[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ostergotland County Council, Sweden\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":144},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,87,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100579976","the-effects-of-diet-on-small-non-coding-rna-i-sperm-cells-and-the-possible-effects-on-reproductive-success-diet-intervention-effects-on-sperm-100579976",false,"NCT06831292","The Effects of Diet on Small Non-coding RNA i Sperm Cells and the Possible Effects on Reproductive Success: Diet Intervention Effects on Sperm","Molecular Mechanisms for Male Fertility: Can Diet Change Sperm sncRNA and the Reproductive Potential?","DIET-IS","Inclusion Criteria:\n\n* Male (biological) partner in infertile couple, scheduled for first IVF treatment\n* Mature sperm cells in semen\n* Able to speak and read Swedish\n* Omnivore\n* Will refrain from nicotine and alcohol during intervention\n* Sperm sampled provided no more than 3 weeks before intervention start\n\nExclusion Criteria:\n\n* Former or present malignant disease\n* Former radiotherapy in pelvic area\n* Former chemotherapy\n* Known genetic\u002Fchromosomal disorder\n* Food allergy","MALE","23 Years","56 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","In this study, patients with infertility treated with IVF at the Center of Reproductive Medicine in Linköping, Sweden, will receive recipes and food according to Nordic dietary guidelines. The purpose is to investigate whether a short diet intervention is sufficient to improve sperm quality and shift the small non-coding RNA profile. In our previous study sperm showed rapid response to diet.",[28,29,30],"Changes in sncRNA in Sperm","Male Fertility","RNA Profile",[32,33,34,35,36,37],"male fertility","small non-coding RNA","diet","infertility","reproduction","diet intervention","RECRUITING","2026-05-04",{"date":41,"type":42},"2026-05-05","ACTUAL",{"date":44,"type":42},"2024-12-26",{"date":46,"type":22},"2027-12",{"name":48,"class":49},"Ostergotland County Council, Sweden","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":4},"100612473","ai-assisted-saliva-diagnostics-using-an-electrochemical-sensor-platform-for-periodontitis-detection-salience-100612473","NCT07254039","AI-Assisted Saliva Diagnostics Using an Electrochemical Sensor Platform for Periodontitis Detection (SALIENCE)","Development and Validation of an AI-Assisted Electrochemical Sensor Platform for Saliva-Based Diagnostics in Periodontitis","SALIENCE","Inclusion Criteria:\n\nAdults ≥18 years.\n\nAble and willing to provide written informed consent.\n\nAbility to provide an unstimulated whole saliva sample per protocol (no food, drink, gum, toothbrushing, or smoking within 60 minutes prior to sampling).\n\nPeriodontitis group: Clinical diagnosis of periodontitis according to 2018 AAP\u002FEFP criteria (e.g., interdental CAL ≥3 mm at ≥2 non-adjacent teeth with radiographic bone loss; probing pocket depth ≥4 mm in ≥2 teeth).\n\nHealthy control group: No clinical signs of periodontal disease (no probing depths \\>3 mm, bleeding on probing \\\u003C10%, and no radiographic bone loss).\n\nExclusion Criteria:\n\nSystemic antibiotics or systemic anti-inflammatory\u002Fimmunosuppressive therapy within the past 3 months.\n\nPeriodontal therapy (scaling\u002Froot planing or surgery) within the past 6 months.\n\nCurrent acute oral infection or abscess.\n\nSystemic conditions known to markedly alter saliva composition\u002Fflow (e.g., Sjögren's syndrome, prior head-and-neck radiation, ongoing chemotherapy, uncontrolled diabetes).\n\nUse of strongly xerogenic medications not on a stable dose ≥4 weeks, or clinically significant hyposalivation preventing sampling.\n\nInability to comply with sampling procedures (e.g., cannot abstain from food\u002Fdrink\u002Ftobacco for 60 minutes prior to sampling).\n\nPregnancy or lactation.",true,"ALL","18 Years","80 Years",{"count":64,"type":22},200,"OBSERVATIONAL","This observational study aims to develop and validate a novel, AI-assisted electrochemical sensor platform for saliva-based diagnostics in periodontitis. Periodontitis is a chronic inflammatory disease affecting the gums and supporting tissues of the teeth. Despite its high global prevalence, early diagnosis remains challenging because the disease often progresses silently until irreversible damage has occurred.\n\nSaliva offers a promising, non-invasive diagnostic medium that reflects both oral and systemic health. However, its biological complexity and variability have limited its clinical use. This project addresses these challenges by combining advanced electrochemical sensing with artificial intelligence (AI) and synthetic data generation to improve diagnostic precision and reliability.\n\nThe study involves the collection of saliva samples from adult participants with diagnosed periodontitis and from healthy controls. The samples will be analyzed using a modular sensor platform equipped with multiple electrodes that detect electrochemical signals from a wide range of salivary biomarkers. The sensor data will then be processed using machine learning models trained on both real and synthetic data to classify disease states.\n\nThe main goals are to:\n\nEvaluate the performance of the electrochemical sensor array for saliva analysis.\n\nDevelop and validate AI-based algorithms for detecting and differentiating between healthy and diseased samples.\n\nGenerate feasibility data supporting future clinical implementation of saliva-based diagnostics for periodontitis.\n\nThis interdisciplinary project combines expertise in clinical dentistry, biomedical engineering, and computer science. It is conducted in collaboration between Linköping University and Malmö University, with patient sampling carried out at an affiliated dental clinic.\n\nThe study is expected to result in a working proof-of-concept device that enables real-time, non-invasive detection of periodontitis at the point of care. By enabling earlier diagnosis and more personalized treatment, this technology may transform periodontal care and serve as a foundation for future saliva-based diagnostics targeting other oral and systemic diseases.",[68,69,70,71],"Periodontal Diseases","Biomarkers (D23.050.301)","Diagnostic","Saliva",[73,74,75,76,77],"Saliva Diagnostics","Electrochemical Sensor","AI-Assisted Diagnostics","Biomarkers","Periodontal diseases","NOT_YET_RECRUITING","2025-11-19",{"date":81,"type":42},"2025-11-28",{"date":83,"type":22},"2025-12-01",{"date":85,"type":22},"2028-06-30",{"name":48,"class":49},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":60,"minAge":61,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":50},"100521483","effectiveness-of-adjunctive-therapy-of-emdogainfl-in-non-surgical-periodontal-treatment-100521483","NCT06070181","Effectiveness of Adjunctive Therapy of Emdogain®FL in Non-surgical Periodontal Treatment","\"Effectiveness of Emdogain® As an Adjunctive Therapy for Non-Surgical Periodontal Treatment- a Randomized, Controlled, Split-Mouth Design Multicenter Clinical Trial\"","Inclusion Criteria:\n\nStudy Population The study population will consist of patients affected by Stage 3 or 4 periodontitis. See below for a full list of inclusion and exclusion criteria.\n\nInclusion Criteria\n\nPatients must meet all of the following criteria for inclusion in the study:\n\n* Over 18 years old\n* Stage 3 or 4 periodontitis\n* Residual pockets with probing depths from 5mm to 9mm with no furcation involvement and adequate plaque control\n\nExclusion Criteria:\n\nPatients who meet any of the following exclusion criteria are not allowed to be included in the study:\n\n* Antibiotic treatment in last 3 months\n* Subgingival scaling and root planning performed in last 12 months\n* Patients for which the use of Emdogain® is contraindicated i. e. patients with uncontrolled diabetes or other uncontrolled systemic diseases, disorders or treatments that compromise wound healing, chronic high dose steroid therapy, bone metabolic diseases, radiation or other immuno-suppressive therapy and infections or vascular impairment at the surgical site.",{"count":95,"type":22},150,[25],"The goal of this clinical trial is to assess the safety and effectiveness of adjunctive Emdogain® therapy in non-surgical periodontal treatment for patients with stage 3 and 4 periodontitis.\n\nThe main questions it aims to answer are:\n\n* Will adjunctive treatment with Emdogain® result in a greater reduction in Bleeding on Probing and probing pocket depth compared to non-surgical periodontal treatment alone? • Will adjunctive treatment with Emdogain® lead to a greater mean Radiographic attachment level (rAL) gain per quadrant compared to non-surgical periodontal treatment alone?\n* Will adjunctive treatment with Emdogain® result in a lower proportion of treated teeth requiring surgery (PPD ≥6mm) at 12 months after treatment?\n\nParticipants in the study will undergo the following tasks:\n\n* Screening and randomization\n* Receival of non-surgical periodontal treatment in all quadrants and in two quadrants adjunctive Emdogain®\n* 6-month follow-up assessment\n* 12-month follow-up assessment\n\nClinical and radiological assesment will be performed in two quadrants treated with adjunctive Emdogain® therapy and two quadrants treated with non-surgical periodontal treatment alone. This comparison will help determine the effects of adjunctive therapy with Emdogain®.\n\nThe study aims to provide insights into the safety and efficacy of adjunctive Emdogain® therapy in non-surgical periodontal treatment, specifically in patients with stage 3 and 4 periodontitis.",[99],"Periodontitis",[101,102,103,104,105],"non-surgical treatment","Periodontal treatment","Periodontitis stage 3 and 4","Enamel matrix derivate","Emdogain flapless","2024-10-29",{"date":108,"type":42},"2024-10-31",{"date":110,"type":42},"2024-03-01",{"date":112,"type":22},"2026-08-01",{"name":48,"class":49},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":60,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":127,"conditions":128,"keywords":134,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":50},"100493764","preterm-delayed-cord-clamping-and-early-skin-to-skin-contact-predecess-100493764","NCT05709392","Preterm DElayed Cord Clamping and Early Skin-to-Skin Contact: PreDECESS","Preterm DElayed Cord Clamping and Early Skin-to-Skin Contact","PreDECESS","Inclusion Criteria:\n\nInfants born in gestational weeks 30+0-34+6 through vaginal delivery and admitted to neonatal ward in Sweden.\n\nParents must be able to read Swedish.\n\nExclusion Criteria:\n\nInfants with known disease when an expanded blood volume is expected will be excluded as early cord clamping is recommended (severe anemia, cardiac disease etc).\n\nInfants with known malformations. Infants with severe or moderate asphyxia (defined as APGAR \\\u003C 4 at 5 minutes of age).\n\nInfants where the physician in charge find it inappropriate with delayed cord clamping.\n\nNo time for cord clamping has been registered.","30 Weeks","34 Weeks",{"count":125,"type":22},126,[25],"The PreDECESS trial is a prospective study where that will evaluate a new method taking care of premature infants in gestational weeks 30+0 to 34+6 at birth. The new method includes delayed cord clamping and early skin-to-skin contact with a parent. Two populations of infants with their parents will be compared. Infants taken care of in the traditional way before the new method is introduced, and infants taken care of with the new method when it is being introduced.\n\nPrimary question:\n\nDoes delayed cord clamping and early skin-to skin contact (SSC) lead to better bonding between parents and their infants?\n\nSecondary questions:\n\nAre there any potential adverse effects with delayed cord clamping and early skin-to skin contact (SSC)? Is there a difference in infants level of bilirubin, haemoglobin or proBNP? Is there a difference in infants growth? Is there a difference in infants neurological development? Is there a difference in infants and parents level of stress? Is there a difference in mothers production of breastmilk, frequency of breastfeeding or experience of breastfeeding? Is there a difference in parents mood? How do parents of preterm infants experience giving birth of their preterm baby before and after the introduction of the new method?",[129,130,131,132,133],"Bonding","Stress","Breastfeeding","Child Development","Adverse Events",[135],"adverse events","2023-01-23",{"date":138,"type":42},"2023-02-02",{"date":140,"type":42},"2022-12-12",{"date":142,"type":22},"2028-12-11",{"name":48,"class":49},""]