[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Oncology Institute of Vojvodina\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100612111","perioperative-complications-after-neoadjuvant-radiotherapy-for-colorectal-cancer-100612111",false,"NCT07249333","Perioperative Complications After Neoadjuvant Radiotherapy for Colorectal Cancer","Effect of Neoadjuvant Radiotherapy on the Incidence of Perioperative Complications After Radical Surgical Treatment of Colorectal Cancer","Inclusion Criteria:\n\n* Adult patients (over 18 years of age)\n* Clinical Frailty Scale 2, 3 or 4 status\n* Patients undergoing radical surgical treatment of colorectal cancer\n\nExclusion Criteria:\n\n* Patients undergoing palliative surgical treatment of colorectal cancer","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","OBSERVATIONAL","Neoadjuvant radiotherapy plays an important role in the treatment of locally advanced colorectal cancer. Although radiation therapy is extremely important in reducing the tumor mass, downstaging, and therefore providing conditions for curative surgery, neoadjuvant therapy can increase the risk of perioperative complications, which can lead to slower patient recovery, greater perioperative morbidity, prolonged hospitalization, and increased treatment costs.\n\nThe aim of the study is to determine whether there is a difference in the incidence of perioperative complications after radical colorectal cancer surgery between patients who received neoadjuvant radiotherapy and those patients who did not undergo neoadjuvant radiation.\n\nData is collected from the medical documentation and information system of the Oncology Institute of Vojvodina. Demographic characteristics of patients, comorbidities, length of hospital stay, length of treatment in the intensive care unit, occurrence of complications in the perioperative period, as well as data on neoadjuvant therapy are analyzed. All included patients are of similar general condition, as determined by the CFS (Clinical Frailty Scale). Intraoperative complications are graded using the ClassIntra classification of intraoperative adverse events, and the presence of postoperative adverse events are assessed and classified using the Clavien-Dindo classification of postoperative complications and the HARM (HospitAl stay, Readmission, Mortality rate) score.",[24,25,26],"Colorectal Cancer","Neoadjuvant Radiotherapy","Perioperative Complication","RECRUITING","2025-11-18",{"date":30,"type":31},"2025-11-25","ACTUAL",{"date":33,"type":31},"2024-06-18",{"date":35,"type":20},"2026-06",{"name":37,"class":38},"Oncology Institute of Vojvodina","OTHER_GOV",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":47,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":39},"100509546","phase-2-ultra-hypofractionated-for-whole-breast-irradiation-wbi-compared-to-partial-breast-irradiation-pbi-100509546","NCT05914831","Ultra-hypofractionated for Whole Breast Irradiation (WBI) Compared to Partial Breast Irradiation (PBI)","Ultra-hypofractionated for Whole Breast Irradiation (WBI) Compared to Partial Breast Irradiation (PBI): A Single-Institution Prospective Phase 2 Trial","Inclusion Criteria:\n\n* Breast-conserving surgery\n* Invasive ductal carcinoma\n* Age ≥ 50\n* Tumor size ≤ 3 cm\n* R0 resection\n* Unicentric\u002Funifocal carcinoma or multifocal carcinoma within 2 cm of the primary neoplasm\n* pN0 (sentinel lymph node biopsy or axillary lymph node dissection performed), N1mi\n* Hormone receptor status - any\n* Histological grade G1 or G2\n\nExclusion Criteria:\n\n* Neoadjuvant systemic therapy\n* TNBC (triple-negative breast cancer)\n* Extensive intraductal component (EIC)\n* Lymphovascular invasion (LVI)\n* associated DCIS \\> 2.5 cm in size or high nuclear grade","FEMALE","50 Years",{"count":50,"type":20},100,"INTERVENTIONAL",[53],"PHASE2","Female patients undergoing surgical treatment for early breast cancer and meeting the inclusion criteria for adjuvant breast radiotherapy were randomized into two groups. One group will receive adjuvant whole-breast radiotherapy in ultra-hypofractionated regimen of 26 Gy in 5 fractions. In contrast, the other group will receive partial breast irradiation with a dose of 26Gy in 5 fractions.\n\nThe study's objective is to compare the effects of both breast radiotherapy protocols in terms of locoregional disease control and survival and to compare the adverse effects of radiotherapy between the two protocols. To determine if there is a correlation between different parameters and the efficacy and degree of toxicity for both protocols.",[56],"Breast Cancer Female",[58,59,60],"Ultra-hypofractionated radiotherapy","Partial breast irradiation","Breast radiotherapy toxicity","2023-06-28",{"date":63,"type":31},"2023-07-03",{"date":65,"type":31},"2023-06-01",{"date":67,"type":20},"2033-05-31",{"name":37,"class":38},""]