[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Papa Giovanni XXIII Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":215},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,71,102,141,167,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641693","long-term-safety-of-preoperative-percutaneous-intercostal-cryoneurolysis-100641693",false,"NCT07657845","Long Term Safety of Preoperative Percutaneous Intercostal Cryoneurolysis","Long Term Safety of Preoperative Percutaneous Intercostal Cryoneurolysis: Neuropathic Pain, Quality of Life and Sensory Recovery in a Paediatric Cohort Following Pectus Excavatum Repair","CRYOFUP","Inclusion Criteria:\n\n* Patients who underwent percutaneous cryoneurolysis.\n* Patients who underwent surgical correction of pectus excavatum according to the Nuss procedure.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Peripheral nervous system disorders\n* Age \\\u003C 14 years\n* Failure to attend scheduled follow-up visits","ALL","14 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","Follow up of patients who underwent percutaneous cryoneurolysis for pectus excavatum repair (the Nuss procedure) pain management",[25,26],"Cryo Analgesia","Pectus Surgery",[28,29,30,31,32,33,34,35],"follow up","lanss","neuropathy","chronic pain","cpsp","neuropathic pain","sensitivity recovery","PedsQL","RECRUITING","2026-06-17",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":40},"2025-02-02",{"date":44,"type":21},"2029-01-15",{"name":46,"class":47},"Papa Giovanni XXIII Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":48},"100615282","phrenic-infiltration-as-cryoanalgesia-adjuvant-for-early-postoperative-pain-following-the-nuss-procedure-100615282","NCT07290582","Phrenic Infiltration as Cryoanalgesia Adjuvant for Early Postoperative Pain Following the Nuss Procedure","PHABULA","Inclusion Criteria:\n\n* patients who undergo minimally invasive repair at the pediatric surgery department of our referral tertiary center\n\nExclusion Criteria:\n\n* patients who refuse OR whose parents refuse to participate in the study",{"count":20,"type":21},"The goal of this observational ambispective study is to compare the effectiveness of two pain management strategies in pediatric patients undergoing the Nuss procedure for pectus excavatum. The main questions it aims to answer are:\n\nDoes the addition of phrenic Infiltration as Cryo Adjuvant (PhICA) to earlier percutaneous intercostal cryoanalgesia (EPIC) reduce postoperative pain scores compared to EPIC alone? Does the combined EPIC + PhICA technique reduce the need for rescue tramadol compared to EPIC alone? Do the two approaches differ in: length of hospital stay, time to transition to oral therapy, and time to mobilization? Are there any side effects\n\nResearchers will compare patients who received EPIC alone to patients who received EPIC + PhICA to see if the combined technique provides superior pain control.\n\nParticipants:\n\nReceived either EPIC alone or EPIC combined with PhICA as part of their surgical anesthesia plan Had pain levels assessed using the Numeric Rating Scale (NRS) at regular postoperative intervals Were monitored for rescue tramadol requirements, medicaments taken, length of hospital stay, and mobilization timing Were monitored for any technique-related complication",[59,25,60],"Pectus Excavatum","Phrenic Nerve-related Diaphragmatic Impairment",[62],"cryoanalgesia pectus phrenic","2026-06-13",{"date":65,"type":40},"2026-06-16",{"date":67,"type":40},"2023-09-14",{"date":69,"type":21},"2026-08-15",{"name":46,"class":47},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":48},"100600946","comparison-between-2-techniques-for-lumbar-espb-100600946","NCT07104097","Comparison Between 2 Techniques for Lumbar-ESPB","Regional Anesthesia in Hip Arthroplasty- Comparison Between Two Techniques for Erector Spinae Plane Block","ESPTA","Inclusion Criteria:\n\n* primary total hip replacement\n* informed consent\n\nExclusion Criteria:\n\n* allergies to study drugs\n* spinal anesthesia contraindicated\n* kidney failure (GFR\\\u003C30)\n* epilepsy, psychiatric disease, neurologic deficits\n* revision surgery\n* neuropathies in the lumbar area (tingling, hypoestesia, numbness, motor deficit)\n* no informed consent\n* pregnancy\n* alcohol\u002Fopioid abuse\n* emergency surgery\u002Fintensive care","18 Years",{"count":81,"type":21},44,"INTERVENTIONAL",[84],"NA","Diffusion of local anesthetics after a lumbar ESPB within fascial planes towards nerve structures is a matter of debate.\n\nThe main objective of the study is to compare the incidence of sensory block between two techniques of needle placement (superficial or translaminar) during lumbar ESPB block.\n\nPatients are treated with lumbar ESPB (randomized to superficial or translaminar), spinal anesthesia and multimodal analgesia.\n\nThe primary endpoint will be the incidence of numbness\u002Freduced skin sensitivity to cold (ice test) in the area innervated by the lumbar plexus. Secondary outcomes are pain and analgesic's consumption, motor block, quality of recovery and discharge ability.",[87],"Hip Surgery",[89,90,91,92,93],"erector spinae plane block","hip surgery","sensory block","motor block","local anesthetic","2026-05-11",{"date":96,"type":40},"2026-05-12",{"date":98,"type":40},"2025-10-06",{"date":100,"type":21},"2026-08-20",{"name":46,"class":47},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":109,"targetDuration":111,"studyType":22,"phases":4,"briefSummary":112,"conditions":113,"keywords":121,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":48},"100636493","overviewing-real-world-outcomes-to-boost-interventional-management-of-calcified-coronary-lesions-the-orobica-registry-100636493","NCT07566403","Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions: the OROBICA Registry.","OROBICA","Inclusion Criteria:\n\n* Patients undergoing percutaneous coronary intervention (PCI) for severely calcified coronary lesions, angiographically defined as radiopacities noted without cardiac motion before contrast injection, generally involving both sides of the arterial wall.\n* Patients undergoing PCI for calcified coronary lesions with intracoronary optical coherence tomography (OCT) showing at least one of the following features:\n\n  * calcium arc ≥180°\n  * calcium thickness ≥0.3 mm\n  * calcium length ≥3 mm\n  * presence of calcified nodules\n* Patients undergoing PCI for calcified coronary lesions with intravascular ultrasound (IVUS) showing at least one of the following features:\n\n  * calcium arc ≥180°\n  * concentric or superficial calcium with extensive acoustic shadowing\n  * presence of calcified nodules\n\nExclusion Criteria:\n\n* Lack of availability of essential clinical or procedural data.\n* Refusal or withdrawal of informed consent for the prospective component of the registry, when applicable.\n* Exercise of the right to object to data processing, according to applicable data protection regulations.",{"count":110,"type":21},3000,"5 Years","The OROBICA (Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions) Registry is a multicenter, ambispective, real-world observational study designed to evaluate clinical, procedural, imaging, and economic outcomes of patients undergoing percutaneous coronary intervention (PCI) for severely calcified coronary artery disease.\n\nCoronary artery calcification represents one of the main determinants of procedural complexity and adverse outcomes in contemporary interventional cardiology. Despite the increasing availability of advanced calcium-modification technologies and intracoronary imaging techniques, evidence regarding the optimal treatment strategy in real-world clinical practice remains limited, particularly among high-risk and complex patients often underrepresented in randomized trials.\n\nThe OROBICA Registry aims to systematically collect longitudinal data from all-comer patients treated for severely calcified coronary lesions using contemporary PCI strategies, including intracoronary imaging guidance (IVUS\u002FOCT), rotational atherectomy, orbital atherectomy, intravascular lithotripsy, specialty balloons, and combined calcium-modification approaches.\n\nThe primary objective is to assess clinical and procedural outcomes, with particular focus on target vessel failure (TVF). Secondary and exploratory objectives include evaluation of procedural success, imaging findings, predictors of adverse outcomes, healthcare resource utilization, and economic impact associated with the treatment of calcified coronary lesions.\n\nThe registry is designed as a flexible research platform intended to support future hypothesis-generating analyses and provide real-world evidence to improve personalized management strategies for calcified coronary artery disease.",[114,115,116,117,118,119,120],"Coronary Artery Disease (CAD)","Calcific Coronary Arteriosclerosis","Intravascular Lithotripsy; Rotational Atherectomy; OFDI","Orbital Atherectomy","Optical Coherence Tomography (OCT)","Intravascular Ultrasound","Percutaneous Coronary Intervention",[122,123,124,125,126,127,128,129,130,131],"Coronary calcifications","coronary artery disease","percutaneous coronary intervention","intravascular imaging","atherectomy","intravascular lithotripsy","rotational atherectomy","orbital atherectomy","cutting balloon","target vessel failure","NOT_YET_RECRUITING","2026-05-04",{"date":135,"type":40},"2026-05-06",{"date":137,"type":21},"2026-06-30",{"date":139,"type":21},"2036-06-30",{"name":46,"class":47},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":148,"sex":17,"minAge":149,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":48},"100599217","percutaneous-intercostal-cryoneuromodulation-onset-timing-100599217","NCT07081620","Percutaneous Intercostal Cryoneuromodulation Onset Timing.","How Long Does it Take for Percutaneous Intercostal Cryoneuromodulation to Produce Cryoanalgesia? A Prospective Observational Study.","Inclusion Criteria:\n\n* Patients who are undergoing preoperative percutaneous intercostal cryoneurolysis for pectus excavatum surgery\n\nExclusion Criteria:\n\n* failure to obtain consent",true,"12 Years","40 Years",{"count":152,"type":21},20,"Percutaneous Intercostal Cryoneurolysis is a promising technique that addresses acute postoperative pain after Nuss procedure for pectus excavatum. However its onset timing has not yet been determined. A physical examination would assess the variation of chest skin sensitivity to soft touch, cold (water at 4°C), and heat (water at 40°C) through days following the cryoneurolysis procedure.",[155,59],"Cryotherapy Effect",[157,158],"Cryoneurolysis","Cryoneuromodulation","2025-07-22",{"date":161,"type":40},"2025-07-23",{"date":163,"type":40},"2025-06-07",{"date":165,"type":21},"2026-11",{"name":46,"class":47},{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":148,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":82,"phases":176,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":48},"100552989","cerebral-blood-flow-helmet-vs-oronasal-mask-during-continuous-positive-airway-pressure-ventilation-100552989","NCT06480253","Cerebral Blood Flow: Helmet vs Oronasal Mask During Continuous Positive Airway Pressure Ventilation","Variation of Cerebral Blood Flow Depending on the Interface Chosen During Continuous Positive Airway Pressure Ventilation","Inclusion Criteria:\n\n* Age ≥ 18 years,\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* known cardiac pathologies\n* known pulmonary pathologies\n* known vascular pathologies\n* history of concussion\n* history of headache",{"count":175,"type":21},19,[84],"In this trial the investigators will evaluate blood flow in common carotid artery of healthy subjects treated with Continuous Positive Airway Pressure (CPAP) Ventilation, comparing two different devices: oronasal mask versus Helmet. The hypothesis is that Helmet CPAP reduces carotid flow compared to oronasal mask.",[179],"Ventilation Therapy",[181],"Continuous Positive Airway Pressure","2024-06-24",{"date":184,"type":40},"2024-06-28",{"date":186,"type":21},"2024-07-01",{"date":188,"type":21},"2024-07-31",{"name":46,"class":47},{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":82,"phases":200,"briefSummary":201,"conditions":202,"keywords":205,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":214,"locationsCount":48},"100325285","high-flow-nasal-cannulae-vs-venturi-mask-in-respiratory-failure-due-to-pneumonia-100325285","NCT03515031","High Flow Nasal Cannulae vs Venturi Mask in Respiratory Failure Due to Pneumonia","Open Randomized Controlled Clinical Trial Comparing Oxygen Therapy by High Flow Nasal Cannulae and by Venturi Mask in the Treatment of Acute Respiratory Failure Due to Severe Pneumonia (Hi Flow Oxygen vs Venturi Mask In Pneumonia)","HiFlOViP","Inclusion Criteria:\n\n* male or female of any ethnic group\n* age greater than or equal to 18 years;\n* respiratory rate (RR) at rest ≥ 20 breaths\u002Fminute or presence of respiratory distress (severe - dyspnea at rest or use of accessory respiratory muscles or paradox abdominal movement) PaO 2\u002F FiO 2 ≤250 during oxygen therapy with Venturi mask with FiO 2 50% administered for at least 60 minutes;\n* diagnosis of pneumonia as the unique cause of acute respiratory failure\n* informed consent obtained from the patient or the closest relative in case of patient's inability to give it.\n\nExclusion Criteria:\n\n* other diagnoses (instead of pneumonia) as a cause of acute respiratory failure\n* unstable angina and acute myocardial infarction in place;\n* Acute respiratory acidosis with pH \\\u003C7.35 and PaCO 2 \\> 45 mmHg;\n* systolic blood pressure \\\u003C90 mmHg unresponsive to fluids or with amines\n* severe arrhythmias;\n* epileptic seizures;\n* the degree of vigilance depending on the Kelly scale \\> 3 (see Appendix II)\n* impaired swallowing, which increases the risk of pneumonia aspiration inability to protect airways\n* craniofacial trauma or burns\n* uncooperative patient\n* presence of open wound (skull, chest, abdomen)\n* respiratory arrest or need for intubation\n* ongoing pregnancy or suspected",{"count":199,"type":21},150,[84],"The primary objective of this study is to compare the efficacy of treatment with HFNC (group A) compared to administration of oxygen therapy by Venturi mask (group B, standard therapy) in terms of reaching of endotracheal intubation criteria during acute respiratory failure due to severe pneumonia.\n\nInclusion Criteria: Respiratory rate (RR) at rest ≥20 bpm or presence of respiratory distress (severe dyspnoea at rest or use of accessory respiratory muscles or abdominal paradox); PaO2 \u002F FiO2 ≤250 during oxygenation with Venturi Oxygenation mask at FiO2 = 50% administered for at least 60 minutes; Diagnosis of pneumonia as the sole cause of acute respiratory failure. Randomization: 150 consecutive patients will be randomized either to High Flow Nasal Cannula Oxygenation (75 patients, HFNCO with flow ≥ 60 L\u002Fmin and FiO2 to maintain SpO2 ≥ ) or Venturi Mask Oxygenation (control, 75 patients).\n\nPatients from both groups will be treated with antibiotic therapy according to the IDSA\u002FATS 2007 guidelines for community-acquired pneumonia and the IDSA\u002FATS 2016 guidelines for hospital-acquired pneumonia.\n\nIntubation Criteria:\n\nMAJOR CRITERIA:\n\nCardiac or respiratory arrest Breathing pauses with loss of consciousness Severe hemodynamic instability Need for sedation\n\nMINOR CRITERIA (maintained for ≥1h):\n\nReduction ≥30% of the value of the PaO2\u002FFiO 2 compared to baseline Increased 20% if PaCO2 PaCO2 previous ≥40mmHg Worsening alertness as increased by one degree on the Kelly scale Persistence or onset of respiratory distress Vital parameters, Kelly scale and arterial blood gas analysis (BGA) will be performed on admission, and at 1, 24, at 48 hours, at the achievement of clinical stability, and whenever there is a clinical worsening.\n\nPatients enrolled in HFNC arm will continue HFNC oxygenation until clinical stability, defined as:\n\nBody temperature ≤ 37°C and ≥36°C for 24 consecutive hours Good ability in swallowing CRP and WBC normalization trend than the admission exams Hemodynamic stability Lack of respiratory distress SpO2 94-98% The primary outcome variable is the proportion of patients who reach the endotracheal intubation criteria - regardless of the actual intubation rate - within the first 48 hours of treatment. The primary analysis will be performed on the ITT population",[203,204],"Respiratory Insufficiency","Pneumonia",[206,207],"High Flow Nasal Cannula","Venturi mask","2024-03-05",{"date":210,"type":40},"2024-03-07",{"date":212,"type":40},"2023-06-01",{"date":137,"type":21},{"name":46,"class":47},""]