[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Palo Alto Veterans Institute for Research\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":228},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,75,98,119,143,180,206],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100609797","engagement-of-veterans-with-lung-cancer-100609797",false,"NCT07219251","Engagement of Veterans With Lung Cancer","Engagement of Veterans With Lung Cancer (EVLC)","EVLC","Inclusion Criteria:\n\n1. Veteran patients with diagnosis of any stage of lung cancer;\n2. 18 years of age or older;\n3. English- or Spanish-speaking;\n4. can self-administer questionnaires in English or Spanish;\n5. valid telephone number;\n6. receiving oncology care at participating sites;\n7. currently newly diagnosed or receiving or having completed systemic anti-cancer therapy and\u002For radiation therapy within 12 months, defined as oral, injection, or intravenous therapy (chemotherapy, targeted therapy, or immunotherapy)\n\nExclusion Criteria:\n\n1. no capacity to consent;\n2. actively receiving hospice care","ALL","18 Years",{"count":20,"type":21},194,"ESTIMATED","INTERVENTIONAL",[24],"NA","This research study will help our understanding of whether additional support for Veterans with lung cancer can improve their quality of life.",[27,28,29,30,31,32],"Lung Cancer (NSCLC)","Lung Adenocarcinoma","Lung Cancer, Non-Small Cell","Lung Carcinoma","Lung Cancer, Small Cell","Lung Adenocarcinoma With Bronchiolo-alveolar Feature",[34,35],"lung","cancer","RECRUITING","2026-03-02",{"date":39,"type":40},"2026-03-03","ACTUAL",{"date":42,"type":40},"2026-02-27",{"date":44,"type":21},"2032-12-31",{"name":46,"class":47},"Palo Alto Veterans Institute for Research","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100570193","online-yoga-vs-acceptance-and-commitment-therapy-for-treating-chronic-musculoskeletal-pain-100570193","NCT06704061","Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain","Inclusion Criteria:\n\n* Veteran of the United States Armed Forces ≥ 18 years old\n* Chronic pain \\> 6 months related to at least one musculoskeletal pain-related diagnosis indicated by an ICD-9 or -10 code\n* Minimum pain intensity at screening ≥4 on a 0-10 using the Defense and Veterans Pain Rating Scale (DVPRS)\n* Not begun new pain treatments or medications in the past month\n* Stable medication regimen for at least 4 weeks prior to entry to the study\n* English literacy\n* Internet connection at home\n\nExclusion Criteria:\n\n* Participation in another clinical trial, unless given prior authorization from both our research team and that of the other study\n* Back surgery within the last 12 months\n* Back pain potentially attributed to a specific known condition\n* Baseline pain \\\u003C4 or ≥9 on a 0-10 Numeric Rating Scale\n* Unstable, serious coexisting medical illness, mental illness or psychiatric conditions\n* Attended or practiced yoga ≥ 1 x in the past 12 months\n* Current suicidal intent or plan\n* Has received ACT in the past",{"count":56,"type":21},274,[24],"This study will compare online yoga with Acceptance and Commitment Therapy (ACT), an established treatment for chronic pain. We will compare the efficacy of the two treatments for reducing chronic musculoskeletal pain in veterans.",[60,61],"Chronic Pain","Musculoskeletal Pain",[63,64,65,66],"chronic pain","veteran","musculoskeletal pain","yoga","2026-01-27",{"date":69,"type":40},"2026-01-29",{"date":71,"type":40},"2026-01-07",{"date":73,"type":21},"2029-11-01",{"name":46,"class":47},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":48},"100616293","intra-procedural-spectral-ct-for-image-guided-embolization-and-ablation-in-interventional-oncology-100616293","NCT07303725","Intra-procedural Spectral CT for Image-guided Embolization and Ablation in Interventional Oncology","Inclusion criteria:\n\n1. Age \\> or = 18 years\n2. Tumor in an area without prior surgical or ablative therapy\n3. At least 1 tumor greater than 1.5 cm in greatest diameter\n\nExclusion criteria:\n\n1. Not eligible for indicated procedure.\n2. BMI \\> 35\n3. Prior surgery.",{"count":82,"type":21},30,"OBSERVATIONAL","This is a pilot study to evaluate the feasibility, image quality, and procedural utility of a novel spectral CT technique using Canon Medical's 4D CT system during image-guided interventional oncology procedures",[86,87],"Liver Cancer (Primary and Metastatic)","Renal Cancer",[89],"spectral CT","2025-12-18",{"date":92,"type":40},"2025-12-26",{"date":94,"type":40},"2025-02-01",{"date":96,"type":21},"2026-09-01",{"name":46,"class":47},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":113,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":48},"100616292","liquid-biopsy-for-hepatocellular-carcinoma-molecular-characterization-after-y90-100616292","NCT07303712","Liquid Biopsy for Hepatocellular Carcinoma Molecular Characterization After Y90","Liquid Biopsy for Hepatocellular Carcinoma Molecular Characterization and Assessment of Treatment Response After Y90 Radioembolization: A Pilot Study","Inclusion Criteria:\n\n1. Age \\> or = 18 years\n2. HCC confirmed on imaging, BCLC stage 0, A, B, or C\n3. Transarterial Y90 radioembolization approved by multidisciplinary tumor board -\n\nExclusion Criteria:\n\n1. Not eligible for Y90 procedure\n2. Prior surgery or ablation on indicated tumors\n3. Patient unable to complete the follow up visits required for clinical care or research -",{"count":106,"type":21},12,"The purpose of this study is to determine if baseline liquid biopsy assays (CTC and cf-DNA) as well as single circulating tumor cell-DNA (sCTC DNA) dynamics in the early post-treatment period can predict subsequent treatment response to Y-90 radioembolization in patients with hepatocellular carcinoma (HCC).",[109],"Hepatocellular Carcinoma (HCC)",[111,112],"Circulating tumor cell (CTC)","y90",{"date":92,"type":40},{"date":115,"type":40},"2024-08-01",{"date":117,"type":21},"2026-12-01",{"name":46,"class":47},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":48},"100598286","accelerated-treatment-for-co-occurring-insomnia-nightmares-and-ptsd-100598286","NCT07069517","Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD","Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Defense Enrollment Eligibility Reporting System (DEERS) eligible active-duty military personnel or veteran, 18-65 years old.\n2. Ability to speak and read English.\n3. Clinically significant PTSD symptoms (CAPS-5 \\> 25 with at least one Intrusion symptom and at least one Avoidance symptom).\n4. Clinically significant symptoms of insomnia disorder (Structured Clinical Interview for Sleep Disturbance DSM-5 (SCISD) Insomnia Criteria are met and Insomnia Severity Index (ISI) \\> 11).\n5. Nightmares \\> 1 monthly (as reported on the SCISD).\n6. Willing to refrain from new behavioral health or medication treatment for issues pertaining to PTSD, sleep, and nightmares during study participation.\n\nExclusion Criteria:\n\n1. Current suicide or homicide risk meriting crisis intervention.\n2. Inability to comprehend the baseline screening questionnaires.\n3. Unwilling to remain abstinent from alcohol during therapy sessions.\n4. Serious mental health symptoms, such as mania, psychosis, alcohol or substance use disorders warranting immediate clinical attention based on interviewer assessment and clinical judgement.\n5. Currently engaged in evidence-based psychotherapy for PTSD (e.g., Prolonged Exposure Therapy, Cognitive Processing Therapy, Written Exposure Therapy) or insomnia or nightmares (e.g., Cognitive Behavioral Therapy for Insomnia or Nightmares).\n6. Pregnancy, as determined by self-report, because pregnancy can adversely affect sleep outside of PTSD, insomnia, and nightmares.\n7. Working duty shifts ending later than 21:00 or starting before 05:30 more than 2 times per month.","65 Years",{"count":128,"type":21},160,[24],"This study is a two-arm individually randomized group treatment clinical trial evaluating behavioral therapies for insomnia, nightmares, and PTSD. The study will compare cognitive-behavioral therapy for insomnia and nightmares to sleep hygiene (Control), both integrated with Written Exposure Therapy for PTSD and delivered in an accelerated (i.e., 5-day) group treatment format, preceded and followed by individual treatment sessions. 160 participants will be randomized into one of two study conditions.",[132,133,134],"Insomnia","PTSD - Post Traumatic Stress Disorder","Nightmares","2025-12-01",{"date":137,"type":40},"2025-12-03",{"date":139,"type":21},"2025-12-02",{"date":141,"type":21},"2028-12-01",{"name":46,"class":47},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":155,"conditions":156,"keywords":164,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":48},"100493094","perfusion-mri-targeted-joint-embolization-for-chronic-musculoskeletal-pain-of-the-shoulder-hip-and-knee-100493094","NCT05700682","Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee","Perfusion MRI-targeted Joint Embolization to Diagnose and Treat Neovascularity Associated With Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee: A Prospective Cohort Study","MRI","Inclusion Criteria (Both Arms):\n\n1. Participants must be Veterans who receive care in the VA system.\n2. Participants must have a history of chronic pain of the shoulder, hip or knee for at least 1 year.\n3. Participants must have mild to moderate degenerative changes of the painful joint as depicted on prior imaging (X-ray, CT or MRI).\n4. Participants must have undergone at least one failed primary treatment for their chronic pain (e.g. physical therapy, NSAIDs, steroid injection).\n5. Participants must have an MRI of their painful joint (shoulder, hip or knee) ordered by a clinical provider.\n\nInclusion Criteria (Therapeutic Arm):\n\n1. Participants must have enrolled in the Diagnostic Arm of the study and must have undergone perfusion MR imaging of their painful joint.\n2. Participants must have evidence of peri-articular hypervascularity on their perfusion MR exams. This will be determined by the study PIs.\n\nExclusion Criteria (Diagnostic Arm):\n\n1. Acute injury in the last 12 weeks.\n2. Age under 25.\n3. Severe degenerative changes of painful joint (shoulder, hip or knee).\n4. History of arthroplasty or metallic implant within the painful joint.\n5. Severe gadolinium contrast allergy.\n6. Severe renal disease or ongoing dialysis.\n7. History of malignancy with life expectancy of less than one year, or malignancy with known bone metastasis.\n8. Current pregnancy.\n9. Formal diagnosis of cognitive impairment.\n\nExclusion Criteria (Therapeutic Arm):\n\n1. Severe iodinated contrast allergy.\n2. Severe coronary or peripheral arterial disease.\n3. Coagulopathy.\n4. Uncontrolled type 2 diabetes or diabetic neuropathy.\n5. History of seizures or other severe complication from conscious sedation.\n6. Prior upper or lower extremity arterial bypass.\n7. Ongoing participation in another interventional (therapeutic) trial for chronic joint pain.\n8. Lack of peri-articular hypervascularity on initial perfusion MRI.\n9. All exclusion criteria for the Diagnostic Arm.","25 Years","80 Years",{"count":154,"type":21},120,"In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild\u002Fmoderate joint degenerative changes will be potential study subjects. Blood flow around joints will be evaluated using perfusion magnetic resonance imaging (MRI). Participants with demonstrably abnormal blood flow around their painful joint will be eligible for enrollment in a pilot study of joint embolization to treat their pain. Participants who choose to not undergo treatment will be re-assessed with MRI after one year to characterize the natural history of joint neovascularity and its relationship to pain.",[157,158,159,160,161,162,163],"Osteoarthritis, Knee","Osteoarthritis, Hip","Osteo Arthritis Shoulders","Synovitis of Knee","Synovitis\u002FTenosynovitis - Hip","Synovitis","Pain, Chronic",[165,166,167,168,169,170,171],"joint","embolization","neovascularity","pain","knee","hip","shoulder","2025-08-04",{"date":174,"type":40},"2025-08-07",{"date":176,"type":40},"2023-07-15",{"date":178,"type":21},"2026-08-01",{"name":46,"class":47},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":187,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":198,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":203,"leadSponsor":205,"locationsCount":4},"100576791","behavioral-health-technician-delivered-written-exposure-therapy-100576791","NCT06789887","Behavioral Health Technician Delivered Written Exposure Therapy","Increasing Access to Evidenced-Based PTSD Treatment in the Military: Behavioral Health Technician Delivered Written Exposure Therapy","Inclusion Criteria:\n\nPatient participants:\n\n1. Adult active duty personnel ages ≥18\n2. Clinically significant PTSD symptoms (CAPS-5 ≥ 25).\n\nClinic staff participants: Individuals working as BHTs, clinic providers, and clinic leaders working at the behavioral health clinics participating in the study\n\nExclusion Criteria:\n\nPatient participants:\n\n1. Current suicide or homicide risk meriting crisis intervention\n2. Serious mental health symptoms, such as mania, psychosis, alcohol or substance use disorders warranting immediate attention\n3. Inability to comprehend the baseline screening questionnaires\n4. Definite plans to leave the military within 10 weeks\n\nClinic staff participants:\n\nNone",true,{"count":189,"type":21},150,[24],"This study has two main goals. First, it aims to test a treatment called written exposure therapy to see if it can help military service members who have posttraumatic stress disorder (PTSD). Second, it aims to test a new way of making this therapy more accessible in military clinics by utilizing task-sharing with Behavioral Health Technicians (BHTs). PTSD is a common and serious issue among service members. Written exposure therapy (WET) has been proven to be effective for improving PTSD that requires five therapy sessions delivered weekly. This study aims to determine:\n\n1. How well does written exposure therapy help to reduce symptoms of posttraumatic stress for service members with PTSD?\n2. Is sharing the therapy tasks with behavioral health technicians is a helpful approach for managing behavioral health clinic patient volume and improving patient outcomes?\n\nWe plan to recruit a total of 40-59 staff participants, as well as 150 active-duty patient participants with PTSD. We will randomize patient participants to one of two treatment conditions: 1) treatment-as-usual (TAU) or 2) TAU and 5 sessions of WET. Staff and participants will be recruited from two military treatment facilities: 1) Fort Sam Houston in San Antonio (Brooke Army Medical Center) and 2) Camp Pendleton (Naval Hospital at Camp Pendleton).\n\nConsented patient participants will:\n\n* Complete a PTSD interview via telehealth with a study team member to determine if you are eligible for the study\n* Be randomly assigned to one of the following conditions: 1) TAU + WET or 2) TAU\n* Complete up to 8 weeks of behavioral health treatment (either TAU + WET or TAU)\n* Complete self-report measures before, during, and after treatment, and at a 3- and 6-month follow up assessment after the treatment period\n* Complete a posttreatment PTSD interview via telehealth with a study team member\n* A subset of participants will be asked to complete a brief treatment experience interview posttreatment\n\nConsented staff participants will:\n\n* Participate in an interview about your perceptions of and experiences supporting BHT-delivered WET with a study team member at the VAPAHCS\n* A subset of participants will also be asked to participate in a brief staff feedback interview approximately 6 months after their first interview",[193,194],"Post Traumatic Stress Disorder","Written Exposure Therapy",[196,193,197,194],"PTSD","Behavioral Health Technician","NOT_YET_RECRUITING","2025-01-16",{"date":201,"type":40},"2025-01-23",{"date":94,"type":21},{"date":204,"type":21},"2028-09-30",{"name":46,"class":47},{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":22,"phases":216,"briefSummary":217,"conditions":218,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":48},"100559656","prehabilitation-and-rehabilitation-in-pad-100559656","NCT06566976","Prehabilitation and Rehabilitation in PAD","Prehabilitation and Rehabilitation in PAD: A Randomized Exercise Intervention Trial (PREPARE-IT)","PREPARE-IT","Inclusion Criteria:\n\n* Male or Female adult diagnosed with peripheral artery disease (PAD)\n* Experiencing leg pain while walking\n* Scheduled to have a stent for PAD\n* Able to perform exercise safely\n* Postmenopausal and not of child bearing capacity\n\nExclusion Criteria:\n\n* Medically unstable patients\n* Recent MI within 3 months\n* Malignancy\n* Uncontrolled diabetes mellitus (HBA1C ≥8 mmol\u002Fl)\n* Alcoholism or other recreational drug use",{"count":215,"type":21},300,[24],"To determine the effectiveness of pre and post-operative exercise therapy in patients undergoing peripheral artery stenting for peripheral arterial disease.",[219],"Peripheral Arterial Disease","2024-08-19",{"date":222,"type":40},"2024-08-22",{"date":224,"type":40},"2024-03-07",{"date":226,"type":21},"2027-07-25",{"name":46,"class":47},""]