and healthy volunteers\\]. The main question\\[s\\] it aims to answer is to:\n\n• better characterise MITO phenotypes (organ involvement, severity, progression) and collect biospecimens to create a biobank that can be used for future biomarker discovery to improve early diagnosis, prognostication and management of mitochondrial disease.\n\nThe study will be a longitudinal, retrospective, prospective, observational study of participants (400) with confirmed MITO and relevant controls followed for up to 10 years. Data will be collected at regularly scheduled standard-of-care (SOC), 6 to 12 monthly appointments.\n\nThe 100 control participants will therefore be comprised of (i) unaffected asymptomatic family members of MITO participants with no genetic risk; (ii) participants with non-MITO movement disorders that are not classified as MITO by their clinical presentation and genetic tests (for example Parkinson's disease) and\u002For (iii) age-matched healthy controls recruited from the NeuRA database of volunteers.\n\nDemographic data, medical history, biochemical, histological, genetic, social and other clinical SOC data will be collected. Additionally, seizure and migraine frequency in participants who experience these, will be collected and a quality-of-life questionnaire (SF-12v2), as part of the validated neurological assessment using the Newcastle Mitochondrial Disease Adult Scale (NMDAS).",[25,26,27],"Mitochondrial Diseases","Neurological Diseases or Conditions","Genetic Disease","RECRUITING","2026-04-15",{"date":31,"type":32},"2026-04-20","ACTUAL",{"date":34,"type":32},"2024-05-07",{"date":36,"type":20},"2034-05-07",{"name":38,"class":39},"Neuroscience Research Australia","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":40},"100563743","pain-education-and-patient-led-goal-setting-in-adults-with-chronic-low-back-pain-a-randomised-controlled-trial-100563743","NCT06620133","Pain Education and Patient-led Goal Setting in Adults With Chronic Low Back Pain: a Randomised Controlled Trial","The Effect of Pain Education and Patient-led Goal Setting Compared to Guideline-based Written Information on Pain and Disability in Adults With Chronic Low Back Pain: a Randomised Controlled Trial","CAPACITY","Inclusion Criteria:\n\n* Low back pain of at least 3 months duration\n* physically inactive (less than or equal to 150min\u002Fweek moderate intensity physical activity; 75 min\u002Fweek vigorous activity, or some combination of the two)\n* no known contraindication(s) to performing physical activity\n* English language proficiency\n* access to internet\n\nExclusion Criteria:\n\n* physically active (more than 150min\u002Fweek moderate intensity physical activity, 75 min\u002Fweek vigorous activity, or some combination of the two)\n* known contraindication(s) to performing physical activity\n* known or suspected serious spinal pathology (fracture, metastatic, inflammatory or infective diseases of the spine, cauda equina syndrome\u002Fwidespread neurological disorder)\n* scheduled for major surgery during the treatment or follow-up period",{"count":50,"type":20},392,"INTERVENTIONAL",[53],"NA","The goal of this clinical trial is to investigate the effectiveness of two treatments for adults with chronic low back pain. The main question this study seeks to answer is \"In adults with chronic low back pain, what is the effectiveness of pain education and patient-led goal setting compared to guideline-based written advice on reducing pain intensity and disability?\".\n\nA total of 392 participants will be randomised into two groups: 1) pain education and patient-led goal setting or 2) guideline-based written advice. Participants randomised to the pain education and patient-led goal setting group will receive 5 sessions of 45-60 min each over 8 weeks delivered online via telehealth. Participants randomised to written advice group will receive information developed for people with chronic low back pain. Outcomes will be assessed at baseline and week 8, 26 and 52.",[56],"Chronic Low Back Pain (Non-specific, Uncomplicated)",[58,59,60],"pain education","patient-led goal setting","chronic low back pain","2026-04-06",{"date":63,"type":32},"2026-04-09",{"date":65,"type":32},"2025-06-26",{"date":67,"type":20},"2029-12-31",{"name":38,"class":39},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":51,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":40},"100608779","adhere-trial-strategies-to-improve-mobile-app-adherence-100608779","NCT07205991","ADHERE Trial: Strategies to Improve Mobile App Adherence","Assisting Digital HEalth REtention (ADHERE Trial): Protocol for a Study Within a Trial (SWAT)","ADHERE","Inclusion Criteria:\n\n* Experiencing non-specific chronic low back pain (LBP), defined as pain between the 12th rib and the buttock crease.\n* LBP with or without leg pain (in case of leg pain, LBP is worse than leg pain).\n* Currently consulting with a general practitioner for their non-specific chronic LBP across Australia.\n* Mean pain intensity score on the Numeric Rating Scale ≥ 3\u002F10 in the past week.\n* A score of at least moderate on question 8 of the physical functioning component of the SF-36 questionnaire.\n* Access to a mobile device with minimal requirements to download the study app (300MB).\n* An internet connection to access the mobile app functionalities.\n* Able to understand English via reading and audio materials.\n* Randomised to experimental group at NOTUS Trial.\n\nExclusion Criteria:\n\n* Known or suspected specific spinal (e.g., radiculopathy, fracture) or specific non-spinal non- (e.g., tumour, infection) pathology.\n* Less than six months post-spinal surgery.\n* Scheduled for major surgery during the program or the follow-up period.\n* Known or suspected serious psychiatric condition not being treated by a health professional that would impact adherence to the trial activities.\n* Known or suspected sight or hearing problems that would limit access to the intervention components (reading and listening using headphones).",{"count":78,"type":20},258,[53],"This study aims to evaluate the effectiveness of two communication interventions, compared to standard app notifications, in increasing adherence to a mobile health app among individuals with chronic low back pain. The main question it aims to answer is:\n\nDo phone calls or text messages increase adherence compared to app notifications in patients receiving a digital health intervention for chronic back pain?\n\nParticipants will:\n\nA) Receive pain education and clinical hypnosis via a mobile app for managing chronic LBP; B) Will be contacted up to twice via phone call or text message, or they will only receive standard notifications from the app.",[82],"Low Back Pain",[84,85,86,87,88],"Back Pain","Digital Health","Hypnosis","Pain Education","Chronic Pain","2026-01-12",{"date":91,"type":32},"2026-01-14",{"date":93,"type":32},"2025-10-30",{"date":95,"type":20},"2028-05-26",{"name":38,"class":39},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":51,"phases":107,"briefSummary":108,"conditions":109,"keywords":114,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":121,"locationsCount":40},"100591740","digitally-delivered-treatments-to-reduce-chronic-low-back-pain-100591740","NCT06984354","Digitally Delivered Treatments to Reduce Chronic Low Back Pain","NOTUS Trial: A Randomised Controlled Trial of Two Digitally Delivered Treatment Options for Chronic Back Pain","NOTUS","Inclusion Criteria:\n\n* Experiencing non-specific chronic low back pain (LBP), defined as pain between the 12th rib and the buttock crease.\n* LBP with or without leg pain (in case of leg pain, LBP is worse than leg pain).\n* Currently consulting with a general practitioner for their non-specific chronic LBP across Australia.\n* Mean pain intensity score on the Numeric Rating Scale ≥ 3\u002F10 in the past week.\n* A score of at least moderate on question 8 of the physical functioning component of the SF-36 questionnaire.\n* Access to a mobile device with minimal requirements to download the study app (300MB).\n* An internet connection to access the mobile app functionalities.\n* Able to understand English via reading and audio materials.\n\nExclusion Criteria:\n\n* Known or suspected specific spinal (e.g., radiculopathy, fracture) or specific non-spinal non- (e.g., tumour, infection) pathology.\n* Less than six months post-spinal surgery.\n* Scheduled for major surgery during the program or the follow-up period.\n* Known or suspected serious psychiatric condition not being treated by a health professional that would impact adherence to the trial activities.\n* Known or suspected sight or hearing problems that would limit access to the intervention components (reading and listening using headphones).",{"count":106,"type":20},720,[53],"This study aims to evaluate the effectiveness of pain education and clinical hypnosis delivered via a mobile app compared to a guideline-informed factsheet for reducing pain and disability in people experiencing chronic low back pain attending general practice.",[82,110,111,85,112,113],"Chronic Pain (Back \u002F Neck)","General Practice (GP), Primary Care Settings","Hypnosis, Chronic Pain Management","Patient Education",[84,85,86,87,88],"2025-07-16",{"date":117,"type":32},"2025-07-20",{"date":119,"type":32},"2025-06-02",{"date":95,"type":20},{"name":38,"class":39},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":51,"phases":132,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":40},"100528942","titan-trial-reducing-phantom-limb-pain-in-people-with-amputations-100528942","NCT06167330","TITAN Trial: Reducing Phantom Limb Pain in People with Amputations","TITAN: a Randomised Controlled Trial Investigating the Effectiveness of Two Treatment Programs for Reducing Phantom Limb Pain Intensity and Its Interference with Function","TITAN","Inclusion Criteria:\n\n* Experiencing phantom limb pain for at least three months.\n* Report at least one episode of phantom limb pain in the previous week.\n* Report at least 4 points in pain intensity over the previous 7 days, assessed using the 11-point Numerical Pain Rating Scale.\n* Be a resident in Australia for the intervention and follow-up period.\n* Have access to the internet and smart device (e.g., mobile phone).\n* Be proficient in English.\n\nExclusion Criteria:\n\n* Bilateral amputation.\n* Scheduled for major surgery during the study period.\n* Pain in the intact limb.\n* Vision impairment that would preclude successful participation.\n* Auditory impairment that would preclude successful participation.\n* Cognitive problems that would preclude effective participation in trial procedures (e.g., Alzheimer's, dementia).\n* Previously diagnosed neurological disorders that affect the movement of the intact limb (e.g., stroke, Parkinson, Multiple Sclerosis).\n* Completed Graded Motor Imagery in the order of left\u002Fright judgements, imagined movements, and mirror therapy.\n* Have contraindications for the use of stimulation devices (e.g., pacemaker, spinal cord stimulator).",{"count":131,"type":20},208,[53],"The goal of this clinical trial is to investigate the effectiveness of two rehabilitation programs for individuals who have undergone amputations and are experiencing phantom limb pain. The main question it aims to answer is:\n\n\\- In individuals who have undergone amputations and are experiencing phantom limb pain, what is the effectiveness of a progressive rehabilitation program compared to a treatment program consisting of transcutaneous electrical nerve stimulation and cranial electrical stimulation on reducing pain intensity and pain interference?\n\nA total of 208 participants will be randomized into two groups: progressive rehabilitation program and stimulation devices. The progressive rehabilitation program includes pain science education, sensory training, and left\u002Fright judgements, imagined movements and mirror therapy. The treatment program for the group receiving the stimulation devices includes transcutaneous electrical nerve stimulation and cranial electrical stimulation. Both interventions will be delivered via eight, up to 1-hour telehealth sessions. Outcome measures will be assessed at baseline and weeks 12, 24 and 52.",[135,136],"Phantom Limb Pain","Amputation","2024-12-03",{"date":139,"type":32},"2024-12-05",{"date":141,"type":32},"2023-12-18",{"date":143,"type":20},"2027-12-18",{"name":38,"class":39},""]