[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Pacific University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100617114","carotenoid-supplementation-and-retinal-health-in-healthy-adults-100617114",false,"NCT07314411","Carotenoid Supplementation and Retinal Health in Healthy Adults","Effect of Carotenoid Supplementation on Retinal Health: An Evaluation of Macular Structure and Function in Healthy Adults","Inclusion Criteria:\n\n* Age between 18-75 years\n* Monocular best corrected visual acuity (BCVA) of 20\u002F20 or better\n* Eye pressure between 8 and 22 mm of Hg (will be screened in study if needed)\n* Ability to provide informed consent\n* Access to the Internet\n\nExclusion Criteria:\n\n* History of or currently active eye diseases or systemic disease\n* History of refractive surgery or ocular surgery\n* Currently pregnant, nursing or planning to become pregnant during the study period\n* Known allergy to any study active or inactive ingredient\n* Current supplementation with any components of MacuHealth or placebo softgel capsules\n* Drugs that may interact with absorption of fat-soluble vitamins\u002Fcarotenoids especially orlistat and bile acid sequestrants (i.e., colestyramine, fat-free substitutes such as Olestra, beta-carotene, and vitamin E), or antidiabetic drugs",true,"ALL","18 Years","75 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this research is to evaluate the effect of oral dietary carotenoid supplements on various aspects of retinal health. This includes assessing its impact on macular pigment optical density (MPOD), which is a protective feature of retinal health in reducing lipofuscin (retinal waste) accumulation in the retina.\n\nOur goal is to investigate the protective role of this oral carotenoid supplement on the macular structure, measured as retinal thickness, macular blood vessel density, choriocapillaris density and ocular perfusion pressure (defined as the difference between blood pressure and eye pressure) as well as evaluating visual functions such as contrast sensitivity (the ability to perceive less bold objects ) and photostress recovery time (the minimum time for a person to read the lowest level on an eye chart after shining a light in front of the eye for several seconds). This study will also investigate the relationship between skin carotenoid level and ocular carotenoid level, using a non-invasive finger measurement. Also, we want to explore the effect of carotenoid supplementation on cognitive function in terms of working memory. Understanding how this supplementation impacts all these markers is crucial for enhancing our knowledge of the potential health benefits of carotenoids in improving dietary assessment methods.\n\nThis study takes 3 visits. Participants will provide written informed consent on the first visit after reviewing the study procedures, potential risks, benefits, confidentiality measures, and their right to withdraw. Then they will undergo a comprehensive history-taking and complete a validated questionnaire to screen for sensitivity to light, as well as a diet questionnaire. Following this, participant will have non-invasive testing, requiring no eye drops or dyes. This involves measurement of contrast sensitivity (CS), photostress recovery, MPOD, blood pressure (BP), intraocular pressure (IOP), skin carotenoid level, retinal thickness and vascular measures using an optical coherence tomographer (OCT), lipofuscin levels using fundus autofluorescence (FAF) pictures and cognitive function assessment of working memory using a computerized 2- back test. Each participant will then be provided with a commercially-made softgel capsule (either carotenoid supplement or placebo containing only the inactive ingredients) in unmarked bottles and instructed to take one softgel capsule daily with a meal for 3 months. Follow-up visits will take place for 1 month and 3 months, during which the same measurements mentioned above will be repeated.",[28],"Healthy","RECRUITING","2026-01-02",{"date":32,"type":33},"2026-01-06","ACTUAL",{"date":35,"type":33},"2025-04-01",{"date":37,"type":22},"2026-05",{"name":39,"class":40},"Pacific University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":41},"100544039","building-community-health-volunteers-capacity-to-support-parents-with-young-children-with-safecare-kenya-100544039","NCT06363695","Building Community Health Volunteers' Capacity to Support Parents With Young Children With SafeCare Kenya","Implementing the Adapted Parenting Program, SafeCare Kenya, to Reduce Noncommunicable Disease Burden: Building Community Health Volunteers' Capacity to Support Parents With Young Children","Parents Inclusion Criteria:\n\n* being the female primary caregiver\n* at least 18 years old of age\n* at least one child between 18 months and age 5\n* reside in Kibera\n* have ability to participate virtually (i.e., owns a smart phone) in English or Swahili.\n\nParent Exclusion Criteria:\n\n* younger than 18 years old\n* unable to participate in English or Swahili\n* does not own smart phone to participate in virtual sessions.\n\nCHV Inclusion Criteria:\n\n* 18 years or older\n* able to participate in English or Swahili\n* has ability to participate virtually (i.e., owns a smart phone)\n* female community health volunteer who is affiliated with one of the project's agencies in Kibera\n\nCHV Exclusion Criteria:\n\n* younger than 18 years old\n* not able to participate in English or Swahili\n* does not have a smart phone\n* is not female\n* is not a community health volunteer affiliated with one of the project's agencies\n\nTrainer Inclusion Criteria:\n\n* 18 years or older\n* able to participate in English and Swahili\n* trained as a SafeCare trainer\n\nTrainer Exclusion Criteria:\n\n* younger than 18 years old\n* not able to participate in English and Swahili\n* not trained as a SafeCare Trainer\n\nStakeholder Inclusion Criteria:\n\n* 18 years or older\n* able to participate in English\n* involved in the project as a stakeholder\n\nStakeholder Exclusion Criteria:\n\n* younger than 18 years old\n* not able to participate in English\n* not a stakeholder for this project",{"count":50,"type":22},369,[25],"The goal of this clinical trial is to implement and examine the impact of SafeCare Kenya, an adapted parenting program, to improve parents' skills and knowledge related to the care of their children between the ages of 18 months and 5 years old. The main questions it aims to answer are:\n\n* Will SafeCare Kenya improve child and parent outcomes?\n* Is virtual delivery as effective as in-person delivery of SafeCare Kenya?\n* Is SafeCare Kenya feasible to deliver by community health volunteers?\n\nMothers will:\n\n* Complete study assessments at three timepoints: baseline, 6 months and 18 months\n* Mothers in the SafeCare Kenya group will receive the program from their community health volunteer\n\nResearchers will compare SafeCare Kenya to care as usual by community health volunteers to see if SafeCare Kenya families show improvements in parent interaction skills, safety and health knowledge, potential for child abuse, child behavior problems, child injuries, parenting stress, and child and parent quality of life.",[54,55],"Child Maltreatment","Parenting","2025-04-15",{"date":58,"type":33},"2025-04-18",{"date":60,"type":33},"2024-03-14",{"date":62,"type":22},"2028-05",{"name":39,"class":40},""]