[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Oregon State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":134},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,77,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100636360","investigating-the-bioavailability-of-broccoli-extract-supplements-100636360",false,"NCT07564674","Investigating the Bioavailability of Broccoli Extract Supplements","Inclusion Criteria:\n\n* Healthy adults, 18-60 years of age\n* Willing to stop taking herbal and phytochemical (plant-based extract or phytochemical) supplements for 1 week prior to and during each study cycle\n* Willing to stop cruciferous vegetable intake 1 week prior to and during each study cycle\n* Must be able to give written informed consent\n\nExclusion Criteria:\n\n* Body Mass Index (BMI) \\\u003C18.5 or \\>30.0 kg\u002Fm2\n* Tobacco use, including e-cigarettes, or smoking of any substance (e.g. cannabis) in the past three months\n* Pregnancy, breastfeeding, or planning to become pregnant before completing the study\n* Engaging in vigorous exercise more than 7 hours per week\n* Have a significant acute or chronic illness such as cardiovascular disease, kidney or liver disease, diabetes, thyroid disorder, or radiation or chemotherapy treatment for cancer within the past five years\n* Use of medications to control cholesterol (e.g. statins, cholestyramine) or fat absorption (e.g. orlistat)\n* Have had bariatric surgery (e.g. gastric bypass, gastric banding, sleeve gastrectomy, etc.), other gastrointestinal procedure (e.g. cholecystectomy) or disorders (e.g. Crohn's disease, celiac disease, ulcerative colitis)\n* Allergic to broccoli, moringa, mustard, or maitake mushrooms\n* Weighs less than 110 pounds\n* Diagnosis of sickle cell disease",true,"ALL","18 Years","60 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare how much glucoraphanin and sulforaphane from 3 different versions of broccoli extract supplements is absorbed into the body and excreted in urine. This study involves generally healthy adults age 18-60 years. The supplements contain glucoraphanin and myrosinase enzyme, both naturally occurring in cruciferous vegetables. Once ingested, glucoraphanin is converted to the bioactive compound sulforaphane, which is thought to have numerous health benefits, including cancer prevention.\n\nParticipants will:\n\n* consume 3 different versions of broccoli extract supplements (glucoraphanin will range from 35-70 mg)\n* complete 3 separate 24 hour study cycles\n* submit blood and urine samples for 24 hours\n* follow diet restrictions (no cruciferous vegetables or condiments or phytochemical\u002Fherbal supplements for 1 week prior to and during each study cycle)",[27],"Diet, Healthy",[29,30,31,32],"cruciferous vegetable","broccoli extract supplement","glucoraphanin","sulforaphane","NOT_YET_RECRUITING","2026-05-01",{"date":36,"type":37},"2026-05-07","ACTUAL",{"date":39,"type":21},"2026-09",{"date":41,"type":21},"2028-09",{"name":43,"class":44},"Oregon State University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100597235","phase-1-virtual-mindful-after-cancer-mac-intervention-to-promote-sexual-health-for-breast-and-gynecologic-cancer-survivors-100597235","NCT07055854","Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors","Virtual Mindful After Cancer Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors","MAC","Inclusion Criteria:\n\n* At least 18 years old\n* Diagnosed with female breast or gynecologic cancer at stage I-IV\n* Diagnosed at least 6 months ago\n* At least one sexual concern in a validated screener\n* Access to high speed internet via smart phone, tablet, and\u002For computer\n\nExclusion Criteria:\n\n• Those who do not comprehend English since the MAC program is only available in English.","FEMALE",{"count":55,"type":21},60,[57],"PHASE1","The goal of this study is to plan for a large scale evaluation of a program called Mindful After Cancer, or MAC. The MAC Program provides training in mindfulness, educational material about sexual health after cancer, and support to cancer survivors experiencing sexual and body image concerns.\n\nThe main study aims are to:\n\n1. Develop effective plans for recruiting participants across multiple sites\n2. Evaluate participation in the program and surveys\n3. Develop plans to train and supervise the professionals who will deliver the program.\n\nResearchers will compare study recruitment across three sites, aiming to identify the most efficient approach for a larger future trial.\n\nParticipants who are randomly assigned to receive the MAC program will receive access to the 8-week program delivered by a trained mindfulness coach using videoconference and online materials. They will asked to participate in an interview about their experiences at the end of the program.\n\nParticipants who are not randomly assigned to the MAC program will receive access to the program's educational materials after completing the final survey.\n\nAll study participants will be asked to complete 3 online surveys. Participants randomly assigned to the MAC Program will also be asked to complete a one-on-one interview about their experience in the program.",[60,61],"Gynecologic Cancers","Breast Cancer",[63,64,65,66],"cancer survivorship","mindfulness","sexual health","intervention","RECRUITING","2026-02-05",{"date":70,"type":37},"2026-02-09",{"date":72,"type":37},"2025-08-25",{"date":74,"type":21},"2027-05",{"name":43,"class":44},3,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":15,"sex":16,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},"100588511","effect-of-walnuts-on-cognitive-function-and-gut-microbiome-in-older-adults-100588511","NCT06942351","Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults","Inclusion Criteria:\n\n* Age 55 years or older\n* Able to hear well enough to understand spoken instructions and questions\n* Able to see well enough to read and respond to printed instructions and fill out questionnaires (corrective lenses are allowed)\n* Able to write legibly and move a computer joystick with at least one hand (i.e., no injury or connective tissue or joint disorder that would impair ability to write or make hand movements)\n* Able to speak, read, and understand English\n* Score of greater than 79 on water maze learning task\n* Willing to maintain current eating patterns\n* Willing and able to complete the cognitive tests\n* Willing to stop consuming almonds, Brazil nuts, cashews, chestnuts, hazelnuts, macadamia nuts, peanuts, pecans, pistachios, walnuts, persimmons and pomegranates for 14 weeks. - are nuts or contain ellagitannins or ellagic acid - compounds\u002Ffoods of interest for this study\n* Willing to limit oak aged wines and spirits to 1 serving\u002Fday and limit blackberries (including similar berries like boysenberries, marionberries, and olallieberries), cloudberries, cranberries, currants, elderberries, lingonberries, raspberries, strawberries, wolfberries, other native berries; guava, mango, muscadine grapes, nectarines, peaches, plums, pluots to 1 cup\u002Fday for 14 weeks; REMAIN CONSISTENT (consistent intake levels of): Coffee, tea, apple, apricots, blueberries, cherries, grapes (table\u002Fcommon)\n* Willing to stop probiotic supplements 2 weeks prior to and during the study (14 weeks)\n\nExclusion Criteria:\n\n* Consumption of walnuts, pecans, and chestnuts combined greater than 2 oz \u002F week in the past 3 months.\n* Use of oral antibiotics in the past month\n* Regular use of oral anti-inflammatory medications in the past month\n* Nut, wheat, or gluten allergy\u002Fintolerance\n* Pregnant or planning to become pregnant during the study period\n* Weighs less than 110 pounds\n* Diagnosis of sickle cell disease\n* Susceptibility to motion sickness\n* Consumes 3 or more alcoholic drinks daily\n* History of smoking tobacco products, including e-cigarettes and vaporizers in the past 2 years (smokeless tobacco use not exclusionary)\n* Use of psilocybin or cannabis products (including CBD-only products) in the past 2 years\n* Current treatment for alcohol or other substance use disorder\n* History of heart attack, heart failure, or stroke, including transient ischemic attack\n* History of liver disease or kidney disease requiring dialysis\n* History of cancer in the past 5 years (Skin cancer that was only surgically treated is not exclusionary)\n* History of bariatric surgery (e.g., gastric bypass, gastric banding, sleeve gastrectomy, etc.) or disorders (e.g., Crohn's disease, unmanaged celiac disease, ulcerative colitis)\n* History of thyroid disorder that requires medication, but subject is not taking medication\n* History of chronic bronchitis or emphysema\n* Diagnosis of dementia or Alzheimer's disease\n* History of head injury requiring hospitalization or loss of consciousness \\> 5 minutes\n* History of chronic migraines (for at least 3 months, headache occurring on 15 or more days per month, where at least 8 of those headache days have migraine symptoms)\n* Blood pressure above 159 (systolic) or 99 (diastolic) mm Hg\n* Corrected vision worse than 20\u002F50\n* Score of less than 10\u002F15 on Ishihara color vision test or diagnosis of color blindness\n* Score of less than 26\u002F30 on Mini-Mental State Exam\n* Score of greater than 15 on Center for Epidemiologic Depression survey\n* History of disease or disorder which causes cognitive impairment, including but limited to: attention-deficit\u002Fhyperactivity disorder (ADHD), amyotrophic lateral sclerosis, autism, bipolar disorder, Down's syndrome, encephalitis, epilepsy\u002Fseizures, human immunodeficiency virus (HIV), Huntington's disease, Korsakoff's psychosis, multiple sclerosis, Parkinson's disease, or psychotic disorders (e.g., schizophrenia, schizoaffective disorder, schizophreniform disorder)\n* Current and regular use of any of the following medications: insulin, opioids, anti-seizure medications, psychotropic medications: stimulants, anti-psychotics, or medications that cause daytime drowsiness or difficulty concentrating","55 Years",{"count":85,"type":21},80,[24],"The purpose of this study is to examine the impact of daily consumption of walnuts for 12 weeks on cognitive function, markers of inflammation and oxidative stress, and the gut microbiome in healthy adults age 55 years and older.",[89,90],"Aging","Inflammation Biomarkers",[92,93,94],"gut microbiome","walnuts","cognitive function","2025-06-17",{"date":97,"type":37},"2025-06-19",{"date":99,"type":37},"2025-06-09",{"date":101,"type":21},"2029-05",{"name":43,"class":44},1,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":103},"100545656","shift-worker-intervention-for-sleep-health-100545656","NCT06384742","Shift Worker Intervention for Sleep Health","Developing a Sleep Health Intervention for Shift Workers","SWISH","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Any gender; Ages 18-65\n* Currently employed as a nurse or nursing staff member (e.g., CNA) in the United States\n* Currently have shift work schedules (i.e., stable night shift or rotating shifts that include nights, \\>=2 nights\u002Fweek) and have worked shift work \\>=2 nights\u002Fweek for at least 3 months\n* Expect to have a shift work schedule \\>=2 nights\u002Fweek over the next 6 months\n* endorse poor sleep, as evidenced by T-score \\>=60 on the PROMIS Sleep Disturbance OR Sleep-Related Impairment measure\n* Have daily access to the internet on a smartphone, table, or computer; and\n* Can read and write in English.\n\nExclusion Criteria:\n\n* Conditions which make study treatment likely to be ineffective. For example, current chronic use of medications that interfere with sleep, alcohol or substance use disorder, or thought disorder (as determined by DIAMOND psychiatric interview), unstable sleep or medical conditions that necessitate additional medical care not provided by study treatments (e.g., known untreated sleep apnea).\n* Presence of safety risk or condition in which study participation may result in increased risk to safety (e.g., elevated risk for suicide, self-reported uncontrolled seizure disorder, history of manic or hypomanic episode, current pregnancy),\n* Currently receiving non-pharmacological treatment for insomnia (e.g., cognitive behavioral therapy for insomnia) and\u002For current unstable hypnotic\u002Falerting medication use OR\n* Currently participating in other research studies with substantial overlap in terms of methods\u002Fprocedures (e.g., PI's ongoing study \"Piloting an Adaptation of Cognitive Behavioral Therapy for Insomnia for Shift Workers (CBTI-Shift)\"","65 Years",{"count":55,"type":21},[24],"The aim of this study is to pilot test a comprehensive, personalized, media-augmented telehealth intervention (\"SWISH\") designed to improve sleep health among shift workers.",[117,118],"Shift Work Type Circadian Rhythm Sleep Disorder","Insomnia, Psychophysiological",[120,121,122,123,124,125],"insomnia","shift work","nurse","sleep psychology","behavioral sleep medicine","circadian rhythm","2025-04-29",{"date":128,"type":37},"2025-05-02",{"date":130,"type":37},"2025-04-28",{"date":132,"type":21},"2028-01-15",{"name":43,"class":44},""]