[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Orygen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":95},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100601776","virtual-reality-for-vocational-recovery-100601776",false,"NCT07114887","Virtual Reality for Vocational Recovery","Enhancing Vocational Support With a Virtual Reality Vocational Skills Building Application: Piloting VR4VR","VR4VR","A young person participant will be considered eligible for inclusion in this study if:\n\n1. They are aged 18-25 seeking vocational support at participating vocational support programs\n2. Have a named care-coordinator or key worker\n3. Comfortable using a VR headset\n4. Consent to recording of interview for transcription\n\nExclusion Criteria:\n\n1. They lack fluency in English (spoken and written), since this is required to understand participate in the VR intervention;\n2. They have a known diagnosis of a moderate intellectual disability, due to some of the content delivered during the intervention requiring a certain level of understanding.\n3. As the therapy uses audio and visual means of communication, participants with impairments so severe that they cannot hear instructions, or are unable to see the virtual reality environments, cannot participate. Mild impairments can be accommodated, as sound volume can be turned up, and the Meta Quest headband is used to comfortably use glasses with the headset.\n\nA vocational specialist or staff participant will be considered eligible for inclusion in this study if:\n\n1. Presently work within a vocational program and hold a caseload of young people\n2. Have worked with at least 5 young people within a vocational intervention.\n3. Sufficient command of the English language\n4. Consent to audio recording of interview\n\nNo exclusion criteria\n\nA staff participant will be considered eligible for inclusion in this study if:\n\n1. Presently work within a role supporting a vocational program\n2. Sufficient command of the English language\n3. Consent to audio recording of interview\n\nNo exclusion criteria","ALL","18 Years","25 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","Unemployment is higher among young people who experience mental ill-health compared to the general population. This can have a lasting impact on young people, many of whom are highly motivated to gain employment and education. There are many challenges to seeking, gaining, and maintaining employment for young people. To address these challenges and help young people meet their employment and education goals, investigators have developed a VR intervention to support vocational skill building. The aim of the current study is to evaluate the feasibility, acceptability, and safety, of the Virtual Reality for Vocational Recovery (VR4VR) intervention. A small group of vocational specialists will support up to 20 young people with their vocational outcomes using VR4VR over a 3-6week period. Both young people and specialists will complete questionnaires related to acceptability of the intervention, including qualitative interviews. Data on feasibility and safety will also be collected. Results will inform whether VR is feasible, acceptable, and safe to support vocational outcomes within vocational services that support young people with mental health difficulties, potentially supporting further intervention development and larger trials.",[28],"Mental Health Disorder","NOT_YET_RECRUITING","2025-08-06",{"date":32,"type":33},"2025-08-11","ACTUAL",{"date":35,"type":22},"2025-08",{"date":37,"type":22},"2025-12",{"name":39,"class":40},"Orygen","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":19,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},"100512853","phase-2-guanfacine-extended-release-for-adolescents-with-cannabis-use-100512853","NCT05957848","Guanfacine Extended-release for Adolescents With Cannabis Use","Guanfacine Extended-release Randomised Controlled Trial for Adolescents With Cannabis usE (GRACE)","GRACE","Inclusion Criteria:\n\n1. 12-25 years of age (inclusive) at consent;\n2. Seeking treatment for cannabis use;\n3. DSM-5 Cannabis Use Disorder, mild, moderate or severe;\n4. Self-reported cannabis use on average at least 5 days\u002Fweek during the 28 days prior to screening with a THC positive urine drug screen on the day of screening; and\n5. Able to provide informed consent (both adequate IQ and English fluency; \\\u003C18-year-olds will provide consent themselves in addition to parent\u002Fguardian consent).\n\nExclusion Criteria:\n\n1. DSM-5 substance use disorder (moderate or severe) except cannabis or nicotine;\n2. Any unstable medical, psychiatric or neurological condition or medical contraindicating study participation;\n3. Diagnosis of a psychotic or bipolar illness;\n4. Acute suicidality as assessed by clinician;\n5. Prescribed antipsychotics, benzodiazepines or other sedative medications, or other medications for the treatment of ADHD. If prescribed antidepressants, the participant must have been on a stable dose for more than 2 weeks at screening;\n6. A history of heart disease or cardiac risk factors (e.g. arrhythmias);\n7. Abnormal liver or thyroid function as indicated by clinically-significant findings on blood tests;\n8. Pregnancy, breast feeding or, if sexually active and able to become pregnant, no effective contraception.\n9. Intention to enter residential rehabilitation after treatment in the YSAS residential withdrawal facility.","12 Years",{"count":51,"type":22},100,[53],"PHASE2","A randomized controlled trial to assess the efficacy of extended-release guanfacine to reduce cannabis use frequency in young people with cannabis use disorder following a period of monitored abstinence.",[56],"Cannabis Use Disorder","RECRUITING","2025-07-29",{"date":60,"type":33},"2025-07-31",{"date":62,"type":33},"2023-07-27",{"date":64,"type":22},"2026-06-30",{"name":39,"class":40},1,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":19,"enrollmentInfo":74,"targetDuration":4,"studyType":23,"phases":76,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":4},"100584859","phase-2-hybrid-type-2-implementation-effectiveness-trial-of-a-third-wave-virtual-reality-treatment-for-youth-depressionanxiety-100584859","NCT06894836","Hybrid Type 2 Implementation-Effectiveness Trial of a Third Wave Virtual Reality Treatment for Youth Depression\u002FAnxiety","Hybrid Type 2 Implementation-Effectiveness Trial of a Third Wave Virtual Reality Treatment for Youth Depression and Anxiety","There are three populations recruited for this trial:\n\nINCLUSION CRITERIA\n\nYoung people\n\n1. Aged between 12-25 years (inclusive)\n2. Current client of a participating youth mental health service\n3. Seeking or receiving treatment for depression and\u002For anxiety\n4. Sufficient command of the English language\n\nClinicians Employed at a participating youth mental health service and involved in the delivery of psychological treatment of young people presenting with depression and anxiety\n\nService staff Work within a participating youth mental health service in a leadership (team lead or service manager) or administrative role.\n\nEXCLUSION CRITERIA:\n\nYoung people\n\n1. Moderate or severe audio or visual condition precluding engagement with the VR equipment (assessed on a case-by-case basis)\n2. Counter indication based on clinical judgement e.g., active suicidal risk or intellectual disability.\n\nClinicians Unable to commit to delivering the MIND intervention (5 sessions over 10-12 weeks).\n\nService staff Nil",{"count":75,"type":22},75,[53],"This research will evaluate a new virtual reality (VR) intervention to support youth with depression and anxiety. While VR has shown promise for adult mental health, little is known about its use in youth or routine clinical care. The VR intervention is based on Acceptance and Commitment Therapy (ACT) and immerses young people in fun, engaging environments to teach practical coping skills for managing distress. Clinicians within youth mental health services will use the VR intervention within their routine treatment of young people. The study will evaluate both the preliminary effectiveness of the VR intervention for improving youth mental health, as well as real-world implementation outcomes to understand how it can be successfully adopted in clinical settings. The trial will use a single-group, pre-post design, with treating clinicians delivering the intervention to up to 75 young people seeking treatment for depression and anxiety over a 12-week period. Assessments will be conducted at baseline, immediately after the intervention (12 weeks), and four weeks post-intervention (16 weeks).",[79],"Depression Anxiety Disorder",[81,82,83,84,85,86],"Virtual reality","Acceptance and commitment therapy","Youth mental health","Depression","Anxiety","Psychological intervention","2025-03-30",{"date":89,"type":33},"2025-04-03",{"date":91,"type":22},"2025-04-01",{"date":93,"type":22},"2026-10-01",{"name":39,"class":40},""]