[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ondokuz Mayıs University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":684},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,58,0,25,[9,51,75,108,138,162,198,232,262,286,314,338,358,385,416,438,459,486,516,537,563,590,616,636,664],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100626195","single-step-vs-stepwise-lung-recruitment-maneuvers-after-cardiopulmonary-bypass-100626195",false,"NCT07432477","Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass","Comparison of Hemodynamic and Pulmonary Outcomes Between Single-Step and Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-80 years\n* ASA (American Society of Anesthesiologists) II-IV\n* Patients undergoing elective cardiac surgery (coronary artery bypass grafting, mitral valve replacement, aortic valve replacement)\n\nExclusion Criteria:\n\n* Emergency surgery\n* Presence of perioperative arrhythmia\n* \\\u003C35% left ventricular ejection fraction\n* \\>50 mmHg systolic pulmonary artery pressure\n* Known chronic obstructive pulmonary disease or interstitial lung disease\n* Pneumothorax\n* Mean arterial pressure \\\u003C60 mmHg during recruitment maneuver\n* New York Heart Association (NYHA) class III-IV heart failure\n* Advanced cardiomyopathy or severe mitral regurgitation\n* Cross-clamp time longer than 2 hours\n* Requirement for high-dose inotropic or vasopressor support\n* Patients who cannot be extubated after postoperative 24 hours","ALL","18 Years","80 Years",{"count":21,"type":22},52,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass. After separation from cardiopulmonary bypass, patients will be randomized to receive either a single-step sustained inflation recruitment maneuver or a stepwise incremental recruitment maneuver, both combined with 8 cmH₂O positive end-expiratory pressure. The primary outcome is the change in cardiac index before and after the recruitment maneuver. Secondary outcomes include lung ultrasound atelectasis score, and hemodynamic parameters.",[28],"Atelectasis, Postoperative",[30,31,32,33,34,35,36,37],"cardiopulmonary bypass","lung recruitment maneuver","atelectasis","cardiac surgery","cardiac index","hemodynamics","lung ultrasound","positive end-expiratory pressure","RECRUITING","2026-06-30",{"date":41,"type":42},"2026-07-01","ACTUAL",{"date":44,"type":42},"2026-02-15",{"date":46,"type":22},"2027-05-01",{"name":48,"class":49},"Ondokuz Mayıs University","OTHER",1,{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":50},"100605604","serratus-posterior-superior-plane-block-for-postoperative-pain-in-cardiac-surgery-100605604","NCT07164677","Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery","Efficacy of the Serratus Posterior Superior Intercostal Plane Block for Postoperative Acute Pain Management in Open-Heart Surgery","Inclusion Criteria:\n\n* Patients aged 18-80 undergoing elective on-pump open-heart surgery via median sternotomy.\n* American Society of Anesthesiologists (ASA) classification II-III patients.\n* Patients who can use PCA.\n* Patients who will sign the informed consent form.\n\nExclusion Criteria:\n\n* History of opioid use for more than four weeks\n* Chronic pain syndromes\n* Patients with a history of local anesthetic or opioid allergy, hypersensitivity\n* Alcohol and drug addiction\n* Conditions where regional anesthesia is contraindicated\n* Failure in the dermatomal examination performed after the block\n* Emergency surgeries and redo surgeries.\n* Individuals with obstructive sleep apnea.\n* Left ventricular ejection fraction less than 30%.\n* Patients with severe psychiatric illnesses (such as psychosis, dementia) that limit cooperation with verbal numerical pain scales.\n* Pregnant and breastfeeding patients.\n* Hematological disorders.\n* Significant impairment in the function of a major organ (e.g., severe hepatic or renal disease). • Patients who cannot be extubated within the first 6 hours postoperatively.",{"count":59,"type":22},50,[25],"The aim of this study is to investigate the efficacy of bilateral serratus posterior superior intercostal plane (SPSIP) block on postoperative acute pain and opioid consumption in patients undergoing on-pump open-heart surgery. Postoperative outcomes including pain scores, cumulative morphine use, quality of recovery, and opioid-related side effects will be evaluated within the first 24 hours after surgery.",[63,64],"Cardiac Surgery","Post Operative Pain, Acute",[66,67],"Cardiac surgery","Serratus Posterior Superior Plane Block",{"date":69,"type":42},"2026-07-02",{"date":71,"type":42},"2025-09-13",{"date":73,"type":22},"2027-02-01",{"name":48,"class":49},{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":50},"100641340","effect-of-mandala-coloring-on-menopausal-attitude-perceived-stress-and-mindfulness-100641340","NCT07657429","Effect of Mandala Coloring on Menopausal Attitude, Perceived Stress and Mindfulness","The Effect of Mandala Coloring on Menopausal Attitudes, Perceived Stress, and Mindfulness in Women During Menopause: A Randomized Controlled Trial","MANDALA-MENO","* Inclusion Criteria:\n\n  * Women aged 45-55 years\n  * Being in the menopausal period (absence of menstruation for at least 12 months)\n  * Ability to read and understand Turkish\n  * Voluntary agreement to participate in the study\n* Exclusion Criteria:\n\n  * Diagnosed psychiatric or cognitive disorders\n  * Communication problems preventing participation\n  * Visual impairment or fine motor limitations preventing mandala coloring\n  * Use of hormone replacement therapy\n  * Regular participation in mandala coloring, mindfulness, or similar mind-body practices","FEMALE","45 Years","55 Years",{"count":87,"type":22},140,[25],"Menopause is a natural life stage associated with hormonal changes that may affect women physically and psychologically. During this period, women may experience increased stress levels, negative attitudes toward menopause, and decreased mindfulness. Mandala coloring is a structured art-based intervention that may promote relaxation and improve psychological well-being. This randomized controlled trial aims to evaluate the effect of mandala coloring on attitudes toward menopause, perceived stress, and mindfulness levels among menopausal women.",[91,92,93],"Menopause","Psychological Stress","Mindfulness",[95,91,96,93,97,98],"Mandala Coloring","Perceived Stress","Women Health","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-06-24",{"date":102,"type":42},"2026-06-29",{"date":104,"type":22},"2026-05-30",{"date":106,"type":22},"2026-09-30",{"name":48,"class":49},{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":125,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":4},"100611303","transversalis-fascia-plane-block-versus-surgical-wound-infiltration-for-postoperative-analgesia-in-open-inguinal-hernia-repair-100611303","NCT07238829","Transversalis Fascia Plane Block Versus Surgical Wound Infiltration for Postoperative Analgesia in Open Inguinal Hernia Repair","Analgesic Efficacy of Ultrasound-Guided Transversalis Fascia Plane Block Versus Surgical Wound Infiltration After Open Inguinal Hernia Surgery: A Randomized Controlled Trial","TFPB-WIN","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for elective unilateral open inguinal hernia repair\n* Planned anesthesia: spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\> 35 kg\u002Fm²\n* Known hypersensitivity to local anesthetics used in the study (e.g., bupivacaine) or to analgesic medications\n* Coagulopathy\n* Infection or hematoma at the planned block site\n* Significant systemic disease (such as chronic kidney disease, hepatic failure, chronic obstructive pulmonary disease, etc.)\n* History of chronic pain or long-term analgesic use\n* Inability to use the patient-controlled analgesia system\n* Presence of psychiatric disorders\n* Refusal to participate in the study.\n* Cases with a surgical duration shorter than 30 minutes or longer than 180 minutes were excluded.",{"count":117,"type":22},104,[25],"The purpose of this clinical trial is to evaluate whether two different analgesic techniques - ultrasound-guided Transversalis Fascia Plane Block (TFPB) and surgical wound infiltration - can improve postoperative pain control in adult patients undergoing open inguinal hernia repair.\n\nThe key questions that this study aims to answer are:\n\nDoes TFPB reduce total intravenous opioid consumption within the first 24 postoperative hours compared with wound infiltration?\n\nDoes TFPB improve postoperative pain scores at rest and during movement compared with wound infiltration?\n\nDoes TFPB improve patient satisfaction, reduce the need for rescue analgesics, and enhance overall postoperative recovery quality?\n\nIf there is a comparison group:\n\nThe investigators will compare the effects of TFPB with wound infiltration to determine whether either technique provides superior postoperative analgesia and reduces opioid requirements.\n\nParticipants will be asked to:\n\nUndergo open inguinal hernia repair under spinal anesthesia.\n\nBe randomly assigned to one of two groups:\n\nTFPB Group: Receive an ultrasound-guided transversalis fascia plane block with local anesthetic.\n\nWound Infiltration Group: Receive local anesthetic infiltration performed by the surgeon along the incision line.\n\nPostoperatively:\n\nReport pain scores at defined intervals.\n\nReceive standardized IV analgesia with documentation of opioid consumption.\n\nAllow assessment of rescue analgesic requirement.\n\nBe monitored for adverse events and recovery outcomes.",[121,122,123,124],"Inguinal Hernia Unilateral","Postoperative Pain Management","Regional Anaesthesia","Transversalis Fascia Plane Block",[126,127,128,129],"transversalis fascia plane block","regional anaesthesia","inguinal hernia","analgesia","2026-06-20",{"date":132,"type":42},"2026-06-25",{"date":134,"type":22},"2027-01-01",{"date":136,"type":22},"2027-04-01",{"name":48,"class":49},{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":145,"enrollmentInfo":146,"targetDuration":148,"studyType":149,"phases":4,"briefSummary":150,"conditions":151,"keywords":155,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":157,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":161,"locationsCount":4},"100603694","magnesium-sulfate-for-prevention-of-emergence-agitation-in-lumbar-disc-surgery-100603694","NCT07139847","Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc Surgery","Effect of Intraoperative Magnesium Infusion on Postoperative Emergence Agitation in Patients Undergoing Lumbar Microdiscectomy","Inclusion Criteria:\n\nAge between 18 and 70 years\n\nASA physical status classification I or II\n\nScheduled for elective single-level lumbar microdiscectomy under general anesthesia\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nSevere cardiovascular disease\n\nHistory of psychiatric disorder\n\nNeuromuscular disease\n\nPregnancy or breastfeeding\n\nHepatic or renal dysfunction\n\nCurrent use of calcium channel blockers, hypnotics, anxiolytics, or antipsychotic medications\n\nKnown allergy to magnesium sulfate or study-related medications\n\nRefusal to participate in the study","70 Years",{"count":147,"type":22},70,"1 Month","OBSERVATIONAL","In this retrospective study, the effect of intraoperative magnesium sulfate infusion on the incidence of postoperative emergence agitation was evaluated in adult patients who underwent elective lumbar microdiscectomy under general anesthesia. The medical records of patients aged 18-70 years with an ASA physical status of I-II were retrospectively reviewed. Patients were evaluated according to whether they received intraoperative magnesium sulfate infusion as part of anesthetic management. The primary outcome measure was the incidence of emergence agitation in the post-anesthesia care unit; this assessment was based on Ramsay Sedation Scale scores recorded in the post-anesthesia care unit at admission and at 5, 10, 15, and 30 minutes. Secondary outcome measures included postoperative pain scores assessed using the Numeric Rating Scale, intraoperative remifentanil consumption, recovery and extubation times, tramadol requirement in the post-anesthesia care unit, and possible adverse events related to magnesium infusion.",[152,153,154],"Lumbar Disc Herniation","Emergence Agitation","Magnesium Sulfate",[154,152,156],"Postoperative Complications",{"date":132,"type":42},{"date":159,"type":22},"2026-07-05",{"date":106,"type":22},{"name":48,"class":49},{"id":163,"slug":164,"hasResults":12,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":171,"conditions":172,"keywords":176,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":50},"100642436","intravenous-fluid-practices-in-turkish-intensive-care-units-tr-fluid-100642436","NCT07649694","Intravenous Fluid Practices in Turkish Intensive Care Units (TR-FLUID)","TR-FLUID: Evaluation of Intravenous Fluid Administration Practices in Turkish Intensive Care Units: A Multicenter, Prospective, Point-Prevalence Observational Study","Inclusion Criteria:\n\n* Aged 18 years or older\n* Present in a participating intensive care unit at the index time (08:00 local time on the center's selected study day); no minimum or maximum ICU length of stay is required\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Refusal of study participation by the patient or their legal representative",{"count":170,"type":22},400,"Intravenous (IV) fluids-fluids given directly into a vein-are among the most common treatments used in intensive care units (ICUs). They are given for several reasons, such as supporting blood pressure, providing daily water and salts, replacing losses, or diluting medications. However, the type of fluid, the amount given, and the salt (sodium and chloride) load can vary widely between hospitals and doctors. In Turkey, there is currently no up-to-date, multicenter information describing how IV fluids are used in adult ICUs in everyday practice.\n\nThis study, called TR-FLUID, aims to describe IV fluid use in adult ICUs across Turkey. It is an observational study, meaning the researchers only observe and record care that is already being provided. No extra tests, medications, or procedures are added, and the study does not change how patients are treated in any way.\n\nOn a single pre-selected study day at each participating ICU, the research team will identify all adult patients (18 years and older) who are in the ICU at 8:00 a.m. For each patient, the team will record the IV fluids given over the following 24 hours-including the fluid type, the volume, the reason it was given, and the resulting sodium and chloride load-together with the patient's fluid balance. All information is taken from the patient's existing medical records.\n\nThe main goal is to determine what proportion of patients receive fluids for resuscitation and which fluid types are used. The study will also describe the total fluid, sodium, and chloride given by indication; the 24-hour fluid balance; and how fluid use relates to short-term events such as the need for blood-pressure-supporting medications, new kidney injury, and ICU and hospital survival. These relationships will be explored to generate hypotheses and are not intended to prove cause and effect.\n\nThe findings will provide a national picture of current fluid practice in Turkish ICUs, help identify where practice differs from guidelines, and serve as a foundation for future quality-improvement and research efforts.",[173,174,175],"Critical Illness","Fluid Therapy","Practices",[177,178,179,180,181,182,183,184,185,186,187,188,189],"TR-FLUID","Intravenous fluid therapy","Fluid resuscitation","Resuscitation fluid","Balanced crystalloids","Normal saline","Albumin","Fluid creep","Maintenance fluids","Fluid balance","Chloride load","Fluid stewardship","Critical care","2026-06-10",{"date":192,"type":42},"2026-06-16",{"date":194,"type":22},"2026-09-01",{"date":196,"type":22},"2027-09-01",{"name":48,"class":49},{"id":199,"slug":200,"hasResults":12,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":206,"targetDuration":208,"studyType":149,"phases":4,"briefSummary":209,"conditions":210,"keywords":214,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":50},"100643401","body-roundness-index-and-mortality-in-icu-patients-100643401","NCT07631429","Body Roundness Index and Mortality in ICU Patients","Body Roundness Index as a Predictor of Mortality in Adult Intensive Care Unit Patients: A Prospective Multicenter Cohort Study (BRI-ICU)","BRI-ICU","Inclusion Criteria:\n\n* Age ≥18 years\n* ICU admission with expected stay ≥24 hours\n* Waist circumference and height measurable within 24 hours of admission\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* ICU stay \\\u003C24 hours\n* Missing or unmeasurable anthropometric data (e.g., severe edema, abdominal wound, morbid obesity precluding measurement)\n* Pregnancy\n* Readmission (only first ICU admission included)",{"count":207,"type":22},550,"28 Days","This study investigates whether Body Roundness Index (BRI), an anthropometric measure derived from waist circumference and height, can predict mortality in adult intensive care unit (ICU) patients. BRI captures central adiposity and body fat distribution more accurately than Body Mass Index (BMI). In this prospective multicenter cohort study, BRI will be measured at ICU admission and its association with ICU mortality, 28-day mortality, hospital mortality, mechanical ventilation duration, ICU length of stay, and acute kidney injury will be evaluated. The predictive performance of BRI will also be compared with BMI.",[173,211,212,213],"Obesity & Overweight","Mortality in Intensive Care Units","Body Composition",[215,216,217,218,219,220,221,222,223],"Body Roundness Index","BRI","ICU mortality","Critical illness","Anthropometric measures","Central adiposity","BMI","Obesity paradox","Waist circumference","2026-06-05",{"date":226,"type":42},"2026-06-08",{"date":228,"type":22},"2026-08-01",{"date":230,"type":22},"2027-12-01",{"name":48,"class":49},{"id":233,"slug":234,"hasResults":12,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":239,"sex":17,"minAge":240,"maxAge":4,"enrollmentInfo":241,"targetDuration":242,"studyType":149,"phases":4,"briefSummary":243,"conditions":244,"keywords":249,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":50},"100642921","role-of-dual-task-cost-in-predicting-fall-risk-among-older-adults-receiving-institutional-care-100642921","NCT07631975","ROLE OF DUAL-TASK COST IN PREDICTING FALL RISK AMONG OLDER ADULTS RECEIVING INSTITUTIONAL CARE","ROLE OF DUAL-TASK COST IN PREDICTING FALL RISK IN OLDER ADULTS RECEIVING INSTITUTIONAL CARE: A CROSS-SECTIONAL CLASSIFICATION MODEL","Inclusion Criteria:\n\n* Being 65 years of age or older\n* Residing in a nursing home or care institution for at least 1 month\n* Ability to walk a distance of at least 10 meters\n* Ability to ambulate independently with an assistive device (e.g., cane, walker), if needed\n* Having a Montreal Cognitive Assessment (MoCA) score of 18 or above\n* Ability to understand and execute single- and two-step verbal commands\n* Voluntary agreement to participate in the study and providing informed consent\n\nExclusion Criteria:\n\n* History of stroke or major orthopedic surgery within the past 6 monthsPresence of Parkinson's disease Stage ≥3 (Hoehn \\& Yahr) or any other neurological condition significantly affecting gait\n* Having a MoCA score below 18\n* History of fracture within the past 3 months\n* Presence of severe pain affecting gait during test administration (Visual Analog Scale \\[VAS\\] ≥ 7)\n* Uncontrolled hypertension (≥ 180\u002F100 mmHg) or unstable cardiovascular status\n* Active vestibular disease or a history of syncope within the past 3 months\n* Visual or hearing impairment severe enough to impede test execution\n* Inability to walk\u002Fambulate without the physical assistance of another person",true,"65 Years",{"count":21,"type":22},"12 Months","There is a need for studies that examine the role of dual-task cost in predicting fall risk among older adults receiving institutional care and that develop classification models that can be used in clinical practice. The planned study aims to determine the discriminative ability of dual-task cost in identifying fall risk and to establish clinically meaningful cutoff values. In this respect, the study will both contribute to a more sensitive assessment of fall risk and provide a scientific basis for a low-cost, practical, and applicable screening approach.",[245,246,247,248],"Older Adults (65 Years and Older)","INSTITUTIONAL CARE","Dual Task Cost","Falls in Old Age",[250,251,252,253,254],"Dual Task","Dual-task cost","Fall risk","Functional mobility","Institutionalized older adults","2026-06-03",{"date":226,"type":42},{"date":258,"type":22},"2026-06-01",{"date":260,"type":22},"2026-11-01",{"name":48,"class":49},{"id":263,"slug":264,"hasResults":12,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":12,"sex":269,"minAge":18,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":271,"conditions":272,"keywords":274,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":283,"leadSponsor":285,"locationsCount":50},"100640519","enucleation-ratio-as-a-novel-predictor-of-symptomatic-improvement-after-holep-100640519","NCT07591688","Enucleation Ratio as a Novel Predictor of Symptomatic Improvement After HoLEP","Predictive Value of Enucleation Ratio for Symptomatic Improvement After HoLEP: A Multicenter Prospective Cohort Study","Inclusion Criteria:\n\n* Men aged 18 years pr older who are planned to undergo HoLEP.\n* Participants who are willing to give informed consent.\n* Participants who have moderate to severe LUTS (referring to IPSS score 8 points or more).\n* No history of previous prostate or urethral surgery.\n\nExclusion Criteria:\n\n* Unwillingness to provide informed consent.\n* Unwillingness to provide contact information or unreachability during follow-up periods.\n* Incidental diagnosis of a urogenital malignancy requiring primary treatment after enrollment (e.g., bladder tumor, renal cell carcinoma, testicular tumor).","MALE",{"count":170,"type":22},"The goal of this observational study is to determine whether the rate of prostate tissue removed during surgery relative to the preoperative total prostate volume (referred to as the \"enucleation ratio\") predicts symptomatic improvement 3 months after HoLEP. The main question it aims to answer is:\n\n\\- What is the minimum enucleation ratio required to achieve clinically important symptomatic improvement? (Symptomatic improvement is referred to as a threshold of having an International Prostate Symptom Score (IPSS) lower than 8 points, which is determined by the American Urological Association (AUA) and European Association of Urology(EAU)).",[273],"Benign Prostate Obstruction (BPO)",[275,276,277,278],"HoLEP","BPO","LUTS","Enucleation Ratio","2026-05-15",{"date":281,"type":42},"2026-05-19",{"date":41,"type":22},{"date":284,"type":22},"2027-03-30",{"name":48,"class":49},{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":239,"sex":17,"minAge":18,"maxAge":240,"enrollmentInfo":293,"targetDuration":4,"studyType":23,"phases":295,"briefSummary":296,"conditions":297,"keywords":300,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":50},"100638846","effect-of-periodontal-therapy-on-asprosin-in-stable-angina-100638846","NCT07591844","Effect of Periodontal Therapy on Asprosin in Stable Angina","Effect of Non-Surgical Periodontal Therapy on Serum Asprosin in Patients With Stable Angina","Inclusion Criteria:\n\n* Willingness to participate in the study and provide written informed consent\n* Age 18 years or older\n* No periodontal treatment within the past 6 months\n* No use of local or systemic antibiotics within the past 3 months\n\nExclusion Criteria:\n\n* Unwillingness to participate in the study or to provide informed consent\n* Age under 18 years\n* Use of local or systemic antibiotics for the treatment of widespread infection within the past 3 months\n* Receipt of periodontal treatment within the past 6 months\n* Pregnancy or lactation (for female participants)\n* History of acute myocardial infarction within the past 6 months",{"count":294,"type":22},60,[25],"This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis. Asprosin is a novel metabolic biomarker reported to have potential protective roles in cardiovascular diseases and inflammatory processes. The study also investigates the relationship between periodontal parameters and serum asprosin levels before and after periodontal therapy.",[298,299],"Stable Angina Pectoris","Periodontitis",[301,302,303,304,305],"Non-surgical periodontal treatment","cardiovascular disease","stable angina","asprosin","periodontitis","2026-05-11",{"date":308,"type":42},"2026-05-18",{"date":310,"type":22},"2026-05-20",{"date":312,"type":22},"2026-10-20",{"name":48,"class":49},{"id":315,"slug":316,"hasResults":12,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":12,"sex":269,"minAge":18,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":323,"conditions":324,"keywords":326,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":337,"locationsCount":50},"100639152","anesthesia-type-and-holep-outcomes-a-multi-center-study-100639152","NCT07585552","Anesthesia Type and HoLEP Outcomes: A Multi-Center Study","Does Anesthesia Type Affect HoLEP Outcomes? A Multi-Center, Real-World Comparative Study","Inclusion Criteria:\n\n* 18 years or older men who have BPO requiring surgical treatment.\n* Participants who can give written informed consent.\n* Having no more than 3 points for the American Society of Anesthesiologists (ASA) physical status classification scale (ASA 1 to 3).\n\nExclusion Criteria:\n\n* Absolute contraindication for spinal or general anesthesia\n* History of previous surgery for prostate (e.g., surgery for prostate cancer, surgery for benign prostate obstruction)\n* Uncorrected bleeding disorder (INR \\> 1.5)\n* Participants who are not willing to give informed consent.\n* Participants who have a proven urinary tract infection at the time of the surgery.\n* Participants who are not able to be contacted for regular follow-ups.",{"count":322,"type":22},320,"1. What is this study about, and why is it required?\n\n   The goal of this observational study is to learn if anesthesia type (e.g., general anesthesia, spinal anesthesia) affects the safety and efficiency of HoLEP surgery. The main question it aims to answer is:\n\n   \\- Is a particular type of anesthesia related to less or more bleeding during the surgery?\n2. What will be assessed to answer the main question of this study? (Outcome measure(s))\n\n   2.1. Primary outcome measure of this study is:\n\n   \\- Change in the hemoglobin level perioperatively.\n\n   2.2. Secondary outcome measures are:\n   * Requirement for the usage of any vasoactive medication due to low blood pressure\n   * Time passed until discharge.\n   * Time passed until the removal of the bladder drainage catheter.\n   * Ratio of the unwanted events that require additional intervention other than medication, fluids, or blood transfusions (Complications, Clavien-Dindo Grade III or higher).\n   * International symptom questionnaire score 3 months after surgery.\n   * Quality of life (QoL) score 3 months after surgery.\n   * Peak urinary current velocity (Qmax) and post-void residual volume measurement 3 months after surgery.\n3. Can anyone participate in this study?\n\nVoluntary participants should meet the following criteria:\n\n* Being older than 18 years old.\n* Having bothersome lower urinary tract symptoms due to prostatic enlargement requiring surgical treatment.\n* Having no untreated or uncontrolled systemic disease, which refers to having an ASA (American Society of Anesthesiologists Physical Status Classification System) score III at most.",[325],"Benign Prostatic Hyperplasia With Symptomatic Lower Urinary Tract Symptoms",[275,327,328,329,330],"Benign Prostate Obstruciton (BPO)","Male LUTS","Real World Study","Observational Study","2026-05-09",{"date":333,"type":42},"2026-05-13",{"date":335,"type":22},"2026-04-23",{"date":196,"type":22},{"name":48,"class":49},{"id":339,"slug":340,"hasResults":12,"nctId":341,"briefTitle":342,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":23,"phases":346,"briefSummary":347,"conditions":348,"keywords":350,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":357,"locationsCount":50},"100582011","effects-of-three-different-methods-applied-to-patients-after-spine-surgery-on-nausea-thirst-and-comfort-100582011","NCT06857760","Effects of Three Different Methods Applied to Patients After Spine Surgery on Nausea, Thirst and Comfort","Inclusion Criteria:\n\n* Adult patients who underwent lumbar disc herniation (LDH) surgery\n* LDH surgery patients who recieve general anesthesia\n* The patients who were conscious\n* The duration of surgery is between 0-3 hours\n\nExclusion Criteria:\n\n* Patients who cannot understand and speak Turkish\n* Allergic patients to menthol\n* Patients who received spinal anesthesia\n* Patients with lesions on the oral mucosa and lips\n* Patients requiring intensive care after surgical intervention",{"count":345,"type":22},128,[25],"The aim of this study was to determine the effects of postoperative methods on nausea, thirst and comfort levels of patients undergoing spinal surgery.",[349],"Spinal Surgery",[351],"nausea, thirst, comfort","2026-05-08",{"date":333,"type":42},{"date":355,"type":42},"2025-02-28",{"date":39,"type":22},{"name":48,"class":49},{"id":359,"slug":360,"hasResults":12,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":365,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":367,"conditions":368,"keywords":370,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":384,"locationsCount":50},"100633351","kinesiophobia-pain-and-disability-in-chronic-neck-pain-100633351","NCT07525557","Kinesiophobia, Pain and Disability in Chronic Neck Pain","Kinesiophobia As A Mediator Of The Association Between Pain Intensity And Disability In Chronic Neck Pain","Inclusion Criteria:\n\n* Individuals aged 18 years or older\n* Presence of chronic neck pain lasting at least 3 months\n* Ability to understand and complete questionnaires\n* Voluntary participation\n\nExclusion Criteria:\n\n* Acute neck pain (\\\u003C 3 months)\n* History of cervical spine surgery\n* Neurological disease or cervical radiculopathy\n* Inflammatory, neoplastic, or traumatic conditions affecting the neck\n* Cognitive impairment preventing questionnaire completion",{"count":366,"type":22},250,"This study aims to investigate the mediating role of kinesiophobia in the relationship between pain intensity and disability in individuals with chronic neck pain. Chronic neck pain is a multidimensional clinical condition influenced not only by biological factors but also by psychological components such as fear of movement. Understanding the mechanisms underlying disability may contribute to more targeted rehabilitation strategies. Participants with chronic neck pain lasting at least three months will be assessed using validated self-report questionnaires measuring pain intensity, kinesiophobia, disability, and physical activity levels.",[369],"Chronic Neck Pain",[371,372,373,374,375,376,377,378],"Kinesiophobia","Chronic Pain","Musculoskeletal Pain","Disability Evaluation","Pain Measurement","Fear Avoidance","Neck Disability Index","Tampa Scale of Kinesiophobia","2026-05-07",{"date":306,"type":42},{"date":382,"type":42},"2026-04-10",{"date":41,"type":22},{"name":48,"class":49},{"id":386,"slug":387,"hasResults":12,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":391,"eligibilityCriteria":392,"healthyVolunteers":12,"sex":83,"minAge":18,"maxAge":4,"enrollmentInfo":393,"targetDuration":4,"studyType":23,"phases":395,"briefSummary":396,"conditions":397,"keywords":402,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":410,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":4},"100627487","breathing-interventions-for-postoperative-breast-surgery-patients-100627487","NCT07449273","Breathing Interventions for Postoperative Breast Surgery Patients","Effects of Pranayama and Pursed-lip Breathing Exercises on Pain, Anxiety and Vital Signs After Breast Surgery","BREATH-RCT","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Able to communicate effectively\n* Patients undergoing elective surgery for the first time, including radical mastectomy, modified radical mastectomy, or simple mastectomy\n\nExclusion Criteria:\n\n* Patients undergoing breast-conserving surgery\n* Patients who develop any postoperative complications, such as bleeding or anesthesia-related complications\n* Individuals with cognitive or mental impairments\n* Patients who wish to withdraw from the study at any stage\n* Patients with hearing or speech impairments\n* Patients with a psychiatric diagnosis or those using psychiatric medications\n* Patients unable to comply with breathing exercises",{"count":394,"type":22},126,[25],"This randomized controlled trial aims to evaluate the effects of pranayama and pursed-lip breathing exercises on postoperative pain, anxiety, and vital signs in patients undergoing breast surgery. Postoperative pain and anxiety are common problems that can negatively affect recovery, physiological stability, and overall well-being. Non-pharmacological interventions such as breathing exercises may help reduce these adverse outcomes and support recovery.\n\nParticipants will be randomly assigned to one of three groups: a pranayama breathing exercise group, a pursed-lip breathing exercise group, or a control group receiving routine postoperative care. Breathing exercises will be performed three times daily for five minutes. Outcomes including pain, anxiety, and vital signs will be measured at baseline (pretest), postoperative day 1, and postoperative day 2. The findings of this study are expected to provide evidence on the effectiveness of breathing exercises as supportive nursing interventions in the postoperative care of breast surgery patients.",[398,399,400,401],"Breast Cancer","Breast Surgery","Postoperative Pain","Anxiety",[403,404,405,406,407,408,409],"Pranayama","Pursed-lip breathing","Breathing exercises","Non-pharmacological intervention","Postoperative care","Randomized controlled trial","Nursing intervention",{"date":306,"type":42},{"date":412,"type":22},"2026-05",{"date":414,"type":22},"2027-04-27",{"name":48,"class":49},{"id":417,"slug":418,"hasResults":12,"nctId":419,"briefTitle":420,"officialTitle":420,"acronym":4,"eligibilityCriteria":421,"healthyVolunteers":239,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":422,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":424,"conditions":425,"keywords":427,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":434,"completionDateStruct":435,"leadSponsor":437,"locationsCount":4},"100636792","comparison-of-artificial-intelligence-and-clinicians-with-different-experience-levels-in-assessing-gingival-phenotype-100636792","NCT07570290","Comparison of Artificial Intelligence and Clinicians With Different Experience Levels in Assessing Gingival Phenotype","Inclusion Criteria for Volunteer Participants Who Will Participate in Transparency and Visual Assessment:\n\n* Systemically and periodontally healthy individuals.\n* Presence of natural maxillary anterior incisors.\n\nExclusion Criteria:\n\n* Presence of fixed crowns or cervical restorations on the evaluated teeth.\n* Pregnant or breastfeeding women.\n* Signs of gingival inflammation or periodontal disease with attachment loss.\n* Presence of buccal gingival recession.\n* Use of medications known to cause gingival enlargement.\n* Presence of congenital anomalies or dental structural defects.\n\nInclusion Criteria for Clinicians:\n\n* Research assistants: Must be currently working in the Department of Periodontology.\n* Dental Intern Students: Fourth- or fifth-year students who have completed periodontology clinical rotation.\n\nExclusion Criteria for Clinicians:\n\n* Those who are confirmed to be color blind by the Ishihara test",{"count":423,"type":22},40,"The goal of this observational study is to compare the performance of clinicians with different experience levels and a deep learning-based artificial intelligence (AI) model in assessing gingival phenotype using two diagnostic methods: the periodontal probe transparency method and visual assessment from standardized clinical photographs. The main questions the study aims to answer are:\n\nCan AI achieve comparable accuracy to human examiners in both probe transparency and visual assessment methods?\n\nDoes examiner experience level influence diagnostic performance and agreement with the reference standard in these methods?\n\nResearchers will compare AI, dental students, and periodontology research assistants to determine accuracy, sensitivity, specificity, and agreement with the gold standard for each method.\n\nParticipants will:\n\nUndergo standardized intraoral photography of maxillary anterior teeth, with and without a periodontal probe in place, following a validated protocol.\n\nHave gingival phenotype determined by a reference periodontologist using the probe transparency method as the gold standard.\n\nHave their photographs evaluated by AI, dental students, and research assistants for phenotype classification using both methods.",[426],"Gingival Phenotype Assessment",[428,429,430,431],"gingiva","Gingival phenotype","Deep Learning","Transparency Method","2026-05-06",{"date":306,"type":42},{"date":279,"type":22},{"date":436,"type":22},"2026-10-15",{"name":48,"class":49},{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":239,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":445,"targetDuration":447,"studyType":149,"phases":4,"briefSummary":448,"conditions":449,"keywords":452,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":456,"completionDateStruct":457,"leadSponsor":458,"locationsCount":50},"100637479","hearing-loss-and-aid-attitudes-in-health-sciences-students-100637479","NCT07575711","Hearing Loss and Aid Attitudes in Health Sciences Students","KNOWLEDGE LEVELS, PERSPECTIVES, AND ATTITUDES OF HEALTH SCIENCES FACULTY STUDENTS TOWARD HEARING LOSS AND HEARING AID USE","Inclusion Criteria:\n\n* Students from the departments of Nursing, Midwifery, Nutrition and Dietetics, Physiotherapy and Rehabilitation, Speech and Language Therapy, Child Development, Orthotics and Prosthetics, Health Management, and Social Work\n* Voluntarily agreed to participate in the study\n* Individuals aged 18 years and older\n* No personal or family history of hearing loss,\n* No history of ear surgery,\n* Who did not use hearing aids\n\nExclusion Criteria:\n\n* Being audiology student\n* Individuals aged under 18 years\n* Who use hearing aids,\n* With a personal or family history of ear surgery or hearing loss",{"count":446,"type":22},600,"600 Days","This study aims to examine the knowledge levels and attitudes of students enrolled in departments other than Audiology within the Faculty of Health Sciences regarding hearing loss and the use of hearing aids. This study is a descriptive. The study included students enrolled in the Faculty of Health Sciences at Ondokuz Mayıs University. Data will collect using the \"Hearing Loss and Hearing Aid Knowledge and Attitudes Questionnaire Among Faculty of Health Sciences Students,\" which consisted of 29 items. The One-Way ANOVA test was used to compare quantitative variables between groups.",[450,451],"Hearing Loss, Bilateral or Unilateral","Hearing Aid",[453],": Attitudes, Faculty of Health Sciences, hearing aid, hearing loss, knowledge level","2026-05-02",{"date":352,"type":42},{"date":104,"type":22},{"date":39,"type":22},{"name":48,"class":49},{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":464,"acronym":4,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":466,"enrollmentInfo":467,"targetDuration":4,"studyType":23,"phases":468,"briefSummary":469,"conditions":470,"keywords":473,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":485,"locationsCount":50},"100634470","serratus-posterior-superior-intercostal-plane-block-versus-intrathecal-morphine-in-vats-100634470","NCT07540104","Serratus Posterior Superior Intercostal Plane Block Versus Intrathecal Morphine in VATs","Comparison of the Effects of Serratus Posterior Superior Intercostal Plane Block and Intrathecal Morphine on Postoperative Acute Pain in Patients Undergoing Video-assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* American Society of Anesthesiologists physical status I to III\n* Scheduled for elective video-assisted thoracoscopic surgery including wedge resection, segmentectomy, or lobectomy\n\nExclusion Criteria:\n\n* Refusal to participate\n* Pregnancy\n* Morbid obesity (body mass index greater than 40 kg per square meter)\n* Allergy to opioids, local anesthetics, or nonsteroidal anti-inflammatory drugs\n* Neuropsychiatric disorders, cognitive impairment, or inability to communicate\n* History of substance abuse\n* Use of anticoagulant therapy or presence of bleeding disorders\n* Active systemic infection\n* Severe cardiovascular, hepatic, renal, or endocrine disease\n* Chronic pain syndrome or ongoing chronic pain treatment\n* Emergency surgery or prior ipsilateral thoracic surgery\n* Preoperative opioid use\n* Significant intraoperative or postoperative bleeding or hemodynamic instability\n* Requirement for prolonged postoperative mechanical ventilation longer than 18 hours","75 Years",{"count":294,"type":22},[25],"This study aims to compare the analgesic effects of the serratus posterior superior intercostal plane block and intrathecal morphine in patients undergoing video-assisted thoracoscopic surgery.\n\nThis is a prospective, randomized, controlled, single-center clinical trial including adult patients undergoing elective thoracoscopic surgery. Participants will be randomly assigned to receive either a serratus posterior superior intercostal plane block or intrathecal morphine before general anesthesia.\n\nThe primary outcome is cumulative opioid consumption during the first 24 postoperative hours, expressed as intravenous morphine milligram equivalents. Secondary outcomes include pain scores, time to first analgesic request, quality of recovery, and postoperative complications.\n\nThe study aims to determine whether these two techniques differ in their effectiveness for postoperative pain management.",[471,400,472],"Thoracic Anesthesia","Video Assisted Thoracic Surgery (VATS)",[474,475,476,477,478],"Thoracic Surgery, Video-Assisted","Analgesia, Postoperative","Morphine","Injections, Spinal","Nerve Block","2026-04-28",{"date":481,"type":42},"2026-05-04",{"date":483,"type":22},"2026-04-15",{"date":106,"type":22},{"name":48,"class":49},{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":12,"sex":17,"minAge":493,"maxAge":494,"enrollmentInfo":495,"targetDuration":4,"studyType":23,"phases":496,"briefSummary":497,"conditions":498,"keywords":503,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":513,"leadSponsor":515,"locationsCount":4},"100635146","comparison-of-needle-free-injection-and-conventional-syringe-for-tooth-extractions-in-children-100635146","NCT07548892","Comparison of Needle-Free Injection and Conventional Syringe for Tooth Extractions in Children","Comparison of Needle-Free Injection and Conventional Syringe in Tooth Extractions in Children: Effects on Pain, Anxiety, and Vital Signs","Inclusion Criteria:\n\n* Being between 6-12 years of age\n* Having a primary tooth to be extracted with buccal and lingual anesthesia\n* Being in category 2, 3, or 4 according to the Frankl Behavior Scale\n* Being systemically healthy\n* No known history of allergy to local anesthetics\n* No antibiotic use in the last month and no analgesic use in the last 12 hours\n* Not having acute dental pain\n* Having sufficient cognitive ability to understand the anxiety assessment scales\n* Voluntary participation with written parental consent\n\nExclusion Criteria:\n\n* Being under 6 years of age or over 12 years of age\n* Displaying category 1 behavior according to the Frankl scale\n* Presence of severe acute dental infection or a condition requiring emergency intervention\n* Presence of a requirement for surgical extraction in the tooth indicated for extraction\n* Incomplete root development of the underlying permanent tooth\n* History of systemic disease (for example heart disease, uncontrolled asthma, epilepsy, diabetes)\n* Inability to use pain\u002Fanxiety scales due to neurological or developmental disorder\n* History of allergic reaction to local anesthetics or other drugs used\n* Presence of hypersensitivity to odors or inhalation intolerance\n* Refusal of participation by the child or parent","6 Years","12 Years",{"count":294,"type":22},[25],"The goal of this clinical trial is to learn whether a needle-free injection system can make tooth extraction less stressful for children than a conventional dental syringe. The study will include healthy children 6 to 12 years old who need a primary tooth extraction with buccal and lingual local anesthesia. The main questions are whether the needle-free method can lower anxiety, lower pain, and reduce changes in vital signs compared with the conventional syringe.\n\nResearchers will randomly assign participants to 1 of 2 groups. One group will receive local anesthesia with a needle-free jet injection system. The other group will receive local anesthesia with a conventional syringe and a 27-gauge dental needle. In both groups, a topical lidocaine spray will be used before the injection, and the same anesthetic solution will be given. All tooth extractions will be performed by the same clinician using standard clinical procedures.\n\nParticipants' anxiety, pain, and vital signs will be checked before the procedure, after anesthesia, and after tooth extraction. Anxiety will be measured with the Face Image Scale (FIS). Pain will be measured with the Face, Legs, Activity, Cry, Consolability (FLACC) scale and the Wong-Baker Faces Pain Rating Scale (WBS). Vital signs will include systolic and diastolic blood pressure, heart rate, and oxygen saturation. No blood, saliva, or tissue samples will be collected, and no audio or video recording will be made.",[499,500,501,502],"Tooth Extraction","Dental Anxiety","Procedural Pain","Anesthesia, Dental",[504,505,499,506,507,500,508,509],"Needle-Free Injection","Conventional Syringe","Pediatric Dentistry","Local Anesthesia","Pain Perception","Vital Signs",{"date":511,"type":42},"2026-04-29",{"date":483,"type":22},{"date":514,"type":22},"2026-12-31",{"name":48,"class":49},{"id":517,"slug":518,"hasResults":12,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":4,"eligibilityCriteria":522,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":523,"enrollmentInfo":524,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":526,"conditions":527,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":4},"100634096","serum-gfap-nfl-vegf-and-clinical-progression-in-progressive-ms-100634096","NCT07535242","Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS","Investigation of the Relationship Between Serum GFAP, NfL, and VEGF Levels and Clinical Progression Markers in Progressive Multiple Sclerosis","Inclusion Criteria:\n\n* Confirmed diagnosis of MS\n* Progressive type MS\n* Voluntary participation\n* Age between 18-60 years\n* Cooperative\n* EDSS score ≥ 5.5\n\nExclusion Criteria:\n\n* Presence of another neurological disorder\n* Change in medication within the last 3 months\n* Relapse within the last 3 months","60 Years",{"count":525,"type":22},22,"This study aimed to investigate whether the biomarkers GFAP, NfL, and VEGF-recently considered important guides for better understanding the pathophysiology of MS-also serve as indicators of clinical progression in MS.",[528],"Multiple Sclerosis","2026-04-14",{"date":531,"type":42},"2026-04-17",{"date":533,"type":22},"2026-04-21",{"date":535,"type":22},"2026-05-05",{"name":48,"class":49},{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":239,"sex":17,"minAge":544,"maxAge":84,"enrollmentInfo":545,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":547,"conditions":548,"keywords":551,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":557,"completionDateStruct":559,"leadSponsor":561,"locationsCount":562},"100633522","prevalence-of-misophonia-and-hyperacusis-among-teachers-100633522","NCT07527780","Prevalence of Misophonia and Hyperacusis Among Teachers","Could Hyperacusis and Misophonia Be Causes of Occupational Stress Among Teachers?","Inclusion Criteria:\n\n* Teachers actively working in preschool, elementary, middle, or high schools.\n* Age between 22 and 45 years.\n* Willingness to participate and provide informed consent.\n* No diagnosed hearing loss.\n* No chronic illnesses.\n* No diagnosed psychological or psychiatric disorders.\n\nExclusion Criteria:\n\n* Individuals with hearing loss.\n* Individuals with chronic illnesses.\n* Individuals with serious psychological or psychiatric diagnoses.\n* Individuals who are not actively teaching.\n* Participants unwilling to provide informed consent.","22 Years",{"count":546,"type":22},500,"This study aims to determine the prevalence of hyperacusis and misophonia among teachers and to explore how these auditory sensitivities may relate to occupational stress. By examining teachers' sensory challenges in school environments, the study seeks to contribute to a better understanding of their impact on professional well-being and to inform strategies that can improve working conditions.",[549,550],"Misophonia","Hyperacusis",[552,549,550,553,554],"Teacher","AMISOS-R","Khalfa Hyperacusis Scale","2026-04-07",{"date":529,"type":42},{"date":558,"type":42},"2025-03-01",{"date":560,"type":22},"2026-05-01",{"name":48,"class":49},2,{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":523,"enrollmentInfo":570,"targetDuration":4,"studyType":23,"phases":572,"briefSummary":574,"conditions":575,"keywords":577,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":583,"startDateStruct":585,"completionDateStruct":587,"leadSponsor":589,"locationsCount":50},"100632721","phase-4-intraoral-cryotherapy-on-anesthetic-efficacy-in-mandibular-incisors-100632721","NCT07517367","Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisors","Evaluation of the Effect of Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisor Teeth With Irreversible Pulpitis","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Classified as ASA Physical Status I or II\n* Presence of symptomatic irreversible pulpitis in a single-rooted mandibular incisor tooth\n* Preoperative pain score ≥8 on the Numerical Rating Scale (NRS) and Wong-Baker FACES scale\n* Positive response to cold test and electric pulp testing\n* Absence of periapical pathology on preoperative periapical radiograph\n* No analgesic intake within 6 hours prior to treatment\n* Ability to understand and complete pain assessment scales\n* Willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Age below 18 years or above 60 years\n* Pregnancy\n* Known allergy to local anesthetic agents\n* Diagnosis of diabetes mellitus\n* Presence of hypothyroidism\n* Diagnosis of adrenal insufficiency\n* Presence of Raynaud disease\n* Uncontrolled diabetes (HbA1c \\>7%)\n* Presence of periapical pathology detected radiographically\n* Presence of sinus tract\n* Presence of intraoral or extraoral swelling\n* Teeth diagnosed with necrotic pulp\n* Presence of referred pain from another tooth or anatomical structure",{"count":571,"type":22},98,[573],"PHASE4","The aim is to compare the contributions of intraoral cryotherapy and supplemental lingual infiltration anesthesia to buccal infiltration anesthesia in mandibular incisor teeth with irreversible pulpitis in terms of anesthetic efficacy, and to evaluate the effect of adding intraoral cryotherapy to buccal anesthesia on anesthetic efficacy.",[576],"Symptomatic Irreversible Pulpitis (SIP)",[578,579,580,581],"Symptomatic Irreversible Pulpitis","Mandibular Incisor","Intraoral Cryotherapy","Buccal Infiltration Anesthesia","2026-04-03",{"date":584,"type":42},"2026-04-08",{"date":586,"type":42},"2025-12-31",{"date":588,"type":22},"2026-08-30",{"name":48,"class":49},{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":239,"sex":83,"minAge":18,"maxAge":240,"enrollmentInfo":597,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":599,"conditions":600,"keywords":605,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":50},"100631416","postural-habits-body-awareness-and-functional-performance-across-bmi-categories-in-women-100631416","NCT07500389","Postural Habits, Body Awareness, and Functional Performance Across BMI Categories in Women","Investigation of Postural Habits and Body Awareness in Relation to Functional Performance Across Body Mass Index Categories in Women","Inclusion Criteria:\n\n* Female individuals aged 18-65 years\n* Classified into BMI categories (normal weight, overweight, obesity class I, obesity class II-III)\n* No obesity-related medical or surgical treatment in the last 6 months\n* Able to understand instructions and complete questionnaires\n\nExclusion Criteria:\n\n* Neurological disorders affecting mobility (e.g., stroke, Parkinson's disease, multiple sclerosis, peripheral neuropathy)\n* Rheumatologic or inflammatory diseases (e.g., rheumatoid arthritis, ankylosing spondylitis)\n* Severe orthopedic conditions limiting mobility (e.g., advanced osteoarthritis)\n* Major surgery within the last 12 months affecting mobility or physical performance\n* Pregnancy\n* Acute musculoskeletal injury within the last 4 weeks",{"count":598,"type":22},80,"This cross-sectional study aims to investigate the relationship between postural habits and body awareness with functional performance across different body mass index (BMI) categories in women. Participants will be categorized into four groups based on BMI (normal weight, overweight, obesity class I, and obesity class II-III). Postural habits and awareness, body awareness, and functional performance will be assessed using validated questionnaires and performance-based tests. The study also aims to explore the potential contribution of central adiposity (waist circumference) and psychological factors to these relationships. Findings are expected to provide a more comprehensive understanding of the biomechanical and perceptual factors associated with obesity.",[211,601,602,603,604],"Body Mass Index","Postural Control","Body Awareness","Functional Performance",[606,607,253,608],"Postural habits","body awareness","Physical activity","2026-04-01",{"date":555,"type":42},{"date":612,"type":22},"2026-04-30",{"date":614,"type":22},"2026-12-01",{"name":48,"class":49},{"id":617,"slug":618,"hasResults":12,"nctId":619,"briefTitle":620,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":239,"sex":17,"minAge":18,"maxAge":466,"enrollmentInfo":623,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":625,"conditions":626,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":634,"leadSponsor":635,"locationsCount":4},"100631758","stroke-mobility-and-caregiver-outcomes-100631758","NCT07504848","Stroke Mobility and Caregiver Outcomes","The Effect of Mobility Level in Stroke Patients on Anxiety, Depression, and Caregiver Burden in Caregivers","Inclusion Criteria:\n\n1. Stroke Patients:\n\n   * Diagnosed with stroke according to WHO criteria (≥20% disability rate documented in Adult Disability Health Board Report)\n   * Having a family member or relative who provides care\n   * First-ever and unilateral stroke\n   * Willing to participate voluntarily\n   * Aged between 18-75 years\n   * Post-stroke duration longer than 3 months\n   * Stable vital signs\n   * Scoring ≥24 on the Standardized Mini-Mental State Examination (SMMT) or the -Modified Mini-Mental State Examination for Illiterate Individuals (MMSE-E)\n   * Able to understand and speak Turkish\n2. Caregivers of Stroke Patients:\n\n   * Willing to participate in the study\n   * Living with the patient for at least 1 year\n   * Being the primary (main responsible) caregiver and not receiving paid professional caregiving services\n   * Aged 18 years or older\n   * Scoring ≥24 on the Standardized Mini-Mental State Examination (SMMT) or MMSE-E\n\nExclusion Criteria:\n\n1. Stroke Patients:\n\n   * Presence of severe comorbid conditions\n   * Unwillingness to participate\n   * History of multiple strokes\n   * Bilateral hemiplegia\n   * Presence of major neurological, orthopedic, or rheumatologic disorders affecting the musculoskeletal system other than stroke\n   * Congenital anomalies or amputation causing disability\n   * Uncontrolled arrhythmia, uncontrolled hypertension, or unstable cardiac conditions\n   * Botulinum toxin injection within the last 6 months\n   * Inability to establish cooperation\n   * Presence of neglect, aphasia, or hemianopsia\n2. Caregivers of Stroke Patients:\n\n   * Unwillingness to participate\n   * Living with the patient for less than 1 year\n   * Presence of mental retardation, dementia, or severe psychotic disorders",{"count":624,"type":22},64,"This study was designed to determine the effect of functional mobility levels of stroke patients on caregiver burden, anxiety, and depression in their caregivers.",[627,628],"Stroke","Caregiver","2026-03-31",{"date":631,"type":42},"2026-04-06",{"date":633,"type":22},"2026-04-02",{"date":483,"type":22},{"name":48,"class":49},{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":641,"acronym":4,"eligibilityCriteria":642,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":643,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":645,"conditions":646,"keywords":650,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":656,"lastUpdatePostDateStruct":657,"startDateStruct":659,"completionDateStruct":661,"leadSponsor":663,"locationsCount":50},"100631415","multimodal-nutritional-and-sarcopenia-assessment-for-risk-stratification-in-lung-cancer-surgery-100631415","NCT07500376","Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery","Prognostic Value of Multimodal Nutritional Status and Sarcopenia Assessment for Postoperative Risk Stratification in Patients Undergoing Lung Cancer Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients undergoing anatomical lung resection (lobectomy or segmentectomy) for primary lung cancer\n* Availability of preoperative thoracic computed tomography (CT) within 30 days before surgery\n* Completion of preoperative nutritional assessment and ultrasonographic muscle measurements\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Receipt of neoadjuvant chemotherapy, immunotherapy, or radiotherapy\n* Emergency surgery\n* Pneumonectomy\n* Combined resection of another organ during the same procedure\n* Inadequate or non-evaluable imaging or measurement data\n* Immunosuppressive therapy or presence of advanced\u002Fmetastatic disease\n* Significant thoracic deformity or prior conditions interfering with muscle measurements\n* Refusal or inability to provide informed consent",{"count":644,"type":22},142,"This prospective observational cohort study aims to evaluate the prognostic value of multimodal nutritional status and sarcopenia assessment in patients undergoing lung cancer surgery. Postoperative complications, mortality, and prolonged hospital stay remain major clinical concerns in thoracic surgery. Although malnutrition and sarcopenia are recognized as important determinants of surgical outcomes, their combined and multidimensional evaluation has not been sufficiently studied.\n\nAdult patients undergoing anatomical lung resection for primary lung cancer will be included. Nutritional status will be assessed using serum biomarkers, inflammatory indices, and validated clinical nutritional scores. Sarcopenia will be evaluated using computed tomography-based muscle mass and density measurements, as well as ultrasonographic muscle thickness.\n\nThese parameters will be analyzed in relation to postoperative complications, intensive care unit (ICU) requirement, length of hospital stay, and mortality. Multivariable analyses will be performed to identify independent predictors, and a combined risk stratification model will be developed.\n\nThis study aims to improve preoperative risk assessment and to support personalized perioperative management strategies, including identification of patients who may benefit from targeted nutritional optimization and prehabilitation.",[647,648,649],"Lung Cancer (Non-Small Cell)","Sarcopenia","Malnutrition Severe",[651,652,653,654,655],"lung cancer surgery","sarcopenia","nutritional status","malnutrition","risk stratification","2026-03-24",{"date":658,"type":42},"2026-03-30",{"date":660,"type":42},"2026-03-15",{"date":662,"type":22},"2026-07-15",{"name":48,"class":49},{"id":665,"slug":666,"hasResults":12,"nctId":667,"briefTitle":668,"officialTitle":669,"acronym":4,"eligibilityCriteria":670,"healthyVolunteers":12,"sex":17,"minAge":523,"maxAge":4,"enrollmentInfo":671,"targetDuration":4,"studyType":23,"phases":673,"briefSummary":674,"conditions":675,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":656,"lastUpdatePostDateStruct":677,"startDateStruct":679,"completionDateStruct":681,"leadSponsor":683,"locationsCount":50},"100631196","whatsapp-radio-taiso-exercise-program-for-adults-aged-60-100631196","NCT07497529","WhatsApp Radio Taiso Exercise Program for Adults Aged 60+","The Effect of the WhatsApp-Based Radio Taiso Exercise Program on Exercise Habits, Physical Performance, and Quality of Life in Individuals Aged 60 and Over","Inclusion Criteria:\n\n* Being 60 years of age or older\n* Being able to use a smartphone and the WhatsApp application\n* Having internet access\n* Being able to walk independently (including using assistive devices)\n* Being able to understand verbal instructions\n* Agreeing to participate in the research voluntarily\n\nExclusion Criteria:\n\n* Having undergone major orthopedic surgery within the last 6 months\n* Having uncontrolled cardiovascular disease\n* Having a serious neurological disease that prevents participation in exercise\n* Being unable to exercise due to severe balance disorders or a history of falls",{"count":672,"type":22},30,[25],"The aim of this research is to examine the contribution of the Radio Taiso exercise program, offered via the WhatsApp application, to the process of establishing exercise habits in individuals aged 60 and over, and to evaluate the effects of this intervention on physical performance and quality of life. The study investigates the usability of WhatsApp, a digital platform, as a support tool in developing exercise habits. Furthermore, it aims to reveal the effects of the traditional Radio Taiso exercise model, widely practiced in Japan, one of the longest-living societies in the world, on the physical performance and quality of life of older adults.",[676],"Older Adults (60 - 85 Years Old)",{"date":678,"type":42},"2026-03-27",{"date":680,"type":42},"2026-03-10",{"date":682,"type":22},"2026-05-31",{"name":48,"class":49},""]