[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ostfold Hospital Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":248},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,44,69,92,123,149,174,197,227],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100596933","phase-3-the-holistic-study-100596933",false,"NCT07051915","The Holistic Study","Comprehensive Evaluation of Two Second-Line Therapeutic Approaches for Immune Thrombocytopenia (ITP) - a Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\n1. Male or female aged ≥18 years.\n2. Diagnosis of primary ITP of less than one-year duration and having a platelet count of \\\u003C 30 x109\u002FL measured within two weeks prior to inclusion with failure to achieve response or relapse after at least one cycle of dexamethasone (20-40 mg daily for 4 days) or prednisone \u002Fprednisolone (1 mg\u002Fkg for at least two weeks). Shorter courses or lower doses are allowed if discontinued or modified due to side effects.\n3. Clinical need for subsequent platelet elevating therapy assessed by the physician in charge.\n4. Signed and dated written informed consent.\n\nExclusion Criteria:\n\n1. Previous treatment for ITP with: Rituximab, other immune suppressants (including mycophenolate mofetil, azathioprine, cyclosporine), dapsone, danazol, chemotherapy (apart from vincristine as rescue therapy) or splenectomy. Short treatment with any thrombopoietic agent is allowed if given for a limited duration of a maximum of 2 weeks as rescue therapy for quick elevation of platelet count in emergency situations e.g. bleeding.\n2. Pregnancy or lactation.\n3. Females of child-bearing potential refusing to follow effective contraceptive methods for at least 12 months following the last administration of Rituximab or during treatment with Avatrombopag.\n4. Secondary ITP: ITP secondary to lymphoma or chronic lymphocytic leukemia; ITP secondary to the following autoimmune disorders: Systemic Lupus Erythematosus, Antiphospholipid Syndrome, or Common Variable Immune Deficiency; ITP secondary the following viral infections: Human Immunodeficiency Virus or Hepatitis C Virus.\n5. Concomitant autoimmune hemolytic anemia.\n6. Active hepatitis B virus (positive HBsAg). Patients with HBsAg negative and HBV core antigen antibody positive (HBcAb) should accept to receive entecavir (Baraclude) for 12 months if they will be allocated to Rituximab. Monthly HBV DNA monitoring will be required while on treatment and for the 6 months after the last dose of the study drug.\n7. Presence of any serious comorbidity where the condition may worsen by and of the study drugs.\n8. Known allergy, sensitivity or contraindication to Rituximab or Avatrombopag.\n9. Patients in a severely immune compromised state.\n10. Presence of active malignancy unless deemed cured by adequate treatment. Participants with the following neoplastic conditions can be included:\n\n    1. Monoclonal gammopathy of undetermined significance (MGUS) or monoclonal B lymphocytosis of undetermined significance (MBUS).\n    2. Basal\u002Fsquamous cell carcinoma of the skin\n    3. Carcinoma in situ of the cervix\n    4. Carcinoma in situ of the breast\n    5. Incidental histological finding of prostate cancer (TNM stage T1a or T1b).\n11. Patients with history of poor compliance or history of alcohol\u002Fdrug abuse or excessive alcohol beverage consumption that would interfere with the ability to comply with the study protocol, or current or past psychiatric disease that might interfere with the ability to comply with the study protocol or give informed consent.","ALL","18 Years",{"count":19,"type":20},220,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","This study is a phase 3 study where eligible patients will be randomized 1:1 to one of two treatment strategies: receiving a thrombopoietin receptor agonist (Avatrombopag), or anti-CD20 (Rituximab).",[26],"Thrombocytopenia Purpura",[28,29,30,31],"Avatrombopag","Rituximab","Thrombocytopenia","Immune thrombocytopenia","NOT_YET_RECRUITING","2025-09-02",{"date":35,"type":36},"2025-09-09","ACTUAL",{"date":38,"type":20},"2025-09-15",{"date":40,"type":20},"2029-12-31",{"name":42,"class":43},"Ostfold Hospital Trust","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":5},"100559756","the-benefit-of-repairing-the-deltoid-ligament-in-unstable-ankle-fractures-100559756","NCT06568276","The Benefit of Repairing the Deltoid Ligament in Unstable Ankle Fractures","The Benefit of Repairing the Deltoid Ligament in Unstable Ankle Fractures: Patient-reported Functional Outcome and Radiological Stability Measurements","Inclusion criteria; fluent in oral and written Norwegian language\n\n* isolated Weber type B fractures and Weber B+ posterior malleolar Mason Molloy class I.\n* Initial medial clear space (MCS)\\>=7mm or weightbearing x-ray evaluated as unstable or primary reposition after fracture dislocation.\n* Pre-injury walking ability without aids.\n\nExclusion criteria\n\n* assumed not compliant (drug use, cognitive- and\u002For psychiatric disorders).\n* previous history of ipsilateral ankle fracture or ipsilateral major ankle-\u002Ffoot surgery.\n* open fx Gustilo Anderson II or more, multi-trauma and pathologic fracture.\n* neuropathies and generalized joint disease such as Rheumatoid Arthritis or other more severe condition in same extremity\n* fixation of tibial fragment or syndesmotic screw or suture button planned prior to surgery","65 Years",{"count":53,"type":20},120,[55],"NA","Ankle fractures occur in 1 out of 800 persons a year and is a common injury. The deltoid ligament is necessary for the stability of the joint and guides choice of treatment. Cadaveric studies have shown that deltoid ligament repair gives more stability than the osteosynthesis of the lateral malleolus itself. The investigators want to show if suture of the deltoid ligament in unstable ankle fractures contribute to a better functional result and\u002For prevent long term osteoarthritis for our participants. Patients sustaining severe ankle fractures have shown a considerable loss of function that might affect their long term activities of daily living (ADL) function. Improving outcome for this group may preserve some patients' ability to work and reduce community expenses.",[58,59],"Ankle Fractures","Deltoid Ligament; Sprain (Strain) (Ankle)","RECRUITING","2025-08-12",{"date":63,"type":36},"2025-08-13",{"date":65,"type":36},"2024-09-20",{"date":67,"type":20},"2032-07-01",{"name":42,"class":43},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":16,"minAge":17,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},"100524846","operative-versus-non-operative-treatment-for-mild-to-moderate-hallux-valgus-deformity-100524846","NCT06114043","Operative Versus Non-operative Treatment for Mild to Moderate Hallux Valgus Deformity","Randomised Controlled Trial; Is Operative Treatment of Mild to Moderate Hallux Valgus Deformity Superior to Conservative Treatment?","Inclusion Criteria:\n\n* Painful Hallux Valgus deformity\n* Hallux Valgus Angle \\\u003C35 degrees\n* Intermetatarsal angle \\\u003C15 degrees\n* 18-80 years\n\nExclusion Criteria:\n\n* Advanced osteoarthritis in first metatarsophalangeal joint\n* Rheumatic diseases\n* Pregnancy\n* Drug abuse\n* Severe psychological disorder\n* Lack of compliance\n* Language barrier",true,"80 Years",{"count":53,"type":20},[55],"The goal of this randomized controlled trial is to investigate operative treatment versus conservative treatment in participants suffering from mild to moderate hallux valgus deformity. The main question it aims to answer are; Is surgery superior to conservative treatment?\n\nThe participants will be randomized in to two groups, operative and conservative group.\n\nInvestigators will compare the groups measuring the clinical results using the patient-reported outcome measure (PROM) Manchester-Oxford Foot Questionnaire (MOxFQ), Visual analog scale (VAS), likert scale 0-5. Participants will be observed for a period og two years.",[82],"Hallux Valgus Deformity","2025-07-30",{"date":85,"type":36},"2025-08-03",{"date":87,"type":36},"2025-06-01",{"date":89,"type":20},"2030-03",{"name":42,"class":43},1,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":76,"sex":100,"minAge":17,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},"100500082","the-norwegian-world-health-organisation-labour-care-guide-trial-norwel-100500082","NCT05791630","The Norwegian World Health Organisation Labour Care Guide Trial (NORWEL)","The Norwegian World Health Organisation Labour Care Guide Trial","NORWEL","Inclusion Criteria:\n\n* Women in active labour\n* Labour and delivery at study sites\n\nExclusion Criteria:\n\n* None","FEMALE",{"count":102,"type":20},23650,[55],"Appropriate and timely care during birth is critical to the survival and health of women and their babies. In 2020, the World Health Organization (WHO) presented the Labour Care Guide (LCG) as the new recommended tool for monitoring birth and assessing progression, replacing the WHO partograph. This evidence-based guide was designed to ensure improved quality and safety of care, and to avoid unnecessary interventions during birth. The LCG was developed to be used in all settings globally, but it has only been tested in health facilities in South America, Asia and Africa, while it has not been tested in high-income settings. Implementing a new guideline for monitoring birth is a comprehensive operation that will affect both the national economy, health systems, and individual patients; therefore, further research on the possible advantages is needed before national enrolment. Hence, the trial proposed in this application is crucial to form the required foundation of knowledge. The trial will be conducted in labour wards at ten hospitals, covering all health regions in Norway, and the established Norwegian Research Network for Clinical Studies in Obstetrics (NORBIRTH), with dedicated local principal investigators, will provide a robust research environment. This trial will test the effect of the LCG. Results from this trial will provide knowledge needed to determine a future implementation of the LCG in Norway.",[106,107,108,109,110,111,112,113],"Labor Dystocia","Labor Complication","Labor Onset and Length Abnormalities","Labor (Obstetrics)--Complications","Experience, Life","Progression","Cesarean Section Complications","Apgar; 4-7 at 1 Minute","2025-04-02",{"date":116,"type":36},"2025-04-04",{"date":118,"type":36},"2025-04-01",{"date":120,"type":20},"2030-12-31",{"name":42,"class":43},10,{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":21,"phases":133,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":91},"100580833","systematic-machine-learning-algorithm-for-rapid-thrombosis-detection-100580833","NCT06842446","Systematic Machine Learning Algorithm for Rapid Thrombosis Detection","Evaluating a New Diagnostic Strategy for Suspected DVT Consisting of Point of Care D-dimer, AI-based Prediction Model and Compression Ultrasound","DVT-SMART","Inclusion Criteria:\n\n* Patients referred to the ED due to suspicion of DVT\n* Age ≥ 18 years\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Ongoing use of anticoagulation for more than 72 hours\n* Previous participation in the study\n* Life expectancy of less than three months.",{"count":132,"type":20},1000,[55],"The goal of this clinical trial is to compare the use of a machine learning-based algorithm and point-of-care D-dimer to laboratory D-dimer and compression ultrasound to exclude deep vein thrombosis in the under extremities in patients referred to a medical department suspected of having deep vein thrombosis. The main aim is to answer are if a machine learning algorithm and point of care D-dimer can exclude deep vein thrombosis in more patients than clinical assessment and D-dimer alone.",[136],"Deep Vein Thrombosis",[138,139,140],"Machine Learning","POC D-dimer","POC Ultrasound","2025-02-24",{"date":143,"type":36},"2025-02-26",{"date":145,"type":36},"2025-01-06",{"date":147,"type":20},"2029-01-05",{"name":42,"class":43},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":158,"phases":4,"briefSummary":159,"conditions":160,"keywords":162,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":91},"100427840","hallux-valgus--radiological-and-clinical-predictors-for-outcome-after-surgery-100427840","NCT04851249","Hallux Valgus- Radiological and Clinical Predictors for Outcome After Surgery","Hallux Valgus - Radiological and Clinical Predictors for Outcome After Surgery","Inclusion Criteria:\n\n* All adult patients accepted for hallux valgus surgery (mild, moderate, severe) at the ØHT will be asked to participate in the study\n\nExclusion Criteria:\n\n* Previous hallux valgus surgery in the same foot\n* Lack of compliance\n* Not available for follow-up\n* Language difficulties (not able to communicate in English or Norwegian)",{"count":157,"type":20},250,"OBSERVATIONAL","Prospective observational study to evaluate the clinical and radiological predictors for outcome in hallux valgus (HV) corrective surgery.",[161],"Hallux Valgus",[163,164,165],"Hallux valgus","Outcome predictors","MOXFQ","2024-07-09",{"date":168,"type":36},"2024-07-10",{"date":170,"type":36},"2022-01-01",{"date":172,"type":20},"2027-12-01",{"name":42,"class":43},{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":181,"targetDuration":4,"studyType":21,"phases":183,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":196},"100427523","treatment-of-fifth-metatarsal-zone-3-fractures-100427523","NCT04847115","Treatment of Fifth Metatarsal Zone 3 Fractures","Treatment of Fifth Metatarsal Zone 3 Fractures - A Prospective, Randomized, Controlled Trial","Inclusion Criteria:\n\n* Zone 3 fracture\n\nExclusion Criteria:\n\n* Neuropathy\n* Open fractures\n* High energy injuries\n* Associated injury in the same or opposite extremity that may affect treatment or rehabilitation\n* Pressure ulcer(s)\n* Lack of consent competence\n* Fracture radiologically confirmed more than six months ago\n* No possibility of follow-up at one of the study centers\n* Established pseudarthrosis\n* Medical condition that contraindicates surgery\n* Non-compliance",{"count":182,"type":20},100,[55],"The fifth metatarsal is one of the bones where stress fractures can occur. Current literature provides support for both operative and non-operative treatment, but is mostly based on retrospective studies. One small randomized controlled trial reported faster recovery in the surgery group, but this study is probably subject to selection bias as well as underpowered design. There is a need to strengthen the knowledge base regarding treatment of stress fractures in the fifth metatarsal. This study seeks to answer whether osteosynthesis with an intramedullar screw fixation gives faster painfree weight bearing compared to non-operative treatment with a walking boot.",[186,187],"Fractures, Stress","Metatarsal Fracture","2024-04-26",{"date":190,"type":36},"2024-04-29",{"date":192,"type":36},"2021-04-10",{"date":194,"type":20},"2030-03-31",{"name":42,"class":43},3,{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":205,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":21,"phases":209,"briefSummary":210,"conditions":211,"keywords":213,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":225,"locationsCount":226},"100368250","norwegian-distal-ulna-resection---replacement-study-100368250","NCT04074863","Norwegian Distal Ulna Resection - Replacement Study","Norwegian Distal Ulna Resection vs. Replacement Study. A Prospective Randomized Multicenter Study","NORDURR","Inclusion Criteria:\n\n* painful osteoarthritis distal radioulnar joint\n* stable DRUJ\n\nExclusion Criteria:\n\n* activ inflammatory disease with significant destruction of the joint\n* \"low demand\" persons\n* significant instability i DRUJ\n* active infections, poor soft tissue conditions\n* accidental wound on the operated hand\n* general contraindications for surgery","30 Years","75 Years",{"count":208,"type":20},40,[55],"Osteoarthritis of the joint between the forearm bones at the wrist (distal radioulnar joint, DRUJ) is a common sequel of fracture and ligament injuries or degenerative disease of the wrist. Intact DRUJ is important for normal load transfer from the hand to the forearm. DRUJ osteoarthritis leads to pain and decreased lifting capacity and rotation of the forearm. The standard treatment is resection of the ulnar head, known as the Darrach procedure. After the resection there is no longer contact in the affected joint, however, some patients can experience instability or impingement between the forearm bones. With ulnar head implant replacement may the load transfer and the stability between the forearm bones less affected. Studies with good long term results are published with both resection and replacement. However, these methods were never compared and thus it is not clear, which of the methods gives the best clinical result and less complications.\n\nThe aim of this study is to compare Darrach procedure with ulnar head replacement in a prospective randomized multicenter study. Several hand surgical centers form Norway would participate this study.\n\nIndividuals seeking treatment for their stable but painful DRUJ joints will be included and randomized to either Darrach procedure or ulnar head implant. Participants will be followed up to 5 years. Range of motion and grip strength measures and functional scores would be registered before operation, after 3 months, 1 and 5 years. Eventual complications and reoperations would be also registered.",[212],"Osteoarthritis Wrist",[214,215,216,217,218],"Distal radioulnar joint","Darrach procedure","Ulnar head resection","Herbert prosthesis","Ulnar head replacement","2024-04-05",{"date":221,"type":36},"2024-04-08",{"date":223,"type":36},"2020-09-16",{"date":40,"type":20},{"name":42,"class":43},6,{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":206,"enrollmentInfo":233,"targetDuration":4,"studyType":21,"phases":235,"briefSummary":236,"conditions":237,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":91},"100498105","use-of-weightbearing-radiographs-to-determine-treatment-of-bi--and-trimalleolar-ankle-fractures-100498105","NCT05765929","Use of Weightbearing Radiographs to Determine Treatment of bi- and Trimalleolar Ankle Fractures","Inclusion Criteria:\n\n* -With bi- and trimalleolar ankle fractures with less than 7 mm medial clear space on non-weightbearing radiographs that are deemed stable by weightbearing radiographs.\n* With type B medial malleolus fractures between the tip and the plafond and type C medial malleolus fractures at the level of the plafond (Herscovici classification). (6)\n* With fractures in the distal 1\u002F3 of fibula (not-Maisonneuve)\n* Enabling stability evaluation within 14 days after injury\n* 18-75 years of age\n* with pre-injury walking ability without aids\n\nExclusion Criteria:\n\n* \\- With primary unstable ankle fractures, \\> 7mm medial clear space on primary radiographs\n* With fracture reduction prior to initial radiographic evaluation, open fracture, fractures resulting from high-energy trauma or multi trauma and pathological fracture\n* With type A medial malleolus avulsion fractures \\\u003C 5mm (at the tip of the malleolus), that are not suitable for surgical intervention.\n* With Herscovici type D fractures, involving Lauge-Hansen SA2 fractures (supracollicular fracture - vertical, oblique or transverse direction of the plafond)\n* With displaced posterior malleolus fractures that needs fixation in the judgement of the attending surgeon\n* With neuropathies and symptomatic joint diseases such as Rheumatoid Arthritis\n* That are assumed not compliant (such as drug abuse, cognitive- and\u002For psychiatric disorders)\n* With previous history ipsilateral ankle fracture\n* With previous history ipsilateral major ankle-\u002Ffoot surgery\n* Who live outside the hospital catchment areas not available to follow up\n* With insufficient Norwegian or English language skills\n* Non-compliant",{"count":234,"type":20},29,[55],"The aim of this study is to evaluate the outcomes after non-operative treatment of weightbearing stable bi-and trimalleolar ankle fractures.",[238,239],"Ankle Fracture, Bimalleolar","Ankle Fracture, Trimalleolar","2023-08-07",{"date":242,"type":36},"2023-08-08",{"date":244,"type":36},"2023-02-28",{"date":246,"type":20},"2032-12-31",{"name":42,"class":43},""]