[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Pakistan Association of Cognitive Therapists\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":200},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,54,80,102,121,146,165,185],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100611344","culturally-adapted-dialectical-behavior-therapy-for-low-middle-income-countries-100611344",false,"NCT07239362","CULTURALLY ADAPTED DIALECTICAL BEHAVIOR THERAPY FOR LOW-MIDDLE-INCOME COUNTRIES","Culturally Adapted Dialectical Behavior Therapy (DBT) for Mental Health in LMICs: A Randomized Controlled Trial (RCT)","Inclusion Criteria:\n\n* Adults aged 18-45 years\n* Adults who are diagnosed with or have significant traits of borderline personality disorder (BPD)\n* Adults who are willing to provide written informed consent\n\nExclusion Criteria:\n\n* Severe psychiatric comorbidity (e.g., active psychosis, substance use, etc.)\n* Acute medical conditions interfering with participation\n* Lack of basic reading and writing, or any learning disability","ALL","18 Years","45 Years",{"count":20,"type":21},220,"ESTIMATED","INTERVENTIONAL",[24],"NA","The study aims to assess the efficacy of culturally adapted dialectical behaviour therapy (DBT) for addressing emotional dysregulation in a low- and middle-income country, as well as to evaluate the impact of DBT on secondary outcomes such as borderline personality traits, self-harm or suicide, depression, anxiety, and individuals' functioning and disability.\n\nThrough a rigorous Randomised Controlled Trial (RCT), the research seeks to assess how cultural adaptations of dialectical behaviour therapy improve its applicability, engagement, and outcomes in diverse socio-cultural settings, contributing to more accessible and effective mental health interventions in resource-limited regions.",[27,28,29,30,31,32],"Borderline Personality Disorder (BPD)","Dialectical Behavior Therapy","Emotional Dysregulation","Self Harm","Suicidal and Self-injurious Behavior","Depression Anxiety Disorder",[34,35,36,37,38,39,40],"BPD","DBT","Self harm","Suicide","Borderline personality","Dialectical behavior therapy","Emotional dysregulation","NOT_YET_RECRUITING","2025-11-22",{"date":44,"type":45},"2025-11-28","ACTUAL",{"date":47,"type":21},"2025-11-20",{"date":49,"type":21},"2026-07-31",{"name":51,"class":52},"Pakistan Association of Cognitive Therapists","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":53},"100611098","effectiveness-of-a-guided-self-help-cbt-manual-kok-in-cancer-patients-100611098","NCT07236164","Effectiveness of a Guided Self-Help CBT Manual 'KOK' in Cancer Patients","Effectiveness of the Guided Self-Help CBT Manual 'Khushi or Khatoon (KoK)' in Cancer Patients: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Adults (≥ 18 years)\n* Clinical diagnosis of cancer\n* Experiencing moderate to severe psychological distress (HADS score ≥ 8)\n* Able to read and write the Urdu language\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Severe psychiatric conditions requiring immediate intervention\u002Fhospitalisation\n* Cognitive impairments preventing understanding of the manual\u002Ftherapy\n* Visual impairments that may prevent the reading of the manual\n* Already been receiving any psychological therapy","65 Years",{"count":63,"type":21},108,[24],"This study aimed to assess the feasibility, acceptability, and preliminary efficacy of the Guided self-help CBT intervention 'Khushi or Khatoon' to treat anxiety and depression, and enhance quality of life and satisfaction with treatment in cancer patients.",[67,68,69],"Depression","Anxiety","Cancer",[67,68,71,69,72],"Guided self-help","CBT",{"date":74,"type":45},"2025-12-01",{"date":76,"type":21},"2025-12-28",{"date":78,"type":21},"2026-02-27",{"name":51,"class":52},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100611347","feasibility-and-efficacy-trial-of-a-culturally-adapted-guided-self-help-cbt-manual-for-ocd-100611347","NCT07239401","Feasibility and Efficacy Trial of a Culturally Adapted Guided Self-Help CBT Manual for OCD","Feasibility and Efficacy Trial of a Culturally Adapted Guided Self-Help CBT Manual for Obsessive-Compulsive Disorder: A Randomised Controlled Study From Pakistan","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Clinical diagnosis of OCD (with or without comorbid depression)\n* Minimum 5 years of formal education\n* Residing within commuting distance of the participating sites\n* Ability to read and write Urdu\n* Provision of informed written consent\n\nExclusion Criteria:\n\n* Current substance use or dependence (diagnosed)\n* Significant cognitive impairment (e.g., dementia or intellectual disability)\n* OCD with active psychosis",{"count":63,"type":21},[24],"This randomised controlled trial (RCT) aims to assess the feasibility, acceptability, and preliminary efficacy of a culturally adapted, guided self-help cognitive behaviour therapy (CBT) manual specifically designed for individuals with OCD in Pakistan.",[91],"Obsessive - Compulsive Disorder",[93,94,71,72],"OCD","Obsessive compulsive disorder","2025-11-15",{"date":47,"type":45},{"date":98,"type":21},"2025-11",{"date":100,"type":21},"2026-02",{"name":51,"class":52},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":117,"startDateStruct":118,"completionDateStruct":119,"leadSponsor":120,"locationsCount":53},"100611346","structured-group-therapy-in-reducing-depression-and-anxiety-in-pakistan-100611346","NCT07239388","Structured Group Therapy in Reducing Depression and Anxiety in Pakistan","Effectiveness of Structured Group Therapy in Reducing Depression and Anxiety Symptoms in Pakistan: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Adults (18-65 years)\n* Diagnosed with moderate to severe depression\n* Residing in urban or rural areas of Pakistan\n* Willingness to attend 12 weekly group therapy sessions and comply with the study protocol\n\nExclusion Criteria:\n\n* Severe psychiatric disorders (e.g., psychosis, bipolar disorder)\n* Ongoing substance abuse or severe substance use disorder\n* Participation in other therapeutic interventions (e.g., individual therapy or group therapy) during the study period\n* Cognitive impairments that would interfere with participation",{"count":63,"type":21},[24],"This study aims to assess the effectiveness of Cognitive Behavioural Therapy (CBT) and Mindfulness-Based Stress Reduction (MBSR) in group settings to reduce symptoms of depression and anxiety, enhance emotional resilience, and improve social support among Pakistani individuals struggling with these conditions.",[113,68],"Depression in Adults",[67,68,115,116],"Group therapy","Social support",{"date":47,"type":45},{"date":98,"type":21},{"date":100,"type":21},{"name":51,"class":52},{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":128,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":53},"100610841","brief-culturally-adapted-cbt-for-ocd-100610841","NCT07232823","Brief Culturally Adapted CBT for OCD","Brief Culturally Adapted Cognitive Behaviour Therapy (CaCBT) for Obsessive-Compulsive Disorder: A Randomised Controlled Trial From Pakistan","Inclusion Criteria:\n\n* Participants aged 18 years or above\n* Participants with at least an elementary level of reading and writing\n* Clinical diagnosis of Obsessive Compulsive Disorder, either alone or comorbid with depression or anxiety\n\nExclusion Criteria:\n\n* Participants with excessive use of alcohol or drugs (using ICD-10 RDC for alcohol or drug abuse or dependence)\n* Those with significant cognitive impairment (for example, intellectual disability or dementia)\n* Or those with OCD comorbid active psychosis",true,{"count":130,"type":21},166,[24],"The purpose aims to assess the efficacy of Brief Culturally Adapted Cognitive Behaviour Therapy (Ca-CBT) for the treatment of Obsessive Compulsive Disorder (OCD).",[134,135],"Obsessive-Compulsive Disorder","Cognitive Behavioral Therapy",[72,137,93],"CaCBT","RECRUITING",{"date":140,"type":45},"2025-11-18",{"date":142,"type":45},"2024-10-20",{"date":144,"type":21},"2025-12-31",{"name":51,"class":52},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":152,"targetDuration":4,"studyType":22,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":53},"100565801","feasibility-and-acceptability-trial-of-a-culturally-adapted-manual-versus-standard-cbt-manual-a-randomized-control-trial-100565801","NCT06646900","Feasibility and Acceptability Trial of a Culturally Adapted Manual Versus Standard CBT Manual: A Randomized Control Trial","Inclusion Criteria:\n\n1. Individuals aged 18 to 65 years\n2. 5 years of education\n3. Symptoms of depression and anxiety\n\nExclusion Criteria:\n\n1. Substance use disorder according to DSM-5 criteria as determined by primary care clinician\n2. Significant cognitive impairment (for example, profound learning disability or dementia) as determined by primary care clinician\n3. Active psychosis as determined by their primary care clinician",{"count":153,"type":21},200,[24],"This randomized controlled trial (RCT) will compare the efficacy and feasibility and acceptability of a culturally adapted CBT manual with a standard CBT manual, focusing on addressing cultural factors in therapy delivery.",[68,67],"2024-10-16",{"date":159,"type":45},"2024-10-17",{"date":161,"type":21},"2024-11-20",{"date":163,"type":21},"2024-12-31",{"name":51,"class":52},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":176,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":182,"leadSponsor":184,"locationsCount":53},"100561554","translation-and-cultural-adaptation-of-the-dysfunctional-attitude-scale-das-into-urdu-100561554","NCT06591676","Translation and Cultural Adaptation of the Dysfunctional Attitude Scale (DAS) Into Urdu","Inclusion Criteria:\n\nIndividuals aged 18 to 65 years At least 5 years of education Individuals with symptoms of Depression and Anxiety\n\n\\-\n\nExclusion Criteria:\n\n* Substance use disorder according to DSM-5 TR criteria Significant cognitive impairment (for example, profound learning disability or dementia) Active psychosis as determined by their primary care clinician",{"count":172,"type":21},620,[24],"Translate and adapt the Dysfunctional Attitude Scale (DAS) into Urdu language and establishing the psychometric properties (reliability, validity, and norms) of the translated scale",[67,68],[177,72],"DAS","2024-09-08",{"date":180,"type":45},"2024-09-19",{"date":178,"type":21},{"date":183,"type":21},"2024-12-30",{"name":51,"class":52},{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":128,"sex":16,"minAge":17,"maxAge":61,"enrollmentInfo":191,"targetDuration":4,"studyType":22,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":138,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":196,"startDateStruct":197,"completionDateStruct":198,"leadSponsor":199,"locationsCount":53},"100561553","can-cognitive-therapy-rating-scale-ctrs-be-used-across-cultures-enhancing-cultural-relevance-of-ctrs-100561553","NCT06591663","Can Cognitive Therapy Rating Scale (CTRS) be Used Across Cultures? Enhancing Cultural Relevance of CTRS","Inclusion Criteria:\n\n* Individuals aged 18 to 65 years At least 5 years of education Score of 8 or higher on Hospital Anxiety and Depression Scale-Depression or Anxiety scales as measured by their primary care clinician\n\nExclusion Criteria:\n\n* Substance use disorder according to DSM-5 TR criteria Significant cognitive impairment (for example, profound learning disability or dementia) Active psychosis as determined by their primary care clinician",{"count":192,"type":21},20,[24],"Translate and adapt the Cognitive Therapy Rating Scale (CTRS) into Urdu language and establishing the psychometric properties (reliability, validity, and norms) of the translated scale",[68,67],{"date":180,"type":45},{"date":178,"type":21},{"date":163,"type":21},{"name":51,"class":52},""]