[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Origin Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100447105","feasibility-study-to-investigate-rectal-mucus-in-aero-digestive-tract-cancer-100447105",false,"NCT05102110","Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.","Feasibility Study to Investigate the Genomic and Epigenetic Changes in Rectal Mucus in Non-Colorectal Cancers of the Aero-Digestive Tract (ORI-EGI-03).","ORI-EGI-03","Inclusion Criteria:\n\nAged 18 years or over Be able to give voluntary, written informed consent to participate in the study\n\nExclusion Criteria:\n\nParticipants with symptoms that would make proctoscopic examination inappropriate, including acute anal fissure, symptomatic thrombosed haemorrhoids or obstructing anorectal lesions as determined by rectal examination Participants with a previous history of cancer Participants who have received previously radiotherapy, chemotherapy or immunotherapy for a malignancy.","ALL","18 Years","99 Years",{"count":21,"type":22},450,"ESTIMATED","OBSERVATIONAL","The aim of the study is to assess the feasibility of genomic and epigenetic analysis of rectal mucus to detect non-colorectal cancers of the aero- digestive tract using samples collected by the OriCol™ Sampling Device.\n\nThe primary objective of the study is to assess whether significant changes in DNA mutation and methylation associated with Non-colorectal cancers of the Aero-digestive Tract (NCRCADT) can be detected in rectal mucus as shed cells and cell-free DNA (cfDNA) pass through the gut and theoretically can be collected from rectal mucus.\n\nSecondary objectives will assess the participant acceptability of the OriCol™ Sampling Device for Pancreatic Ductal Adenocarcinoma, Non-Small Cell Cancer of the Lung, Colorectal Cancer and Urological Cancer controls as well as contributing to a genomic library collating information about rectal mucus.",[26,27,28,29],"Non Small Cell Lung Cancer","Pancreatic Cancer","Bladder Cancer","Colorectal Cancer","RECRUITING","2026-03-12",{"date":33,"type":34},"2026-03-16","ACTUAL",{"date":36,"type":34},"2021-12-01",{"date":38,"type":22},"2027-12-01",{"name":40,"class":41},"Origin Sciences","INDUSTRY",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":42},"100565972","triple-assay-of-rectal-mucus-in-the-diagnosis-of-colorectal-cancer-100565972","NCT06649123","Triple Assay of Rectal Mucus in the Diagnosis of Colorectal Cancer","Development of a Multiomics Assay for Use on OriColTM Sampled Rectal Mucus for Detection of Cancer and Significant Polyps in Symptomatic Patients on the Colorectal Urgent Suspected Cancer Pathway","TRIOMIC","Inclusion Criteria:\n\n1. Patients 18 years and over\n2. Patients referred from primary care to the 'urgent suspected cancer' CRC pathway during the study period.\n3. Patients who provide voluntary written informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients who are unable to undergo digital rectal examination (DRE).\n2. Patients with peri-anal\u002Fanal symptoms that may limit DRE and proctoscopy examination and it would be clinically inappropriate to attempt to assess these patients. This may include conditions such as:\n\n   * Patients who have undergone radiotherapy.\n   * An acute or chronic anal fissure\n   * Perianal haematoma\n   * Acute thrombosed haemorrhoids\n   * Post- operative anal stenosis\n   * The presence of an obstructing anal\u002Flow rectal tumour or discomfort as a result of previous pelvic radiotherapy\n3. Current pregnancy or suspicion of pregnancy.",{"count":52,"type":22},6600,"Development of a multiomics assay for use on OriColTM sampled rectal mucus for detection of cancer and significant polyps in symptomatic patients on the Colorectal Urgent Suspected Cancer pathway.",[29,55],"Adenoma Colon Polyp",[57,58,59,60,61],"colon","rectum","mucus","adenoma","microbiome","2025-04-02",{"date":64,"type":34},"2025-04-04",{"date":66,"type":34},"2024-11-01",{"date":68,"type":22},"2027-04-01",{"name":40,"class":41},""]