[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"New York University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":644},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,28,0,25,[9,45,76,106,129,153,181,201,221,249,270,291,316,337,365,388,410,433,459,486,514,546,566,598,623],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100633404","motor-based-intervention-for-childhood-apraxia-of-speech-dttc-connect-100633404",false,"NCT07526246","Motor-based Intervention for Childhood Apraxia of Speech: DTTC-Connect","A Randomized Control Trial of Motor-based Intervention for Childhood Apraxia of Speech: Dynamic Temporal and Tactile Cueing-Connect (DTTC-Connect)","Inclusion Criteria:\n\n1. Diagnosis of childhood apraxia of speech (CAS). The diagnosis will be made by two speech language pathologists (SLPs) who have extensive experience in the differential diagnosis of CAS.\n2. Age between 3;6 and 12;11 years.\n3. Normal structure of the oral-peripheral mechanism as determined by a motor speech examination using established lab protocol.\n4. Participants must pass a hearing screening conducted at 20 dB SPL at 500, 1000, 2000 and 4000 Hz.\n5. Not receiving speech treatment elsewhere over the course of this study, although language, augmentative and alternative communication (AAC) treatment, or similar non-speech treatment, would be permitted.\n6. Language Testing: Receptive Language Index standard score greater than or equal to 70 on the Clinical Evaluation of Language Fundamentals - Preschool 3rd edition (CELF-P3) for children 3;6-5;11 years of age, or the Clinical Evaluation of Language Fundamentals - 5th edition (CELF-5) for children 6;0-12;11 years of age.\n7. Nonverbal Cognition Testing: Standard score greater than or equal to 70 on the Developmental Assessment of Young Children-2nd edition (DAYC-2) for children 3;6- 5;11 years of age, or the Reynolds Intellectual Assessment Scales- 2nd edition, Remote (RIAS) for children 6;0-12;11 years old.\n8. Evidence of multi-word spontaneous speech up to five syllables in length.\n9. English as the primary language.\n\nExclusion Criteria:\n\n1. Primary dysarthria diagnosis, even if CAS is a secondary diagnosis.\n2. Abnormal structure of the oral peripheral mechanism.\n3. Fluency disorder, even if the child meets criteria for CAS.\n4. Conductive or sensorineural hearing loss, even if the child meets criteria for CAS.\n5. English is not the primary language.","ALL","3 Years","12 Years",{"count":21,"type":22},68,"ESTIMATED","INTERVENTIONAL",[25],"NA","Childhood apraxia of speech (CAS) is a complex motor speech disorder that significantly limits a child's ability to communicate in daily activities, with difficulties often persisting into adolescence and adulthood. There is solid evidence that motor-based interventions, such as Dynamic Temporal and Tactile Cueing (DTTC), improve word production in children with CAS. Building on this strong foundation, the next critical step is to extend this work to support functional communication in connected speech, where children with CAS often continue to struggle. There is a critical need for a systematic bridge within the context of treatment from word-level practice to connected speech, as robust word-level gains often fail to generalize to other speaking contexts. This work addresses this gap by transitioning children from word- to phrase-level practice using Dynamic Temporal and Tactile Cueing-Connect (DTTC-Connect), a novel, structured adaptation of DTTC that targets connected speech production. Our approach builds on established DTTC principles while incorporating progression to more complex utterances, offering a developmentally appropriate, research-informed pathway to functional communication.\n\nThis study is a Phase II randomized controlled trial (RCT) designed to examine the efficacy of DTTC-Connect, a motor-based treatment that includes phrase-level practice to refine connected speech and support communicative participation for children with CAS. The overall objectives of this work are to test the efficacy of DTTC-Connect and document changes in speech motor control at the connected speech level in 68 children with CAS (3;6 - 12;11 years of age) who receive treatment twice a week for 8 weeks (16 sessions). The central hypothesis is that DTTC-Connect will lead to lasting improvements in phrase accuracy, speech intelligibility and speech motor control, ultimately enhancing a child's communicative participation.",[28],"Childhood Apraxia of Speech",[30,31,32],"Pediatric Motor Speech Disorder","Speech Motor Control","Communicative Participation","NOT_YET_RECRUITING","2026-06-24",{"date":36,"type":37},"2026-06-29","ACTUAL",{"date":39,"type":22},"2026-09-15",{"date":41,"type":22},"2031-03-31",{"name":43,"class":44},"New York University","OTHER",{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100536234","parenting-stair-adapting-a-trauma-focused-parenting-intervention-for-military-connected-mothers-and-their-children-100536234","NCT06262178","Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children","Inclusion Criteria:\n\n1. Military-connected mother, defined as a mother who is either a female service member or veteran or female spouse of a service member or veteran;\n2. Has a child aged 2-10;\n3. Legal guardian of index child with legal and physical custody;\n4. Lifetime trauma exposure (Life Events Checklist (LEC-5); Adverse Childhood Experiences Questionnaire (ACE-Q));\n5. Screen positive for PTSD (defined as a PCL-5 score ≥32 or meeting ≥3 out of 4 DSM-5 symptom criteria \\[B, C, D, E\\] on the PCL-5), and\u002For depression (PHQ-9 score ≥8), and\u002For low parenting self-efficacy (PSOC score \\\u003C59);\n6. Able to speak and understand English or Spanish;\n7. Eligible to receive services at a Steven A. Cohen Military Family Clinic at Endeavors.\n\nExclusion Criteria:\n\n1. High risk for suicide (Ask Suicide-Screening Questions (ASQ));\n2. Current psychotic symptoms (DSM-5-TR Self-Rated Level 1 Cross-Cutting Symptom Measure Domain VII);\n3. Disability affecting communication, such as deafness;\n4. Index child with severe developmental disability;\n5. Severe substance or alcohol use (The Alcohol, Smoking and Substance Involvement Screening Test - Lite (ASSIST-Lite); Cannabis Use Disorder Identification Test-Short Form (CUDIT-SF)).","FEMALE","18 Years",{"count":54,"type":22},120,[25],"The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10). PSTAIR-M aims to help mothers manage the strong feelings that sometimes happen after experiencing something scary or stressful, as well as to better connect with their children and manage their behavior effectively.\n\nThe main questions the study aims to answer are: 1) Does PSTAIR-M reduce maternal PTSD and\u002For depression symptoms?, and 2) Does PSTAIR-M improve parental functioning?\n\nResearchers will compare PSTAIR-M to treatment as usual (TAU) - other EBTs offered at participating study sites - to determine if PSTAIR-M is more effective in improving mental health and parenting.\n\nParticipants will: 1) attend 12-16 weekly, 1-hour online treatment sessions with their assigned clinicians, 2) complete three 1-hour online assessments administered by research staff, 3) engage with their child in three 15-30-minute online, observed play sessions, 4) have assessments and observed play sessions audio and video recorded.\n\nParticipants may also be invited to participate in an optional, 30-minute online one-on-one qualitative interview, which would be audio and video recorded and would cover participants' experiences with the intervention, the clinic sites, and their providers.",[58,59,60],"PTSD","Depression","Parent-Child Relations",[58,59,62,63,64,60,65],"STAIR","PC-CARE","Parenting","Military Family","RECRUITING","2026-06-11",{"date":69,"type":37},"2026-06-15",{"date":71,"type":37},"2025-07-21",{"date":73,"type":22},"2027-09-30",{"name":43,"class":44},3,{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":17,"minAge":19,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},"100489521","wecare-a-system-of-care-for-black-youth-100489521","NCT05654207","WeCare: A System of Care for Black Youth","Answering the Alarm: A System of Care for Black Youth at Risk for Suicide","WeCare","Inclusion criteria adolescent and parent\u002Fguardians:\n\n* Adolescents aged 12-17 years and their parents or guardians, and adolescents 18-19 years who have the option for their parent or guardian to participate\n* Having a parent\u002Fcaregiver present in the ED to consent or available to consent remotely (12-17 year olds, only)\n* Having a cellular phone with text messaging capacity\n* Adolescent able to speak English, and understand study questions\n* Parents able to consent in English, Spanish, French or Creole\n* Meet screening criteria\n\nExclusion criteria adolescent and parent\u002Fguardians:\n\n* Adolescent is medically unstable\n* Adolescent present with severe cognitive impairment\n* Parents are not present in the ED, unable to consent remotely, and not able to give consent in either English, Spanish, French or Creole (12-17 year olds, only)\n* Adolescent does not have access to cellular phone\n* Adolescents active in mental health treatment (e.g., seen a therapist, social worker, or mental health provider in the last week)",true,"19 Years",{"count":87,"type":22},2200,[25],"The overall goal of this study is to respond to the urgent need for an effective suicide prevention strategy for Black youth by examining the effectiveness of a systems-level strategy to recognize and respond to suicide risk among Black adolescents who present to emergency departments (EDs). The proposed strategy, WeCare, combines combines three components: (1) universal screening using the Computerized Adaptive Screen for Suicidal Youth (CASSY), (2) a brief intervention designed for Black youth with elevated suicide risk in for ED settings, Connections for Safety (CFS), that combines safety planning and strategies to support linkage to outpatient mental health services, and (3) supportive text messages to youth and parent\u002Fcaregivers for six weeks following the youth's ED visit. Study objectives are (1) to integrate input from multiple stakeholders to inform and facilitate WeCare implementation, and (2) to use a hybrid one effectiveness-implementation design to evaluate its effectiveness.",[91],"Suicidal Ideation",[93,94,95,96],"suicide","ideation","Black youth","depression","2026-06-08",{"date":99,"type":37},"2026-06-10",{"date":101,"type":37},"2024-04-08",{"date":103,"type":22},"2027-04-01",{"name":43,"class":44},1,{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":84,"sex":17,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":105},"100517965","a-stepped-care-approach-to-treating-dental-fear-100517965","NCT06024395","A Stepped Care Approach to Treating Dental Fear","A Stepped-Care Approach to Treating Dental Fear: A Sequential, Multiple Assignment, Randomized Trial for Cognitive-Behavioral Treatment Via Mobile App and Evidence-Based Collaborative Care","Inclusion Criteria:\n\n* Provide signed and dated informed consent form\n* Access to a smartphone or tablet\n* Willing to comply with all study procedures and be available for the duration of the study\n* 13 years or older, and if under 18 years, a parent or legal guardian can consent to their participation in the study\n* Proficient in English\n* Score 4 or above on the Gatchel single-item dental fear rating scale\n* Willingness to allow access to dental attendance records\n* Located in the USA\n\nExclusion Criteria:\n\nGiven the scope and nature of the study, there is no exclusion criteria.","13 Years","99 Years",{"count":116,"type":22},1000,[25],"The purpose of this study is to compare an intervention for dental fear to the usual approach (i.e., whatever participants' dentist typically does to help participants manage their fear). The dental fear intervention has 2 separate steps. Step 1 (the less intensive or 'light touch' intervention step) involves using a mobile application (app). Step 2 consists of a one-hour telehealth session with a mental health provider tailored to individualized dental fear.\n\nThis is a randomized study. The time spent participating in the study will depend on which study condition(s) participants are randomly assigned to. Because this study compares the dental fear intervention to the standard approach, 25% of participants will not get the intervention during the study period. These participants (called controls) will be offered the opportunity to provide feedback about their experiences with dentists. Participants will be offered the intervention free of charge at the conclusion of the study.\n\nFor each step of the intervention (Dental FearLess app or one-on-one session) relative to treatment as usual, the investigators hypothesize that participants will show greater declines in self-reported dental fear and improved oral health-related quality of life at post-treatment and follow-up period. De-identified attendance records will be collected from dental practices.",[120],"Dental Fear","2026-05-13",{"date":123,"type":37},"2026-05-15",{"date":125,"type":37},"2023-09-11",{"date":127,"type":22},"2028-06-30",{"name":43,"class":44},{"id":130,"slug":131,"hasResults":12,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":84,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":105},"100591528","prevention-of-psychological-health-problems-via-integrated-operational-support-100591528","NCT06981598","Prevention of Psychological Health Problems Via Integrated Operational Support","Optimizing Psychological Health and Preventing Clinical Problems: Testing the Effectiveness of an Evidence-Based Toolkit for Integrated Operational Support","IOS Toolkit","Inclusion Criteria:\n\n* Service members seeing a behavioral health (BH) technician.\n* Currently embedded BH technicians.\n\nExclusion Criteria:\n\n* Service members who are not currently seeing a BH technician.\n* BH technicians who are not embedded or have taken a clinic role.",{"count":138,"type":22},5586,[25],"Sub-clinical behavioral health services in the military are performed by BH technicians, who receive minimal training. Due to this, embedding more technicians in military units is unlikely to benefit service members. Giving technicians training in, and access to, evidence-based interventions (EBI) could make their work more effective. The proposed study is a training trial examining the efficacy of the full integrated operational support (IOS) toolkit (evidence-based interventions for behavioral health), relative to routine care using standard resources, as a prevention resource for active-duty airmen.",[142,143,144,145],"Depression, Anxiety","Grief","Leadership","Dissatisfaction","2026-05-12",{"date":123,"type":37},{"date":149,"type":37},"2025-03-10",{"date":151,"type":22},"2028-03-01",{"name":43,"class":44},{"id":154,"slug":155,"hasResults":12,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":12,"sex":17,"minAge":161,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":165,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":180},"100584100","phase-2-generalization-with-ai-navigation-using-start-100584100","NCT06884943","Generalization With AI Navigation Using StaRt","Randomized Trial of AI-Enhanced Maintenance Training With Visual-Acoustic Biofeedback","GAINS","Inclusion Criteria:\n\n* • Must be between 9;0 and 17;11 (years;months) old at the time of enrollment.\n\n  * Must speak English as the dominant or equally dominant language\n  * Must have begun learning English by age 3, per parent report.\n  * Must hear a rhotic dialect of English from at least one speaker in the home if the home language is English.\n  * Must pass a pure-tone hearing screening.\n  * Must pass a brief examination of oral structure and function.\n  * Must demonstrate age-appropriate receptive and expressive language abilities on the Clinical Evaluation of Language Fundamentals-5 (CELF-5).\n  * Must have access to a laptop or desktop computer for study sessions.\n  * Must have home wifi sufficient to support video calls in the event of randomization to the telepractice condition.\n  * Must have completed participation in the VISIT randomized controlled trial.\n  * Must score at least 60% correct in at least one treatment session during the related previous study, VISIT.\n\nExclusion Criteria:\n\n* • Must not exhibit voice or fluency disorder of a severity judged likely to interfere with the ability to participate in study activities.\n\n  * Must not currently have orthodontia that crosses the palate and cannot be removed.\n  * Must not have history of permanent hearing loss.\n  * Must not have an existing diagnosis of developmental disability such as cerebral palsy or Down Syndrome.\n  * Must not have history of major brain injury, surgery, or stroke in the past year.\n  * Must not have epilepsy with active seizure incidents with in the past 6 months.\n  * Must not show clinically significant signs of apraxia of speech or dysarthria.","9 Years","17 Years",{"count":164,"type":22},76,[166],"PHASE2","Speech Sound Disorder (SSD) affects a significant portion of school-aged children, leading to social and emotional challenges that can persist into adolescence and adulthood. The number of productions necessary for a remediated speech sound to generalize to connected speech is challenging to achieve in practice, leading clinicians to call for accessible, reliable resources allowing children to continue therapy outside of direct clinical interactions. Artificial intelligence (AI) tools hold promise as a means to extend direct service delivery in speech-language pathology, but research investigating the topic has been limited. This study (Generalization with AI Navigation using staRt, or GAINS) will measure the effects of a course of AI-mediated home practice intended to promote generalization of gains made through biofeedback treatment in a related study, Visual-acoustic Intervention with Service Delivery In-person and Via Telepractice Trial (VISIT; NCT06517225).",[169],"Speech Sound Disorder",[171,172],"speech","articulation","2026-05-11",{"date":121,"type":37},{"date":176,"type":37},"2024-12-18",{"date":178,"type":22},"2029-07-01",{"name":43,"class":44},2,{"id":182,"slug":183,"hasResults":12,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":84,"sex":17,"minAge":188,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":195,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":105},"100540538","managing-sickle-cell-disease-through-increased-adoption-of-hydroxyurea-in-nigeria-100540538","NCT06318143","mAnaging siCkle CELl disEase Through incReased AdopTion of hydroxyurEa in Nigeria","ACCELERATE","Inclusion Criteria:\n\n* SCD patients18 years older that have provided consent;\n* Pediatric SCD patients aged 12 months to 17 years with an accompanying guardian and have provided informed consent or assent;\n* Registration in the electronic medical records (EMR) database with clinical charts and received care at the local clinical sites or health facilities and not on HU therapy;\n* Hb Genotype: SCD-SS, SCD-Sβo thal, SCD-SOArab (On a case by case basis, a severely affected person with SCD-SC may be offered HU therapy under a modified treatment protocol)\n\nExclusion Criteria:\n\n* Any SCD patient not registered in the EMR database without informed consent or assent;\n* Physically unable to participate in study activities;\n* An SCD patient on HU","12 Months",{"count":190,"type":22},900,[25],"Large knowledge gaps remain regarding strategies to promote the adoption of hydroxyurea (HU), particularly in sub-Saharan African countries including Nigeria, where more than 75% of annual sickle cell anemia births occur. The vast majority of people with SCD in Africa do not receive evidenced-based health care (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, blood transfusion, transcranial Doppler screening, and HU therapy), despite its effectiveness in reducing SCD-related adverse outcomes and mortality. The use of HU in SSA is \\\u003C1% among SCD patients. The investigators' preliminary findings indicate that provider-level barriers are significant and must be addressed to improve HU adoption. To address HU adoption, the investigators will use the NIH-funded study (e.g., Realizing Effectiveness Across Continents with Hydroxyurea (REACH) Clinical Trial (NCT01966731)) that developed an evidence-informed, clinical, practical, and easy-to-follow algorithm to 1) Screen patients for sickle cell disease (SCD), 2) Initiate HU treatment, and 3) Maintain HU dosage over time (SIM) for the improved management of SCD as our intervention. The Nigerian government released guidelines supporting the SIM intervention for HU adoption for improved SCD management, and HU is on the list of essential medicines for Nigeria. The investigators' implementation strategy for improving SCD management in Nigeria uses a practical and replicable evidence-based task-sharing strategy, TAsk-Strengthening Strategy for Hemoglobinopathies (TASSH), adopted from the TAsk-Strengthening Strategy for Hypertension control (TASSH) trials in Ghana and Nigeria containing the essential components of i) Training healthcare workers\u002Fproviders to be more patient-centered in clinical consultations, ii) Clinical reminders, and iii) Practice facilitation (TCP) known as (TASSH TCP) for SCD management. Using a sequential exploratory mixed-methods study design, the investigators will conduct this study using the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework in four sequential phases to assess the effectiveness of SIM adoption by providers in the context of the TASSH TCP implementation strategy in Nigeria.",[194],"Sickle Cell Disease",{"date":121,"type":37},{"date":197,"type":37},"2024-07-01",{"date":199,"type":22},"2028-05-31",{"name":43,"class":44},{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":84,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":23,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":220,"locationsCount":4},"100632919","promoting-change-in-practice-for-respiratory-failure-100632919","NCT07519941","Promoting Change in Practice for Respiratory Failure","Promoting Change in Practice for Respiratory Failure: the PRECIPICE Study","PRECIPICE","Inclusion Criteria:\n\n* We will include physicians, nurses, and other staff at participating ICUs who consent to participate.\n\nExclusion Criteria:\n\n* We will exclude potential participants who cannot speak either English or Spanish.",{"count":210,"type":22},20,[25],"Approximately 300,000 Hispanic individuals experience respiratory failure each year in the U.S. Hispanic patients are twice as likely to die from respiratory failure as non-Hispanic patients. There is an urgent need to identify and remediate mechanisms that increase risk of death from respiratory failure. The team's preliminary work identified two potential mechanisms: Hispanic patients with respiratory failure are more likely to be deeply sedated and less likely to receive physical therapy than non-Hispanic patients, which are both associated with mortality and poor long-term functional outcomes. The overall objective of this proposal is to improve outcomes for patients with respiratory failure through changes in intensive care unit (ICU) practice. This trial will refine and pilot an intervention to promote guideline-concordant care. The team's preliminary intervention will be iteratively refined through patient, family, and clinician engagement and piloted at two U.S. ICUs. The outcome of this study will be an intervention aimed at reducing mortality from respiratory failure.",[214],"Acute Respiratory Distress Syndrome (ARDS)","2026-05-07",{"date":173,"type":37},{"date":218,"type":22},"2026-08-01",{"date":103,"type":22},{"name":43,"class":44},{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":84,"sex":17,"minAge":52,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":23,"phases":232,"briefSummary":233,"conditions":234,"keywords":237,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":243,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":105},"100633762","prediction-of-visual-feedback-effects-on-speech-motor-adaptation-in-healthy-adults-100633762","NCT07530900","Prediction of Visual Feedback Effects on Speech Motor Adaptation in Healthy Adults","Prediction of Visual Feedback Gain in Altered Auditory Feedback Tasks Using Computational Modeling","PVF","Inclusion Criteria:\n\n* Age 18 to 45 years\n* Self-reported English as dominant or equally dominant language (learned English by age 3)\n* No self-reported history of significant speech, language, or hearing difficulty\n* Pass pure-tone hearing screening at 25 dB HL\n* Pass qualitative screening of speech, voice, and resonance based on connected speech sample\n\nExclusion Criteria:\n\n* Learned English after age 3\n* English is not a dominant language\n* History of speech or language disorder, hearing loss, or neurodevelopmental disorder (e.g., autism spectrum disorder, Down syndrome)\n* Failure to pass pure-tone hearing screening\n* Failure to pass qualitative screening of speech, voice, and resonance","45 Years",{"count":231,"type":22},40,[25],"This study examines whether individual differences in how speakers respond to hearing versus physical sensation during speech can predict who benefits most from visual feedback during a speech task. Healthy adults will complete a series of tasks in which auditory feedback is altered in real time through headphones, with and without an added visual display of the speech signal. A computational model will be used to estimate how strongly each participant relies on hearing versus physical sensation when monitoring speech. The study will then test whether this individual profile predicts how much the visual display improves each participant's ability to respond to the altered feedback.",[235,236],"Healthy Volunteers","Speech",[238,239,240,241,242],"speech motor control","altered auditory feedback","biofeedback","sensorimotor adaptation","computational modeling",{"date":173,"type":37},{"date":245,"type":37},"2026-04-27",{"date":247,"type":22},"2026-11-30",{"name":43,"class":44},{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":23,"phases":259,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":105},"100420275","safe-mothers-safe-children-initiative-100420275","NCT04752618","Safe Mothers, Safe Children Initiative","Treating Maternal PTSD to Enhance and Reduce Maltreatment Recidivism: Safe Mothers, Safe Children","SMSC","Inclusion Criteria (mothers):\n\n* Receiving preventive services at the time of the consent session to participate in the study\n* Meeting a severity score of 28 or higher OR probable DSM-5 diagnostic criteria for PTSD (PDS-5)\n* Having 1-10-year-old child\n* Being the legal guardian for the child with physical and legal custody\n* Being able to read, write, and speak English or Spanish\n\nExclusion Criteria (mothers):\n\n* Having suicidal ideation present in the past month prior to pre-assessment or reports of a suicide attempt in the past year (SCID-5)\n* Meeting a diagnosis of severe substance or alcohol use disorder (≥ 6 symptoms on SCID) AND not in early remission (≥3 months without meeting any substance or alcohol use disorder criteria (except craving)\n* Having current or active symptoms of psychosis in the past month\n* Having a disability affecting communication, such as deafness\n* Having an index child with a developmental condition that impedes cognitive and\u002For physical functioning, e.g. autism\n* Having an index child with current symptoms or diagnosis of psychosis as defined by the DSM-5 in the past 3 months\n* Experiencing current or history of intimate partner violence (IPV) or family violence:\n\nIf there is a history of IPV\u002Ffamily violence and the relationship is no longer active, the relationship must have ended for at least ninety days with no intention of restarting; If there is a history of IPV\u002Ffamily violence, but the relationship is ongoing, there must not have been an IPV\u002Ffamily violence event for at least one year\n\nInclusion criteria (clinicians):\n\n\\- Must be a currently or formerly hired Study Clinician or Clinical Director with Safe Mothers, Safe Children.\n\nExclusion criteria (clinicians):\n\n\\- There are no exclusion criteria for this population. Participants in this population will cease completion of therapist-copy measures upon the conclusion of their role with Safe Mothers, Safe Children, or upon withdrawal from participation in these measures.",{"count":258,"type":22},160,[25],"The purpose of this study is to assess the efficacy of the combined interventions, Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment recidivism.",[58,59,262],"Child Maltreatment","2026-05-01",{"date":215,"type":37},{"date":266,"type":37},"2021-05-01",{"date":268,"type":22},"2027-04-30",{"name":43,"class":44},{"id":271,"slug":272,"hasResults":12,"nctId":273,"briefTitle":274,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":84,"sex":17,"minAge":161,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":278,"briefSummary":280,"conditions":281,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":105},"100594170","phase-4-kupewa-optimizing-implementation-strategies-for-cervical-cancer-prevention-100594170","NCT07015957","Kupewa: Optimizing Implementation Strategies for Cervical Cancer Prevention","Inclusion Criteria:\n\n* Health workers: People who provide medical care and counseling (typically medical assistants, clinical officers, and nurses), and interact with adolescent girls and young women aged 9-24 and\u002For their parents\u002Fcaregivers.\n* Clients: Non-pregnant females aged 9-24 (for those aged 9-17, their male or female parent\u002Fguardian will also be eligible for participation) who present for HIV care at a participating health facility during the study period.\n\nExclusion Criteria:\n\n* Health workers: Less than 18 years of age, or not an active and regular provider of medical care or counseling at the facility, or unable or unwilling to provide informed consent.\n* Clients: \\\u003C9 or \\>24 years old, or pregnancy, or unable or unwilling to provide informed consent.",{"count":277,"type":22},7000,[279],"PHASE4","The goal of this clinical trial is identify an effective and implementable set of implementation strategies to increase cervical cancer prevention in Malawi. The main questions it aims to answer are:\n\n1. Which implementation strategies produce the greatest increase in provider recommendation for, and uptake of, cervical cancer prevention tools among people receiving HIV care.\n2. What is the acceptability, appropriateness, feasibility, and cost of these implementation strategies.\n3. What is the sustained effect of these implementation strategies. The implementation strategies will be conducted with health workers (clinical officers, nurses, and medical assistants): training, coaching, and a reminder system.",[282],"Cervical Cancer Prevention","2026-04-29",{"date":285,"type":37},"2026-04-30",{"date":287,"type":37},"2025-07-08",{"date":289,"type":22},"2029-08",{"name":43,"class":44},{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":297,"enrollmentInfo":298,"targetDuration":4,"studyType":23,"phases":300,"briefSummary":301,"conditions":302,"keywords":305,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":105},"100501331","rct-of-an-intersectional-stigma-intervention-to-sustain-viral-suppression-among-women-living-with-serious-mental-illness-and-hiv-in-botswana-100501331","NCT05807867","RCT of an Intersectional Stigma Intervention to Sustain Viral Suppression Among Women Living With Serious Mental Illness and HIV in Botswana","(A) WOMEN WITH SMI AND HIV\n\nAt Sbrana Psychiatric Hospital, the investigators will recruit women with SMI and HIV who are receiving treatment at that facility. Women with SMI and HIV will be receiving psychiatric care and ART and must:\n\n1. Meet DSM-5 criteria for current psychotic disorder or mood disorders or other disorders causing functional impairment except substance use disorders and developmental disorders, per clinician interview based on the MINI\n2. Have confirmed HIV positive status\n3. Be 18-55 years of age\n4. Be female\n5. Have capacity to provide consent and written informed consent\n6. Speak English or Setswana\n7. Be a Botswana citizen\n\n   The investigators will also recruit 6 to 8 women with SMI and HIV as peer co-leaders to facilitate the intervention. For women who are peer co-leaders, inclusion criteria include #1 to #7 above in addition to:\n8. Remaining adherent to psychiatric medications\n9. Being symptomatically stable for \\>2 years\n10. Maintaining consistent ART adherence.\n\n(B) FAMILY MEMBERS OF WOMEN WITH SMI AND HIV.\n\nIn Botswana, families are usually contacted and engaged in psychiatric treatment planning during inpatient stay or on admission. The involvement of family continues during outpatient follow-ups since most patients are accompanied by some relative or caregiver on such visits. Eligible participants include:\n\n1. Identified by participant and\u002For clinician as the relative 'most involved in the client's care'.\n2. Be 18-65 years of age\n3. English or Setswana speaking\n4. Botswana citizen.\n\n(C) POLICY MAKERS AND OTHER STAKEHOLDERS.\n\nPolicy makers will be\n\n1. Be 18-55 years of age\n2. Include: (a) bureaucratic officials of Botswana, public sector ministries (government) at the national level holding appointment to senior offices that develop, interpret and\u002For implement national mental health and HIV programs (prevention and treatment) or related clinical services; (b) senior bureaucratic officials of the National AIDS and Health Promotion Agency (NAHPA); and (c) senior members of civil society organizations (CSOs), nongovernment organizations (NGOs) or other entities that support the national Botswana government to implement services to People Living With HIV (PLWH) and mental health patients.","65 Years",{"count":299,"type":22},360,[25],"The study goal is to promote viral load suppression among women with serious mental illness (SMI) and HIV in Botswana, given that these women are especially vulnerable to psychiatric medication nonadherence and symptom exacerbation, which are made worse by stigma and threaten antiretroviral therapy (ART) adherence.\n\nThe investigators propose to test an intervention to reduce stigma due to the statuses of SMI and HIV, against an attention control condition, in the high-risk transition period after discharge from an initial psychiatric hospitalization. Specifically, the investigators are conducting a two-arm randomized controlled trial (RCT) with a 4-month follow-up to compare the effectiveness of 1) What Matters Most (WMM)-based intersectional stigma intervention delivered as clients transition from psychiatric hospitalization to outpatient care; and 2) an attention placebo control condition that follows a similar format to isolate the effects of the intervention.\n\nThe investigators will also assess policymaker workshops where peer women with SMI and HIV co-lead the reporting of RCT findings via lived experience to policymakers to initiate structural change.\n\nEnabling women with SMI and HIV to resist stigma has the potential to improve their HIV outcomes and empower these women to elicit broader, structural-level change.",[303,304],"Hiv","Serious Mental Illness",[306,307],"HIV","Stigma","2026-04-20",{"date":310,"type":37},"2026-04-23",{"date":312,"type":37},"2024-08-01",{"date":314,"type":22},"2027-12",{"name":43,"class":44},{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":84,"sex":17,"minAge":322,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":105},"100614387","testing-the-impact-of-family-based-intervention-to-improve-developmental-and-health-outcomes-for-female-adolescents-100614387","NCT07278934","Testing the Impact of Family-Based Intervention to Improve Developmental and Health Outcomes for Female Adolescents","Inclusion Criteria:\n\nAdolescent girls' inclusion criteria are:\n\n* Enrolled in school and living within a family (defined broadly -not necessarily biological parents)\n* Ages 11 to 14\n* Skipping school in the past academic term (with at least 10% of unexcused absences).\n* Capable of giving assent\n\nThe caregiver inclusion criteria\n\n* Age 18 or older\n* Self-identified as primary caregiver of the adolescent girl\n* Capable of providing informed consent.\n\nExclusion Criteria:\n\n\\- Participants that do not meet the criteria or exhibit a lack of understanding of the study procedures and hence not able to provide informed consent will be excluded.","11 Years",{"count":324,"type":22},1920,[25],"This study seeks to address the urgent need for theoretically and empirically informed interventions that would address the increasing numbers of unaccompanied minors migrating from rural to urban centers in developing countries for better economic opportunities. This process often results in hazardous child labor defined as work that is mentally, physically, socially or morally dangerous and harmful; interfering with schooling and health and mental health functioning, and leading to several other disproportionate risks. Unaccompanied migrant child laborers' vulnerability is further intensified by the lack of parental protection and community belonging in the host urban center. The International Labor Organization (ILO) estimates that 9.6% of children (ages 5 to 17) across the globe are child laborers and draws attention to migrant child laborers as an underreported and highly vulnerable group, a significant portion of which are female with no education. Poverty has been identified as the main driver of child labor, with family context also being a critical contributing factor. Sub-Saharan Africa (SSA) has the highest rates of child labor (24%), with Ghana -the focus of this study- registering one of the highest child labor prevalence at 22%, including unaccompanied child migrant laborers. In Ghana, unaccompanied adolescent girls migrate from the Northern region to urban centers in the south to work in the informal economy. Load carrying is the most common type of labor for this population and exposes migrant girls to multiple developmental and health risks. Building on the recently concluded R21 study (with 97 adolescent girls aged 11 to 14 years and their caregivers) that showed high feasibility and acceptability, and promising preliminary impact of the ANZANSI (resilience in Dagbani -local language) combination intervention in the same region, we propose to test its effectiveness in a larger two-arm cluster randomized clinical trial among 960 adolescent girls (age 11 to 14 years) at risk of school dropout nested within 32 public junior high schools in the Northern region of Ghana and their caregivers. The schools will be randomly assigned to one of two study conditions: 1) ANZANSI (FEE+MFG) and 2) bolstered usual care. The intervention will be delivered for 12 months, with assessments conducted at baseline and at 12-, 24-, and 36-month follow-ups post-intervention initiation. The study specific aims are: Aim 1: Examine the short- and medium-term impacts of ANZANSI intervention on the incidence of unaccompanied migration for child labor (primary outcome), and academic progress and psychosocial outcomes (secondary); Aim 2: Examine the impact of the ANZANSI intervention on potential mechanisms of change at the individual, family, and community levels; Aim 3: Evaluate the cost and cost-effectiveness of each intervention condition; and Aim 4: Qualitatively examine participants, facilitators, and school leadership's experiences with the intervention.",[328],"Unaccompanied Migration","2026-04-08",{"date":331,"type":37},"2026-04-13",{"date":333,"type":37},"2026-04-07",{"date":335,"type":22},"2030-08-15",{"name":43,"class":44},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":23,"phases":346,"briefSummary":347,"conditions":348,"keywords":352,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":359,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":105},"100566459","phase-2-supplemental-postoperative-bupivacaine-following-non-surgical-endodontic-treatment-100566459","NCT06655454","Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment","The Effects of Supplemental Postoperative 0.5% Bupivacaine With 1:200,000 Epinephrine Following Non-Surgical Endodontic Treatment on Patients' Quality of Life, Pain, and Analgesic Consumption","Inclusion Criteria:\n\n1. Medical ASA Class I or II\n2. Patients above 18 years old\n3. Patients with a blood pressure below 160\u002F100\n4. Patients who are treatment planned and have agreed to have emergency endodontic therapy or non-surgical root canal therapy with a pulpal diagnosis of symptomatic irreversible pulpitis according to the AAE Glossary of Endodontic Terms.\n5. Patients must be able to comprehend and complete all study protocols, written consent, and questionnaires in English.\n\nExclusion Criteria:\n\n1. Medical ASA III or above\n2. Patients who reported the use of tobacco or nicotine-containing products such as vapes, e-cigarettes, gums, or pouches and will not in the 48 hours following treatment\n3. Patients who reported the use of any marijuana products or illicit drugs in the 48 hours prior to treatment and will not in the next 48 hours.\n4. Patients who have taken opioids to control pain.\n5. Pregnant patients\n6. Patients with a blood pressure of 160\u002F100 or greater\n7. Patients with a known hypersensitivity or allergy to any local anesthetic agent of the amide group, or any other components of the two anesthetic solutions such as epinephrine, sodium metabisulfite used in the study.\n8. Patients who have more than one tooth with odontogenic pain at the time of the screening.\n9. Patients who are unable to consent and do not understand or are unable to read the questionnaires.\n10. Patients who have had 4 1.7 ml carpules or more of anesthetic (Lidocaine and\u002F or Septocaine, 1:100,000) during standard care of treatment.",{"count":345,"type":22},150,[166],"The study will investigate the impact of an additional injection of long-acting anesthetic on pain level, quality of life, and use of pain medication after a nonsurgical endodontic treatment. The long-acting anesthetic will be compared to a mock injection group and a group with no additional anesthetic to determine any differences in effects.",[349,350,351],"Pain Assessment","Quality of Life (QOL)","Analgesic Use",[353,354,355,356,357,358],"bupivacaine","nonsurgical endodontic treatment","root canal therapy","irreversible pulpitis","pain management","anesthetic use",{"date":331,"type":37},{"date":361,"type":37},"2024-11-01",{"date":363,"type":22},"2026-12-31",{"name":43,"class":44},{"id":366,"slug":367,"hasResults":12,"nctId":368,"briefTitle":369,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":23,"phases":373,"briefSummary":374,"conditions":375,"keywords":378,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":383,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":387,"locationsCount":105},"100562071","phase-4-using-multiphase-optimization-strategy-most-to-optimize-a-cost-effective-sustainable-and-scalable-smoking-cessation-package-for-smokers-in-hiv-clinical-care-100562071","NCT06598397","Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care","Inclusion Criteria:\n\n* Status as HIV+\n* Age 18 or older\n* Currently smokes ≥ 5 CPD, on average, in past month\n* Positive for salivary cotinine\n* Able to understand the nature of the study and the consenting process\n* Is engaged in HIV clinical care\n* Living in larger NYC metropolitan area currently and for the next 6-8 months\n\nExclusion Criteria:\n\n* Suffers from any medical condition or contraindication precluding use of nicotine replacement therapy\n* Current use of any tobacco cessation medications (varenicline, NRT patch, nicotine gum, lozenge, spray or inhaler, or bupropion)\n* Currently participating in a smoking cessation program\n* Pregnant or nursing and plans to be in next 6 months\n* Has schizophrenia\u002Fschizo-affective disorder\n* Does not have a functioning mobile phone that can receive text messages",{"count":372,"type":22},500,[279],"This study's long-term goal is to improve clinical outcomes among smokers living with HIV (SLWH) by providing smoking cessation interventions in HIV clinical care that will increase the chances of quitting smoking, limits costs and burden on staff and reach many smokers living with HIV.",[376,377],"Human Immunodeficiency Virus (HIV)","Smoking Cessation",[379,380,381,382],"MOST","multiphase optimization strategy","implementation","HIV clinical care",{"date":331,"type":37},{"date":385,"type":37},"2024-10-18",{"date":127,"type":22},{"name":43,"class":44},{"id":389,"slug":390,"hasResults":12,"nctId":391,"briefTitle":392,"officialTitle":393,"acronym":4,"eligibilityCriteria":394,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":395,"targetDuration":4,"studyType":23,"phases":397,"briefSummary":398,"conditions":399,"keywords":401,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":405,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":409,"locationsCount":105},"100498169","reducing-alcohol-exposed-pregnancies-100498169","NCT05766761","Reducing Alcohol Exposed Pregnancies","Designing a Hybrid Intervention Strategy to Reduce Alcohol Exposed Pregnancies","Inclusion Criteria:\n\n* 18 years and above\n* Gestational age is 28 weeks or less\n* Recent alcohol use as assessed by self-report of alcohol use in the previous 30 days\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Not pregnant or gestational age over 28 weeks\n* No recent alcohol use as assessed by self-report",{"count":396,"type":22},600,[25],"The goal of this clinical trial is to compare an active intervention versus a standard of care control in reducing alcohol use among pregnant women. The main questions it aims to answer are whether a motivational intervention can:\n\n1. increase the proportion of women detected with a laboratory-confirmed negative phosphatidylethanol (PEth) test during pregnancy, and\n2. reduce the proportion of adverse birth outcomes among infants. Participants will be offered (1) a self-paced computer-delivered alcohol reduction intervention to enhance knowledge, norms, and motivation for alcohol reduction and (2) a nurse-delivered component to reinforce the computer-delivered content and address women's questions. Both components are theory-driven, based on Motivational Enhancement Theory (MET), and use motivational strategies to promote alcohol reduction.",[400],"Alcohol Drinking",[402,403,404],"alcohol drinking in pregnancy","alcohol-exposed pregnancies","alcohol-related adverse birth outcomes",{"date":331,"type":37},{"date":407,"type":37},"2024-04-15",{"date":268,"type":22},{"name":43,"class":44},{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":417,"enrollmentInfo":418,"targetDuration":4,"studyType":23,"phases":420,"briefSummary":421,"conditions":422,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":105},"100602828","3mtm-filtektm-supreme-flowable-composites-for-class-iv-and-veneers-100602828","NCT07128589","3M(TM) Filtek(TM) Supreme Flowable Composites for Class IV and Veneers","Clinical Evaluation of 3M(TM) Filtek(TM) Supreme Flowable Composites for Class IV and Veneers","Inclusion Criteria:\n\n* Age between 18 -75 years old\n* must be willing and able to provide informed consent to participate in the study\n* must be available for the required post-operative follow-up study visits\n* must be in good general health\n* must be in good oral health hygiene (FMPS \\\u003C 20%)\n* have at least 6 anterior maxillary teeth\n* Central and lateral incisors with class IV or Veneer indications. Veneers will be performed exclusively with its contralateral teeth (pairs).\n\nExclusion Criteria:\n\n* Single tooth veneers\n* Canines\n* Periodontal disease\n* Pulpal diseases\n* Occlusal dysfunctions (end-to-end bite)\n* Lack of occlusal stability\n* Missing posterior teeth, affecting the occlusal distribution\n* Study tooth, adjacent tooth, or opposing tooth with mobility \\> grade 2 using the Miller's tooth mobility index\n* Systemic or local disorders that contra-indicate the dental procedures needed in this study\n* Rampant, uncontrolled caries\n* Heavy use of smoking tobacco (1 pack or equivalent a day) or chewing tobacco\n* Evidence of xerostomia\n* Evidence of severe bruxing or clenching, or in need of Temporomandibular Joint (TMJ) related therapy\n* Known allergic reaction and\u002For sensitivity to research materials being used\n* Condition or history of chronic use of anti-inflammatory, analgesic (pain), and\u002For mind altering drugs for medical (including psychiatric) and pharmacotherapeutic therapies that might alter the perception of pain\n* Tooth surface loss (attrition, erosion, abrasion, or abfraction) on study tooth or adjacent teeth that could impact the perception of pain.\n* Taking part in a clinical evaluation of any other dental material\n* In the opinion of the Investigator, unsuitable for enrollment in the study for reasons other than those specified in the above exclusion criteria\n* Pregnant at the time of enrollment or procedure visit (determined by urine pregnancy test).","75 Years",{"count":419,"type":22},75,[25],"This clinical study aims to evaluate the clinical performance of 3M™ Filtek™ Supreme Flowable Composite in class IV and veneer indication. Follow-ups of 7 days, 6, 12, and 24 months will be conducted following an Fédération Dentaire Internationale (FDI) modified score (2023). A minimum of 50 Class IV and 25 veneers will be included in the evaluation. Research data and pictures will be provided for each patient pre-op and at 7 days (baseline, 6 months, 12 months and 24 months. Evaluation will be conducted by two calibrated evaluators different from the operator according to FDI clinical criteria.",[423,424],"Dental Restoration","Dental Veneers","2026-02-26",{"date":427,"type":37},"2026-02-27",{"date":429,"type":37},"2025-08-07",{"date":431,"type":22},"2028-09",{"name":43,"class":44},{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":439,"eligibilityCriteria":440,"healthyVolunteers":12,"sex":17,"minAge":441,"maxAge":4,"enrollmentInfo":442,"targetDuration":4,"studyType":23,"phases":443,"briefSummary":444,"conditions":445,"keywords":448,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":4},"100598458","optimizing-online-purchasing-of-fruits-vegetables-and-legumes-for-low-income-families-100598458","NCT07071753","Optimizing Online Purchasing of Fruits, Vegetables, and Legumes for Low-Income Families","OPT-FRESH: Optimizing Online Purchasing of Fruits, Vegetables, and Legumes for Low-Income Families","OPT-FRESH","Inclusion Criteria:\n\n* Adult (\\> 21 years old)\n* Live in a household with a young child(ren) under the age of 10 years and above age 2.\n* Primary shopper for the household\n* Have access to a smartphone or computer to place online orders\n* Participation in the Supplemental Nutrition Assistance Program in the past year or income eligible (annual household income =\\\u003C 130% of the federal poverty line)\n* Agree to share itemized grocery receipts during the study (12 months)\n* Willing to order groceries online\n* English or Spanish speaker\n* Informed consent","2 Years",{"count":299,"type":22},[25],"Food insecurity, that is, the lack of consistent access to nutritious and affordable food, is associated with poor diet, increased cardiovascular disease (CVD) risk, and has a negative long-term impact on the economy through increased health care costs. CVDs and food insecurity disproportionately affect Black and Hispanic families, and most of these racial health disparities can be attributed to social determinants of health, including poor access to healthy foods. A recent policy in the U.S. authorized the Supplemental Nutrition Assistance Program (SNAP) benefits to be used online to increase grocery access and promote healthy eating. Although online grocery shopping has been growing among populations of low-income, the selection of fruits, vegetables, and legumes (FVL), which are protective against CVD, is lower than in-store. Distrust of online hired shoppers' choices, fear of losing money on unsatisfactory purchases, and impulse of unhealthy food purchases have been the major barriers to online healthy food selection. Thus, there is a need for intervention packages that are effective, economical, and easily scalable into policies that address CVD-related outcomes and improve health equity. The proposed work will use a highly efficient methodological approach, the Multiphase Optimization Strategy (MOST), to test three experimental components aimed at barriers to online healthy food selection, called OPT-FRESH. This approach addresses weaknesses in prior studies, which cannot determine which elements of multicomponent interventions meaningfully improve outcomes. 360 families with children living in low-income urban communities of NYC will be randomized to receive some combination of the three experimental components for 12 weeks: 1) weekly text messages to improve the trust in online grocery services (off\u002Fon); 2) weekly match-up to $10 as a financial incentive for purchasing FVL online targeting loss aversion (off\u002Fon); 3) weekly instant shoppable grocery lists of culturally tailored meal suggestions using SNAP recipes targeted at impulse purchases (off\u002Fon). Delivery fee waiver and a tutorial video addressing digital literacy will be constant components to promote equity in participant enrollment. Aim 1 will determine the combination(s) of the three experimental components that improve overall household FVL purchase and food insecurity (primary outcomes) and FVL intake of children (secondary outcome). Aim 2 will identify the optimized intervention that balances component(s) that are affordable and scalable (high adoption, implementation, maintenance) that still produce meaningful effects on the outcomes, using decision analysis for intervention value efficiency. Aim 3 will determine the mechanistic effects of the three intervention components on the outcomes using factorial mediation analysis. Working with community-based organizations and nutrition and hunger relief programs in NYC, a grocery delivery service, and a team with unparalleled expertise in experimental trials, policy, and MOST, we will implement optimized, affordable, and scalable intervention strategies to improve neighborhood food access and ultimately CVD outcomes in socially vulnerable families.",[446,447],"Food Insecurity","Healthy Eating",[379,449,450,451],"Healthy eating","Online grocery purchase","SNAP",{"date":453,"type":37},"2026-03-02",{"date":455,"type":22},"2026-07-01",{"date":457,"type":22},"2029-12-30",{"name":43,"class":44},{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":463,"acronym":464,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":466,"targetDuration":4,"studyType":23,"phases":468,"briefSummary":469,"conditions":470,"keywords":474,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":105},"100627081","evidence-based-intervention-for-diabetes-prevention-100627081","NCT07443995","Evidence-based Intervention for Diabetes Prevention","EID","Inclusion Criteria:\n\n* Men and women 18 years or older\n* Diabetes risk score \\> 5\n* BMI \\>=25kg\u002Fm\\^2\n* Arabic or English speaking\n* Able to read and write in Arabic or English\n* Access to a smartphone\n* Provide informed consent\n\nExclusion Criteria:\n\n* Prevalent diabetes\n* Prior participation in a diabetes prevention program\n* Taking FDA-approved weight loss medications\n* Pregnant or lactating",{"count":467,"type":22},30,[25],"The goal of this behavioral intervention trial is to develop strategies to decrease the incidence of diabetes within the UAE. The investigators will investigate the effectiveness of a group-based telehealth intervention facilitated by a health coach in adults at risk for developing diabetes who live in the UAE.\n\nThe investigators will conduct a single-arm feasibility trial of the Evidence-based Intervention for Diabetes prevention among thirty adults with prediabetes. All participants will receive 12 weekly virtual intervention sessions over the course of three months, facilitated by a trained DPP lifestyle coach who is from the same cultural community and can deliver the material in either Arabic or English.\n\nThe primary feasibility measure is acceptability, as measured by intervention session attendance. Other outcome assessments will be conducted at baseline and three months at NYU Abu Dhabi, where study staff will assess weight, hemoglobin A1c, diet, and physical activity.",[471,472,473],"Pre-diabetes","Lifestyle Risk Reduction","Diet Prevention of Metabolic Diseases",[475,476,477,478],"pre-diabetes","behavioral intervention","diet","physical activity","2026-02-24",{"date":453,"type":37},{"date":482,"type":22},"2026-04",{"date":484,"type":22},"2027-08",{"name":43,"class":44},{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":17,"minAge":492,"maxAge":493,"enrollmentInfo":494,"targetDuration":4,"studyType":495,"phases":4,"briefSummary":496,"conditions":497,"keywords":499,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":507,"startDateStruct":509,"completionDateStruct":511,"leadSponsor":513,"locationsCount":105},"100591138","understanding-the-associations-between-romantic-relationship-conflict-psychophysiological-responding-and-alcohol-misuse-among-emerging-adults-100591138","NCT06976528","Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults","Inclusion Criteria:\n\n1. Age 21-29 years old\n2. Must be in a committed romantic relationship of at least 3 months duration\n3. Must report at least 2 HED episodes in the past 30 days (5 or more drinks within 2 hours for males, 4 or more drinks within 2 hours for females)\n4. Must self-report that they have - on at least three occasions during the past year - consumed a quantity of alcohol that is equal to or greater than the standard dose administered for their weight in the laboratory\n\nExclusion Criteria:\n\n1. Meeting DSM-5 criteria for a history of or current neurological, psychotic, or bipolar disorders\n2. History of self-reported head trauma requiring medical treatment\n3. Body weight exceeding 250 pounds\n4. Current enrollment in treatment or seeking treatment for a substance or alcohol use disorder\n5. Current suicidal or homicidal intent\n6. Serious cardiovascular health conditions (e.g. pacemaker, cardiac arrhythmia, hypertension) that may alter normative cardiac functioning\n7. Treatment on medications such as lithium, methadone, alpha or beta blockers or cholinergic\u002Fanticholinergic medications likely to confound normative cardiovascular responding or response to alcohol administration. Stimulant or benzodiazepine medication use is permissible provided participants do not take medication on the day of study participation\n8. Severe and\u002For unilateral physical IPV with your current partner at any time\n9. Sexual IPV with current partner at any time\n10. Fear of current partner\n11. Pregnancy or breastfeeding\n12. Severe Alcohol Use Disorder (as defined by the DSM-5)\n13. Current diagnosis of anorexia or bulimia","21 Years","29 Years",{"count":258,"type":22},"OBSERVATIONAL","Emerging Adults (EA) engage in heavy episodic drinking (HED) at a greater quantity and frequency than any other time in their lives, which may lead to significant short- and long-term consequences. Although much is known about the influence of peers in EA alcohol use, there is a dearth of research examining the ways in which romantic partners influence EA drinking behaviors. The proposed study bridges a crucial gap in the existing literature by examining behavioral and physiological risk and resilience factors in the acute link between EA relationship conflict and alcohol consumption. EA couples will engage in two conflict resolution tasks interspersed with two puzzle tasks and two alcohol administration procedures. Because high frequency heart rate variability (HF-HRV) is associated with alcohol use and emotion regulation during stressful experiences, HF-HRV and other physiological data will be collected throughout the laboratory procedures.",[498],"Heavy Episodic Drinking",[500,501,502,503,504,505],"couples","emerging adults","young adults","binge drinking","alcohol use","conflict","2026-02-18",{"date":508,"type":37},"2026-02-20",{"date":510,"type":37},"2025-09-26",{"date":512,"type":22},"2028-07-31",{"name":43,"class":44},{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":84,"sex":17,"minAge":52,"maxAge":520,"enrollmentInfo":521,"targetDuration":4,"studyType":23,"phases":523,"briefSummary":524,"conditions":525,"keywords":531,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":541,"completionDateStruct":543,"leadSponsor":545,"locationsCount":105},"100615517","identifying-the-neural-correlates-of-mental-simulation-in-multi-step-planning-100615517","NCT07293637","Identifying the Neural Correlates of Mental Simulation in Multi-Step Planning","Inclusion Criteria:\n\n* N\u002FA\n\nExclusion Criteria:\n\n* History of neurological or psychiatric illness\n* Vulnerable populations","64 Years",{"count":522,"type":22},50,[25],"Planning is the ability to think ahead by considering possible future actions and their consequences. This research study aims to understand how the brain supports multi-step planning by testing whether people simulate promising future move sequences while deciding what to do next. Healthy adult volunteers will learn and play a strategy game called \"Four-in-a-Row\" (similar to Connect Four). Participants will complete two sessions on successive days: an online behavioral training\u002Fplaying session and an in-person brain-recording session at New York University. During the brain-recording session, participants will view mid-game board positions and choose the best move while the study team records brain activity (using magnetoencephalography \\[MEG\\] or functional MRI \\[fMRI\\]) and eye movements. Data from the game and eye tracking will also be used to fit computational models of planning that help interpret the neural measurements.",[526,527,528,529,530],"Decision Making","Cognition","Mental Simulation","Problem Solving","Planning",[532,530,533,534,535,536,537],"Four-in-a-Row","Tree search","Computational modeling","Eye tracking","MEG","fMRI","2026-01-07",{"date":540,"type":37},"2026-01-08",{"date":542,"type":37},"2025-07-10",{"date":544,"type":22},"2026-12",{"name":43,"class":44},{"id":547,"slug":548,"hasResults":12,"nctId":549,"briefTitle":550,"officialTitle":550,"acronym":4,"eligibilityCriteria":551,"healthyVolunteers":84,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":552,"targetDuration":4,"studyType":23,"phases":554,"briefSummary":555,"conditions":556,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":565,"locationsCount":105},"100600293","defining-trpv4-contribution-of-schwann-cells-to-oral-cancer-pain-100600293","NCT07095608","Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain","Inclusion Criteria:\n\nFor healthy subjects to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Provide signed and dated informed consent form\n* Willing to comply with all study procedures and be available for the duration of the study\n* Male or female, at least 18 years of age\n* In good general health as evidenced by medical history\n\nFor oral cancer patients to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Provide signed and dated informed consent form\n* Willing to comply with all study procedures and be available for the duration of the study\n* Male or female, at least 18 years of age\n* Biopsy-proven squamous cell carcinoma (SCC) of the oral cavity that requires surgical resection\n* Lesion is at least 1 cm in greatest surface dimension\n\nExclusion Criteria:\n\n* Healthy subjects who meet any of the following criteria will be excluded from participation in this study:\n\n  * Clinically and\u002For histologically proven oral pre-cancer, oral cancer\n  * Pregnancy or lactation (Female subjects of child-bearing potential will have a rapid urine pregnancy test)\n  * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.\n\nOral cancer patients who meet any of the following criteria will be excluded from participation in this study:\n\n* History of prior surgical, chemotherapeutic, or radiation treatment for head and neck cancer\n* Pregnancy or lactation\n* Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.\n\nFor participants with impaired kidney function (chronic kidney\u002Frenal disease) who wish to participate in the proposed research study, consultation with their primary care provider will be done prior to enrollment to determine safety",{"count":553,"type":22},80,[25],"This is a prospective study involving human participants. Pressure and stretch sensitivity measures between oral cancer patients and healthy subjects will be compared. Pain stimulation will be conducted on the site of the cancer in 40 oral cancer patients, and on the tongue in 40 healthy volunteers, using pressure and stretch sensitivity tests.",[557,558],"Oral Cancer","Squamous Cell Carcinoma","2025-11-20",{"date":561,"type":37},"2025-11-21",{"date":563,"type":37},"2025-09-01",{"date":457,"type":22},{"name":43,"class":44},{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":571,"acronym":572,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":17,"minAge":574,"maxAge":575,"enrollmentInfo":576,"targetDuration":4,"studyType":23,"phases":578,"briefSummary":579,"conditions":580,"keywords":582,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":590,"lastUpdatePostDateStruct":591,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":105},"100602718","music-listening-for-mental-health-recovery-after-stroke-100602718","NCT07127159","Music Listening for Mental Health Recovery After Stroke","Feasibility of a Music Listening Intervention for Mental Health Recovery in Chronic Stroke","IML","Inclusion Criteria:\n\n* Participants aged 50 to 90\n* Confirmed diagnosis of ischemic or hemorrhagic stroke occurring at least six months prior to enrollment.\n\nExclusion Criteria:\n\n* Significant hearing loss, defined by a score \\>26 on the Hearing Handicap Inventory for the Elderly Screening (HHIE-S; Ventry and Weinstein, 1982)\n* Contraindications for MRI\n* Significant cognitive impairment, defined as a Montreal Cognitive Assessment (MoCA; Nasreddine et al., 2005) score below 22 (unless the lower score is attributable to expressive aphasia)\n* Specific musical anhedonia, defined as a score below 60 on the Barcelona Music Reward Questionnaire (BMRQ; Mas-Herrero et al., 2013)\n* Amusia, defined as a score below 70% on the Montreal Battery of Evaluation of Amusia (MBEA; Peretz et al., 2003).\n* Participants will not be excluded if currently taking medications that may affect brain function (e.g., antidepressants) or if engaged in other complementary therapies (e.g., mindfulness, yoga). Participants will be allowed to initiate new medications or therapies during the study period.","50 Years","90 Years",{"count":577,"type":22},60,[25],"This study aims to explore whether listening to music intentionally can support the mental health of people recovering from a stroke. The question the investigators aim to answer is: Can intentional music listening improve emotional well-being in stroke survivors? And if so, what kinds of changes might music listening induce in mental health, thinking and memory (cognition), and brain activity? Participants will be randomly assigned to listen to either music or an audiobook for one hour each day, at home, for four weeks. Participants will also attend four in-person sessions with the researchers: at the start of the study (baseline), just before the listening period begins, after the four weeks are complete, and at a follow-up. During these visits, researchers will gather information about participants' mood and mental health (via questionnaires), assess memory and attention (via cognitive tasks), and use MRI scans to look at brain activity.",[581],"Stroke",[583,584,585,586,587,588,589],"intentional music listening","music intervention","stroke","mental health","stroke recovery","music therapy","emotional well-being","2025-09-23",{"date":592,"type":37},"2025-09-25",{"date":594,"type":37},"2025-07-01",{"date":596,"type":22},"2026-09-30",{"name":43,"class":44},{"id":599,"slug":600,"hasResults":12,"nctId":601,"briefTitle":602,"officialTitle":603,"acronym":604,"eligibilityCriteria":605,"healthyVolunteers":84,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":606,"targetDuration":4,"studyType":23,"phases":608,"briefSummary":609,"conditions":610,"keywords":612,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":619,"completionDateStruct":621,"leadSponsor":622,"locationsCount":105},"100606961","designing-care-management-for-hospice-transitions-for-persons-living-with-advanced-dementia-100606961","NCT07182357","Designing Care Management for Hospice Transitions for Persons Living With Advanced Dementia","ENGAGE-D: Designing Care Management for Hospice Transitions for Persons Living With Advanced Dementia","ENGAGE-D","Inclusion:\n\nCare Partners and PLWD Dyad:\n\n1. Care partners of PLWD who have a diagnosis of moderate to severe dementia.\n2. Able to provide informed consent\n\nHHC Professionals:\n\nCare Managers and Field Nurses:\n\n1. Care managers who regularly engage hospice transitions with care partners of PLWD\n2. Age 18 or older\n\nMedical Providers:\n\n1. Medical providers (e.g., physicians and nurse practitioners) who refer patients for hospice enrollment.\n2. Age 18 or older\n\nHHC Administrators:\n\n1. Home healthcare administrators who work with the Certified Home Health Agency or the Advanced Illness Management Program that refers patients to hospice care\n2. Age 18 or older\n\nExclusion\n\nCare Partner and PLWD Dyad\n\n1. Under age 18\n2. Care partners who are caring for PLWD with Mild Cognitive Impairment\n3. PLWD with Mild Cognitive Impairment\n\nHHC Professionals: Care Managers, Medical Providers, Administrators\n\n1\\. Do not have experience managing hospice transitions for PLWD",{"count":607,"type":22},96,[25],"This study will test a care management intervention to guide end-of-life care and hospice transitions for persons with dementia and their care partners receiving home healthcare and ascertain feasibility, acceptability, fidelity, and usability of a dementia care management hospice transitions checklist. This study will also examine hospice enrollment, time to enrollment, and care partner satisfaction with the intervention. The intervention will be delivered within usual care management within a large home healthcare agency.",[611],"Alzheimer Disease and Related Dementias",[613,614,615],"hospice care","care transitions","Alzheimer's disease and related dementias","2025-09-11",{"date":618,"type":37},"2025-09-19",{"date":620,"type":22},"2025-10",{"date":512,"type":22},{"name":43,"class":44},{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":628,"acronym":629,"eligibilityCriteria":630,"healthyVolunteers":12,"sex":51,"minAge":161,"maxAge":162,"enrollmentInfo":631,"targetDuration":4,"studyType":23,"phases":632,"briefSummary":633,"conditions":634,"keywords":635,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":641,"leadSponsor":643,"locationsCount":75},"100555833","phase-2-visual-acoustic-intervention-with-service-delivery-in-person-and-via-telepractice-trial-100555833","NCT06517225","Visual-acoustic Intervention With Service Delivery In-person and Via Telepractice Trial","Visual-acoustic Intervention With Service Delivery In-person and Via Telepractice (VISIT) Non-Inferiority Trial","VISIT","Inclusion Criteria:\n\n* Must be between 9;0 and 17;11 (years;months) old at the time of enrollment.\n* Must speak English as the dominant or equally dominant language\n* Must have begun learning English by age 3, per parent report.\n* Must hear a rhotic dialect of English from at least one speaker in the home if the home language is English.\n* Must pass a pure-tone hearing screening.\n* Must pass a brief examination of oral structure and function.\n* Must exhibit less than thirty percent accuracy, based on trained listener ratings, on a probe list eliciting \u002Fr\u002F in various phonetic contexts at the word level.\n* Must demonstrate age-appropriate receptive and expressive language abilities on the Clinical Evaluation of Language Fundamentals-5 (CELF-5).\n* Must have access to a laptop or desktop computer for study sessions in the event of randomization to the telepractice condition.\n* Must have home wifi sufficient to support video calls in the event of randomization to the telepractice condition.\n\nExclusion Criteria:\n\n* Must not exhibit voice or fluency disorder of a severity judged likely to interfere with the ability to participate in study activities.\n* Must not currently have orthodontia that crosses the palate and cannot be removed.\n* Must not have history of permanent hearing loss.\n* Must not have an existing diagnosis of developmental disability such as cerebral palsy or Down Syndrome.\n* Must not have history of major brain injury, surgery, or stroke in the past year.\n* Must not have epilepsy with active seizure incidents with in the past 6 months.\n* Must not show clinically significant signs of apraxia of speech or dysarthria.",{"count":164,"type":22},[166],"Children with speech sound disorder show diminished intelligibility in spoken communication and may thus be perceived as less capable than peers, with negative consequences for both socioemotional and socioeconomic outcomes. New technologies have the potential to transform interventions for speech sound disorder, but there is a lack of rigorous evidence to substantiate this promise. This research will meet a public health need by systematically evaluating the efficacy of visual-acoustic biofeedback intervention delivered in-person versus via telepractice.\n\nThe objective of this study is to test the hypothesis that treatment incorporating visual-acoustic biofeedback can be delivered via telepractice without a significant loss of efficacy. Participants will be randomly assigned to receive identical treatment either via online telepractice or in the laboratory setting. The same software for visual-acoustic biofeedback, staRt, will be used in both conditions. Participants' progress in treatment will be evaluated based on blinded listeners' perceptual ratings of probes produced before and after treatment. Pre and post treatment evaluations will be carried out in person for all participants.",[169],[171,172,636],"motor development","2025-06-23",{"date":639,"type":37},"2025-06-25",{"date":197,"type":37},{"date":642,"type":22},"2028-12-31",{"name":43,"class":44},""]