[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"North Carolina State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":228},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,47,76,103,131,155,178,201],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100550831","restoration-of-normative-postural-control-100550831",false,"NCT06452186","Restoration of Normative Postural Control","Toward Restoration of Normative Postural Control and Stability Using Neural Control of Powered Prosthetic Ankles","Inclusion Criteria:\n\n* 18 years or older;\n* unilateral bower limb amputee\n* K-level 2 or higher (who are frequent prosthesis users and may benefit from the proposed prosthesis training and use of dEMG controlled powered prosthesis)\n* Amputation occurred over 2 years ago\n* At least 1 year of experience using their prosthetic leg\n* Has used the current socket for at least 6 months without a significant skin issue or major modification\n* Are willing to come to NC State University's Centennial Campus to participate in research and be photographed while doing research activities\n\nExclusion Criteria:\n\n* Have a very short residual shank (the length of the residual limb is ≤15% of the length of intact limb)\n* Cannot perform functional ambulation in the community on a daily basis without assistive devices\n* Cognitive or visual impairment that affects the participant's ability to provide informed consent or to follow simple instructions during the experiments\n* Congenital amputees\n* Amputees who use powered prosthetic ankles\n* Weight more than 300lbs\n* Pregnant Person\n* Allergic to latex, which is often contained in medical tapes.","ALL","18 Years","99 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'.\n\nThe aimed questions to answer:\n\n1. whether dEMG control will improve balance and postural stability of amputees,\n2. whether dEMG control will lead to more natural neuromuscular control and coordination, 3) whether dEMG control will reduce cognitive processes.\n\nParticipants will go through PT guided training on using dEMG controlled prosthetic ankles and are evaluated for their capability on functional tasks.\n\nThe results will be compared with a comparison group, which goes through the same training but with their everyday passive prostheses on balance capability, neuromuscular coordination, and cognitive load during locomotion.",[27],"Lower Limb Amputation Below Knee (Injury)",[29,30,31,32,33],"powered ankle prosthesis","direct EMG control","balance","cognitive load","muscle synergy","RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":38},"2023-10-01",{"date":42,"type":21},"2028-06-30",{"name":44,"class":45},"North Carolina State University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":46},"100609776","ripe-for-revival-outcomes-evaluation-of-a-mobile-produce-market-with-vouchers-100609776","NCT07218978","Ripe for Revival: Outcomes Evaluation of a Mobile Produce Market With Vouchers","Inclusion Criteria:\n\n* 18 years of age or older\n* Communicates fluently in English or Spanish\n* An active participant in an NC Cooperative Extension program May 2026 - March 2028\n* At risk of food insecurity\n* Willing to shop at or visit a Ripe for Revival mobile produce market\n* Willing to use the provided $20 monthly voucher to shop at the Ripe for Revival mobile produce market\n* Works or lives in a North Carolina county where this study is being conducted, including Bertie, Halifax, Hertford, Jones, Lenoir, Northampton, Warren, or Washington\n\nExclusion Criteria:\n\n* Individuals who do not meet the inclusion criteria above cannot participate",{"count":54,"type":21},150,[24],"Increasing access to healthy foods is crucial to combating chronic disease in rural communities. The Ripe for Revival mobile market, a non-profit eastern NC-based mobile market, seeks to improve healthy food access among those at greatest risk of food insecurity and poor health. By implementing vouchers at the mobile market, this study will help make healthy food affordable and accessible. This project is poised to improve diet and health among rural residents in eight counties and promote sustainable local food systems in North Carolina.",[58,59,60,61],"Diet Interventions","Food Security","Nutrition Security","Fruit and Vegetable Intake",[63,64,61,65,66,67],"Mobile market","Lower-income","Quasi-Experimental","Vouchers","Nutrition Incentives","2026-06-22",{"date":70,"type":38},"2026-06-26",{"date":72,"type":38},"2026-05-01",{"date":74,"type":21},"2028-03-31",{"name":44,"class":45},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":46},"100608697","phase-1-towards-efficient-personalization-of-computerized-lower-limb-prostheses-via-reinforcement-learning-in-a-clinical-setup---group-1-100608697","NCT07204925","Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1","Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Patient Study","Inclusion Criteria:\n\n* Unilateral transfemoral amputees between 18-75 with K level three or higher\n* More than one year after amputation\n* Using current prosthetic socket and leg for more than three months\n* No major skin issues on the residual limb for more than six months\n* Can walk for more than 4 minutes continuously without any other assistive devices\n\nExclusion Criteria:\n\n* Have very short residual thighs (the length of the residual limb is \\\u003C15% of the length of the unimpaired limb)\n* Are \\\u003C1.50m in height or \\>116Kg in weight (who would not fit our prosthesis or the PowerKnee)\n* Have cognitive, visual, audio impairments that would affect their ability to give informed consent or to follow simple Instructions during the experiments\n* Have any significant co-morbidity that interferes with the study (e.g. stroke, pacemaker placement, pain, etc.).","75 Years",{"count":85,"type":21},24,[87],"PHASE1","The goal of this clinical trial is to understand the feasibility and effectiveness of using reinforcement learning to personalize robotic prosthetic legs (an experimental prototype) for unilateral transfemoral amputees. The main questions it aims to answer are:\n\n* With the developed RL-based Recommendation Interfacing System (RISE), clinicians are able to personalize prosthetic legs faster compared with existing manual personalization procedures.\n* With the developed RL-based Recommendation Interfacing System (RISE), clinicians are able to personalize prosthetic legs without detailed knowledge about how the prosthetic legs are controlled.\n* Patients perform better when the prosthetic legs are personalized with RISE system compared with the ones personalized manually Researchers will compare two arms (RISE guided personalization and manual personalization) to see if the tuning speed will increase and if patients can perform better.\n\nParticipants will go through the standard prosthetic fitting procedures, such as alignment adjustment, then they will experience repeated prosthesis personalization procedures conducted by tuning specialists without RISE, tuning specialists with RISE, and prosthetists (without tuning expertise) with RISE on different types of terrains. In the end, the participants will go through a testing trial, in which they will experience the prototype personalized through the three different approaches without knowing how the control parameters are decided. Their walking performance will be recorded. It is expected that the participants will visit the testing site 8 times, which including alignment (1 visit), three personalization procedures (twice for each), and one testing trial (1-2 visits).",[90],"Transfemoral Amputation",[92,93,94],"Powered prosthesis legs","control parameter personalization","reinforcement learning","2026-05-18",{"date":97,"type":38},"2026-05-19",{"date":99,"type":38},"2025-08-01",{"date":101,"type":21},"2029-11-01",{"name":44,"class":45},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":110,"sex":16,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":46},"100609935","a-food-as-medicine-approach-to-address-food-insecurity-in-rural-north-carolina-100609935","NCT07221045","A Food As Medicine Approach to Address Food Insecurity in Rural North Carolina","PhytoRx Families: A Pilot Test Study to Address Food Security and Fruit and Vegetable Intake in Rural North Carolina","Inclusion Criteria:\n\n* Fluent in English or Spanish (speaking, reading, writing)\n* An adult (18 years of age or older) who's a parent or caregiver of a child ages 8 to 14 years old or a child ages 8 to 14 years old\n* Served at participating clinic in a county where the program is being implemented (Goldsboro Pediatrics, Bertie County Rural Health Association, and Roanoke Chowan Community Health in Bertie, Halifax, Lenoir, Northampton, or Wayne Counties)\n* Living in a county where the program is being implemented (Bertie, Halifax, Lenoir, Northampton, or Wayne Counties)\n* Free living to the extent they are able to receive and use a box of fresh produce and participate in direct nutrition education classes\n* Willing and able to provide written consent and participate in all study activities.\n\nExclusion Criteria:\n\n* Adults not at risk of food insecurity\n* Adults, who are not parents nor caregivers of a child 8 to 14 years\n* Adults who do not want to or could not fully participate (e.g., an adult family member with advanced kidney disease with severe dietary restrictions).",true,"8 Years","64 Years",{"count":114,"type":21},30,[24],"Increasing fruit and vegetable (FV) intake, and reducing saturated fat, salt, and added sugar are central lifestyle recommendations in the Dietary Guidelines for Americans to prevent chronic disease. Yet, while diet is modifiable, numerous barriers exist for lower-resourced families to engage in healthy dietary behaviors. In particular, rural families face structural and systemic disparities, such as inadequate access to affordable healthy food. Thus, this project. Thus, this study, PhytoRx Families, an innovative produce prescription (Prx) program, addresses health disparities in rural North Carolina (NC). This project will pilot test and explore the impact of PhytoRx Families (PhtyoRxF) on nutrition-related, health-related, and healthcare utilization outcomes.",[118,119,120,121,122],"Diet, Healthy","Health Behavior","Blood Pressure","Diabetes Mellitus Risk","Utilization, Health Care","2025-10-23",{"date":125,"type":38},"2025-10-27",{"date":127,"type":38},"2025-04-18",{"date":129,"type":21},"2026-05-31",{"name":44,"class":45},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":110,"sex":16,"minAge":17,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":46},"100608841","ultrasound-for-quantifying-muscle-activation-elicited-by-spinal-cord-stimulation-and-functional-electrical-stimulation-100608841","NCT07206797","Ultrasound for Quantifying Muscle Activation Elicited by Spinal Cord Stimulation and Functional Electrical Stimulation","Inclusion Criteria:\n\n* Between 18 and 60 years of age\n* Weight less than 220 lb\n* Healthy and able to walk at preferred speed without an assistive device\n* Able to tolerate functional electrical stimulation and tSCS.\n\nExclusion Criteria:\n\n* Active infection\n* history of cancer,\n* broken skin, sores, or areas of acute eczema near the electrode sites\n* metal implants, such as staples or pins, near the electrode sites\n* any neurological disorders\n* difficulty walking or an orthopedic condition that would impede walking normally without assistance\n* absent sensation in the lower extremities or trunk (torso),\n* allergies to adhesive skin tapes and\u002For ultrasound gels,\n* heart conditions\n* an implanted electronic device such as a pacemaker\n* current pregnancy\n* having no physiological response to FES and\u002For tSCS.","60 Years",{"count":114,"type":21},[24],"Transcutaneous (non-invasive) spinal cord stimulation (tSCS) has been shown to facilitate volitional motor activity in patients with spinal cord injury. tSCS is known to activate the same neural structures as invasive SCS, meaning it may have the potential for functional restoration without an expensive surgical implant. Functional electrical stimulation (FES) is also used in therapy for patients with spinal cord injury to locally activate paralyzed or weakened muscles. There is evidence that combining FES and tSCS may elicit greater muscle activation than either modality alone.\n\nThe objective of this study is to quantify the torque at the ankle joint generated by tSCS, by FES, and by tSCS + FES. Additionally, ultrasound images will be collected during stimulation to provide a metric of muscle activity. The correlation between ultrasound and torque will be assessed to determine if ultrasound is a useful modality for quantifying tSCS-elicited muscle activity.",[142],"Neuromodulatory Effects of TSCS and FES in Lower Limbs",[144,145,146],"Ultrasound","Spinal Stimulation","Functional Electrical Stimulation","2025-10-09",{"date":149,"type":38},"2025-10-14",{"date":151,"type":38},"2025-06-01",{"date":153,"type":21},"2026-06-01",{"name":44,"class":45},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":164,"conditions":165,"keywords":167,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":172,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":46},"100609561","phase-1-epidermal-sensors-for-wireless-and-enhanced-amputee-skin-tracking-e-sweat-part-1-100609561","NCT07216183","Epidermal Sensors for Wireless and Enhanced Amputee Skin Tracking (E-SWEAT) Part 1","Inclusion Criteria:\n\n* Be 18 years or older\n* Have a unilateral lower limb amputee (below the knee). The tibial length on the residual limb must be greater than half of the length of the tibial on the unaffected side\n* Have an amputation that occurred over 2 years ago\n* Have at least 1 year of experience using your prosthetic leg\n* Have used the current socket for at least 6 months without a significant skin issue or major modification\n* Be able to comfortably walk 6 mins (with prosthetic legs) without pausing to rest\n* Be willing to come to North Carolina State University's Centennial Campus to participate in research and be photographed while doing research activities\n\nExclusion Criteria:\n\n* Have a cognitive or visual impairment that affects the participant's ability to provide informed consent or to follow simple instructions during the experiments\n* Have any neuropathy observed on the residual limb\n* Experience numbness, tingling, muscle weakness, and\u002For pain in your residual limb\n* Weigh more than 300lbs\n* Do not want to take photos\n* Are pregnant or plan to get pregnant\n* Are allergic to latex, which is often contained in medical tapes.\n* If you are using medication to control sweat on your residual limb, and your medical provider does not think that it is OK to avoid these medications for 48 hours.",{"count":162,"type":21},16,[87],"The goal of this clinical trial is to 1) demonstrate the feasibility of monitoring pressure, temperature, and lactic acid density of sweat inside the prosthetic socket, and 2) verify the relationship between mechanical pressure and Lactic acid density of sweat for lower limb amputees among transtibial amputees. The main questions it aims to answer are:\n\n* Is it feasible to reliably monitor pressure, temperature, and lactic acid density inside the prosthetic sockets simultaneously?\n* Will the lactic acid density increase with higher pressure exposure? The participants are expected to wear the newly developed E-SWEAT system on their residual limb and are exposed to two activities, walk which generate mechanical load on the residual limb, and a yoga post - birddog, which does not generate mechanical loading on the residual limb. The E-SWEAT will measure pressure, temperature, and lactic acid density of sweat during these tasks.",[166],"Transtibial Amputation",[168,169,170,171],"sweat biomarker","prosthetic socket","pressure ulcer","residual limb health",{"date":149,"type":38},{"date":174,"type":38},"2025-09-16",{"date":176,"type":21},"2029-07-30",{"name":44,"class":45},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":46},"100471971","r21-an-easy-to-use-intelligent-affordable-liner-enable-system-for-socket-fit-assessment-100471971","NCT05425810","R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment","ENABLE","Inclusion Criteria:\n\n* Unilateral transtibial amputees\n* At least 1 year of experience using his\u002Fher prosthetic leg\n* Has used the current socket for at least 6 months without a significant skin issue or major modification\n* Can comfortably walk 3 mins without pausing to rest\n* The fibula length on the residual limb must be greater than half of the length of the fibula on the unaffected side\n\nExclusion Criteria:\n\n* Cognitive or visual impairment that affects the participant's ability to provide informed consent or to follow simple instructions during the experiments\n* neuropathy observed on the residual limb\n* regnant female",{"count":186,"type":21},3,[24],"Lower limb amputees (LLA) rely on their prosthetic legs to remain active and lead an independent life. For most LLAs, a well-fitted prosthetic socket is the only option to interface with their prosthetic leg, however, it is a real challenge to make a prosthetic socket to interface with residual limbs accurately. One of the reasons is that there lack of accurate approaches to evaluate the pressure distribution on the residual limb accurately and effectively. To overcome this issue, the research team will develop an innovative sensing system, which permits the prosthetists to track the pressure distribution on the residual limb visually. The capability of the new sensing system will be demonstrated on lower limb amputees.",[27],[191,169,192,170],"amputee","residual skin","2025-05-19",{"date":195,"type":38},"2025-05-20",{"date":197,"type":38},"2021-04-20",{"date":199,"type":21},"2026-02-27",{"name":44,"class":45},{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":16,"minAge":208,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":211,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":46},"100487046","finger-movement-training-after-stroke-100487046","NCT05621980","Finger Movement Training After Stroke","A Multimodal Intervention to Improve Manual Dexterity in Subacute Stroke Survivors","Inclusion Criteria:\n\n* A single, unilateral stroke 2-18 months prior to enrollment\n* Moderate to mild hand impairment, as determined by a rating of Stage 4-6 on the Stage of Hand section of the Chedoke-McMaster Stroke Assessment\n* Visual capacity to discern specific shapes on the computer screen\n* Capacity to provide informed consent\n\nExclusion Criteria:\n\n* Rigid contractures in the joints of the upper limbs, or orthopedic issues precluding joint movement\n* Hemispatial neglect (as assessed by the Behavioral Inattention Test)\n* Excessive pain in the paretic upper limb (visual analog scale of shoulder pain \\\u003C 70)","21 Years",{"count":210,"type":21},36,[24],"Human development as a species has been strongly associated with the ability to dexterously manipulate objects and tools. Unfortunately, current therapy efforts typically fail to restore fine manual control after stroke. The goal of this study is to evaluate a new intervention that would combine targeted electrical stimulation of selected nerves with use a soft, pneumatically actuated hand exoskeleton to enhance repetitive practice of independent movements of the fingers and thumb in order to improve rehabilitation of hand function after stroke.\n\nThe investigators will recruit stroke survivors in the subacute phase of recovery (2-18 months post-stroke). These participants will be involved in a 5-week intervention involving 15 training sessions. During these sessions, participants will train independent movement of the digits of the paretic hand. Evaluation of motor control of the paretic hand will occur prior to initiation of training, at the midpoint of the training period, after completion of training, and one month later.",[214],"Stroke",[216,217,218,219],"stroke","FES","virtual reality","rehabilitation","2024-11-12",{"date":222,"type":38},"2024-11-14",{"date":224,"type":38},"2023-09-05",{"date":226,"type":21},"2026-08",{"name":44,"class":45},""]