[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Old Dominion University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":180},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,83,113,135,159],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100643421","olive-oil-supplementation-for-heart-failure-with-reduced-ejection-fraction-100643421",false,"NCT07644806","Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction","Olive Oil Supplementation to Enhance Exercise Tolerance in Cardiac Rehabilitation in Patients With Heart Failure With Reduced Ejection Fraction: The OLEA-HF Study","OLEA-HF","Inclusion Criteria:\n\n* Diagnosed with HFrEF with left ventricular ejection fraction ≤35 %.\n* Referred to and enrolled in the standard cardiac rehabilitation program at Sentara Cardiac Rehabilitation Center, but has not yet initiated\u002Fstarted cardiac rehabilitation (i.e., has not attended the first cardiac rehab session).\n* Able and willing to comply with study procedures and provide informed consent.\n\nExclusion Criteria:\n\n* Co-morbidity expected to limit survival (e.g., terminal illness).\n* End-stage renal disease.\n* Unstable fluid overload.\n* Current pregnancy (self-disclose).\n* Habitual use of EVOO greater than 4 tablespoons per day.\n* Known allergy or sensitivity to olive oil or its components.\n* Unwillingness or inability to incorporate EVOO or dietary recommendations.","ALL","18 Years","85 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","The OLEA-HF study aims to explore whether daily supplementation of extra-virgin olive oil (EVOO) for 12 weeks during participation in a cardiac rehabilitation program (standard of care) is feasible in patients with heart failure with reduced ejection fraction (HFrEF). The investigators will also determine the effects of EVOO on functional capacity and quality of life.",[28],"Heart Failure With Reduced Ejection Fraction (HFrEF)",[30,31],"Cardiomyopathy","Dietary fat quality","NOT_YET_RECRUITING","2026-06-08",{"date":35,"type":36},"2026-06-12","ACTUAL",{"date":38,"type":22},"2026-07-01",{"date":40,"type":22},"2028-03-31",{"name":42,"class":43},"Old Dominion University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":65,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":44},"100609847","early-intervention-in-infants-with-unrepaired-cleft-palate-language-palatal-function-and-articulation-100609847","NCT07219901","Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.","Inclusion Criteria:\n\n* Infants with unrepaired cleft palate (with or without cleft lip)\n* Aged between 6 and 10 months at the time of study commencement\n\nExclusion Criteria:\n\n* Medically fragile status that would preclude participation in this community-based study.\n* Palatoplasty completed.\n* Aged over one year\n* Infants with cleft lip only","6 Months","12 Months",{"count":54,"type":22},200,[25],"The goal of this clinical trial is to learn if teaching speech skills to infants with cleft palates, prior to palate repair, will help them to develop speech and language skills. It will also learn about whether the skills are linked to fewer speech sound difficulties when they start school. The main questions it aims to answer are:\n\nDo standard, early intervention techniques to promote language development, that are used in children who are late talkers, work in infants with cleft palates? Will infants with cleft palates increase the number of sounds they use after targeted intervention? Can infants attempt to make stop sounds, like b and p, after targeted intervention? Can infants with cleft palate learn new words more quickly when they are used with gestures?\n\nParticipants will:\n\nParticipate in a baseline evaluation of speech and language skills, either in person, or via Telehealth.\n\nAttend the clinic for twice-weekly visits, for six weeks, to learn techniques to help their infants develop their speech and language skills, in a group setting with other families of infants with cleft palate.\n\nParticipate in a final evaluation of speech and language skills, either in person, or via Telehealth.",[58,59,60,61,62,63,64],"Cleft Lip and Cleft Palate","Cleft Lip Palate","Cleft Lip and\u002For Palate","Cleft Palate","Cleft Palate Children","Cleft Palates","Cleft Palate Repair",[66,67,68,69,70,71,72,73,74],"cleft-type speech","hypernasality","palatal function","compensatory speech patterns","obligatory speech patterns","velopharyngeal dysfunction","communication","language","speech","2025-10-20",{"date":77,"type":36},"2025-10-22",{"date":79,"type":22},"2025-10-21",{"date":81,"type":22},"2027-01-31",{"name":42,"class":43},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":18,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":44},"100605769","the-role-of-mobile-apps-in-promoting-cardiovascular-health-and-motivation-to-exercise-during-pregnancy-100605769","NCT07166822","The Role of Mobile Apps in Promoting Cardiovascular Health and Motivation to Exercise During Pregnancy","Inclusion Criteria:\n\n* Age: 18-45 years.\n* Pregnant women who are 20-24 weeks pregnant at enrollment\n* Sedentary, as defined by completing less than 90 minutes of exercise each week.\n* Generally healthy, uncomplicated pregnancies.\n* Free of physical limitations that may interfere with alterations in daily physical activity levels.\n* Single gestation.\n* Have a smartphone\n* Under the routine medical care of an obstetrician or certified nurse midwife during their current pregnancy.\n* Women speaking English.\n\nExclusion Criteria:\n\n* Physician diagnosed cardiovascular\u002F vascular complications (heart disease, high blood pressure, Raynaud's phenomenon etc.)\n* Physician diagnosed metabolic diseases (diabetes, hypothyroidism)\n* Musculoskeletal injuries (broken bones, back pain, ankle sprain, muscle pull, etc.)\n* Medications that may impact blood vessel function such as hypertension medication (Angiotensin converting enzyme inhibitor, Angiotensin receptor blocker, Calcium channel blocker, beta blocker), lipid lowering agents (statins), Nitrates, steroids, etc.\n* Complications associated with pregnancy that would be exacerbated by exercise such as lung disease, persistent spotting\u002Fbleeding or Placental Previa, premature labor, ruptured membranes, evidence of intrauterine growth restriction, pregnancy induced hypertension or pre-eclampsia, uncontrolled epileptic fits\u002Fseizures.\n* Smoking within the previous 3 months.",true,"FEMALE","45 Years",{"count":93,"type":22},50,[25],"The goal of this study is to determine the effectiveness of a mobile exercise app in improving cardiovascular health and motivation to exercise in pregnant women who are healthy, in their 2nd trimester, between 18-45 years age, and do not do exercise currently. The aims of this study are determine i) the effect of a mobile app (BumptUp) to increase motivation to exercise as assessed by questionnaire, and ii) the changes may occur in cardiovascular health outcomes such as increased percent Flow-Mediated Dilation (FMD), Heart Rate Variability (HRV), and decreased Pulse Wave Velocity (PWV) over an 8-week period of intervention. Researchers will compare this to pregnant women who are healthy, in their 2nd trimester, between 18-45 years age, and who will not be using the mobile app (BumptUp) for exercise. Participants who are in the experimental group will be given access to the mobile app (BumptUp) for 8 weeks. Both the control and experimental group will visit the lab for their baseline measurements (study visit 1), followed by two visits at 4 weeks (study visit 2) and 8 weeks (study visit 3) to have their heart rate variability, arterial stiffness (PWV), and vascular function (FMD) assessed. At each study visit, blood pressure, heart rate, height, and weight will also be measured. Additionally, at all three study visits, participants will fill out a questionnaire to determine motivation to exercise.",[97,98],"Cardiovascular (CV) Risk","Exercise",[100,101,102,103],"pregnant","cardiovascular","mobile app","exercise","RECRUITING","2025-09-03",{"date":107,"type":36},"2025-09-10",{"date":109,"type":22},"2025-09-15",{"date":111,"type":22},"2028-08-01",{"name":42,"class":43},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":89,"sex":17,"minAge":18,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":44},"100455978","the-influence-of-different-mood-states-and-emotions-on-the-physiologic-metabolic-and-perceptual-responses-to-feeding-before-exercise-100455978","NCT05217589","The Influence of Different Mood States and Emotions on the Physiologic, Metabolic, and Perceptual Responses to Feeding Before Exercise","Inclusion Criteria:\n\n1. Aged 18 to 55 years\n2. Able to run for 30 min at a moderate-to-vigorous intensity without stopping\n3. No diagnosis or signs\u002Fsymptoms of cardiovascular disease (CVD) or metabolic disorders\n4. Currently physically active (at least 3 days\u002Fweek of exercise at a moderate or higher intensity)\n5. No visual or hearing impairments interfering with ability to see and hear video clips\n6. No allergies to ingredients in Boost drink\n\nExclusion Criteria:\n\n1. Aged \\\u003C18 or \\>55 years\n2. Unable to run for 30 min at a moderate-to-vigorous intensity without stopping\n3. A diagnosis or signs\u002Fsymptoms of CVD or metabolic disorders\n4. Currently physically inactive (\\\u003C 3 days\u002Fweek of exercise at a moderate or higher intensity)\n5. Visual or hearing impairments interfering with ability to see and hear video clips\n6. Allergies to ingredients in Boost drink","55 Years",{"count":121,"type":22},90,[25],"Many athletes anecdotally report modifying their nutritional intake before competition in order to avoid gut problems, but no studies have evaluated whether emotional state impacts tolerance to pre-exercise feeding. Therefore, this study will use movie clips (stressful, horror, and funny\u002Famusing) to induce different mood states and emotions, which will be followed by ingestion of food before endurance running on a treadmill. In addition, metabolic and physiologic responses to mood induction will be evaluated.",[125,126],"Other Gastrointestinal Disorders","Cramp, Abdominal","2025-03-17",{"date":129,"type":36},"2025-03-20",{"date":131,"type":36},"2022-04-01",{"date":133,"type":22},"2025-12-31",{"name":42,"class":43},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":89,"sex":17,"minAge":18,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":44},"100574767","food-orders-on-blood-glucose-and-fuel-use-at-rest-100574767","NCT06763562","Food Orders on Blood Glucose and Fuel Use At Rest","The Impact of Different Food Orders on Blood Glucose and Fuel Use At Rest","Inclusion Criteria:\n\n* 18-70 years old\n* Free from any allergy or condition that precluding consumption of edamame, butter, and rice\n* Not currently pregnant\n* Free of any medical conditions requiring the use of insulin\n* Have no history of bariatric surgery\n* Have no implanted electrical devices such as a pacemaker\n\nExclusion Criteria:\n\n* Younger than 18 and older than 70 years old\n* Having an allergy or condition that precludes consumption of edamame, butter, and rice\n* Currently pregnant\n* Any medical conditions requiring the use of insulin\n* A history of bariatric surgery\n* Having an implanted electrical device such as a pacemaker","70 Years",{"count":144,"type":22},60,[25],"Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.",[148,149,150],"Glucose Metabolism Disorders","Hunger","Fat Burn","2025-02-16",{"date":153,"type":36},"2025-02-19",{"date":155,"type":36},"2025-01-05",{"date":157,"type":22},"2026-06-30",{"name":42,"class":43},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":89,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":44},"100475233","the-impact-of-removal-of-exercise-on-glycemic-control-and-vascular-health-in-older-active-adults-100475233","NCT05468255","The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults","The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active","Inclusion Criteria:\n\n1. 55 years and older, 18-40 years old\n2. Healthy, physically active, performing at least 90 min\u002Fweek of physical activity\n3. Free of physical limitations that may interfere with alterations in daily physical activity levels\n\nExclusion Criteria:\n\n1. Physician diagnosed HIV, hepatitis, or tuberculosis.\n2. Body weight change of greater than 5% within the previous 2 months\n3. Smoking within the previous 2 months.\n4. Taking medications that alter blood glucose levels",{"count":21,"type":22},[25],"The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.",[170,98,171],"Glucose Intolerance","Vascular Function","2024-04-09",{"date":174,"type":36},"2024-04-10",{"date":176,"type":36},"2022-07-25",{"date":178,"type":22},"2025-04-01",{"name":42,"class":43},""]