[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Nguyen Dang Thu\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":108},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100617055","eit-guided-peep-optimization-in-trauma-and-postoperative-ards-100617055",false,"NCT07313644","EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS","Electrical Impedance Tomography-Guided Positive End-Expiratory Pressure Optimization in Patients With Trauma-Related and Postoperative Acute Respiratory Distress Syndrome","EIT-PEEP-SURG","Inclusion Criteria:\n\n* Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>90 years.\n* Severe acute brain injury or acute stroke with Glasgow Coma Scale \\\u003C8.\n* Thoracic trauma with pneumothorax or pneumomediastinum.\n* End-stage diseases under palliative care (e.g., metastatic cancer, cirrhosis, end-stage renal disease).\n* Severe multiorgan failure with expected survival \\\u003C7 days.\n* Conditions requiring prolonged mechanical ventilation (e.g., Guillain-Barré syndrome, cervical spinal cord injury).\n* Contraindications to hypercapnia (e.g., elevated intracranial pressure, acute coronary syndrome).\n* Prior use of advanced respiratory therapies (e.g., ECMO, inhaled nitric oxide, prone positioning, high-frequency ventilation).\n* Pregnancy, breastfeeding, or skin lesions at electrode placement sites.\n* Implanted electrical devices interfering with EIT (e.g., pacemaker, ICD).\n* Known allergy to electrode materials.\n* Refusal to participate or concurrent enrollment in another study","ALL","18 Years","90 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery. Mechanical ventilation is essential for supportive care in this population, but may aggravate lung injury when suboptimal ventilatory settings are applied. Positive end-expiratory pressure (PEEP) is crucial for maintaining alveolar recruitment; however, optimal PEEP selection in trauma- or postoperative-associated ARDS remains uncertain. Electrical impedance tomography (EIT) enables bedside, real-time assessment of regional ventilation and may support optimal PEEP titration by balancing alveolar overdistension and collapse. This study compares EIT-guided PEEP optimization with the conventional low FiO₂-PEEP strategy in terms of oxygenation and respiratory mechanics in patients with moderate to severe ARDS following trauma or surgery.",[28,29,30,31],"Acute Respiratory Syndrome Distress","Positive End-Expiratory Pressure","Electrical Impedance Tomography","Trauma and Postoperative Pulmonary Insufficiency",[33,29,34,35,36,37],"Acute respiratory syndrome distress","electrical impedance tomography","Trauma and Postoperative","blood oxygenation","pulmonary mechanics","RECRUITING","2025-12-17",{"date":41,"type":42},"2026-01-02","ACTUAL",{"date":44,"type":42},"2025-03-15",{"date":46,"type":22},"2026-12-15",{"name":48,"class":49},"Nguyen Dang Thu","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":70,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":50},"100583690","high-flow-nasal-oxygen-for-preoxygenation-in-emergency-surgery-patients-with-full-stomachs-100583690","NCT06879600","High-Flow Nasal Oxygen for Preoxygenation in Emergency Surgery Patients With Full Stomachs","Research on Pre-Anesthetic Blood Oxygenation Effect of High-Flow Nasal Oxygen for Emergency Surgery Patients With Full Stomachs","HFNC","Inclusion Criteria:\n\n* Emergency surgical patients at risk of gastric fullness requiring endotracheal intubation.\n* Patients aged 18 years or older.\n* Health status classified as ASA I or II.\n* Mallampati classification I or II.\n\nExclusion Criteria:\n\n* Patients with a predicted difficult airway, facial deformities, or an inability to achieve a proper mask seal.\n* Patients with respiratory diseases.\n* Pregnant patients.\n* Patients allergic to anesthesia or resuscitation drugs.\n* Patients who do not consent to participate in the study.",{"count":60,"type":22},200,[25],"Patients with full stomachs face a high risk of regurgitation and aspiration under general anesthesia. To minimize the time between the loss of airway protective reflexes and successful tracheal intubation, rapid sequence induction intubation is commonly used. However, these patients are particularly vulnerable to hypoxemia during anesthesia induction, especially in emergency cases. Pre-oxygenation before induction is crucial for ensuring patient safety during apnea.\n\nHigh-flow nasal oxygen (HFNO) therapy, which consists of an air\u002Foxygen blender, an active humidifier, and a single heated circuit, has recently gained widespread use in intensive care units (ICUs) for managing hypoxemic respiratory failure. HFNC can deliver a constant fraction of inspired oxygen (FiO₂) from 0.21 to 1.0 at high flow rates (up to 60 L\u002Fmin or higher). Its advantages include generating continuous positive airway pressure, reducing anatomical dead space, improving ventilation-perfusion matching, enhancing mucociliary clearance, and decreasing the work of breathing.\n\nGiven these benefits, HFNO has the potential to improve pre-oxygenation before and during anesthesia induction in emergency surgery patients with full stomachs.",[64,65,66,67,68,69],"High-flow Nasal Cannula","Oxygenation","General Anesthesia","Induction Anesthesia","Emergency Surgery Patients","Full Stomach",[71,72,73,68,74],"High-flow nasal cannula","oxygenation","Induction anesthesia","full stomach","2025-03-10",{"date":77,"type":42},"2025-03-17",{"date":79,"type":42},"2023-07-19",{"date":81,"type":22},"2026-12-31",{"name":48,"class":49},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":50},"100581479","recruitment-maneuvers-and-peep-guided-electrical-impedance-tomography-for-abdominal-laparoscopic-surgery-patients-100581479","NCT06850844","Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients","Impact of Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography on Regional Ventilation, Gas Exchange, and Pulmonary Mechanics in in Abdominal Laparoscopic Surgery Patients","PEEP-EIT","Inclusion Criteria:\n\n* Age \\> 18 years\n* Scheduled for abdominal laparoscopy surgery\n* At increased (i.e., intermediate or high) risk of postoperative pulmonary complications according to the \"Assess Respiratory Risk in Surgical Patients in Catalonia\" (ARISCAT) score (≥ 26 points)\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Major previous lung surgery (e.g., lung resection)\n* Severe chronic obstructive pulmonary disease and\u002For severe emphysema\n* Increased intracranial pressure\n* Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application)\n* Presence of pneumothorax that is either undrained or newly occurred.\n* Unstable hemodynamics with a mean arterial pressure \\\u003C 60 mmHg and unresponsive to resuscitation measures, and\u002For heart rate \\\u003C 60 bpm.\n* Pregnancy.\n* Severe neuromuscular disease.",{"count":92,"type":22},70,[25],"Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays. However, the use of intraoperative pneumoperitoneum and general anesthesia with mechanical ventilation may lead to postoperative pulmonary complications, such as atelectasis. This condition can result in diminished respiratory mechanics and impaired gas exchange.\n\nIn recent years, intraoperative lung-protective mechanical ventilation techniques, including recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) strategies, have gained popularity. These approaches aim to prevent the repeated collapse and reopening of alveoli, thereby reducing the risk of atelectasis. Nonetheless, determining the optimal PEEP level for individual patients remains a complicated and unresolved issue.\n\nElectrical impedance tomography (EIT) is a bedside imaging technique that assesses regional ventilation distribution, providing a method for personalizing PEEP settings in mechanically ventilated patients. By addressing the competing risks of alveolar overdistension and collapse, EIT enhances the precision of PEEP titration.\n\nThis study aims to compare the effects of recruitment maneuvers and EIT-guided PEEP selection against conventional ventilation on regional ventilation, gas exchange, and pulmonary mechanics in patients undergoing abdominal laparoscopic surgery.",[96,29,30],"Laparoscopic Surgery",[96,29,98,34,36,99,37],"Recruitment Maneuver","regional ventilation","2025-02-23",{"date":102,"type":42},"2025-02-27",{"date":104,"type":42},"2024-08-01",{"date":106,"type":22},"2025-12-30",{"name":48,"class":49},""]