[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Northeastern University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":328},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,45,67,93,119,148,168,189,215,243,265,283,307],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100592556","multi-component-breath-alcohol-intervention-phase-3-100592556",false,"NCT06994962","Multi-Component Breath Alcohol Intervention Phase 3","Development and Initial Testing of a Multi-Component Breath Alcohol-Focused Intervention for Young Adults, Stage 3","BAMTECH","1. Be between the ages of 18-25\n2. Be able to read English and complete study evaluations\n3. Report at least four days with heavy episodic drinking (i.e., 4 or more drinks for women and 5 or more drinks for men) out of the prior 30 days\n4. Report having consumed at least one alcoholic drink during a minimum of 12 days out of the prior 30 so that subjects will have multiple opportunities to use the moderate drinking technologies during the intervention period.\n5. Meet, at minimum, DSM-5 criteria for a mild alcohol use disorder (i.e., meet at least 2 diagnostic criteria)\n6. Self-report interest in using a smartphone app to help reduce drinking with a score of at least 3 on a 0-10 scale indicating at least a degree of openness to using technology to moderate drinking.\n\nExclusion Criteria\n\nNo subject may:\n\n1. Have been in inpatient or intensive outpatient treatment within the past 12 months\n2. Have used a smartphone application to facilitate moderate drinking more than 1 time within the past 12 months\n3. Meet DSM-5 criteria for current substance use disorder with the exception of tobacco use disorder, mild or moderate alcohol use disorder or mild cannabis use disorder.\n4. History of alcohol withdrawal or medically-assisted detoxification as individuals with this history will likely be in need of more intensive treatment than is offered in this study.\n5. Be psychotic or otherwise severely psychiatrically disabled\n6. Report a history of a medical condition that would contraindicate the consumption of alcohol (e.g., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, and gastrointestinal disorders).",true,"ALL","18 Years","25 Years",{"count":22,"type":23},90,"ESTIMATED","INTERVENTIONAL",[26],"NA","This is the third stage of a three-stage, NIH-funded study to develop and test a multi-modal intervention concerning blood\u002Fbreath alcohol concentration for young adults who drink heavily. The multimodal intervention will be made up of brief telehealth counseling and psychoeducation and use of three existing mobile technologies. The brief counseling\u002Fpsychoeducation and mobile technologies provide personalized feedback regarding blood or breath alcohol content. The long-term goal of use of these mobile technologies will be to facilitate moderate drinking. However, the main goals of the proposed research are to learn more about feasibility of our procedures, perceived value of the technologies and ease of use from the research participants' points of view. In this third stage of the study, the investigators will conduct a randomized controlled trial building on the formative research conducted in Stages 1 and 2.",[29,30,31],"Alcohol Use","Alcohol Drinking","Drinking Behavior","RECRUITING","2026-05-18",{"date":35,"type":36},"2026-05-20","ACTUAL",{"date":38,"type":36},"2025-05-01",{"date":40,"type":23},"2027-01-31",{"name":42,"class":43},"Northeastern University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":24,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":44},"100639418","overcoming-the-barriers-to-effective-transcranial-temporal-interference-stimulation-in-humans-100639418","NCT07593859","Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans","Inclusion Criteria:\n\n* Free of neurological or orthopedic conditions that may impact the ability to participate.\n* Right-hand dominant (self-reported)\n* Aged 18-65 years\n\nExclusion Criteria:\n\n* Ferromagnetic metal implants in the brain\u002Fskull or elsewhere (dental implants excluded).\n* Any implanted electronic device (e.g. cardiac pacemaker, cochlear implant, deep brain stimulator, medication infusion pump; vagal nerve stimulator)\n* Diseased or damaged skin on face or scalp\n* History of migraines, fainting, seizures\u002Fepilepsy, or psychiatric illness\n* Neurological disorder or intracranial lesion\n* Frequent or severe headaches\n* Prior adverse reaction to transcranial magnetic stimulation\n* Currently pregnant\n* Suspected or diagnosed heart problems (e.g. arrhythmia, cardiac disturbances).\n* Insulin-dependent diabetes\n* Suspected or diagnosed epilepsy or a familial history of epilepsy\n* Use of alcohol or recreational drugs in the prior 12 hours\n* Use of prescription and over the counter medications will be grounds for exclusion except for: contraceptive (birth control) drugs (e.g. those containing ethinyl estradiol and\u002For norethindrone), and seasonal allergy medications (e.g. cetirizine (Zyrtec), fexofenadine (Allegra), and loratadine (Claritin)).","65 Years",{"count":53,"type":23},30,[26],"Transcranial temporal interference stimulation (TIS) is an emerging novel tool for non-invasive transcranial brain stimulation that holds the potential for focal and steerable neuromodulation, and the possibility to stimulate focally at depth. TIS involves combining two high frequency waveforms to create a waveform with a \"beat\" frequency that is physiological relevant for neuromodulation. Successful applications to deep brain targets as well as steerability of the stimulation focus have been demonstrated in mice. Numerous recent investigations in humans have shown great clinical potential for this technology, however several questions about the basic mechanism of TIS action remain. The investigators will apply TIS to the motor cortex of humans and use established transcranial magnetic stimulation techniques to assess cortical excitability in relation to the phase of the TIS waveform. Using TMS, the investigators will i) validate that effects of TIS are due to the \"beat\" frequency and not the high frequency carrier signal, ii) evaluate the effect of the TIS carrier frequency, and iii) evaluate that whether changes in corticospinal excitability outlast the period of stimulation. Knowledge gained from this experiment will provide a basis for the future use of TIS for clinical applications, including informing parameter optimization.",[57],"Healthy Adult Participants",[59],"transcranial temporal interference stimulation","2026-05-14",{"date":33,"type":36},{"date":63,"type":36},"2026-02-01",{"date":65,"type":23},"2029-10-01",{"name":42,"class":43},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":24,"phases":76,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},"100578513","mediators-and-moderators-of-auditory-training-100578513","NCT06812273","Mediators and Moderators of Auditory Training","Inclusion Criteria:\n\n* 18-30 and 60-85 years of age.\n* No self-reported auditory difficulties and normal or near-normal hearing sensitivity as measured by SRTs.\n* Older adults aged 50-85 should have no more than typical hearing loss for their age and no evidence of dementia.\n* Fluent in English and\u002For Spanish\n\nExclusion Criteria:\n\n* Abnormal vision or hearing prohibitive of training\n* History of seizures, focal brain lesion, or head injury with loss of consciousness\n* Physical handicap (motor or perceptual) that would impede training procedures\n* Medical illness requiring treatment during the study timeline\n* Social, educational or economic hardship prohibitive to training schedule\n* Concurrent enrollment in other cognitive training studies\n* History of major psychiatric illness, including psychosis, bipolar disorder, depression, alcohol or substance abuse, recent bereavement\n* Plans to travel out of the area for more than 1 week during the intervention period\n* Residence too far from the testing site, which would prevent attending the testing sessions (\\> 60 miles)\n* Not being proficient enough in English or Spanish that would prevent following and understanding all instructions and completing all testing sessions\n\nAdditional exclusion criteria for older adults:\n\n* Diagnosis of dementia or other neurological disease, including mild cognitive impairment (MCI)\n* Telephone-Montreal Cognitive Assessment (t-MoCA) score of 16 or less or Montreal Cognitive AssessmentMoCA) score of 20 or less","85 Years",{"count":75,"type":23},1260,[26],"The goal of this clinical trial is to learn how Auditory Training (AT) may help people better understand speech in noisy environments. As people get older, it becomes harder for them to hear speech clearly when there is background noise. This can be frustrating, and it can affect their independence and quality of life. AT is often used to support people with and without hearing loss, especially when a person is not a good candidate for a hearing aid or when amplification from a hearing aid does not improve performance.\n\nThe investigators want to gather reliable data to understand how AT works and what affects its success.\n\nThe main questions the trial aims to answer are:\n\n* How do different types of sounds influence the effectiveness of auditory training?\n* Which auditory training approaches are most successful in improving speech understanding?\n* How do personal traits impact the results of auditory training?\n\nThe investigators will study a large and diverse group of 1,260 participants, including both young and older adults, to evaluate various auditory training approaches.\n\nYou will:\n\n* Take part in auditory training sessions that include different types of auditory tasks.\n* Complete tests that measure how well they understand speech in both quiet and noisy settings.\n* Complete surveys on personal data like demographics, hearing challenges and other factors to help researchers understand what might influence training results.\n\nThe investigators will measure and compare the results of these approaches to find out which ones are most effective. This could help people who are at risk of cognitive decline, like those at risk for Alzheimer's disease.",[79],"Hearing Handicap",[81,82,83],"audition","auditory training","cognition","2026-04-15",{"date":86,"type":36},"2026-04-20",{"date":88,"type":36},"2025-01-06",{"date":90,"type":23},"2027-05-31",{"name":42,"class":43},3,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":17,"sex":18,"minAge":100,"maxAge":73,"enrollmentInfo":101,"targetDuration":4,"studyType":24,"phases":103,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":113,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":44},"100565705","visual-arts-interventions-with-older-adults-100565705","NCT06645652","Visual Arts Interventions With Older Adults","Feasibility and Preliminary Effects of a Drawing-based Intervention on Cognition and Wellbeing of Community-Dwelling Adults at Risk for ADRD","Inclusion Criteria:\n\n* 55-85 years of age\n* Able to understand and speak English and follow study procedures\n* Does not have a psychological or neurological condition that would prevent from being able to give consent to participate\n* Less than 2 years of formal visual arts training\n\nExclusion Criteria:\n\n* Formal diagnosis of dementia or other neurological disease, including Mild Cognitive Impairment\n* A final score below 17 on the Montreal Cognitive Assessment - Blind (phone) version\n* Abnormal visual acuity prohibitive of tablet-based training\n* Physical handicap (motor or perceptual) that would impede training procedures\n* Medical illness requiring treatment and\u002For significant absences during the study timeline","55 Years",{"count":102,"type":23},50,[26],"The present study investigates the feasibility, acceptability, and preliminary effects of a novel visual arts-based intervention in an older adult population. In a randomized controlled design, two arts-based interventions will be evaluated with a group of 50 participants.",[106],"Feasibility Study",[108,109,110,111,112],"Cognition","Perception","Aged","Healthy Volunteers","Learning",{"date":86,"type":36},{"date":115,"type":36},"2025-10-01",{"date":117,"type":23},"2026-09-30",{"name":42,"class":43},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":24,"phases":128,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":44},"100625376","an-empowering-parent-training-intervention-to-increase-physical-activity-in-preschool-aged-children-with-autism-100625376","NCT07421830","An Empowering Parent Training Intervention to Increase Physical Activity in Preschool Aged Children With Autism","An Empowering Parent Training Intervention to Increase Physical Activity in Preschool Aged Children With Autism: A Randomized Control Trial","Inclusion Criteria:\n\n* Parents or caregivers (who are at least 18 years of age) of children with a diagnosis of autism.\n* The autism diagnosis for the child can be from a school or medical setting.\n* The parent or caregiver's child with autism must be between 2 years 11 months and 5 years, 11 months of age.\n* Parent or caregivers must be able to read and write in English.\n\nExclusion Criteria:\n\n* Parents or caregivers who do not have a child with autism.\n* Adults who do not have children.\n* Parents or caregivers who cannot read and write in English.",{"count":127,"type":23},114,[26],"The goal of this clinical trial is to learn if WE PLAY for Parents can improve caregivers' knowledge, attitudes, confidence, and skills promoting physical activity with their young child with autism. The main questions it aims to answer are: (1) Do participants who complete WE PLAY for Parents improve their knowledge, behavior intentions, perceived behavior control, self-efficacy, and parenting practices related to physical activity promotion with their child (Primary Hypotheses); and (2) Do participants view WE PLAY for Parents as acceptable, understandable, and feasible \\[secondary hypothesis)?\n\nResearchers will compare the WE PLAY for Parents group \\[experimental arm\\] to a Waitlist Control group to see if there are differences in the variables listed in the primary hypothesis.\n\nParticipants will: (1) Complete a set of questionnaires at three timepoints: pre-training, post-training, and 3-month follow-up that each take between 10-15 minutes; (2) be randomly assigned to take the training over the next two weeks or be offered the training after 3 months.\n\nThe online training takes about 90 minutes. It includes watching informational videos, viewing video clips of adults helping children be active, reading handouts on behavior management tips and social stories, participating in an anonymous discussion board with other parents, and completing a self-assessment.",[131],"Autism Spectrum Disorder (ASD)",[133,134,135,136,137,138,139],"parents","autism","physical activity","preschoolers","health promotion","active play","caregivers","2026-04-06",{"date":142,"type":36},"2026-04-08",{"date":144,"type":36},"2026-02-20",{"date":146,"type":23},"2026-12-31",{"name":42,"class":43},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":73,"enrollmentInfo":155,"targetDuration":4,"studyType":24,"phases":157,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":44},"100548802","dance-and-energy-expenditure-among-adults-with-parkinsons-100548802","NCT06425731","Dance and Energy Expenditure Among Adults With Parkinson's","Characterizing Dance-related Physical Activity Behaviors Among Adults Living With Parkinson's Disease for Automated Analyses of Energy Expenditure","Inclusion Criteria:\n\n* Adults (18-85 years old)\n* Diagnosis of idiopathic PD (as confirmed by a neurologist), who are at a Hoehn and Yahr stage \\\u003C=3 (i.e., physically independent, some postural instability, mild to moderate bilateral involvement or less severe symptoms; Bhidayasiri et al., 2012), and who are\n* enrolled in Dance for PD® classes at the time of recruitment as a participant\n\nExclusion Criteria:\n\n* Adults with a score of \\>3 on the Hoehn \\& Yahr scale (i.e., those presenting with severely disabling disease, but still able to walk or stand unassisted or those who are confined to a bed or wheelchair unless aided; Bhidayasiri et al., 2012)\n* history of a prior neurological condition that is not PD, including epilepsy\n* pregnant or trying to become pregnant\n* those with contraindications to exercise as determined by the Physical Activity Readiness Questionnaire for Everyone (PARQ+)\n* currently smoke cigarettes or use tobacco products\n* have a pacemaker or other implanted medical device\n* have been hospitalized due to a psychological disorder within the last 5 years\n* have a respiratory disease (including chronic obstructive pulmonary disease- COPD, asthma, pulmonary high blood pressure)\n* have a metabolic condition (including type 1 diabetes, type 2 diabetes, pre-diabetes, chronic kidney disease, or liver problems)\n* have a kidney condition, a heart condition, history of stroke or cancer\n* experienced a blackout, fainted, or lost consciousness as a result of a head injury or had diagnosed concussion within the last 12 months\n* take a medication that affects cardiovascular responses to exercise\n* prospective participants with a diagnosis of PD who score \\\u003C 17 on the Telephone Interview for Cognitive Status (TICS-30)\n* currently residing outside of the United States",{"count":156,"type":23},60,[26],"The first purpose of the study is to develop and test new methods for quantifying dance among adults with a diagnosis of Parkinson's using various kinds of cameras, wearable activity monitors, and questionnaires. The second reason we are conducting the study is to better understand the relationship between the intensity of dance classes specifically designed for adults with Parkinson's and individual-level factors like the kinds of routine activities one does beyond dancing and one's health status.\n\nParticipants in the study may be asked to engage in any of the following activities:\n\n* complete a small number of assessments on their physical and cognitive functioning\n* complete their routine group-based dance classes, specifically designed for adults with a diagnosis of Parkinson's, while being recorded\n\nDepending upon the group that a participant joins, one may also be asked to:\n\n* wear an activity monitor on their waist while engaged in their daily business as usual for nine (9) days\n* complete an iDXA scan\n* describe their perceptions on how the use of technology can integrated into their dancing",[160],"Parkinson Disease",{"date":162,"type":36},"2026-04-13",{"date":164,"type":36},"2024-07-01",{"date":166,"type":23},"2026-07-31",{"name":42,"class":43},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":17,"sex":18,"minAge":175,"maxAge":19,"enrollmentInfo":176,"targetDuration":4,"studyType":24,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":188,"locationsCount":44},"100510035","preventing-depression-of-chinese-american-adolescents-by-rre-100510035","NCT05921201","Preventing Depression of Chinese American Adolescents by RRE","Preventing Depression of Chinese American Adolescents Through Mobile Health Application","Inclusion Criteria: Participants must be CAAs (ethnic Chinese descent, born or grew up in the U.S) from the Greater Boston Area, Massachusetts, and meet the following inclusion criteria:\n\n1. 14 -18 years old enrolled in school.\n2. Understand and sign an informed consent (or assent for minors) document.\n3. Sixth grade reading level (in order to understand and complete proposed tasks).\n\nExclusion Criteria:\n\n1. Those who do not have sixth grade reading level to understand and complete the measures\n2. Those who have a diagnosis of major depression or other mental disorders (that needs more extensive treatment than the Relax, Reflect, and Empower application -RRE program can provide)\n3. Those who have a score of 3 or above in Patient Health Questionnaire-2 or Generalized Anxiety Disorder- 2 (who need more extensive treatment than the RRE program can provide)","14 Years",{"count":177,"type":23},110,[26],"The goal of this clinical trial is to test if a culturally sensitive mobile health application (Relax, Reflect, Empower-RRE) is feasible and effective in promoting psychological wellbeing and reducing depressive symptoms among Chinese American adolescents (CAA). We will conduct a pilot study of a community sample of 110 CAAs, ages 14-18. We will use adaptive randomization to assign 55 participants to the RRE intervention for 5 days\u002Fweek for 3 months and 55 to the control group who will receive a wellness check-in text message 5 days\u002Fweek for 3 months. The main aims\u002Fresearch questions are, 1) To evaluate feasibility and acceptability of RRE. Assessments include both subjective (CAAs' perceptions of feasibility and acceptability of RRE through Mobile Application Rating Scale and open-ended questions) and objective (CAAs' frequency and duration of RRE access automatically recorded) measures. Our hypothesis is that participants in the RRE group will find RRE feasible and acceptable. 2) To investigate CAAs' changes in depressive symptoms, coping self-efficacy, and psychological wellbeing. We will compare if these changes differ in the RRE group and control group. Participants in both RRE and control groups will complete measures of outcomes (depression, coping self-efficacy, psychological wellbeing) and influencing factors (acculturative stress, experiences of discrimination, life events) at three time points: baseline, the end of the preventive intervention (the12th week), and one-month after the intervention (the16th week). Our hypothesis is that CAAs in the RRE group will exhibit lower levels of depressive symptoms and higher levels of coping self-efficacy and psychological well-being in Weeks 12 and 16 than the baseline. Additionally, CAAs in the RRE group will exhibit greater improvement than the control group in the outcome measures from baseline to Weeks 12 and 16.",[181],"Subclinical Depressive Symptoms","2026-03-11",{"date":184,"type":36},"2026-03-13",{"date":186,"type":36},"2024-03-25",{"date":40,"type":23},{"name":42,"class":43},{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":196,"minAge":19,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":24,"phases":199,"briefSummary":200,"conditions":201,"keywords":203,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":44},"100625433","body-acceptance-after-baby-intervention-100625433","NCT07422571","Body Acceptance After Baby Intervention","BABI","Individuals must:\n\n* Be currently residing in the U.S.\n* Be able to read and write in English\n* Be aged 18 or above\n* Identify as a woman\n* Have given birth to a live infant in the past year\n* Endorse dissatisfaction with their appearance (i.e., in answering the question \"Indicate how satisfied you are with your overall appearance\" they must answer neutral, mostly dissatisfied, or very dissatisfied)","FEMALE",{"count":198,"type":23},375,[26],"The purpose of this study is to learn if a novel online single-session intervention can help improve body dissatisfaction in new moms. The active intervention condition, Body Acceptance After Baby (BABI), uses acceptance-based skills to help participants cope with body dissatisfaction. BABI will be evaluated against another active intervention condition (a brief infographic that provides psychoeducation about body image during postpartum) and a waitlist control condition.",[202],"Body Dissatisfaction",[204,205,206,207],"Body dissatisfaction","Postpartum","Single-session intervention","Acceptance and commitment therapy","2026-02-12",{"date":144,"type":36},{"date":211,"type":36},"2026-01-20",{"date":213,"type":23},"2027-12",{"name":42,"class":43},{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":17,"sex":18,"minAge":222,"maxAge":223,"enrollmentInfo":224,"targetDuration":4,"studyType":24,"phases":226,"briefSummary":227,"conditions":228,"keywords":230,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":44},"100604313","executive-function-training-for-children-and-adolescents-100604313","NCT07147894","Executive Function Training for Children and Adolescents","Understanding Mediating and Moderating Factors That Determine Transfer of Working Memory Training in Adolescents","Inclusion Criteria:\n\n* 12-17 years old.\n* Child must have a caregiver (parent\u002Fguardian) who is available to participate as a training aide.\n* Child and parent\u002Fcaregiver are able to understand\u002Fspeak adequate English or Spanish to follow and participate in study procedures\n* Both child and parent\u002Fguardian are willing to give informed consent\u002Fassent, be randomized to either intervention condition, and be willing to follow the assigned study protocol.\n* \\~50% of the participants: Meet criteria for ADHD DSM-5 diagnosis.\n\nExclusion Criteria:\n\n* Child is taking ADHD medication\u002Fstimulants.\n* Child has been formally identified as intellectually disabled.\n* Abnormal visual acuity or hearing challenges that are prohibitive to participating in the intervention\u002Fassessment.\n* History of organic mental disorders (conditions or disturbances that may be caused by injuries and\u002For neurodegenerative diseases affecting brain tissues), psychosis, history of autism spectrum disorders, intellectual disability, or active substance use or suicidal ideation (such individuals will be referred to psychiatric services).\n* Major sensory or motor impairment that would preclude valid cognitive testing.\n* Participants with color blindness, if they are unable to discriminate the task relevant stimuli.\n* Populations considered vulnerable such as wards and those with neurological or other health conditions that may prevent the ability to give informed consent.","12 Years","17 Years",{"count":225,"type":23},780,[26],"The goal of this clinical trial is to evaluate how different approaches to executive function (like adding game-like features, varying the number of tasks, and providing coaching) can enhance executive function outcomes in adolescents with and without ADHD. The main questions it aims to answer are:\n\n* What components of executive function training contribute most to improving outcomes?\n* How do training components vary in their impacts on adolescents diagnosed with ADHD compared to those without a diagnosis?\n* What individual characteristics influence the effectiveness of executive function training?\n\nResearchers will test six different training setups to examine which setups are the most effective for different people. They will evaluate both how well participants follow the training schedule and whether there are changes in psychological and cognitive outcomes after training.\n\nParticipants will complete:\n\n* 40 training sessions over 4 weeks\n* A set of tests and surveys before and after the training\n* Follow-up assessments and surveys 6 months after finishing the training",[229],"Cognitive Change",[231,232,233,234],"ADHD","Executive Function Training","Motivational coaching","Cognitive Training","2025-12-16",{"date":237,"type":36},"2025-12-23",{"date":239,"type":36},"2025-12-14",{"date":241,"type":23},"2028-06-30",{"name":42,"class":43},{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":24,"phases":252,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":264},"100549576","eca-enhanced-document-explanation-rct-100549576","NCT06435819","ECA-enhanced Document Explanation RCT","Advancing Medical Illustration in Patient Education Materials: From Art to Science. Study 2: ECA-enhanced Document Explanation RCT","Inclusion Criteria:\n\n* Over 18 years old\n* Speaks English or Spanish fluently\n* Is able to independently consent\n* Has adequate corrected vision to read patient education documents\n\nExclusion Criteria:\n\n\\* None",{"count":251,"type":23},300,[26],"The investigators will evaluate a computer-animated character that explains medical illustrations to people, comparing the character to having people understand the illustrations on their own, and also comparing the computer character on a computer display to one in immersive virtual reality. The investigators will determine which method leads to the best understanding and lowest anxiety.",[255],"Healthy","2025-09-29",{"date":258,"type":36},"2025-10-03",{"date":260,"type":36},"2025-09-05",{"date":262,"type":23},"2027-09-01",{"name":42,"class":43},2,{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":24,"phases":273,"briefSummary":274,"conditions":275,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":280,"leadSponsor":282,"locationsCount":264},"100549575","medical-illustration-design-characteristic-evaluation-100549575","NCT06435806","Medical Illustration Design Characteristic Evaluation","Advancing Medical Illustration in Patient Education Materials: From Art to Science. Study 1: Medical Illustration Design Characteristic Evaluation",{"count":272,"type":23},8200,[26],"The goal of this study is to understand what people understand from medical illustrations, and what meaning and emotions (such as anxiety) they derive from different design elements.",[255],"2025-07-30",{"date":278,"type":36},"2025-08-03",{"date":186,"type":36},{"date":281,"type":23},"2027-01-01",{"name":42,"class":43},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":290,"enrollmentInfo":291,"targetDuration":4,"studyType":24,"phases":293,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":44},"100533690","multimodal-musical-stimulation-for-healthy-neurocognitive-aging-100533690","NCT06229093","Multimodal Musical Stimulation for Healthy Neurocognitive Aging","Multimodal","Inclusion Criteria:\n\n* normal or corrected-to-normal vision\n* no more than mild hearing loss\n* no recent history of neurological or psychiatric disorders, including mood disorders or use of medications that may affect cognition or responsiveness to music.\n\nExclusion Criteria:\n\n* moderate or severe hearing loss (40+ dB)\n* visual impairment (including color blindness) that cannot be corrected with glasses or contacts\n* recently changed dosage of cholinesterase inhibitors or psychotropic medication\n* recent history of psychotic or schizophrenic episodes\n* major neurologic diagnosis or other condition that might impair cognition or confound assessments (dementia, ADRD; Parkinson's disease, stroke, brain injury, epilepsy, or recent cardiovascular or neurovascular event)\n* recent history of serious physical trauma or diagnosis of serious chronic health condition requiring medical treatment and monitoring .","95 Years",{"count":292,"type":23},100,[26],"This is a Stage I randomized, sham-controlled trial on the effects of multimodal musical stimulation on working memory in aging. Neurologically healthy older and younger adults will be tested on working memory and electroencephalography in the first randomized controlled trial of music as a form of brain stimulation, with multimodal musical stimulation and control stimulation conditions. Results will test the causal role of oscillatory mechanisms of the brain on cognition, and will lay the groundwork to the first musical, neurophysiologically targeted, brain-stimulation device for reversing cognitive decline in aging.",[296],"Aging",[298],"Music","2025-07-08",{"date":301,"type":36},"2025-07-10",{"date":303,"type":36},"2022-12-11",{"date":305,"type":23},"2027-12-31",{"name":42,"class":43},{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":17,"sex":18,"minAge":314,"maxAge":290,"enrollmentInfo":315,"targetDuration":4,"studyType":24,"phases":316,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":44},"100514901","gamma-music-based-intervention-for-mild-alzheimers-disease-100514901","NCT05984524","Gamma-Music Based Intervention for Mild Alzheimer's Disease","NUGammaMBI","Mild AD participants will be ages 55-90, amnestic (single or multiple domain) who perform below an education- adjusted cut-off score on the Logical Memory II subscale delayed paragraph recall of the Wechsler Memory Scale-Revised (WMS-R LM-IIa) (Wechsler 1987) (≥16 years: ≤8; 8-15 years: ≤4; 0-7 years: ≤2), have a CDR global score of 0.5 (with a memory box score of 0.5 or 1), have an MMSE score of 20-24, and have preserved instrumental activities of daily living (ADL) as determined by the Alzheimer's Disease Cooperative Study ADL Prevention Instrument (ADCS ADL-PI). All participants will be medically stable. Participants will not have significant cerebrovascular disease determined by history of stroke, and will have a Modified Hachinski Ischemic score (Rosen et al. 1980) of ≤ 4. Participants will not have significant psychiatric disorders including a Geriatric Depression Scale (long form) (Yesavage et al. 1982) of ≤10, and will not have a history of substance or alcohol abuse. All participants must be on stable doses of any medications with psychotropic effects (including cholinesterase inhibitors, memantine, and antidepressants) for at least 3 months prior to randomization. Participants will be screened to be amyloid positive via plasma test. They must also have no contraindications to MRI scanning, and will have a study partner who is able to provide collateral information about the participant. A pure tone audiogram will be administered to ensure that participants have no more than mild levels of hearing loss (\\\u003C40dB). If a subject fails audiometric screening, they will be excluded from the study and provided with a list of audiologists. An Institutional Review Board (IRB) approved telephone screen will be used for demographic information, study inclusion\u002Fexclusion criteria and MRI contraindications. Participants will complete an MRI screening questionnaire before each MRI session.","50 Years",{"count":156,"type":23},[26],"The study will test and refine a novel brain-stimulation tool using gamma-frequency lights coupled with self-selected music for a gamma-music-based intervention for participants with mild Alzheimer's Disease. Results will yield a gamma-stimulation protocol that reliably influences brain activity (Aim 1), is adaptive, motivating and rewarding to use (Aim 2), and will generate predictions as to who might benefit the most from gamma-MBI (Aim 3). By bridging the gap between neurostimulation and behavioral intervention by combining music therapy with gamma- band neurostimulation, the present project aims to find a sustainable intervention that delays the progression of AD.",[319],"Alzheimer Disease","2023-10-04",{"date":322,"type":36},"2023-10-06",{"date":324,"type":36},"2022-07-01",{"date":326,"type":23},"2027-06-30",{"name":42,"class":43},""]