[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Nordsjaellands Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":598},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,46,75,106,135,163,186,211,238,269,292,322,343,383,415,434,467,489,515,546,573],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100640624","outpatient-rehabilitation-programmes-for-myocardial-ischemia-heart-failure-and-copd-satisfaction-participation-test-outcomes-and-factors-associated-with-positive-changes-in-test-results-as-well-as-level-of-participation-100640624",false,"NCT07591792","Outpatient Rehabilitation Programmes for Myocardial Ischemia, Heart Failure, and COPD: Satisfaction, Participation, Test Outcomes, and Factors Associated With Positive Changes in Test Results as Well as Level of Participation","Inclusion Criteria:\n\n* Patients from North Zealand Hospital (Hillerød and Frederikssund) referred with a rehabilitation plan for group-based rehabilitation for myocardial ischemia, heart failure, or COPD at North Zealand Hospital\n* Patient consent to participate in the project\n\nExclusion Criteria:\n\n* None","ALL","18 Years",{"count":18,"type":19},840,"ESTIMATED","26 Weeks","OBSERVATIONAL","Aim The aim of this project is to investigate the level of participation, satisfaction, changes in tests, and factors associated with these results in existing rehabilitation programmes at North Zealand Hospital and in the surrounding municipalities among patients with heart diseases and the lung disease chronic obstructive pulmonary disease (COPD). The project is conducted in clinical practice in a non-selected population.\n\nParticipants Individuals with heart disease and COPD who commence training at North Zealand Hospital. Up to 840 participants may be included over a two-year period. Participants will be recruited at the start of training at North Zealand Hospital.\n\nInclusion criteria:\n\nPatients from North Zealand Hospital (Hillerød and Frederikssund) referred with a rehabilitation plan for group-based rehabilitation for heart disease or COPD at North Zealand Hospital Patient consent to participate in the project. There are no exclusion criteria for the project.\n\nIntervention Participants will be invited to participate in the project when enrolling in the already existing group-based training programme lasting 6-10 weeks as part of rehabilitation for heart disease and COPD.\n\nData\n\nParticipation:\n\nNumber of patients commencing the training period relative to the number of patients referred from the cardiology department\n\nAttendance:\n\nNumber of completed training sessions relative to the total number of possible training sessions during the periods at the hospital and in the municipalities\n\nDropout:\n\nDropout during the hospital-based and municipality-based periods and reasons for dropout The data listed below will, as far as possible, be collected before and after the training period. Physical activity (the final variable) will additionally be measured three months after completion of the municipal programme.\n\n30-second sit-to-stand test\\* Six-minute walk test\\* Quality of life measured using the CAT questionnaire for COPD and EQ-5D for the two groups of patients with heart disease Musculoskeletal pain measured using a questionnaire with the Numeric Rating Scale for five body regions Physical activity measured using a modified version of the IPAQ questionnaire from the Danish Health and Morbidity Surveys\n\n\\*These tests are standard and implemented in the existing rehabilitation programmes.\n\nOther Data\n\nAdditional data will include:\n\nFrom questionnaire: educational level and BMI (height and weight) From patient records: age, sex, treatment for heart disease, and extent of other chronic diseases Data from patient records are already collected as part of routine clinical practice independently of this project.\n\nEthics Participants will be invited to the study with written and oral information. Participation will take place after informed consent. The study will be conducted in accordance with the regulations of the Scientific Ethical Committee, to which it will be submitted as soon as possible, and it will be reported in the Capital Region of Denmark's legal system via PRIVACY. The study will be registered in the project database www.clinicaltrials.gov. Data will be stored in the REDCap database system.\n\nDissemination of Results Results will be presented at local and regional meetings and symposia and published in international peer-reviewed scientific journals indexed in PubMed.",[24,25],"Heart Disease","COPD",[27,25,28,29,30,31,32,33],"heart disease","Exercise training","Physical activity","Physical function","Quality of life","Muscoloskeletal pain","Adherence","NOT_YET_RECRUITING","2026-05-15",{"date":37,"type":38},"2026-05-19","ACTUAL",{"date":40,"type":19},"2026-08-01",{"date":42,"type":19},"2029-06-30",{"name":44,"class":45},"Nordsjaellands Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":16,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100605821","continuous-remote-vital-sign-monitoring-during-labour-analgesia-with-remifentanil-100605821","NCT07167498","Continuous Remote Vital Sign Monitoring During Labour Analgesia With Remifentanil","Continuous Remote Vital Sign Monitoring During Labour Analgesia With Remifentanil - a Prospective Observational Study","Inclusion criteria:\n\n* Minimum 18 years of age\n* Able to provide written informed consent\n* Giving birth to a singleton, cephalic presenting, expected healthy child, gestational age \\> 37 weeks.\n* In active labour\n\nExclusion criteria\n\n* Respiratory or cardiac disease\n* BMI ≥ 40 Other opioids within the last 4 hours.",true,"FEMALE","50 Years",{"count":57,"type":19},80,"Continuous remote vital sign monitoring during labour analgesia with remifentanil - a prospective observational study\n\nRemifentanil PCA represents a well-tolerated, effective and valuable option for labour analgesia, yet its wider implementation is still limited by concerns of opioid side-effects particularly the risk of respiratory depression leading to desaturation, potentially affecting the foetus. Thus, continuous one-to-one observation and monitoring in the delivery room, with the midwife unable to leave the patient unattended, is recommended. Such constant one-to-one monitoring may be challenging in present health-care settings where staffing constraints may limit the implementation of remifentanil as routine obstetric care.\n\nContinuous remote vital sign monitoring to display oxygen saturation (SpO₂), respiratory rate, and heart rate on a handheld device (smartphone), has the potential to address this barrier by allowing the midwife to leave the labour room for short, predefined intervals while maintaining continuous surveillance of maternal vital signs. Such an approach could free staff resources without compromising patient safety. While centralised foetal monitoring (CTG) is standard practice in many units, the application of continuous remote vital sign monitoring for women receiving remifentanil during labour has, to our knowledge, never been formally studied.\n\nObjectives The aim is to study whether remote monitoring during remifentanil patient-controlled analgesia (PCA) for labour affects the incidence of maternal desaturation and other safety outcomes (bradypnoea, bradycardia, and neonatal outcomes, assessed via Apgar scores and umbilical cord pH.) The study will be conducted in a setting where remifentanil PCA is administered for labour analgesia and the midwife is permitted to leave the labour room for intervals of up to 10 minutes while the woman is remotely monitored using a handheld device carried by the midwife. Predefined criteria for when the woman must be accompanied (e.g., if SpO₂ \\\u003C 94%, supplemental oxygen \\>2L\u002Fmin., or decreased consciousness). Outcomes in this group will be compared with a control group where the midwife remains continuously present in the labour room.",[60],"Labor Pain",[62,63,64,65],"remifentanil","labour analgesia","remote monitoring","safety","2026-04-06",{"date":68,"type":38},"2026-04-08",{"date":70,"type":19},"2026-11-01",{"date":72,"type":19},"2028-06-30",{"name":44,"class":45},1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":74},"100603453","phase-4-does-semaglutide-improve-depressive-symptoms-in-patients-with-major-depressive-disorder-and-overweight-or-obesity-100603453","NCT07136714","Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity","Is the GLP-1 Receptor Agonist Semaglutide Able to Alleviate Mood in Patients With Major Depressive Disorder and Overweight or Obesity","SEMAMOOD","Inclusion Criteria:\n\n1. Informed oral and written consent.\n2. Diagnosed with unipolar disorder according to the criteria of ICD10 (International Classification of Diseases, World Health Organization (WHO)) or the DSM-V (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the American Psychiatric Association\n3. Hamilton Depression Rating Scale, 17-items (HDRS-17)47 score ≥14,\n4. Age 18 years to 65 years (both included)\n5. Body mass index (BMI) ≥27 kg\u002Fm2\n6. Able to speak and understand Danish\n\nExclusion Criteria:\n\n1. Any significant medical disorder or conditions that contraindicate the investigational drug, e.g., pregnancy, presence of known allergy GLP-1 receptor agonists, severe neurological disorder, on-going drug, or alcohol abuse\n2. Coercive measures\n3. Females of childbearing potential who are pregnant, breast-feeding or have the intention of becoming pregnant within the next 9 months (26 weeks plus two months after discontinuation of semaglutide), or are not using contraceptives (during the whole study period) considered as highly effective (combined (oestrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, transdermal), progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, implantable) intrauterine device - IUD, IUS, bilateral tubal occlusion, vasectomised partner, sexual abstinence)\n4. Patients treated with corticosteroids or other hormone therapy (except oestrogens).\n5. Any active substance abuse or dependence (except for nicotine)\n6. Impaired hepatic function (plasma liver transaminases \\>2 times upper normal limit).\n7. Impaired renal function (serum creatinine \\>150 μmol\u002Fl)\n8. Cardiac problems defined as decompensated heart failure (NYHA class III\u002FIV), unstable angina pectoris, and\u002For myocardial infarction within the last 12 months\n9. Hypertension with systolic blood pressure \\>180 mmHg or diastolic blood pressure \\>100 mmHg\n10. Impaired pancreatic function (acute or chronic pancreatitis and\u002For plasma amylase \\>2 times upper normal limit). Receiving any experimental or pre-marketing drug within the last 3 months\n11. Use of diabetes medication or weight-lowering pharmacotherapy e.g. semagultid within the preceding 3 months\n12. Known type 1 and 2 diabetes or HbA1c\\>48mmol\u002Fl\n13. Suicidal behaviour as judged by the investigator and based on clinical evaluation. At all contact with patient attendance (please see Table 1) possible suicidality will be evaluatedaccording to the guidelines. If the patient is evaluated as suicidal, the person will be excluded from the study and evaluated by a senior consultant in psychiatry, who will take further action.\n14. Any condition that the investigator feels would interfere with trial participation.","65 Years",{"count":85,"type":19},116,"INTERVENTIONAL",[88],"PHASE4","This 26-week long, double-blinded randomized clinical trial aims to investigate the effects of semaglutide once-weekly vs. placebo on depressive symptoms in 116 patients with Major Depressive Disorder (MDD) and co-existing overweight or obesity. The treatment will be an add-on treatment to the patient's usual medication. The investigators hypothesize that adjunctive treatment with semaglutide, will lead to a significant improvement in mood compared to placebo in patients with MDD and overweight or obesity.\n\nThe primary endpoint is the change in depressive symptoms measured as difference in the 12-item self-report mood questionnaire Major Depression Inventory (MDI) from start to follow-up after 26 weeks. The MDI measures the extent to which symptoms of depression have been present in the past two weeks.",[91],"Major Depressive Disorder",[93,94,95,96],"GLP-1","Glucagon-like peptide 1","Semaglutide","Depression","RECRUITING","2026-02-04",{"date":100,"type":38},"2026-02-06",{"date":102,"type":38},"2025-09-11",{"date":104,"type":19},"2027-09",{"name":44,"class":45},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":86,"phases":115,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":74},"100622611","performance-of-a-novel-concept-for-internal-fixation-of-a-novel-peripheral-nerve-block-catheter-100622611","NCT07385872","Performance of a Novel Concept for Internal Fixation of a Novel Peripheral Nerve Block Catheter","Feasibility and Performance of a Novel Concept for Internal Fixation of a Peripheral Nerve Block Catheter in Patients Undergoing Femoral Amputation","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective transfemoral amputation\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics",{"count":114,"type":19},15,[116],"NA","The goal of this study is to test a new type of nerve block catheter (a thin, flexible tube used to deliver pain medication). Researchers want to see if this new design stays in its original position better than current catheters and if it is easy for doctors to use.\n\nThe main questions the study aims to answer are:\n\nDoes the catheter tip stay in the correct position over time without moving or slipping (dislocation)?\n\nCan the catheter be placed quickly and accurately using the new deployment system?\n\nResearchers will test this prototype in a small group of participants. There is no comparison group for this initial study.\n\nParticipants will:\n\nHave the catheter placed near a nerve in their leg a few days before a scheduled femoral (leg) amputation.\n\nUndergo imaging or checks to see if the catheter has moved.\n\nHave the catheter removed just before their scheduled surgery.\n\nThe catheter will be placed in an area of the leg that is already scheduled to be removed during surgery. This ensures that the study carries minimal risk to the participants.",[119,120,121],"Primary Condition: Nerve Block","Secondary Condition: Catheter Displacement","Focus of Study: Sciatic Nerve",[123,124,125,126,127],"Sciatic Nerve Block","Peripheral Nerve Catheter","Catheter Migration","Internal Fixation Device","Proof-of-Concept Study","2026-02-03",{"date":98,"type":38},{"date":131,"type":19},"2026-02",{"date":133,"type":19},"2026-11",{"name":44,"class":45},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":162},"100611238","colorectal-omics-and-ofcs-proteoglycans-coco-in-screening-and-a-diagnostic-pathway-100611238","NCT07237984","Colorectal Omics and ofCS Proteoglycans (COCO) in Screening and a Diagnostic Pathway","Colorectal OmiCs and Oncofetal Chondroitin Sulfate-modified Proteoglycans in Screening and Colorectal Cancer Diagnostic Pathway","COCO-S","Inclusion Criteria:\n\n* Patients planned to undergo a colonoscopy either as part of the colorectal cancer screening programme due to a positive FIT or within a 'cancer patient pathway' for CRC at one of the study sites.\n* Able to speak Danish, English, or other languages with sufficient interpretation provided by relatives.\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Patients previously included in the study\n* Patients known to be pregnant (pregnancy test not required)\n* Non-resident in Denmark.",{"count":144,"type":19},2000,"Colorectal Cancer (CRC), or bowel cancer, is a serious disease that affects many people globally. The earlier CRC is diagnosed, the better the patient outcomes.\n\nThe problem with the current diagnostic methods is that they lead to many unnecessary endoscopies (colonoscopies). In Denmark alone, over 30,000 patients every year undergo a colonoscopy without having a serious disease. This puts a major strain on both patients and the healthcare system.\n\nThis research project aims to solve that problem. COCO-S is investigating oncofoetal chondroitin sulphate-modified proteoglycans (ofCS) to see if ofCS can be used as a novel, unique cancer marker found in the blood.\n\nofCS are special molecules that reappear in most tumour tissues. A method has been developed to detect ofCSs in a simple blood sample.\n\nInitial findings from an ongoing study are highly promising. A test using five different ofCS markers has shown very high accuracy in detecting CRC: it correctly identifies 86% of cancer cases (sensitivity) and correctly gives a \"negative\" result in 97% of cases without cancer (specificity).\n\nThe results also suggest that high ofCS levels might help clinicians detect adenomas (polyps), which are early precursors to cancer.\n\nCombining the analysis of ofCS in the blood with the existing stool test (FIT) and other promising blood markers can significantly improve patient selection for a colonoscopy.\n\nThis project will collect blood samples from patients scheduled for a colonoscopy. The blood will be analysed for ofCS and other substances to determine the combined predictive value for patients who truly require the procedure.\n\nThe findings from this project could revolutionize CRC diagnosis. By more accurately identifying patients who need a colonoscopy, the number of unnecessary, invasive procedures can be reduced while maintaining patient safety and ensuring cancer is found in time.",[147,148,149],"Colorectal Cancer","Colorectal Adenoma","Inflammatory Bowel Disease (IBD)",[151,147,152,153],"Biomarker","Glycoproteins","Proteomics","2026-01-15",{"date":156,"type":38},"2026-01-20",{"date":158,"type":19},"2026-03-01",{"date":160,"type":19},"2031-12-31",{"name":44,"class":45},2,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":171,"enrollmentInfo":172,"targetDuration":173,"studyType":21,"phases":4,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":162},"100551430","the-duration-of-spinal-anaesthesia---a-prospective-observational-cohort-study-100551430","NCT06459986","The Duration of Spinal Anaesthesia - a Prospective, Observational Cohort Study","The Duration of Spinal Anaesthesia - a Prospective Observational Cohort Study","Spinalrocks","Inclusion Criteria:\n\n* Scheduled for elective orthopaedic surgical procedures performed in spinal anaesthesia\n* ASA 1-4.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Anticoagulant medication therapy not paused according ESAIC\u002FESRA 2022 guidelines\n* Local infection at the lumbar puncture site\n* Bleeding disorder\n* Unable to cooperate with the spinal anaesthesia procedure.","100 Years",{"count":144,"type":19},"1 Day","Today, surgery in an ambulatory setting is preferred for many reasons. Total hip and knee arthroplasty (THA and TKA) are now procedures where patients can be sent home on the same day of the surgical procedure. However, this requires substantial knowledge of factors affecting the length of hospital stay. In this prospective, observational cohort study, we will investigate factors that affect the duration of spinal anaesthesia which is often used in THA and TKA. The aim is to gather enough data to be able to determine how local anaesthetic volume and dose affect the duration of spinal anaesthesia. This will enable us to decide whether spinal anaesthesia is a good option when performing TKA and THA in an ambulatory setting.",[176],"Orthopedic Disorder",[178,179],"Regional anaesthesia","Spinal anaesthesia",{"date":156,"type":38},{"date":182,"type":38},"2024-06-03",{"date":184,"type":19},"2026-12-01",{"name":44,"class":45},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":86,"phases":196,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":162},"100559494","phase-4-remifentanil-versus-rocuronium-for-optimizing-video-laryngoscopy-assisted-tracheal-intubation-100559494","NCT06564857","Remifentanil Versus Rocuronium for Optimizing Video Laryngoscopy-assisted Tracheal Intubation","Remifentanil Versus Rocuronium for Optimizing Video Laryngoscopy-assisted Tracheal Intubation in Patients Undergoing General Anaesthesia - a Multicentre Randomised Controlled Trial -The ROCVIDEO Trial","ROCVIDEO","Inclusion Criteria:\n\n* Adults ≥ 18 years\n* Undergoing general anaesthesia requiring oro-tracheal intubation\n* Absence of indication for rapid sequence induction\n* American Society of Anesthesiologists (ASA) physical status score I - III\n\nExclusion Criteria:\n\n* Known allergies or contraindications to rocuronium (e.g. neuromuscular disease) or remifentanil\n* Awake intubation\n* Double-lumen endotracheal tube\n* Oral, pharyngeal, and laryngeal surgery\n* Surgical contraindication for NMBAs (e.g. use of nerve stimulator)\n* Patients who are pregnant or breastfeeding\n* Patients who do not understand Danish or are unable to give informed consent",{"count":195,"type":19},2648,[88],"Globally, we are approaching 1 million surgical procedures each day. Tracheal intubation is the mainstay of securing the patient's airway and breathing during general anaesthesia. Approximately 100.000 tracheal intubations are performed annually in Denmark. Airway management remains the primary reason for anaesthesia-related morbidity and mortality. It has been traditionally accepted that best tracheal intubation conditions are obtained by paralysing the patient's muscles, including vocal cords, using a neuromuscular blocking agent (NMBA) such as rocuronium. However, using NBMA may increase the risk of pulmonary complications, intra-operative awareness, in which the patient is paralysed but awake during surgery, anaphylaxis, and re-intubation. In addition, there is a risk of residual neuromuscular blockade postoperatively. In the US, prolonged ventilation and unplanned intubation are the top two most costly perioperative complications. An alternative to NMBA is a large dose of opioids to depress laryngeal reflexes during intubation. The most commonly used non-NMBA modality includes bolus administration of remifentanil. However, remifentanil may cause bradycardia and hypotension. Even short periods of hypotension have been shown to increase the risk of myocardial injury and other serious adverse events such as renal failure, delirium, and even mortality.\n\nEvidence also indicates that intubation conditions using only opioids to facilitate intubation, including remifentanil, are inferior to NMBA. However, these trials are underpowered to assess effects on patient-important outcomes and are mostly at high risk of bias. A recent trial has suggested that remifentanil intubation conditions may not be very different. Almost all existing research comparing NMBA to opioids has focused on intubation conditions for direct laryngoscopy using a conventional Macintosh laryngoscopy blade. In recent years, the implementation and availability of the video laryngoscope have grown exponentially and become universal. The video laryngoscope has vastly improved the ease of tracheal intubation, and the number of failed intubations has decreased by two-thirds in Denmark, where a rapid implementation of the video laryngoscope took place. However, limited evidence exists on whether NMBA improves intubation conditions compared to remifentanil when performing video laryngoscope-assisted tracheal intubation.",[199,200,201,202],"Tracheal Intubation","Video Laryngoscopy","Remifentanil","Rocuronium","2025-12-03",{"date":205,"type":38},"2025-12-10",{"date":207,"type":38},"2025-11-17",{"date":209,"type":19},"2027-04-08",{"name":44,"class":45},{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":86,"phases":221,"briefSummary":222,"conditions":223,"keywords":226,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":237},"100569056","physical-rehabilitation-of-older-persons-following-a-community-acquired-infection-hospitalization---a-randomised-controlled-trial-100569056","NCT06689280","Physical Rehabilitation of Older Persons Following a Community-Acquired Infection Hospitalization - A Randomised-Controlled Trial","Physical Rehabilitation of Older Persons Following a Community-Acquired Infection Hospitalization: A Feasibility Study","REHAB-CAI","Inclusion Criteria:\n\n* Patients aged ≥65 years or 18-64 years if the presence of at least one chronic disease (e.g., diabetes, COPD, heart failure, etc.)\n* Suspicious of a lower respiratory tract infection AND\n* Presence of one or more symptoms of a lower respiratory tract infection such as fever ≥38.3°C, hypothermia \\\u003C35.0°C, new onset of cough, pleuritic chest pain, dyspnea, or altered breath sounds on auscultation.\n* Positive urine nitrate test and\u002For leukocyturia as depicted by positive esterase test or microscopy AND\n* Presence of one or more symptoms of urinary tract infection such as dysuria, urgent or frequent urination, perineal or suprapubic pain, costo-vertebral tenderness or flank pain, fever (ear or rectal temperature of ≥38.2°C or axillary temperature of ≥38.0°C), or history of feeling feverish with shivering or rigors in the past 24 hours.\n* Functionally independent before hospitalization and expected to be discharged to their own homes.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Hospitalization within the past 14 days.\n* Inability to participate in the study due to dementia, paralysis, or other disorders.\n* Severe aortic valve stenosis or terminal illness.\n* Unstable cardiac arrhythmic disease.\n* High risk for non-adherence as determined by screening evaluation.\n* Already participating in regular exercise training.\n* Unable to understand Danish.\n* Unwilling or unable to give informed consent.",{"count":220,"type":19},460,[116],"Community-acquired infections such as community-acquired pneumonia (CAP) and urinary tract infection (UTI) remain leading causes of hospitalization and death due to infections in older persons in Europe. Hospitalization often results in further disabilities and frailty for older and frail individuals, from which some may never recover. Physical activity is well-established as a cornerstone in the primary prevention and treatment of several noncommunicable diseases. However, there is currently no established rehabilitation model following a pneumonia or other infection, nor is there any evidence to support the impact of rehabilitation on the mental and physical health of older and frail individuals following a pneumonia hospitalization or other infection.\n\nThe aim of the feasibility study is to evaluate a patient-centered and individualized exercise intervention that is kick-started during hospitalization and continued for 3 months after discharge with video-supervised home-based exercise training to patients hospitalized with CAP or UTI compared to standard care with regard to safety, clinical outcomes, patients' perception, functional ability, organizational aspects, and economic aspects.",[224,225],"Community-acquired Pneumonia","Urinary Tract Infections",[227,228],"CAP","UTI","2025-11-26",{"date":231,"type":38},"2025-12-02",{"date":233,"type":19},"2026-01-01",{"date":235,"type":19},"2029-12-31",{"name":44,"class":45},3,{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":248,"conditions":249,"keywords":254,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":268},"100611786","the-pro-chol-study-100611786","NCT07245108","The Pro-Chol Study","The ProChol Study - Prospective Assessment of Symptoms Following Cholecystectomy in Patients With Symptomatic Uncomplicated Gallstones","ProChol","Inclusion Criteria:\n\n* Ultrasound examination with presence of gallstones and description of size, number and presence of stones in infundibulum or cystic duct\n* Abdominal symptoms believed to be caused by symptomatic uncomplicated gallstones\n* Indication and candidate for elective laparoscopic cholecystectomy\n* Above 18 years of age\n* Ability to give oral and written consent\n* Ability to understand, speak and read Danish\n* Ability to receive digital post\n\nExclusion Criteria:\n\n* History of complicated gallstone disease including acute cholecystitis, pancreatitis, common bile duct stones, or cholangitis\n* Previous sphincterotomy\n* Abnormal liver function test (ALAT\u002FASAT, alkaline phosphatase, bilirubin) without magnetic resonance cholangio-pancreatography or endoscopic ultrasound to rule out common bile duct pathology\n* Indication for urgent cholecystectomy\n* Current pregnancy",{"count":247,"type":19},800,"This prospective clinical cohort study will include patients with gallstones and abdominal pain scheduled for surgery (laparoscopic cholecystectomy). Data on quality of life, abdominal pain, gallstone disease, and patient characteristics will be collected before surgery. The outcomes will be assessed three months following surgery and will primarily be determinants for resolution of pain. The aim is to make a prediction score that may aid clinicians and patients in decision making about surgery.",[250,251,252,253],"Gallstones","Gallstone Attack","Uncomplicated Cholelithiasis","Cholecystolithiasis",[255,256,257,258,259],"Cohort study","Prospective clinical study","Cholecystectomy","Laparoscopic cholecystectomy","Pain relief","2025-11-20",{"date":262,"type":38},"2025-11-24",{"date":264,"type":38},"2024-01-22",{"date":266,"type":19},"2027-04",{"name":44,"class":45},7,{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":86,"phases":279,"briefSummary":280,"conditions":281,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":74},"100401476","rapid-response-teams---how-and-who-100401476","NCT04507737","Rapid Response Teams - How and Who?","Rapid Response Teams - How and Who? A Randomized Controlled Trial Examining the Composition of the RRT in a General Hospital","RRT-Comp","Inclusion Criteria:\n\n* Admitted to any general ward of the hospital AND\n* Aged ≥ 18 years AND\n* In need of RRT attention\n\nExclusion Criteria:\n\n* Age \\\u003C 18\n* Admitted to the delivery ward\n* Admitted to any ward in the anesthetic department\n\n  * ICU\n  * High Dependency Unit\n  * Post Operation Department\n  * Operating Theatre\n  * Same Day Admissions - Surgery Ward\n* Not admitted at the time of call\n\n  * Evaluation track in Emergency department (prior to being seen by a doctor)\n  * Out-Patient departments\n  * X-ray department\n* Any patient who cannot be randomized at the time of call",{"count":278,"type":19},1500,[116],"This will be an investigator initiated One-sided blinded Randomized Clinical Trial.\n\nThe study will examine the composition of the Rapid Response Team (RRT). the investigators will examine to see if a Critical Care Outreach Team (CCOT) consisting of an ICU-Nurse and a general ward physician and nurse are non-inferior to a Medical Emergency Team (MET) consisting of an ICU-Doctor and ICU Nurse as well as a general ward physician and nurse. The randomization will be done using an Analogue randomization sequence using sealed opaque envelopes with central randomization.The experimental intervention will be the CCOT. The statistical analyses will be done on the primary outcomes in the intention to treat population and on the secondary outcomes on an per-protocol basis exempting those with protocol violations.",[282,283,284],"Hospital Rapid Response Team","Early Warning Score","Intensive Care Units",{"date":286,"type":38},"2025-09-17",{"date":288,"type":38},"2021-09-01",{"date":290,"type":19},"2026-01-31",{"name":44,"class":45},{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":53,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":300,"targetDuration":4,"studyType":86,"phases":302,"briefSummary":303,"conditions":304,"keywords":306,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":237},"100605756","hospital-at-home-education-as-implementation-tool---rct-100605756","NCT07166653","Hospital-at-Home Education as Implementation Tool - RCT","Nordic Digital Health Education as an Implementation Tool for Hospital-at-home - Protocol for a Multicenter Randomized Controlled Trial","HAH-EDUCATION","Inclusion criteria:\n\nHospitals with clinical departments treating acutely ill in-patients that have, or are ready to establish, the prerequisites and infrastructure for HaH - regardless of the specific approach, envisioned HaH model, primary sector collaborations, or local sector collaboration agreements and frameworks. Each hospital must have or be ready to establish:\n\n1. a governance structure to organize and oversee HaH-services.\n2. an IT-platform capable of managing data from and to HaH patients.\n3. a safe communication pathway between HaH-patient and the hospital.\n4. clear agreements on types of data to be exchanged between HaH-patient and hospital.\n5. agreements on roles, responsibilities, and capacity (incl. possibly primary sector entities).\n6. clinical guidelines, standard operating procedures, and action plans to support the HaH work.\n\nExclusion Criteria:\n\n* Hospitals that do not have or are not ready to secure relevant pre-requisites listed above (a to f).",{"count":301,"type":19},14,[116],"To enhance implementation of Hospital-at-home (HaH) in Scandinavia, the Nordic Digital Health \\& Education (NorDigHE) project has developed a comprehensive virtual education on HaH for clinical staff. The goal of this clinical trial is to evaluate whether an online education for clinical staff can enhance the implementation of HaH services in hospitals across Denmark, Norway, and Sweden.\n\nThe primary outcome of the RCT is HaH implementation measured at organization level, understood as a change in clinical practice by increased HaH activity. Secondary outcomes are HaH knowledge and motivation among clinical staff as well as patient days in hospital, days hospitalized at home, 30-day readmission, and mortality.\n\nResearchers will compare hospitals receiving the NorDigHE education (intervention group) to hospitals continuing treatment as usual (control group) to see if the education leads to greater adoption of HaH and changes in service delivery.\n\nParticipants will:\n\n* Complete baseline, 3-month, and 6-month surveys assessing HaH activity, staff knowledge, and motivation.\n* Participate in a 12-month follow-up assessment (intervention group only).\n* Be invited (patients, staff, and management) to take part in semi-structured interviews to share experiences and preferences related to HaH.\n* (For staff in the intervention group) Complete the NorDigHE virtual education program embedded in the WHO Fast-IM.\n\nAfter the study, the control group will be offered access to the NorDigHE education as a participant retention measure.",[305],"Hospital",[307,308,309,310,311,312,313],"clinical competence","digital health","education","hospital at home","hospital in the home","implementation","telemedicine","2025-09-08",{"date":316,"type":38},"2025-09-10",{"date":318,"type":19},"2025-09-01",{"date":320,"type":19},"2026-12-31",{"name":44,"class":45},{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":331,"conditions":332,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":340,"leadSponsor":342,"locationsCount":74},"100603146","associations-between-time-to-reduction-and-complications-in-patients-with-dislocated-total-hip-arthroplasty-100603146","NCT07132723","Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty","Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty - A Protocol for an Observational Cohort Study","Inclusion Criteria:\n\nPatients will be considered eligible for inclusion if they meet all of the following criteria:\n\n* Aged 18 years or older\n* Presented to the emergency department with a dislocated total hip arthroplasty.\n* Undergo closed reduction of the dislocated total hip arthroplasty in the operating theatre, with the involvement of the Department of Anesthesiology.\n\nExclusion Criteria:\n\n* Were primarily booked for open surgical reduction.\n* Did not have a complete case log (i.e. time of admission; referral to the operation theatre; anesthesia induction; discharge, etc.) and we were unable to recreate the log using simple code rules.",{"count":330,"type":19},3700,"The aim of the study is to investigate the impact of time to closed reduction on both patient related and organizational factors. These include, length of stay, hospitalization, admission to intensive care unit, rehospitalizations, delirium, all-cause mortality, infection requiring hospital contact, and cardiovascular complications. It is also intended to investigate whether different anaesthetic strategies and airway management are associated with different complication rates.\n\nIt is hypothesized that longer waiting time until reduction increase the postoperative length of stay, readmissions, and risk of complications.",[333,334,335],"Closed Reduction","Arthroplasty, Replacement, Hip","Length of Stay","2025-08-11",{"date":338,"type":38},"2025-08-20",{"date":338,"type":19},{"date":341,"type":19},"2025-10-01",{"name":44,"class":45},{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":349,"eligibilityCriteria":350,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":351,"targetDuration":4,"studyType":86,"phases":353,"briefSummary":355,"conditions":356,"keywords":365,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":74},"100585948","phase-3-semaglutide-treatment-in-type-1-diabetes-100585948","NCT06909006","Semaglutide Treatment in Type 1 Diabetes","Obesity and Semaglutide in Type 1 Diabetes Therapy: A Multicentre, Randomised, Double-Blinded, Placebo-Controlled, Investigator-Initiated Trial","OBES1TY","Inclusion Criteria:\n\n* Type 1 Diabetes for more than 3 years\n* BMI ≥ 30 or ≥ 27 and atleast one comorbidity (hypertension, hypercholesterolemia, microalbuminuria, ischemic heart disease, history of stroke, atherosclerosis or arthrosis\n\nExclusion Criteria:\n\n* Treated with GLP1-RAs within last 6 months\n* Known intolerance for semaglutide\n* Other forms of diabetes\n* Pregnant or nursing women\n* Fertile women not using chemical (hormonal) or mechanical (spiral) contraceptives\n* Liver disease with elevated plasma alanine aminotransferase (ALT) \\> five times and plasma aspartate aminotransferase (AST) \\> five times the upper limit of normal (measured at visit 0 with the possibility of one repeat analysis within a week, and the last measured value as being conclusive)\n* Acute or chronic pancreatitis\n* Cancer, unless in complete remission for \\> 5 years or unless basocellular carcinomas\n* History of thyroid adenoma or carcinoma\n* Alcohol\u002Fdrug abuse\n* Other concomitant disease or treatment that according to the investigator's assessment makes the patient unsuitable for study participation\n* Receipt of an investigational drug within 30 days prior to visit 0 \u002F Simultaneous participation in any other clinical intervention trial",{"count":352,"type":19},122,[354],"PHASE3","The goal of this clinical trial is to investigate the efficacy of semaglutide on body weight, insulin dose requirements and improvements in glucose control and safety aspects in regards to risk of hypoglycemia and diabetic ketoacidosis for patients with established Type 1 Diabetes.",[357,358,359,360,95,361,362,363,364],"Obesity in Diabetes","Obesity\u002FTherapy","Type 1 Diabetes Mellitus (T1DM)","Insulin Sensitivity\u002FResistance","Lipidomics","Metabolomics","Weight Loss","Glycemic Control for Diabetes Mellitus",[95,366,367,368,369,370,371,372,373,374],"Obesity","Type 1 Diabetes","Obese Type 1 Diabetics","Insulin sensitivity","Insulin resistance","Weight loss","GLP1-RA","GLP1","Wegovy","2025-08-04",{"date":377,"type":38},"2025-08-08",{"date":379,"type":19},"2025-10",{"date":381,"type":19},"2028-06",{"name":44,"class":45},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":86,"phases":393,"briefSummary":394,"conditions":395,"keywords":405,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":74},"100601686","post-operative-hospital-at-home-after-colorectal-surgery-100601686","NCT07113717","Post Operative Hospital at Home After Colorectal Surgery","Early Post-operative Discharge of Colorectal Surgical Patients to a Virtual Hospital at Home Model (Post Operative Hospital at Home) - a Clinical Feasibility Study","POPHaH","Inclusion Criteria:\n\n* Planned minimally invasive (laparoscopic or robot-assisted) CRS\n* No epidural analgesia\n* No new stoma\n* Bleeding \\\u003C 500 ml\n* Actual condition assessed to be clinically stable\n* Meeting the Chung score discharge criteria for ambulatory surgery\n* Self-reliant or receives sufficient formal care to be care-independent of a primary informal caregiver\n* Home-based admission will be located within catchment area of the hospital (according to the official address of the individual)\n* Signed informed written and oral consent\n\nExclusion Criteria:\n\n* Patients who cannot comply with self-assessment\n* Improficiency in Danish\n* Pregnancy\n* Conversion to emergency surgery (uncontrolled perforation of bowel, ileus)\n* Complications during surgery warranting in-hospital admission (observation in intensive care unit or close observation from other specialities, e.g. cardiology)",{"count":392,"type":19},20,[116],"The goal of this feasibility study is to investigate whether a virtual Hospital at Home is safe and possible for patients undergoing planned minimally invasive colorectal surgery. The study aims to answer the following main questions:\n\nWhat are the patient- and next-of-kin-related effects, as well as the clinical and organizational effects, of home-based admission? What are the implementation barriers for a full-scale randomized controlled trial? Participants will follow a standardized protocol for their care befor, during and after surgery. However, the care after surgery will be conducted at home using telemedicine.",[396,397,398,399,400,401,402,403,404],"Colo-rectal Cancer","Colo-rectal Surgery","Colocolic and Ileocolic Anastomosis","Colon and\u002For Rectal Resection With Anastomosis for Cancer","Diverticular Disease of Colon","Colon Benign Tumor","Crohn Disease and Ulcerative Colitis","Ileostomy Closure","Stoma Reversal Procedure",[406,407],"hospital at home for colorectal surgery","postoperative hospital at home","2025-08-02",{"date":336,"type":38},{"date":411,"type":19},"2025-12-15",{"date":413,"type":19},"2027-06",{"name":44,"class":45},{"id":416,"slug":417,"hasResults":11,"nctId":418,"briefTitle":419,"officialTitle":420,"acronym":4,"eligibilityCriteria":421,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":422,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":424,"conditions":425,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":433,"locationsCount":162},"100596240","cultural-adaptation-and-validation-of-fundamentals-of-care-pro-tool-100596240","NCT07042880","Cultural Adaptation, and Validation of Fundamentals of Care PRO-tool","Facilitating the Assessment of Fundamental Nursing Care in Denmark: Translation, Cultural Adaptation, and Validation of a 41-Item Fundamentals of Care Questionnaire","Inclusion Criteria:\n\n* Hospitalized for more than 24 hours at a cardiology department\n\nExclusion Criteria:\n\n* Inability to provide informed consent",{"count":423,"type":19},205,"A research team from the University of Seville and Flinders University has created a new 41-item questionnaire to assess fundamental nursing care. This questionnaire focuses on three main areas: the nurse-patient relationship, addressing patients' basic care needs (physical, relational, and psychosocial), and the context of care. This tool helps nurses evaluate and track the quality of care they provide over time.\n\nThe questionnaire is a self-administered, patient-reported tool. The questionnaire has been translated into English and adapted for use in Australia, but not yet in Danish. Senior Researcher Maria Kjøller Pedersen from Copenhagen University Hospital, North Zealand is leading the effort to translate and adapt it for Denmark in collaboration with University College Copenhagen.\n\nThe goal of this study is to translate, adapt, and validate the questionnaire for use in the Danish healthcare system.",[426],"Hospitalized Patients","2025-06-29",{"date":429,"type":38},"2025-07-02",{"date":431,"type":38},"2025-06-23",{"date":320,"type":19},{"name":44,"class":45},{"id":435,"slug":436,"hasResults":11,"nctId":437,"briefTitle":438,"officialTitle":438,"acronym":4,"eligibilityCriteria":439,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":440,"targetDuration":4,"studyType":86,"phases":442,"briefSummary":443,"conditions":444,"keywords":450,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":466,"locationsCount":74},"100568224","phase-4-brachial-plexus-nerve-block-versus-haematoma-block-for-closed-reduction-of-distal-radius-fracture-in-adults---the-block-trial-a-multicentre-randomised-controlled-trial-100568224","NCT06678438","Brachial Plexus Nerve Block Versus Haematoma Block for Closed Reduction of Distal Radius Fracture in Adults - The BLOCK Trial. A Multicentre Randomised Controlled Trial.","Inclusion Criteria:\n\n* Adults (age ≥ 18 years) with a distal radius fracture in need of closed reduction\n\nExclusion Criteria:\n\n* Patients who would never qualify for surgery according to local guidelines\n* Lack of informed consent\n* No Danish Central Person Register (CPR) number\n* Allergies to the trial medication\n* Distal radius fracture initially deemed to require surgery regardless of the outcome of the closed reduction\n* Open fractures (fracture-related wound requiring sutures)\n* Other fractures on the same extremity ((NOT including distal ulna fracture(s))\n* Bilateral distal radius fractures both requiring closed reduction\n* Concomitant medical or surgical condition taking priority over the closed reduction of the distal radius fracture.",{"count":441,"type":19},1716,[88],"The aim of the project is to evaluate the beneficial and harmful effects of an ultrasound-guided brachial plexus nerve block for patients with a distal radius (wrist) fracture in the need of realignment of fractured bone endings without cutting the skin (closed reduction), in comparison to a haematoma block, which is standard care in Denmark.\n\nEvery participant will receive one of the following types of anaesthesia for the realignment of the wrist fracture:\n\n1. A nerve block of the arm (plexus brachialis block)\n2. A haematoma block, which is the current standard anaesthesia in the emergency departments.",[445,446,447,448,449],"Distal Radius Fractures","Fracture Dislocation","Fracture Dislocation of Upper Limb Joint","Colles' Fracture","Closed Reduction of Fracture and Application of Plaster Cast",[451,452,178,453,454,455,456,457,458,459],"Lidocaine","Local anaesthesia","Peripheral nerve block","Brachial plexus block","Lateral infraclavicular block","Axillary plexus block","Distal radius fracture","Colles' fracture","Wrist fracture","2025-06-12",{"date":462,"type":38},"2025-06-17",{"date":464,"type":38},"2024-12-10",{"date":266,"type":19},{"name":44,"class":45},{"id":468,"slug":469,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":474,"targetDuration":4,"studyType":86,"phases":476,"briefSummary":477,"conditions":478,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":488,"locationsCount":162},"100438395","impact-of-physical-exercise-at-a-hospital-100438395","NCT04988724","Impact of Physical Exercise at a Hospital","Impact of Physical Exercise at a Hospital Tested in a Pilot Trial","Inclusion Criteria:\n\n\\- Employed nurses, doctors, secretaries and other staff on Nordsjællands Hospital, Denmark\n\nExclusion Criteria:\n\n\\- If exercise training is not allowed",{"count":475,"type":19},700,[116],"Aims and Hypotheses Aims\n\n* to investigate associations between an intelligent exercise training intervention and clinical health parameters, well-being, sick leave and productivity at Nordsjællands Hospital (NOH)\n* to generate data and experiences to a larger cluster randomized trial with more included departments at NOH\n* to analyze how the intervention could be successfully implemented in the organization to ensure long-term effects\n\nOutcomes\n\n* Aerobic capacity (Åstrand's ergometer test)\n* Blood pressure and heart rate\n* Physical activity (steps measured by tracker)\n* Self-reported health (questionnaire EQ-5D)\n* Self-reported physical activity (questionnaire IPAQ)\n* Well-being (questions from the Danish Health and Morbidity Survey)\n* Musculoskeletal pain and use of anti-pain medications (Numeric Rating Scale)\n* Monetized value of productivity loss\n* Productivity using an employer´s perspective (scale 1-10)\n* Sick leave (days in short term (≤14 days) and long term (\\>14 days), data will be delivered by The Department of HR)\n* Muscle strength in knee extension (dynamometer)\n\nIntervention The concept of intelligent training at the worksite is an individualized exercise training where the exercises are: 1) balanced to the physiological capacity of the employees relative to their occupational exposure, 2) tailored to the individual capacities and disorders to improve employees' health, 3) motivating by offering evidence based and enjoyable programs implemented with care, and 4) cost-effective for the company.\n\nThe intervention period is 20 weeks of intelligent exercise training. Every week, several exercise sessions will be offered to the participants in the intervention group during the working hours. The exercise sessions will be of 30 min durations twice a week and include aerobic exercise with high intensity (≥16 on the Borg scale, rate of perceived exhaustion), resistance training and\u002For functional training. In addition, there will be a number of intelligent exercise sessions of 30 min durations before and after the most common working hours with a primary focus on aerobic exercise. The exercise sessions will be supervised by exercise experts (education in sport or physiotherapy).\n\nThe intelligent exercise interventions will be adjusted to the individual participant's physical capacity and limitations; thus, as one participant may perform aerobic exercise, another person may perform resistance training.",[479,480,481],"Pain","Quality of Life","Health Behavior","2025-06-02",{"date":484,"type":38},"2025-06-05",{"date":486,"type":38},"2022-04-16",{"date":320,"type":19},{"name":44,"class":45},{"id":490,"slug":491,"hasResults":11,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":495,"eligibilityCriteria":496,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":497,"targetDuration":499,"studyType":21,"phases":4,"briefSummary":500,"conditions":501,"keywords":505,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":5},"100535960","fluid-administration-and-fluid-accumulation-in-the-intensive-care-unit-100535960","NCT06258616","Fluid Administration and Fluid Accumulation in the Intensive Care Unit","Fluid Administration and Fluid Accumulation in the Intensive Care Unit (FLUID-ICU) - an International Inception Cohort Study","FLUID-ICU","Inclusion Criteria:\n\n* Acute admission to the ICU during the 14-day inception period.\n* Adults (≥ 18 years).\n\nExclusion Criteria:\n\n* Patients previously included in the FLUID-ICU study.\n* Patients with major burns (≥ 10% of body surface)",{"count":498,"type":19},1000,"90 Days","The goal of this international inception cohort study is to describe fluid administration during admittance to the intensive care unit (ICU), and provide contemporary epidemiological data on fluid accumulation, risk factors, management and outcome in critically ill adult patients.",[502,503,504],"Fluid Accumulation","Fluid Therapy","Fluid Overload",[504,502,506],"Fluid Administration","2025-02-05",{"date":509,"type":38},"2025-02-06",{"date":511,"type":38},"2024-04-01",{"date":513,"type":19},"2025-09",{"name":44,"class":45},{"id":516,"slug":517,"hasResults":11,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":521,"eligibilityCriteria":522,"healthyVolunteers":11,"sex":15,"minAge":523,"maxAge":4,"enrollmentInfo":524,"targetDuration":526,"studyType":21,"phases":4,"briefSummary":527,"conditions":528,"keywords":530,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":541,"completionDateStruct":543,"leadSponsor":545,"locationsCount":74},"100551492","ultrasound-guided-peripheral-nerve-blocks---a-database-100551492","NCT06460792","Ultrasound-guided Peripheral Nerve Blocks - a Database","The Quality of Ultrasound-guided Peripheral Nerve Blocks, Nerve Injury, Bleeding Complications and Learning - a Prospective Observational Cohort Study","Blockbase","Inclusion Criteria:\n\n\\- age \\> 2 years\n\nExclusion Criteria\n\n* Infection at puncture site\n* Allergy to local anesthetics\n* Unable to understand given oral instruction","2 Years",{"count":525,"type":19},5000,"5 Years","Peripheral nerve blocks are often used in anaesthesia. They can be used as the only method of anaesthesia during surgery or in combination with other methods, e.g., general anaesthesia and sedation. Moreover, peripheral nerve blocks are used to treat postoperative pain, alleviate pain in trauma patients, and for painful procedures.\n\nFor a method to be clinically useful, it is essential to understand the factors contributing to high success rates. It is equally important to know the complications related to the method. Finally, it is essential to establish a robust learning system where the anesthesiologists can track their nerve block performance over time and compare it to high performers and general performance. Therefore, we aim to establish a prospective and ongoing database to gain insight into 1) Factors contributing to block quality, e.g., success rate and nerve block duration; 2) Frequencies and types of nerve injuries and bleeding complications associated with the block procedure; 3) Tracking of block performance by anaesthesiologists.",[529],"Regional Anesthesia",[531,532,533,534,535,536,537],"nerve block","ultrasound guidance","complications","nerve injury","bleeding","success rate","learning","2024-06-13",{"date":540,"type":38},"2024-06-14",{"date":542,"type":38},"2024-06-04",{"date":544,"type":19},"2029-06-04",{"name":44,"class":45},{"id":547,"slug":548,"hasResults":11,"nctId":549,"briefTitle":550,"officialTitle":551,"acronym":552,"eligibilityCriteria":553,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":554,"enrollmentInfo":555,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":557,"conditions":558,"keywords":559,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":566,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":162},"100550926","diabetes-self-management-with-continuous-glucose-monitoring-100550926","NCT06453434","Diabetes Self-management With Continuous Glucose Monitoring","The Impact of Continuous Glucose Monitoring Based Self-management on Patient-Reported Outcomes and Glycaemia in Type 1 Diabetes","DIASELF","Inclusion Criteria:\n\n1. Age between 18 and 85 years.\n2. Diagnosed with T1D over one year ago.\n3. Actively using FreeStyle Libre 2 (\\>80% sensor activity).\n4. Used FreeStyle Libre 2 for over three months.\n5. Uses multiple daily insulin injections.\n6. Capable of providing written informed consent.\n7. Willing and able to complete study procedures, including using smart caps or pens and completing questionnaires at the investigator's discretion.\n\nExclusion Criteria:\n\n1. History of allergic reactions to materials or adhesives used in CGM devices.\n2. Presence of severe cognitive or psychiatric conditions that could hinder the effective use of CGM or smart caps or pens - at the investigator's discretion.\n3. Current use of steroids unless part of a chronic therapy plan.\n4. Daily consumption of vitamin C ≥ 500 mg.","85 Years",{"count":556,"type":19},500,"The overall goal of this observational study is to investigate the interaction between people with type 1 diabetes and continuous glucose monitoring (CGM) and the impact of this interaction on quality of life, particularly the level of diabetes distress, and glycaemic metrics.\n\nParticipants will:\n\n* Visit the clinic twice with a 14-day interval\n* Fill out a survey before the first and at the last visit\n* Use CGM as usual and use smart insulin pens and an activity tracker\n* Register food intake\n* Answer two-three questions twice a day in REDCap",[367],[560,561,562,367,563,564],"Continuous Glucose Monitoring","Self-management","Diabetes Technology","Diabetes Distress","Patient-reported Outcomes","2024-06-05",{"date":567,"type":38},"2024-06-11",{"date":569,"type":19},"2024-07-01",{"date":571,"type":19},"2026-08",{"name":44,"class":45},{"id":574,"slug":575,"hasResults":11,"nctId":576,"briefTitle":577,"officialTitle":577,"acronym":4,"eligibilityCriteria":578,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":579,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":581,"conditions":582,"keywords":583,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":590,"lastUpdatePostDateStruct":591,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":74},"100346816","surviving-pneumonia-100346816","NCT03795662","Surviving Pneumonia","Inclusion Criteria:\n\n* Infiltrate on chest radiograph plus one or more of the following:\n\n  * Fever (temperature, ≥38.0°C)\n  * Hypothermia (\\\u003C35.0°C),\n  * New cough with or without sputum production\n  * Pleuritic chest pain\n  * Dyspnea\n  * Altered breath sounds on auscultation.\n\nExclusion Criteria:\n\n* Patients unable to give informed consent\n* Patients unwilling to give informed consent",{"count":580,"type":19},2500,"The study aims to explore risk factors for poor prognosis among patients admitted with community-acquired pneumonia (CAP). During a 5-year study period, all patients (aged ≥ 18 years) admitted with CAP at North Zealand Hospital will be invited for inclusion. Questionnaires, anthropometric measures, laboratory tests, and biomaterials will be collected at admission, daily during admission, at discharge and at follow-up. The main clinical outcomes of the study consist of deaths and development of diabetes.",[224],[584,585,586,587,588,589],"Community-acquired pneumonia","Diabetes","Immune status","Nutritional status","Physical inactivity","Risk factors","2021-04-28",{"date":592,"type":38},"2021-04-29",{"date":594,"type":38},"2019-01-07",{"date":596,"type":19},"2038-12-31",{"name":44,"class":45},""]