[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Pakistan Institute of Medical Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":473},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,39,64,95,125,150,171,197,220,244,265,295,316,348,373,398,423,446],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100638196","effect-of-manual-and-mechanical-glide-path-preparation-on-working-length-accuracy-100638196",false,"NCT07612228","Effect of Manual and Mechanical Glide Path Preparation on Working Length Accuracy.","Comparison of Working Length Accuracy Following Manual and Mechanical Glide Path Preparation: An In Vitro Study.","Inclusion Criteria:\n\nExtracted permanent single-rooted teeth. Teeth with fully formed mature apices. Teeth with intact roots and no structural defects. Root canals with curvature less than 15 degrees. Teeth with patent canals allowing negotiation with a size #10 K-file.\n\nExclusion Criteria:\n\nTeeth with caries, fractures, cracks, or root defects. Teeth with previous endodontic treatment. Teeth showing root resorption or calcified canals. Teeth with unusual root canal anatomy or multiple canals. Teeth with severe canal curvature greater than 15 degrees. Teeth with immature apices or open apices.",true,"ALL",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","Accurate working length determination is essential for successful root canal treatment and is influenced by proper glide path preparation. This in vitro study aims to compare the accuracy of working length achievement following manual and mechanical glide path preparation techniques. Sixty extracted single-rooted permanent teeth will be randomly allocated into two groups. Group 1 will undergo manual glide path preparation using stainless steel K-files, while Group 2 will receive mechanical glide path preparation using rotary PathFile instruments. Initial and final working lengths will be measured using an electronic apex locator and confirmed with digital radiographs. The difference between the initial and final working lengths will be analyzed statistically. The results of this study will help identify the more effective glide path preparation technique for maintaining working length accuracy and improving endodontic treatment outcomes.",[26],"Achievement of Working Length After Manual Versus Mechanical Glide Path","NOT_YET_RECRUITING","2026-06-29",{"date":30,"type":31},"2026-07-01","ACTUAL",{"date":33,"type":20},"2026-06-04",{"date":35,"type":20},"2026-11-10",{"name":37,"class":38},"Pakistan Institute of Medical Sciences","OTHER_GOV",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":4},"100644277","phase-4-risperidone-vs-cariprazine-in-acute-mania-100644277","NCT07665073","Risperidone vs Cariprazine in Acute Mania","Risperidone vs Cariprazine in Acute Mania a Head to Head Comparison of Efficacy vs Tolerability","RCAM","Inclusion Criteria:\n\npatients with bipolar mania Age 18-60 YMRS\\>20 -\n\nExclusion Criteria:\n\nPatients with substance use Patients already taking antipsychotics Secondary mood disorder\n\n\\-","18 Years","60 Years",{"count":50,"type":20},50,[52],"PHASE4","Randomized, double-blind, parallel-group study comparing efficacy and safety of Risperidone versus Cariprazine in adults with acute manic episodes. Participants will receive oral study drug for 6 weeks. Primary outcome is change in YMRS total score from baseline to week 6.",[55],"Bipolar 1 Disorder","2026-06-18",{"date":58,"type":31},"2026-06-24",{"date":60,"type":20},"2027-06",{"date":62,"type":20},"2028-06",{"name":37,"class":38},{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":74,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},"100641138","a-study-comparing-carotid-doppler-ultrasound-and-echocardiography-to-assess-fluid-responsiveness-in-septic-patients-on-ventilator-100641138","NCT07653568","A Study Comparing Carotid Doppler Ultrasound and Echocardiography to Assess Fluid Responsiveness in Septic Patients on Ventilator","Comparative Evaluation of Common Carotid Artery Blood Flow (CCABF) and Transthoracic Echocardiographic Cardiac Output (TTE-CO) for Assessing Fluid Responsiveness in Septic Patients on Ventilator.","Inclusion Criteria:\n\n* • Adults with sepsis requiring mechanical ventilation in the intensive care unit\n\n  * Patients requiring fluid assessment or fluid resuscitation based on clinical findings, including one or more of the following:\n\n    * Heart rate greater than 100 beats per minute\n    * Systolic blood pressure less than 90 mmHg\n    * Mean arterial pressure less than 65 mmHg\n    * Urine output less than 0.5 mL\u002Fkg\u002Fhour for at least 2 hours\n\nExclusion Criteria:\n\n* Intracranial pathology associated with raised intracranial pressure, including intracerebral hemorrhage or space-occupying lesions\n* Recent neurosurgical procedures or conditions where passive leg raising may increase intracranial pressure\n* Known heart failure\n* Significant cardiac arrhythmias\n* Significant valvular heart disease\n* Status asthmaticus\n* Pulmonary hypertension\n* Pulmonary embolism\n* Pregnancy\n* Lower limb conditions preventing passive leg raising, including fractures\n* Intra-abdominal hypertension\n* Recent abdominal surgery\n* Known carotid artery disease or common carotid artery stenosis greater than 50%","12 Years",{"count":73,"type":20},94,[23],"The goal of this clinical trial is to determine whether common carotid artery blood flow measured by bedside Doppler ultrasound can accurately identify fluid responsiveness in mechanically ventilated adults with sepsis. The study will compare this method with transthoracic echocardiography-derived cardiac output, which is a commonly used non-invasive technique for assessing hemodynamic status in critically ill patients. The study also aims to evaluate whether carotid artery ultrasound can provide a faster and more practical bedside assessment during fluid resuscitation in the intensive care unit.\n\nIn patients with sepsis, giving too little intravenous fluid may worsen organ perfusion and shock, while excessive fluid administration may lead to complications such as pulmonary edema, worsening oxygenation, prolonged mechanical ventilation, and longer intensive care unit stay. Because of this, clinicians need reliable methods to identify which patients are likely to benefit from fluid administration. This concept is known as fluid responsiveness.\n\nThe main questions this study aims to answer are:\n\n* Can common carotid artery blood flow measured by ultrasound predict fluid responsiveness as accurately as transthoracic echocardiography-derived cardiac output?\n* How closely do changes in carotid artery blood flow correspond to changes in cardiac output during passive leg raising?\n* Can carotid ultrasound provide a quicker and simpler bedside method for assessing fluid responsiveness in critically ill patients receiving mechanical ventilation? Researchers will compare two ultrasound-based methods during a passive leg raising test. Passive leg raising is a temporary bedside maneuver used to simulate a fluid challenge without immediately giving intravenous fluids. During this maneuver, the patient's legs are elevated while the upper body is lowered, allowing blood from the lower limbs to temporarily return to the central circulation. This increases blood flow to the heart and may increase cardiac output in patients who are likely to respond to fluid administration.\n\nThe study team will first record baseline measurements of common carotid artery blood flow and transthoracic echocardiographic cardiac output while the patient is in a semi-recumbent position. The passive leg raising maneuver will then be performed, and both measurements will be repeated to evaluate changes in blood flow and cardiac output. If the predefined criteria for fluid responsiveness are met, the participant will receive intravenous crystalloid fluid according to the study protocol.\n\nParticipants will:\n\n* Undergo bedside Doppler ultrasound measurement of common carotid artery blood flow\n* Undergo transthoracic echocardiography to measure cardiac output\n* Have ultrasound measurements recorded before and after passive leg raising\n* Receive intravenous fluid administration if fluid responsiveness criteria are met\n* Continue routine monitoring of blood pressure, heart rate, oxygenation, urine output, and other intensive care parameters during the study period The findings from this study may help determine whether carotid artery ultrasound can be used as a practical bedside tool for fluid assessment in mechanically ventilated patients with sepsis, particularly in settings where rapid and non-invasive monitoring is needed.",[77],"Fluid Responsiveness Predictability in Sepsis",[79,80,81,82,83,84,85],"Fluid responsiveness","LVOT","Common carotid artery blood flow","Sepsis","TTE-CO","Carotid doppler","Ventilated patients","RECRUITING","2026-06-16",{"date":56,"type":31},{"date":90,"type":31},"2026-05-01",{"date":92,"type":20},"2027-05-29",{"name":37,"class":38},1,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":21,"phases":105,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":94},"100643557","phase-4-low-dose-versus-conventional-dose-oral-isotretinoin-for-acne-vulgaris-100643557","NCT07639073","Low-Dose Versus Conventional-Dose Oral Isotretinoin for Acne Vulgaris","Comparing the Efficacy and Safety of Low-Dose Oral Isotretinoin Versus Conventional-Dose in the Treatment of Acne Vulgaris","Inclusion Criteria:\n\n* Both genders\n* Age 18-45 years\n* Patients who are clinically diagnosed with moderate to severe acne vulgaris as per criteria defined in operational definition.\n\nExclusion Criteria:\n\n* Patients who are pregnant or lactating\n* Patients with history of endocrine disorders such as PCOS etc. or having drug induced acne\n* Patients on corticosteroid treatment\n* Patients who have hypersensitivity to the isotretinoin\n* Patients who are taking any acne treatment\n* Patients with hyperlipidemia, chronic renal failure or liver failure","45 Years",{"count":104,"type":20},164,[52],"Background and Purpose:\n\nAcne vulgaris is a common skin condition that can cause significant physical and emotional distress. Oral isotretinoin is a highly effective treatment for severe or persistent acne. While the standard (conventional) dose is effective, it is often associated with side effects like dry skin, chapped lips, and altered labs.\n\nThe purpose of this study is to compare a lower daily dose of oral isotretinoin against the conventional daily dose in individuals with acne vulgaris.\n\nWhat the Study Aims to Find Out:\n\nResearchers want to determine if a low-dose regimen can match the effectiveness (efficacy) of the conventional dose while reducing the frequency and severity of side effects (safety).\n\nStudy Design:\n\nParticipants will be randomly assigned to receive either the low-dose oral isotretinoin or the conventional-dose oral isotretinoin. Researchers will monitor and compare acne clearance rates, patient satisfaction, and any side effects experienced by the participants throughout the treatment period.",[108],"Acne Vulgaris",[110,111,112,113,114,115,116],"Isotretinoin","Accutane","Acne Treatment","Dermatology","Low dose Isotretinoin","Conventional Dose Isotretinoin","Retinoids","2026-06-05",{"date":119,"type":31},"2026-06-10",{"date":121,"type":20},"2026-07",{"date":123,"type":20},"2026-10",{"name":37,"class":38},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":16,"sex":17,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":147,"leadSponsor":149,"locationsCount":4},"100595563","phase-2-the-impact-of-palatal-rugae-addition-to-complete-dentures-on-patients-satisfaction-and-oral-health-related-quality-of-life-100595563","NCT07034079","The Impact of Palatal Rugae Addition to Complete Dentures on Patients' Satisfaction and Oral Health Related Quality of Life","The Impact of Palatal Rugae Addition to Complete Dentures on Patients' Satisfaction and Oral Health Related Quality of Life: A Randomized Crossover Clinical Trial","Palatal rugae","Inclusion Criteria:\n\n* Patients aged 45-80 years.\n* Completely edentulous for at least 3 months.\n* Seeking new complete maxillary dentures for the first time.\n* Provided written informed consent\n* Motivated and compliant patients, willing to return for follow-up (helps reduce attrition bias)\n* Patients with Class I maxillomandibular relationship\n\nEXCLUSION CRITERIA\n\n* Patients with severe systemic diseases or neuromuscular dysfunction.\n* Presence of mental or auditory impairment.\n* History of oral pathology, xerostomia, or ankyloglossia (tied tongue).\n* Previous or experienced complete denture wearers.\n* Patient with strong gag reflex","40 Years","80 Years",{"count":19,"type":20},[137],"PHASE2","In conventional maxillary complete dentures, the palatal surface is typically smooth and polished, lacking the natural anatomy of the palatal rugae. While this design facilitates ease of cleaning, it may compromise the functional feedback required for speech and other oral functions. Since the palatal rugae contain mechanoreceptors essential for guiding the tongue during phonation and mastication, replicating these structures may enhance oral function and patient adaptation.\n\nGiven the variation in clinical outcomes reported in prior studies, a randomized crossover clinical trial is warranted to assess the impact of adding anatomically replicated palatal rugae to complete dentures.",[140],"Edentulism",[131,142,140,143],"Oral health impact profile","complete denture",{"date":145,"type":31},"2026-06-08",{"date":30,"type":20},{"date":148,"type":20},"2026-12-31",{"name":37,"class":38},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":21,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":94},"100643727","phase-4-efficacy-of-topical-tapinarof-versus-betamethasone-in-the-treatment-of-plaque-psoriasis-100643727","NCT07635043","Efficacy of Topical Tapinarof Versus Betamethasone in the Treatment of Plaque Psoriasis","Inclusion Criteria:\n\n* Age 18 years-65 years\n* Clinically diagnosed plaque psoriasis involving body surface area ( BSA) of 2-20% (mild to moderate severity)\n* Disease duration of at least 6 months\n* Willing and able to provide written informed consent\n* Not currently using any other topical and systematic psoriasis therapy, or willing to undergo a washout period (2 weeks for topical therapies)\n\nExclusion Criteria:\n\n* Severe psoriasis (BSA \\>20% or requiring systemic therapy)\n* Pregnant and lactating mothers\n* Known hypersensitivity to Tapinarof or any of its excipients\n* Concurrent dermatological conditions that may interfere with assessment e.g fungal infections,atopic dermatitis\n* Use of systemic immunosuppressants (methotrexate, cyclosporine, biologics ) or phototherapy within 4 weeks before enrollment\n* History of malignancy or current active infection\n* Known hypersensitivity to betamethasone or Tapinarof\n* Use of powerful topical corticosteroids within two weeks previously","65 Years",{"count":158,"type":20},120,[52],"To assess the effectiveness of topical tapinarof to topical betamethasone in patients with mild to moderate plaque psoriasis presenting to tertiary care hospital in Islamabad",[162],"Psoriasis (PsO)","2026-06-03",{"date":165,"type":31},"2026-06-09",{"date":167,"type":20},"2026-08-01",{"date":169,"type":20},"2026-11-30",{"name":37,"class":38},{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":21,"phases":181,"briefSummary":182,"conditions":183,"keywords":185,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":94},"100635019","comparison-of-two-surgical-methods-winograd-vs-sleeve-method-in-the-treatment-of-ingrown-toenail-100635019","NCT07547241","Comparison of Two Surgical Methods (Winograd vs. Sleeve Method) in the Treatment of Ingrown Toenail.","COMPARISON OF TWO SURGICAL METHODS (WINOGRAD VS SLEEVE METHOD) IN THE TREATMENT OF INGROWN TOE NAIL","Inclusion Criteria:\n\n* Patients presenting with ingrown toenail (onychocryptosis)\n* Patients for whom surgical intervention is indicated\n* Age between 12 and 75 years\n* Both male and female participants\n* Patients willing to provide informed consent\n\nExclusion Criteria:\n\n* Patients with diabetes mellitus\n* Patients with peripheral vascular disease\n* Immunocompromised patients\n* Patients with coagulopathy\n* Patients receiving chemotherapy\n* Patients with localized infection or abscess at the surgical site\n* Patients with previously treated or recurrent ingrown toenail\n* Patients presenting with delayed complications of prior ingrown toenail surgery","75 Years",{"count":180,"type":20},312,[23],"This randomized clinical trial aims to compare the recurrence rates of two surgical techniques-Winograd procedure and sleeve (gutter) method-in the treatment of ingrown toenails (onychocryptosis). A total of 312 nails will be randomized into two groups, with patients receiving either the Winograd procedure or sleeve method. Participants will be followed for 30 days post-intervention to assess recurrence and other clinical outcomes. The study seeks to determine the more effective treatment modality for reducing recurrence in a tertiary care setting.",[184],"Ingrown Toenail (Onychocryptosis)",[186,187,188],"IGTN","Ingrown nail","In-grown toe nail","2026-04-20",{"date":191,"type":31},"2026-04-23",{"date":193,"type":31},"2025-06-01",{"date":195,"type":20},"2026-07-31",{"name":37,"class":38},{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":16,"sex":17,"minAge":47,"maxAge":48,"enrollmentInfo":204,"targetDuration":4,"studyType":21,"phases":205,"briefSummary":206,"conditions":207,"keywords":211,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":217,"leadSponsor":219,"locationsCount":94},"100632016","phase-4-comparison-of-post-operative-analgesia-in-patients-undergoing-lower-abdominal-surgeries-receiving-ultrasound-guided-block-with-dexmetomidine-vs-dexmethasone-100632016","NCT07508202","Comparison of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving Ultrasound Guided Block With Dexmetomidine vs Dexmethasone","Comparison of Mean Duration of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving US Transversus Abdominis Plane Block (TAP) With Bupivacaine and Dexmetomidine vs Bupivacaine nd Dexmethasone","Inclusion Criteria:\n\n* ASA I and ASA II BMI 25-35 kg\u002Fm2 Lower abdominal surgeries below L2-L3 leves\n\nExclusion Criteria:\n\n* Infection at block site Coagulopathy Antiplatelet",{"count":19,"type":20},[52],"Lower abdominal surgeries cause significant pain and can be managed by injecting local anesthetic agents between muscles of abdominal wall that can provide post operative pain relief and its duration can be prolonged by adding drugs to local anesthetic regimen",[208,209,210],"Post Operative Analgesia","Dexmedetomidine","TAP Block",[212],"Post opertive analgesia in lower abdominal surgeries","2026-03-27",{"date":215,"type":31},"2026-04-02",{"date":213,"type":31},{"date":218,"type":20},"2026-06-26",{"name":37,"class":38},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":227,"enrollmentInfo":228,"targetDuration":4,"studyType":21,"phases":229,"briefSummary":230,"conditions":231,"keywords":234,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":243,"locationsCount":94},"100629898","phase-4-pv-aco-gap-guided-resuscitation-in-adult-polytrauma-patients-a-prospective-randomized-controlled-trial-100629898","NCT07480655","Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial","Evaluation of Effect of Pv-aCO2-Gap on Clinical Outcomes With Standard Resuscitation End-points in Adult Poly-trauma Patients Admitted to the ICU --- Prospective Randomized Control Trial","Inclusion Criteria:\n\n* Either Gender\n* Poly-trauma patients\n\n  ○ Both penetrating and blunt trauma\n* Both surgical and non-surgical\n* Shock States\n\nExclusion Criteria:\n\n* Any Chest trauma\n* Patients with Obstructive and restrictive lung disease\n* Obstructive sleep apnea\n* Septic shock\n* Pregnant patients\n* Patients who will require readmission within 48 h after step-down from the ICU.\n* Patients who will need extra-corporeal membrane oxygenation support","70 Years",{"count":19,"type":20},[52],"dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or their legal guardian. Participants will be randomly divided into two groups: one group will receive treatment guided by the difference between carbon dioxide levels in venous and arterial blood, while the other group will receive treatment based on standard resuscitation parameters commonly used in critical care. As part of routine monitoring, all patients will have a central venous catheter and an arterial line inserted to measure blood parameters. Blood samples from both lines will be taken shortly after ICU admission and at regular intervals during the first three days. These samples will be analyzed using a bedside blood gas machine, and the results will be compared between the two groups to determine whether monitoring the difference in carbon dioxide levels between venous and arterial blood improves patient outcomes compared with standard care.",[232,233],"Polytrauma","Resuscitation, Trauma Patients",[235,236],"Veno-arterial carbondioxide gap","Polytrauma resuscitation","2026-03-15",{"date":239,"type":31},"2026-03-18",{"date":241,"type":20},"2026-03-16",{"date":87,"type":20},{"name":37,"class":38},{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":156,"enrollmentInfo":250,"targetDuration":4,"studyType":21,"phases":252,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":4},"100628010","effectiveness-of-chlorhexidine-impregnated-gauze-versus-povidone-iodine-dressing-in-post-trauma-wound-care-100628010","NCT07456072","Effectiveness of Chlorhexidine Impregnated Gauze Versus Povidone Iodine Dressing in Post Trauma Wound Care","Inclusion Criteria:\n\n* Patients 18-65 years of age with acute post-trauma wounds.\n* Wounds that are clean contaminated at presentation.\n\nExclusion Criteria:\n\n* Patients with the known allergies to Chlorhexidine or Povidone-Iodine.\n* Chronic wounds or those with underlying chronic conditions, such as diabetes.\n* Patients with compromised immune systems.\n* Pregnant females",{"count":251,"type":20},176,[23],"To compare rate of infection and wound healing between chlorhexidine impregnated paraffin gauze and dry povidone-iodine dressings in post-traumatic wounds.",[255,256],"Wound Infection Post-Traumatic","Wound Healing","2026-03-03",{"date":259,"type":31},"2026-03-06",{"date":261,"type":20},"2026-03-01",{"date":263,"type":20},"2026-05-31",{"name":37,"class":38},{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":21,"phases":274,"briefSummary":275,"conditions":276,"keywords":283,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":294,"locationsCount":94},"100617511","comparison-of-chest-tube-wound-closure-comparison-between-purse-string-method-and-plug-method-100617511","NCT07319572","Comparison of Chest Tube Wound Closure: Comparison Between Purse String Method and Plug Method.","Optimizing Chest Tube Removal: A Comparison of Purse-string Suture Closure and Plug Method.","Inclusion criteria :\n\n1. All patients \\>18 years of age\n2. Patients undergoing chest tube insertion for traumatic causes including Pneumothorax, hemothorax and hemopneumothorax.\n\nExclusion criteria:\n\n1. Previous ipsilateral thoracic surgery\n2. Patients with large wounds necessitating suture closure\n3. Patients with bleeding disorders",{"count":273,"type":20},246,[23],"This prospective, comparative clinical study evaluates two techniques of chest tube wound closure-purse-string suture and the simple suture\u002Fplug method-to determine differences in cosmetic outcomes, wound complications, and overall patient satisfaction following chest tube removal. The study aims to identify the closure technique that provides optimal wound healing with fewer postoperative complications.",[277,278,279,280,281,282],"Pneumothorax","Hemothorax","Chest Tube","Chest Tube Removal","Purse String","Plug Method",[284,285,286,277,287],"Purse-string","Plug method","Chest tube","hemothorax","2025-12-19",{"date":290,"type":31},"2026-01-06",{"date":292,"type":20},"2026-01-01",{"date":148,"type":20},{"name":37,"class":38},{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":17,"minAge":47,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":21,"phases":305,"briefSummary":306,"conditions":307,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":315,"locationsCount":94},"100615307","effectiveness-of-home-based-cardiac-rehabilitation-100615307","NCT07290907","Effectiveness of Home-Based Cardiac Rehabilitation","EFFECTIVENESS OF HOME-BASED CARDIAC REHABILITATION TO IMPROVE QUALITY OF LIFE AND HEALTH BEHAVIOR OF PATIENTS WITH CARDIOVASCULAR DISEASES IN LOW-RESOURCE SETTINGS IN PAKISTAN","NCD CVD HBCR","Inclusion Criteria:\n\nDiagnosed with coronary artery disease, myocardial infarction and heart failure Diagnosed with cardiovascular diseases based on clinical history and diagnosis, including electrocardiogram (ECG), biochemical markers, or non-invasive tests like, echocardiography, exercise tolerance test (ETT), Thallium stress test, and selected for procalcitonin PCI, a biomarker for the diagnosis of the infection Either gender included Found medically stable and discharged from the hospital. Resident of the surrounding areas other than the sectors of Islamabad as defined by the Capital Development Authority (CDA) of Pakistan.\n\n\\-\n\nExclusion Criteria:\n\n\\-",{"count":304,"type":20},92,[23],"Statement of the Problem WHO stated that the average life expectancy has been recorded as 40 years among these in South Asian countries and 98 million people relate to Pakistan. Wang pointed out that the significant difference has been seen regarding provision of the health care facilities being provided in the rural and urban settings, called as health poverty in rural area as compared to urban areas. Therefore, accessibility of essential healthcare facilities such as experienced staff, vaccination and necessarily supply of medicines in rural population would be supporting reducing health poverty and will maintain equal and equitable opportunities. Andersen and Newman argued that there are main factors such as distance, time and travel costs that affect health accessibility for the poor people living in rural settings which are deprived of emergency care and common in developing economies.\n\nCardiac Rehabilitation is a efficient, safe and affordable intervention that lowers overall health service financial burden. Additionally, CR are planned to optimize and restore physical, psychological, and social functioning by combining medical consultation, individualized exercise sessions, education, cardiac risk factor modification, and health counseling. CR is highly and mostly suggested as the key multicomponent and multi-dimensional intervention for the prevention of death by cardiac attacks, the lowering chances of hospital readmissions, and the enhancement of quality of life (QoL) of the people. Therefore, CR is one of the effective techniques to decrease the increasing number of cases and provide an efficient cardiac health intervention program with appropriate planning and organization.\n\nDespite the evidence of cost-effective rehabilitation program to optimize cardiac functioning at the hospital-based settings but the participation in cardiac rehabilitation, traditionally delivered in hospital outpatient departments or community, Despite the evidence of cost-effective rehabilitation program to optimize cardiac functioning at the hospital-based settings but the participation in cardiac rehabilitation, traditionally delivered in hospital outpatient departments or community centers, has remained low, with average participation rates \\\u003C 20% recorded in the United States and similarly in the Europe. Low participation has predominantly recorded mostly in few groups like women, elder population, ethnic minorities, and those living in rural settings or who are socioeconomically and financially resource constrained. Subsequently, these patients were contacted through calls for alternative options to center-based cardiac rehabilitation. Recommended interventions included cardiac rehabilitation at home transited by healthcare professionals with the support of telehealth technologies to maximize participation. Thus, the home-based cardiac rehabilitation program was recommended by the American Heart Association and the American College of Cardiology in 2019 through a scientific statement. Guidelines from NICE on chronic heart failure in the UK in 2018 said that \"delivery of home-based rehabilitation may enhance the accessibility and participation. For changing behavior and improving quality of life, HBCR is an essential component of secondary prevention and an important alternative technique, for those patients who suffered a cardiac incident or experienced any other cardiac event. Hence, HBCR is one of the effective t strategies to reduce the higher number of cases. HBCR contains techniques for secondary prevention that facilitate cardiac patients to rebuild their functional cardiac capacity and decrease the magnitude of hospital visits and workload in emergency management in coronary critical areas.\n\nMost of the studies were done on cardiovascular disease and on the conventional approach of hospital-based cardiac rehabilitation, but rare literature in the context of Pakistan, especially Islamabad, was found on home-based cardiac rehabilitation to improve the quality of life and behavior of the patients. Thus, the study aims to evaluate the effectiveness of home-based cardiac rehabilitation to improve the quality of life and health behavior of patients with cardiovascular disease in low resource settings in Islamabad.",[308],"Cardiac Rehabilitation","2025-12-17",{"date":311,"type":31},"2025-12-18",{"date":313,"type":20},"2025-12-15",{"date":237,"type":20},{"name":37,"class":38},{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":16,"sex":324,"minAge":47,"maxAge":325,"enrollmentInfo":326,"targetDuration":4,"studyType":21,"phases":328,"briefSummary":329,"conditions":330,"keywords":332,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":344,"leadSponsor":346,"locationsCount":347},"100613841","place-trial-preserving-long-acting-contraception-through-education-100613841","NCT07271836","PLACE Trial: Preserving Long-Acting Contraception Through Education","Effect of Structured Counseling on Continuation Rates of Long Acting Reversible Contraception Among Clients Requesting Early Removal: A Multicenter Randomized Controlled Trial (PLACE Trial)","PLACE","Inclusion Criteria:\n\n* Women presenting at the clinics exclusively for removal of a copper-T IUD or Jadelle subdermal implant within 2 years of use and within the first 2 months of the study.\n\nExclusion Criteria:\n\n* Women not wishing to participate or unable to provide informed consent.","FEMALE","49 Years",{"count":327,"type":20},900,[23],"Study Overview Summary\n\nThis randomized controlled trial will evaluate the effectiveness of structured counseling in improving the continuation rates of long-acting reversible contraception (LARC) among women in Islamabad, Pakistan, who present to family planning clinics for early removal of their contraception devices (copper-T IUD or Jadelle implant). The study, starting December 15, 2025, will recruit women from three federal government-approved clinics.\n\nThe trial will randomly assign participants to either an intervention group, where they will receive culturally sensitive counseling to encourage continued use of LARC, or a control group, where contraception will be removed upon client request without counseling. The goal is to determine if structured counseling can increase the likelihood of women continuing their LARC method.",[331],"Contraception",[333,334,335,336,337,338,339],"long acting reversible contraception","LARC","subdermal implant","jadelle","intrauterine contraceptive device","copper-t","counseling","2025-12-14",{"date":342,"type":31},"2025-12-16",{"date":313,"type":31},{"date":345,"type":20},"2026-08",{"name":37,"class":38},3,{"id":349,"slug":350,"hasResults":11,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":355,"targetDuration":4,"studyType":21,"phases":356,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":94},"100608765","comparison-of-leakage-in-endodontically-treated-teeth-obturated-with-different-types-of-gutta-percha-coatings-and-bioceramic-sealer-100608765","NCT07205809","Comparison of Leakage in Endodontically Treated Teeth Obturated With Different Types of Gutta Percha Coatings and Bioceramic Sealer","In Vitro Comparison of Leakage in Endodontically Treated Teeth Obturated With Different Types of GP Coatings Using Bioceramic Sealer: A Randomized Controlled Trial.","Inclusion Criteria:\n\n1\\. Extracted human teeth with single canal and mature root apex\n\nExclusion Criteria:\n\n1. Teeth with calcified (non-negotiable) canals.\n2. Teeth with internal\u002Fexternal root resorption (as seen on radiograph)\n3. Teeth with caries extending to the floor of pulp chamber.\n4. Teeth with a single canal but open apex.",{"count":19,"type":20},[23],"In vitro study to compare the sealing ability of bioceramic-coated gutta-percha with bioceramic sealer against conventional gutta-percha with bioceramic sealer in root canal obturation. A total of 60 extracted human single-canal teeth will be prepared and obturated according to standardized protocols, then evaluated for microleakage. Data will be analyzed using SPSS (version 25) with appropriate non-parametric tests at a significance level of p\\\u003C0.05. The outcomes are expected to identify the more effective obturation material combination in achieving a fluid-tight seal, thereby contributing to improved success rates in endodontic therapy.",[359],"Leakage Testing",[361,362,363,364],"leakage","gutta percha","bioceramic","sealer","2025-09-26",{"date":367,"type":31},"2025-10-03",{"date":369,"type":20},"2025-11-05",{"date":371,"type":20},"2026-06-12",{"name":37,"class":38},{"id":374,"slug":375,"hasResults":11,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":4,"eligibilityCriteria":379,"healthyVolunteers":16,"sex":17,"minAge":380,"maxAge":381,"enrollmentInfo":382,"targetDuration":4,"studyType":21,"phases":384,"briefSummary":385,"conditions":386,"keywords":4,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":94},"100606845","comparing-the-antiplaque-effects-of-novel-titania-nanoparticle-infused-fluoride-varnish-vs-conventional-fluoride-varnish-in-fixed-orthodontic-patients-100606845","NCT07180849","Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.","Comparing the Antiplaque Efficacy of Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients-A Triple Blind Randomised Controlled Trial.","Inclusion criteria:\n\n* Patients planned for fixed orthodontic treatment.\n* Patients within age group 16-30 years.\n* Patient with no history of previous orthodontic treatment.\n* Patients with no active periodontal diseases.\n\nExclusion criteria:\n\n* Patient undergoing any antibiotic therapy.\n* Patients with any craniofacial abnormality.\n* Patient with mixed dentition","16 Years","30 Years",{"count":383,"type":20},20,[23],"In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.",[387,388,389],"Dental Plaque Accumulation","Nanoparticles","Fluoride Varnishes","2025-09-20",{"date":392,"type":31},"2025-09-25",{"date":394,"type":20},"2025-11",{"date":396,"type":20},"2027-12",{"name":37,"class":38},{"id":399,"slug":400,"hasResults":11,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":16,"sex":17,"minAge":47,"maxAge":381,"enrollmentInfo":405,"targetDuration":4,"studyType":21,"phases":406,"briefSummary":407,"conditions":408,"keywords":413,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":420,"leadSponsor":422,"locationsCount":94},"100607019","comparison-of-traditional-instructions-vs-ai-based-instructions-with-customized-chat-gpt-as-remote-support-system-on-education-of-orthodontic-patients-100607019","NCT07183111","Comparison of Traditional Instructions Vs AI Based Instructions With Customized Chat GPT as Remote Support System on Education of Orthodontic Patients","Comparison of Traditional Instructions Vs AI Based Instructions With Customized Chat GPT as Remote Support System on Education of Orthodontic Patients:A Randomised Control Trial","Inclusion Criteria:\n\n* Patients aged 18-30 years undergoing bracket placement\n* No prior experience of orthodontic treatment\n* In good state of physical and mental health\n* Understand the medium of instructions properly which will be Urdu language in this study\n* Internally motivated patients with fairly good oral hygiene at the start of treatment\n* Access to smart phone or internet at home\n\nExclusion Criteria:\n\n* Systemic conditions affecting oral hygiene\n* Cognitive impairments that may hinder comprehension\n* Patients with language barriers that might affect their understanding of",{"count":19,"type":20},[23],"This study will assess the impact of voice instructions delivered by advance voice feature of Chat gpt followed by remote support with chatbot in form of customized chat gpt named Brace AI which is customized by principal investigator.AI generate post operative instructions will be compared with post bracketing instructions given verbally in traditional chair side manner and home support with pamphlet in terms of oral hygiene outcome ,satisfaction with both modalities of instruction , recall ability and knowledge of the orthodontic patients",[409,410,411,412],"Focus of the Study is Plaque and Gingival Index Score Before and After Instructions","Satisfaction Assessment of Orthodontic Patients With Both Instruction Modalities","Knowledge Assessment","Recall Ability of Orthodontic Instructions With Both Modalities",[414,415],"AI in orthodontics","Chatbots and health education","2025-09-13",{"date":418,"type":31},"2025-09-19",{"date":394,"type":20},{"date":421,"type":20},"2026-11",{"name":37,"class":38},{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":16,"sex":17,"minAge":430,"maxAge":431,"enrollmentInfo":432,"targetDuration":4,"studyType":21,"phases":434,"briefSummary":435,"conditions":436,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":445,"locationsCount":94},"100599331","effect-of-crown-material-on-gingival-microbial-colonization-100599331","NCT07083102","Effect of Crown Material on Gingival Microbial Colonization","Effect of Crown Material on Gingival Microbial Colonization: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age between 20 to 50 years.\n* Both male and female patients will be selected.\n* Good oral hygiene (Defined as a plaque index score ≤ 1 across all assessed surfaces and no visible calculus deposits)\n* Dentate patients require fixed prostheses for the first time on mandibular pre-molars and molars.\n* Patient with no history of any dental and bony pathosis (cysts, cancerous lesion).\n\nExclusion Criteria:\n\n* Untreated periodontal diseases\n* Xerostomia\n* Pregnancy, lactation\n* Smokers\n* Individuals with systemic conditions like diabetes and immunosuppressive diseases","20 Years","50 Years",{"count":433,"type":20},30,[23],"* Prior approval from SOD ethical committee has been received.\n* All patients presenting to the General OPD of School of Dentistry, Islamabad will be screened. Those patients who fulfill the criteria will be referred to the Prosthodontics department.\n* The patients will undergo detailed history and oral examination after informed consent (Annexure-A). Patients will undergo radiographic investigation and based on this information they will be selected for the study according to the exclusion and inclusion criteria.\n* Eligible participants will be randomly assigned to one of the following groups using a computer-generated sequence with allocation concealment via sealed opaque envelopes:\n\n  * Group A: Control group\n  * Group B: Full-coverage PFM crowns\n  * Group C: Full-coverage Zirconia crowns\n* Baseline gingival samples will be collected with the help of sterile swab from the target tooth region prior to prosthesis placement and at the follow-up visits i.e. 1, and 3 months; both for experimental groups and control group.\n* Microbial analysis will be conducted through culture techniques to quantify CFUs and identify species.\n* A summary of the micro-organisms, their incubation media, temperature and time is presented in the following table:\n\nTable 1: Summary of the micro-organisms, their incubation media, temperature and time Micro-organism Growth Media Temperature Incubation time Candida albicans Saboraud Agar 370C 24-48 hours Streptococcus mutans BHI broth 370C 24-48 hours Staphylococcus aureus BHI broth 370C 24-48 hours Porphyromonas gingivalis BHI broth 370C 18-24 hours\n\n* Alongside, the same sample from sterile swabs will be smeared by fixating it on a microscopic slide and then Candida albicans will be stained by Periodic Acid Schiff technique, and the bacterial species using Gram staining.\n* All participants will receive standardized verbal and written instructions oral hygiene instructions to control for hygiene-related variation",[437,438],"Microbial Colonization","Missing Teeth","2025-07-16",{"date":441,"type":31},"2025-07-24",{"date":443,"type":20},"2025-08-15",{"date":313,"type":20},{"name":37,"class":38},{"id":447,"slug":448,"hasResults":11,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":11,"sex":17,"minAge":453,"maxAge":380,"enrollmentInfo":454,"targetDuration":4,"studyType":21,"phases":456,"briefSummary":457,"conditions":458,"keywords":462,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":94},"100563767","efficacy-of-psychological-intervention-for-children-with-cancer-100563767","NCT06620445","Efficacy of Psychological Intervention for Children With Cancer","Efficacy of Psychological Intervention for Children With Cancer: A Randomized Controlled Trail","Eligibility Criteria:\n\nInclusion Criteria:\n\n1. Children aged 16-18 years\n2. Diagnosed with malignancy\n3. Recieving chemotherapy at the Pediatric Oncology Department of PIMS Islamabad\n4. Able to understand and participate in CBT sessions\n5. Parent\u002FCaregiver consent and child assent\n\nExlusion Criteria:\n\n1. Children with severe cognitive impairment or intellectual disability\n2. Children with a comorbid medical conditions\n3. Children whose parents or caregivers are unable to provide consent","8 Years",{"count":455,"type":20},80,[23],"The study will be conductued at the Pediatric Oncology Department of the Children's Hospital, PIMS Islamabad, over the peroid of six months. This single-blinded, two-arm RCT study will involve 80 children aged 8 to 16 years with maligancies recieving chemotherapy. Participants will be randomly allocated to either interventional or CBT group which will recieve weekly five sessions of Cognitive Behaviour Therapy (CBT) or the control group, which will recieve the usual care. CBT session will be contducted by Clinical Psychologist will last 30-35 minutes. Outcomes will be measured at Baseine and one month post intervention using Revised Child Anxiety and Depression Scale (RCADS) and Pediatric Quality of Life Generic Core Score 4.0.",[459,460,461],"Clinical Depression","Clinical Anxiety","Quality of Life",[463,464],"Psychological Intervention","Pediatric Cancer","2024-09-26",{"date":467,"type":31},"2024-10-01",{"date":469,"type":20},"2024-10-10",{"date":471,"type":20},"2025-06-30",{"name":37,"class":38},""]