[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Oulu University Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":362},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,44,72,102,129,159,188,218,240,267,290,315,338],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100645228","cholecystitis-outcomes-in-the-investigation-of-cholecystectomy-versus-eus-gbd-100645228",false,"NCT07678541","Cholecystitis Outcomes in the Investigation of Cholecystectomy Versus EUS-GBD","Recurrence of Acute Cholecystitis After EUS-Guided Gallbladder Drainage Versus Cholecystectomy in Elderly Patients: A Multicenter Randomized Controlled Trial","CHOICE","Inclusion Criteria:\n\n* Age 75 years or older.\n* Radiologically confirmed acute cholecystitis.\n* Elevated inflammatory parameters.\n* Able to provide written informed consent.\n* Able to complete follow-up questionnaires.\n\nExclusion Criteria:\n\n* Age under 75 years.\n* Considered unfit for surgery.\n* ASA physical status classification below III.\n* Unwillingness to participate in follow-up assessments.\n* Lack of written informed consent.\n* Clinical Frailty Scale score of 8 or higher.","ALL","75 Years",{"count":20,"type":21},116,"ESTIMATED","INTERVENTIONAL",[24],"NA","Acute cholecystitis is common in elderly patients and becomes more frequent with increasing age. Standard treatment is laparoscopic cholecystectomy (LCC), but operative treatment may be associated with increased risk in older patients with substantial comorbidity or reduced tolerance of general anesthesia.\n\nEndoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is a minimally invasive internal drainage procedure performed through the stomach or duodenum using endoscopic ultrasound guidance and a lumen-apposing metal stent. This approach may provide an alternative to operative treatment in selected elderly patients.\n\nThe CHOICE study (CHolecystitis Outcomes in the Investigation of Cholecystectomy versus EUS-GBD) is a multicenter randomized controlled trial comparing EUS-GBD with LCC in patients aged 75 years or older with acute cholecystitis. Participants are randomly assigned to undergo either laparoscopic removal of the gallbladder or endoscopic ultrasound-guided internal gallbladder drainage.\n\nThe objective of the study is to determine whether EUS-GBD provides clinically acceptable outcomes compared with standard operative treatment in this patient population. Participants are followed using medical record review and scheduled follow-up contacts.",[27],"Acute Cholecystitis",[29,30,27],"EUS-GBD","LCC","RECRUITING","2026-06-30",{"date":34,"type":35},"2026-07-02","ACTUAL",{"date":37,"type":35},"2026-02-01",{"date":39,"type":21},"2036-02-27",{"name":41,"class":42},"Oulu University Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100537832","health-outcomes-in-c-section-infants-with-fecal-microbiota-transplantation-100537832","NCT06282952","Health Outcomes in C-Section Infants With Fecal Microbiota Transplantation","Section-Born Infants and SUccessful Health Outcomes After Fecal Microbiota Transplantation (SISU-FMT)","SISU-FMT","Inclusion Criteria:\n\n* Pregnant women age 18-49 years who are scheduled for elective CS at term, are recruited at 36 weeks of gestation during a visit for the assessment of mode of delivery at Oulu university Hospital, Oulu, Finland.\n\nExclusion Criteria:\n\n* Use of regular immunosuppressive biological medication; inflammatory bowel disease in the mother; immunodeficiency disorder of the mother or any first-degree family member of the unborn baby; known or suspected major fetal congenital abnormality; travel outside Europe, the United States, Canada, Japan, Australia, or New Zealand within the last three months; and antibiotic treatment within three months of delivery (excluding prophylactic cefuroxime - or an alternative in case of allergy - administered prior to the elective cesarean section).\n* Infant exclusion criteria are preterm birth (birth before 37 weeks of gestation), birth weight below 2500 g, admission to neonatal intensive care unit, need for respiratory support or antibiotic treatment of the newborn before discharge. In case of a suspected infection or newborn screening result for severe combined immunodeficiency (SCID) is out of the normal range, of the newborn the randomization code can be opened.","FEMALE","18 Years","49 Years",{"count":56,"type":21},534,[24],"The goal of this clinical trial is to investigate the differences in microbiota, height and weight between infants born by cesarean section and randomized to receive fecal microbiota transplant after birth. The main questions it aims to answer are:\n\n* Could micobiota transplant be used improve gut microbiota and prevent overweight or obesity.\n* Is the source of colonization a modifiable factor and can it be changed by using an early fecal microbiota transplant.",[60,61,62],"Fecal Microbiota Transplantation","Cesarean Section","Overweight and Obesity",[60,61,62],"2026-04-01",{"date":66,"type":35},"2026-04-07",{"date":68,"type":35},"2026-03-31",{"date":70,"type":21},"2036-12-31",{"name":41,"class":42},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},"100618430","integrating-smoking-cessation-with-low-dose-ct-screening-for-lung-cancer-100618430","NCT07331519","Integrating Smoking Cessation With Low-dose CT-screening for Lung Cancer","Integrating Smoking Cessation With Low-dose CT-screening for Lung Cancer - a Randomized Study","ISC-LDCT","Inclusion Criteria:\n\n1. Able to provide written informed consent\n2. Age between 50-74\n3. Smoked ≥ 15 cigarettes\u002Fday for ≥ 25 years or smoked ≥ 10 cigarettes\u002Fday for ≥ 30 years and are active smokers (smoking during the last two weeks)\n4. Access to a smartphone (iPhone or Android)\n\nExclusion Criteria:\n\n1. Current or past melanoma, lung, renal or breast cancer\n2. A chest CT examination less than one year before inclusion\n3. Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial\n4. No access to a smartphone (iPhone or Android)\n5. Participant is unwilling or unable to comply with treatment and trial instructions\n6. Any condition that study investigators consider an impediment to safe trial participation","50 Years","74 Years",{"count":83,"type":21},1200,[24],"The study investigates effectiveness of different smoking cessation methods and low-dose CT based lung cancer screening",[87],"Smoking Cessation",[89,90,91,92],"smoking cessation","lung cancer","low-dose CT","lung cancer screening","2026-02-05",{"date":95,"type":35},"2026-02-06",{"date":97,"type":35},"2026-02-02",{"date":99,"type":21},"2036-08-31",{"name":41,"class":42},5,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":109,"targetDuration":111,"studyType":112,"phases":4,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100617113","emergency-hernia-repair-100617113","NCT07314398","Emergency Hernia Repair","Prospective Cohort Study on Surgical Methods and Outcomes in Emergency Groin and Ventral Hernia Repairs in Finland","Inclusion Criteria:\n\n* Emergency repair of a groin or ventral hernia\n\nExclusion Criteria:\n\n* Pregnancy\n* Age under 18 years\n* Advanced malignancy\n* Inability to follow up (e.g., long travel distance or poor functional status)\n* Participation in another study\n* Lack of informed consent",{"count":110,"type":21},600,"5 Years","OBSERVATIONAL","Emergency hernia repairs are associated with significantly higher morbidity and mortality compared with elective hernia surgery. In Finland, approximately 500 emergency groin hernia repairs and 600 ventral hernia repairs are performed annually, but treatment practices vary widely, and high-quality evidence is lacking.\n\nThis prospective multicenter cohort study will evaluate outcomes of emergency groin and ventral hernia repairs in Finland. About 600 patients will be recruited over two years and followed for five years postoperatively. The study will collect standardized data on patient demographics, comorbidities, surgical technique, intraoperative findings, postoperative course, and long-term follow-up. Quality of life will be assessed with RAND-36, AAS, and PROMIS questionnaires.\n\nThe primary endpoint is hernia recurrence within two years after surgery. Secondary outcomes include 30- and 90-day complications, infection rates, readmissions, recovery time, and quality of life at 1, 2, and 5 years.\n\nThe results will provide robust evidence to guide clinical practice, optimize surgical techniques, and refine urgency classification and surgeon competence requirements for emergency hernia repair.",[115,116],"Emergency Inguinal Hernia Repair","Emergency Ventral Hernia Repair",[118,119,120],"inguinal hernia","ventral hernia","emergency surgery","NOT_YET_RECRUITING","2025-12-17",{"date":124,"type":35},"2026-01-02",{"date":37,"type":21},{"date":127,"type":21},"2032-09-30",{"name":41,"class":42},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":43},"100608997","the-effectiveness-of-conservative-treatment-in-patients-with-complex-regional-pain-syndrome-100608997","NCT07208825","The Effectiveness of Conservative Treatment in Patients With Complex Regional Pain Syndrome.","The Effectiveness of Individualized Physical Therapy and Functional Neurology Treatment Protocol in Conjunction With Optimizing Medication and Repetitive Transcranical Magnetic Stimulation in Patients With Complex Regional Pain Syndrome.","Inclusion Criteria:\n\n* CRPS symptoms maximum of 5 year at the time of diagnosis (CRPS 1 and 2)\n* 18 to 70-year-old\n* rTMS treatment is granted by university hospital pain clinic (by multidisciplinary group)\n* Voluntary to participate into the study\n\nExclusion Criteria:\n\n* CRPS symptoms started over five years ago (although diagnosed first time now)\n* No other outpatient\u002Finpatient rehabilitation during the study rehabilitation period (insurance company or other third party)\n* Under 18-years-old of over 70-years-old\n* No eligible to rTMS treatment or for other reason rTMS treatment was not granted by university hospital pain clinic (by multidisciplinary group)","70 Years",{"count":138,"type":21},156,[24],"The aim of the study is to investigate and improve non-pharmacological rehabilitation methods for patients with Complex Regional Pain Syndrome (CRPS) to reduce pain and restore work and functional capacity to lower overall treatment costs. Current treatment methods offer limited rehabilitation potential for this challenging pain condition, so efforts should be made to raise the level of care and rehabilitation for a disease that often causes long-term and severe reductions in patients' functional and occupational abilities. CRPS patients almost always have to substantially reduce their work hours or withdrawn from the workforce for extended periods, and often permanently, increasing the urgency of strengthening rehabilitation approaches; a CRPS symptoms can end a patient's productivity for society. In addition, commonly used medications are a significant expense for both individuals and the healthcare system. CRPS rarely resolves fully, and even with extensive rehabilitation only a small proportion of patients regain sufficient improvement to return to work at a level of at least 60% capacity.\n\nParticipants will be recruited from the Department of Physical Medicine and Rehabilitation at Oulu University Hospital, where CRPS diagnostics for the Northern Ostrobothnia area are primarily conducted. The study will be carried out at OYS rehabilitation outpatient clinics. A total of 39 participants will be recruited into each of four study groups, for an overall sample size of 156 individuals. Each study group will receive repetitive transcranial magnetic stimulation (rTMS) at some point, and functional neurological rehabilitation will be combined with rTMS in varying ways (content and timing will differ between groups). All participants will receive basic CRPS rehabilitation (physiotherapy and occupational therapy) that is provided for all RPS patients, and the timing of this relative to rTMS will also be varied. Recruitment is planned to begin in a autumn 2025.",[142],"CRPS (Complex Regional Pain Syndromes)",[144,145,146,147,148,149,150],"CRPS","GMI","Graded motor imaginary","Rehabilitation","Functional neurology","rTMS","medication","2025-09-28",{"date":153,"type":35},"2025-10-06",{"date":155,"type":21},"2025-09-30",{"date":157,"type":21},"2033-12-31",{"name":41,"class":42},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":169,"briefSummary":170,"conditions":171,"keywords":175,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":101},"100607747","prevention-of-pulmonary-complications-after-laparoscopic-liver-surgery-100607747","NCT07192575","Prevention of Pulmonary Complications After Laparoscopic Liver Surgery","Enhanced Perioperative Pulmonary Physiotherapy for Prevention of Pulmonary Complications After Laparoscopic Liver Surgery","PREPULCION","Inclusion Criteria\n\n* Patients who undergo elective, laparoscopic surgery of liver\n* Patients who are able to provide informed written consent\n* Patients capable of completing questionnaires at the time of consent\n* Patients compliant in taking in preoperative pulmonary counseling and conducting the exercises\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Emergency surgery\n* Planned open surgery\n* Unwillingness to participate in the follow up assessment\n* No informed consent",{"count":168,"type":21},364,[24],"* Background: Postoperative pulmonary complications (PPCs) are the most common complications after major upper abdominal surgery. PPCs include respiratory infections, severe atelectasis, pleural effusion, bronchospasm, aspiration pneumonitis, pneumothorax, exacerbation of chronic pulmonary condition, and respiratory failure. Although PPC rates are higher after open liver surgery, PPCs still occur in approximately 12-13% of patients undergoing laparoscopic liver surgery. Preoperative respiratory physiotherapy education reduces PPCs after open major abdominal surgery and after laparoscopic colorectal surgery. The aim of this study is to investigate the impact of enhanced perioperative pulmonary physiotherapy on the incidence of PPCs after laparoscopic liver surgery.\n* Methods: A prospective, multicentre, single-blinded, randomized controlled trial will be conducted according to the study protocol at participating centers. A total of 326 patients scheduled for laparoscopic liver surgery will be randomized at a 1:1 ratio into intervention group or standard Enhanced Recovery After Surgery (ERAS) -based perioperative education group. Surgeons\u002F researchers are blinded to the patient allocation. Patients in the intervention group receive preoperative breathing education in a single session and an educational video to guide pulmonary training at home. Pulmonary training lasts for 7 days prior to surgery and for 7 days postoperatively. The training includes deep breathing, and coughing, pursed lip breathing and positive expiratory pressure (PEP) therapy. Patients receive instructions for conducting exercises along with an individual risk assessment at a preoperative ambulatory visit. The exercise session (10min) is to be performed two times daily for total of 14 days. The control group receives standard perioperative breathing education. Primary outcome is the rate of postoperative pulmonary complications within 14 days of operation. Secondary outcomes include 90-day mortality, Clavien-Dindo classified complications, length of hospital stay, intensive care unit (ICU) stay, and hospital costs.\n* Discussion: Little effort is currently put into preventing pulmonary complications after surgery, although PPCs aggravate considerable morbidity and costs to health care system. ERAS Society protocols concentrate mainly on optimizing postoperative recovery. Laparoscopic techniques as such and frequent manipulation of the diaphragm during liver surgery provoke PPCs at a considerable rate. Aim of the study is to present a short-and-easy perioperative pulmonary physiotherapy initiative and evaluate its impact on PPC rate and PPCs ramifications, including direct costs, after laparoscopic liver surgery.",[172,173,174],"Liver Surgery","Pulmonary Complications","Laparoscopic Liver Surgery",[176,177,178,179],"liver surgery","prehabilitation","pulmonary complications","laparoscopic liver surgery","2025-09-21",{"date":182,"type":35},"2025-09-25",{"date":184,"type":35},"2024-09-15",{"date":186,"type":21},"2027-10-15",{"name":41,"class":42},{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":195,"sex":17,"minAge":53,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":204,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":43},"100604269","virtual-vs-traditional-cpr-training-effects-on-stress-100604269","NCT07147322","Virtual vs. Traditional CPR Training: Effects on Stress","The Effect of Basic Life Support Training in a Virtual Environment on Perceived Stress and Measured Stress Responses Compared to Conventional Basic Life Support Training","Inclusion Criteria:\n\n* Volunteers (18-30 years old) will be recruited from first- and second-year medical students\n* Participants must be healthy young individuals with no known heart disease, normal physical performance capacity, and no current physical limitations that would affect the ability to perform chest compressions.\n\nExclusion Criteria:\n\n* Pregnant individuals will not be included\n* Individuals with previous healthcare experience will not be included.\n* Participants must not have received basic life support training within the past six months.",true,"30 Years",{"count":198,"type":21},60,[24],"This medical education study investigates stress levels among undergraduate medical students during basic life support (BLS) training. It compares traditional face-to-face teaching session with virtual reality (VR) training simulating a resuscitation scenario in a public place. We will measure heart rate, heart rate variability, and self-reported stress to assess acute stress responses. The study also examines physical sensations related to VR, the realism of the virtual environment, and the suitability of VR for BLS training.",[202,203],"Heart Rate Variability, Biomarker of Stress","Stress and Anxiety",[205,206,207,208,209],"heart rate variability","perceived mental workload","Virtual reality","Medical education","Basic life support","2025-08-21",{"date":212,"type":35},"2025-08-29",{"date":214,"type":35},"2025-08-13",{"date":216,"type":21},"2026-08-31",{"name":41,"class":42},{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":52,"minAge":4,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":43},"100602893","strengthening-healthy-emotional-co-regulation-of-mothers-with-pcos-and-obesity-and-their-infants-100602893","NCT07129434","Strengthening Healthy Emotional Co-regulation of Mothers With PCOS and Obesity and Their Infants","ECoFam","Inclusion Criteria:\n\n* Diagnosis of PCOS\n* Obesity according to BMI\n* Gave birth at Oulu University Hospital in 2024-25\n* PEPPI cohort study participation\n* uWECS emotional connection score \\\u003C9.0 at pre-test\n\nExclusion Criteria:\n\n\\- Infant death",{"count":226,"type":21},40,[24],"It is both timely and important to invest in interventions that can improve healthy emotional co-regulation. It is proposed to evaluate the feasibility and limited efficacy of an adapted, brief, multimodal intervention: ECoFam (Emotional connection and Co-regulation for Families). Evidence from the US suggests intervention effects on maternal and infant outcomes that are large in effect size (i.e., Cohen's d \\>0.6 for increasing emotional connection and decreasing maternal depressive symptoms) (21-23). The study results will directly translate evidence into practice and, if found feasible, allow rapid scaling-up.\n\nObjectives:\n\n1. Build capacity for implementation of a novel diagnostic screening tool for emotional co-regulation, the uWECS, as part of clinical follow-up for mother-infant dyads with high fibrobesity risk in Finland.\n2. Test the feasibility and limited efficacy of the brief, multimodal ECoFam intervention to foster healthy emotional co-regulation between mothers with PCOS and obesity and their infants.",[230,231],"Polycystic Ovary Syndrome (PCOS)","Obesity &Amp;Amp; Overweight","2025-08-11",{"date":234,"type":35},"2025-08-19",{"date":236,"type":35},"2025-04-15",{"date":238,"type":21},"2026-12",{"name":41,"class":42},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":195,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":247,"targetDuration":249,"studyType":112,"phases":4,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":43},"100524929","peppi-study-identification-of-women-at-risk-for-placental-dysfunction-100524929","NCT06115122","PEPPI Study: Identification of Women at Risk for Placental Dysfunction","PEPPI Study: Identification of Women at Risk for Placental Dysfunction During the First and Third Trimesters of Pregnancy","Mothers\n\nInclusion Criteria for PEPPI-study\n\n* Pregnant (first trimester)\n* Understands Finnish\n* ≥18 years\n* Signed informed consent\n\nExclusion Criteria\n\n* Multiple pregnancy\n* Miscarriage\u002Ftermination of the index pregnancy\n* No first trimester blood sampling\n\nInclusion Criteria for FERPPI-study\n\n* Participates in PEPPI-study (criteria above)\n* Blood samples at first and third trimester of pregnancy\n* Permits blood sampling from the umbilical cord when the baby is born\n\nExclusion Criteria\n\n* No first or third trimester blood sampling\n* No umbilical cord blood sample after baby is born\n\nFathers\n\nInclusion Criteria\n\n* Biological father to the child born for the mother who participated in PEPPI study\n* ≥18 years\n* Signed informed consent\n\nExclusion Criteria\n\n• Does not understand Finnish\n\nChildren\n\nInclusion Criteria for PEPPI-study\n\n* Born to mother who participated in PEPPI study\n* Signed informed consent from parent(s)\n\nExclusion Criteria\n\n• No consent from parent(s)\n\nInclusion Criteria for PEPPI-offspring study • Mother in risk-, control-, or PCOS group during PEPPI-study with ultrasound information at gestational weeks 30-32 or a mother who developed pre-eclampsia during the pregnancy regardless of their study group during PEPPI-study\n\nExclusion Criteria\n\n• Mother\u002Ffather declines participation\n\nInclusion Criteria for FERPPI-study\n\n* Signed informed consent from parent(s)\n* Mother has blood samples taken at first and third trimester (iron status)\n* Child has blood samples taken at birth and at 3 months of age\n\nExclusion Criteria\n\n* No consent from parent(s)\n* No blood samples from mother\n* No blood samples from child",{"count":248,"type":21},3000,"15 Years","The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population.\n\nCondition or disease: pre-eclampsia, intrauterine growth restriction, polycystic ovary syndrome",[252,253,254,255,256,257,258],"Pre-Eclampsia","Intrauterine Growth Restriction","Polycystic Ovary Syndrome","Iron-deficiency","Cardiovascular Diseases","Hypertensive Disorder of Pregnancy","Proteinuria in Pregnancy","2025-07-31",{"date":261,"type":35},"2025-08-05",{"date":263,"type":35},"2022-02-15",{"date":265,"type":21},"2041-12-31",{"name":41,"class":42},{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":22,"phases":277,"briefSummary":278,"conditions":279,"keywords":281,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":289,"locationsCount":43},"100566748","effectiveness-of-mentalization-based-therapy-mbt-100566748","NCT06659211","Effectiveness of Mentalization-based Therapy (MBT)","Effectiveness of Mentalization-based Therapy (MBT) as Part of a Stepped Mental Health Care in Finland - a Pilot Study","Inclusion Criteria:\n\nMBT Group:\n\n* Age 18-64 years.\n* Severe psychological symptoms, decreased functioning ability for long-term\n* Challenges with interpersonal relationships and emotional regulation\n* Patients willing to receive MBT\n* At least two of the following:\n\n  * Depression (diagnosis codes: F31.3-F31.5, F32.0-F32.9, F33.3-F33.9, F34.1) or anxiety disorder (diagnosis codes: F40-F48)\n  * Trauma background either as diagnosis or as need for treatment\n  * Signs of personality disorder (suspected or diagnosed)\n\nTAU group:\n\n* Age 18-64 years.\n* Severe psychological symptoms, decreased functioning ability for long-term\n* Challenges with interpersonal relationships and emotional regulation\n* At least two of the following\n\n  * Depression (diagnosis codes: F31.3-F31.5, F32.0-F32.9, F33.3-F33.9, F34.1) or anxiety disorder (diagnosis codes: F40-F48)\n  * Trauma background either as diagnosis or as need for treatment\n  * Signs of personality disorder (suspected or diagnosed)\n\nExclusion Criteria:\n\nMBT Group:\n\n* Active substance use disorder (i.e., intoxication F1x.0, active dependence F1x.24, Continuous use F1x.25), a physiological withdrawal state F1x.3 and F1x.4, or psychotic disorder F1x.5).\n* Acute psychosis (defined as the recent onset of severe psychotic symptoms that interfere with functioning and are not yet in a therapeutic state. Non-acute psychotic symptoms are not exclusionary)\n* Disorder requiring inpatient treatment\n* Previously received MBT\n* Currently receiving psychotherapeutic treatment (previous psychotherapeutic treatment is not an exclusion)\n\nThe exclusion criteria, therefore, do not exclude psychotic disorders or any other psychiatric illness (except substance abuse disorders).\n\nTAU group:\n\n* Active substance use disorder (i.e., intoxication F1x.0, active dependence F1x.24, Continuous use F1x.25), a physiological withdrawal state F1x.3 and F1x.4, or psychotic disorder F1x.5).\n* Acute psychosis (defined as the recent onset of severe psychotic symptoms that interfere with functioning and are not yet in a therapeutic state. Non-acute psychotic symptoms are not exclusionary)\n* Disorder requiring inpatient treatment\n* Previously received MBT\n* Intensive psychotherapy (e.g. rehabilitative psychotherapy or similar weekly long-term psychotherapy)","64 Years",{"count":276,"type":21},128,[24],"The effects of psychological treatment, mentalization-based therapy, will be studied among persons with mental disorders seeking help from mental health care services.",[280],"Severe Mental Illness",[282],"mentalization, MBT, severe mental disorder, therapy, psychotherapeutic","2025-04-22",{"date":285,"type":35},"2025-04-25",{"date":287,"type":35},"2024-09-25",{"date":32,"type":21},{"name":41,"class":42},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":297,"targetDuration":4,"studyType":22,"phases":299,"briefSummary":300,"conditions":301,"keywords":303,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":101},"100419147","finnish-venous-ulcer-study-finnulcer-study-100419147","NCT04737941","Finnish Venous Ulcer Study (FINNULCER Study)","Finnish Venous Ulcer Study","Inclusion Criteria:\n\n* Patient informed consent\n* Venous ulcer, aged from one month to one year\n* Duplex ultrasonography verified (vein reflux greater than \\>0.5 second) superficial venous insufficiency\n* Sufficient arterial circulation (at least on criterion met: Palpable distal pulses \u002F ankle-brachial index \\> 0,8 \u002F Toe pressure \\>60mmhg)\n\nExclusion Criteria:\n\n* Leg ulcers other than venous etiology\n* Ulcers requiring operation theater revision\n* Patent foramen ovale\n* Several times recurrent (over 3 recurrences) venous ulcer\n* Body Mass Index over 40\n* Pregnancy",{"count":298,"type":21},248,[24],"This multicenter randomized controlled trial evaluates the effect of first-visit foam sclerotherapy (including sub-ulcer foam sclerotherapy) in patients with venous leg ulcer.",[302],"Venous Leg Ulcer",[302,304,305,306],"Foam Sclerotherapy","Endothermal Ablation","Sub-ulcer Foam Sclerotherapy","2025-01-13",{"date":309,"type":35},"2025-01-15",{"date":311,"type":35},"2021-02-26",{"date":313,"type":21},"2026-03-01",{"name":41,"class":42},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":52,"minAge":53,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":22,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":43},"100534616","supporting-lifestyle-changes-after-delivery-100534616","NCT06241144","Supporting Lifestyle Changes After Delivery","Information and Communication Technology -Based Health Behavior Change Support System to Modify Lifestyle After Delivery: Randomized Controlled Intervention Study","STELLA","Inclusion Criteria:\n\n* Pre-pregnancy BMI ≥ 30.0 kg\u002Fm\\^2\n* Smartphone user\n\nExclusion Criteria:\n\n* Eating disorder\n* Severe mental disorder\n* Use of other lifestyle support system or medication\n* Non-Finnish speaker",{"count":324,"type":21},200,[24],"Use of information and communication technology -based health behavior change support system in modifying lifestyle after delivery among women with obesity.",[328,329],"Obesity, Maternal","Lifestyle","2024-04-01",{"date":332,"type":35},"2024-04-03",{"date":334,"type":35},"2024-02-09",{"date":336,"type":21},"2032-12-31",{"name":41,"class":42},{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":22,"phases":347,"briefSummary":348,"conditions":349,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":43},"100454743","sutures-versus-polyglactin-mesh-in-hiatal-hernia-repair-100454743","NCT05201508","Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair","Sutures Only Versus Absorbable Polyglactin (Vicryl®) Mesh in Closure of Hiatal Defect in Laparoscopic Paraesophageal Hernia Repair: Randomized Controlled Trial.","Inclusion Criteria:\n\n* Over 18 years old\n* Type III-IV PEH with either radiologic or endoscopic confirmation\n* Scheduled for laparoscopic PEH repair\n* The informed consent is acquired\n\nExclusion Criteria:\n\n* Need for esophagus lengthening procedure (Collis gastroplasty)\n* Recurrent PEH\n* Emergency surgery\n* No written consent",{"count":346,"type":21},110,[24],"Paraesophageal hernia causes pain, heartburn, regurgitation, anemia and in extreme, life-threatening strangulation. For symptomatic patients, laparoscopic surgery is offered which includes hiatal defect closure and antireflux surgery. However, recurrence rates are high between 12 and 42%. In order to reduce recurrences, mesh has been used with various materials and techniques with conflicting results. Non-absorbable mesh has been linked with adverse events including erosion of esophageal wall. Traditionally used biological mesh materials are expensive and therefore problematic in routine use. Use of polyglactin (Vicryl®) mesh, which degrades in 6-8 week, has been reported in paraesophageal hernia surgery. Previously, no randomized controlled trial comparing sutures only and polyglactin mesh has been performed. In this trial, the aim was to randomize total of 110 patients to receive sutures only or mesh repair. Primary outcome was recurrence of paraesophageal hernia at 6 months after the repair based on computed tomography scan. Secondary outcomes included symptomatic recurrences, reoperation rate, quality of life, reoperations up to 20-years after surgery and use of proton pump inhibitors up to 20-years after surgery.",[350,351,352,353],"Paraesophageal Hernia","Hiatal Hernia","Hiatal Hernia, Paraesophageal","Recurrence","2023-03-24",{"date":356,"type":35},"2023-03-27",{"date":358,"type":35},"2022-01-21",{"date":360,"type":21},"2043-01-01",{"name":41,"class":42},""]