[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Oxford Brookes University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100636062","effect-of-beetroot-juice-on-cardiovascular-and-autonomic-responses-to-exercise-in-adults-with-type-2-diabetes-100636062",false,"NCT07560800","Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 Diabetes","Effect of Beetroot Juice on Cardiovascular and Autonomic Responses During and After Exercise in Adults With Type 2 Diabetes","DiaBEET","Inclusion Criteria:\n\n* Clinically diagnosed Type 2 Diabetes Mellitus\n* Aged 40 to 65 years\n* Not treated with insulin\n* Stable diabetes medication regimen for at least 3 months\n* Able to understand the study information and provide informed consent\n* Able to safely perform light-to-moderate cycling exercise\n\nExclusion Criteria:\n\n* Current or recent use of insulin\n* Use of organic nitrates (e.g., glyceryl trinitrate) or phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)\n* Use of systemic antibiotics within the specified preparation period or regular use of antiseptic\u002Fantibacterial mouthwash during study participation\n* Use of supplements known to interfere with nitric oxide metabolism within the defined preparation period\n* Unstable or clinically significant cardiovascular disease\n* Uncontrolled hypertension or any condition that makes exercise unsafe\n* Chronic kidney disease, history of kidney stones, or other relevant renal conditions\n* Neurological, musculoskeletal or systemic disorders that impair safe participation\n* Known or suspected allergy or intolerance to beetroot, lemon or any component of the study products\n* Pregnancy or breastfeeding\n* Inability to comply with study preparation requirements","ALL","40 Years","65 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will investigate whether a single dose of beetroot juice can improve cardiovascular responses and recovery after exercise in adults with Type 2 Diabetes.\n\nType 2 Diabetes is associated with higher blood pressure, impaired blood vessel function, and reduced autonomic control of the heart, all of which increase cardiovascular risk and may affect how the body responds to and recovers from physical activity. Beetroot juice is naturally rich in dietary nitrate, which is converted in the body into nitric oxide, a molecule that helps blood vessels relax and improve blood flow. While these effects have been demonstrated in healthy individuals, less is known about their impact in people with Type 2 Diabetes.\n\nIn this study, approximately 16 to 20 adults aged 40 to 65 years with Type 2 Diabetes will take part. After an online screening and consent process, eligible participants will attend two laboratory visits at Oxford Brookes University. In a randomised, double-blind, placebo-controlled crossover design, participants will receive beetroot juice during one visit and a nitrate-depleted placebo during the other visit.\n\nDuring each visit, participants will undergo physiological measurements, including blood pressure, heart rate, oxygen saturation, and capillary blood glucose. Participants will then complete a short session of supervised, light-to-moderate cycling exercise. Measurements will continue during the recovery period to assess how quickly the cardiovascular system returns to resting levels.\n\nThe main outcomes are systolic blood pressure and heart rate variability during recovery, which reflect cardiovascular regulation and autonomic function. Secondary outcomes include diastolic blood pressure, heart rate, blood glucose, and markers related to nitric oxide availability.\n\nThis study may help determine whether a simple, dietary-based intervention such as beetroot juice can support cardiovascular function and improve recovery after exercise in people living with Type 2 Diabetes.",[28,29,30],"Type 2 Diabetes Mellitus","Hypertension","Autonomic Nervous System Diseases",[32,33,34,35,36,37,38,39,40,41],"Beetroot juice","Dietary nitrate","Nitric oxide","Heart rate variability","Autonomic function","Blood pressure","Exercise recovery","Submaximal exercise","Endothelial function","Crossover trial","NOT_YET_RECRUITING","2026-04-28",{"date":45,"type":46},"2026-05-01","ACTUAL",{"date":48,"type":22},"2026-04-02",{"date":50,"type":22},"2026-07-31",{"name":52,"class":53},"Oxford Brookes University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":54},"100558467","postnatal-perineal-wound-assessment-100558467","NCT06551493","Postnatal Perineal Wound Assessment","The Assessment of Postnatal Perineal Wound: Perspectives of Midwives and Women.","Inclusion Criteria:\n\nMidwives:\n\n* NMC Registered midwives\n* Working in the NHS\n* Working in the community or postnatal ward\n* Who assess perineal wounds\n\nWomen:\n\n* Postnatal women who had a vaginal birth within the last ten days and had an uncomplicated perineal tear (first, second-degree or episiotomy).\n* Had a healthy newborn (for example, the newborn is not currently admitted to newborn intensive care or the woman did not have a stillbirth)\n* Located in the community or in hospital being cared for by midwives, within ten days postpartum when postnatal perineal wound assessment occurs.\n* Over the age of 18, who can consent to participation\n* English-speaking\n\nExclusion Criteria:\n\nMidwives:\n\n* Non-registered midwives and those working outside the NHS\n* Who do not perform postnatal perineal wound assessment due to clinical settings or task restrictions.\n\nWomen:\n\n* Who had a cesarean section\n* Who had a stillbirth or fetal\u002Fneonatal complications\n* Who had a vaginal birth but sustained severe perineal tears (third or fourth-degree tears)\n* Who have not received NHS care or are outside standard postnatal locations\n* Who are over 10 days postpartum at the time of perineal wound assessment\n* Who are below the age of 18\n* Non-English-speaking women",true,"FEMALE","18 Years","100 Years",{"count":21,"type":22},"OBSERVATIONAL","Around 85% of women who give birth vaginally experience a perineal wound, which could be a tear or an incision between the vaginal opening and the anus. Despite that, there is often insufficient exploration of how postnatal perineal wound assessment is conducted in healthcare research.\n\nClinical guidelines from the National Institute for Health and Care Excellence (NICE) touch on the typical signs of wound infection but do not offer detailed guidance on the execution of perineal assessment. Existing research evidence is mostly focused on long-term complications, management of perineal trauma immediately after birth or severe perineal trauma. The limited research on perineal wound care highlights how poor communication and information provision harm women at a physical and psychological level, negatively affecting daily tasks such as caring for their newborns.\n\nAlthough there have been few studies examining women's or midwives' perspectives on perineal wound assessment in the context of uncomplicated wounds, their perspectives have never been jointly investigated to produce a comprehensive overview. Moreover, no research has had a clinical focus, investigating how the assessment is conducted in practice and what informs this practice, except from women's reports of perceived sub-standard care received.\n\nTherefore, this proposed research is clinically grounded and aims to explore women's and midwives' perspectives on postnatal perineal wound assessment. This is needed to identify evidence-based practices, or lack thereof, in order to determine ways in which the experience can be improved for women and to have a more positive impact on their wellbeing.\n\nEight to ten pairs of midwives-women will be first observed whilst the routine assessment is conducted to understand what happens during this episode of care, and then they will be separately interviewed within a few days to gather further understanding. Recruitment will be in a single centre, which is a tertiary unit in the UK.",[70],"Perineum; Wound","RECRUITING","2025-08-04",{"date":74,"type":46},"2025-08-08",{"date":76,"type":46},"2024-11-20",{"date":78,"type":22},"2025-08",{"name":52,"class":53},""]