[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Patan Academy of Health Sciences\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100593308","etiology-of-febrile-illness-in-nepal-define-study-100593308",false,"NCT07004751","Etiology of Febrile Illness in Nepal (DEFINe Study)","Determination of Etiology of Febrile Illness in Nepal (DEFINe Study)","DEFINe","Inclusion Criteria:\n\n* Age 16 years or older\n* Documented fever (T ≥100.4F or ≥38C) of 3 days to 21 days duration\n* No obvious diagnosis found on the basis of clinical, radiological, or initial routine laboratory tests\\*\n* Admitted to the medical unit of hospital\n* Signed ICF (informed consent form)\n\nExclusion Criteria:\n\n* Outpatients\n* Fever of less than 3 days or more than 21 days duration\n* Patients being discharged from Emergency Room\n* Children (younger than 16 years in age)\\*\\*\n* Immunocompromised patients\n* Neutropenia (ANC \\\u003C500 per cumm)\n* Known case of HIV infection\n* Admission to a hospital for 48-hours or longer within past 30 days","ALL","16 Years",{"count":20,"type":21},194,"ESTIMATED","INTERVENTIONAL",[24],"NA","In the absence of a microbiological lab testing, majority of the cases of febrile illnesses in Nepal are diagnosed on a clinical basis alone. These cases of \"undifferentiated febrile illness\" are treated empirically with multiple antibiotics without an etiological diagnosis. Unnecessary use of antibiotics can increase the risk of antibiotic resistance and adds unnecessary burden of cost to the patients and their families.\n\nThis study aims to determine the etiology of infections using additional microbiological techniques in patients admitted to the hospital with acute undifferentiated febrile illness of 3 days to 21 days duration, and assess its impact on use of antimicrobial drugs. In addition to the clinical features, the etiological diagnosis will be confirmed by using additional tests including culture techniques and ELISA based serological tests for 7 additional pathogens which are currently not tested in Nepal. Patients meeting definition of undifferentiated fever of 3 days to 21 days duration will be enrolled from a major tertiary care center using predefined inclusion and exclusion criteria.This study will help to identify additional infectious diseases prevalent in Nepal, decrease unnecessary empirical use of multiple antibiotics, and improve patient outcome. Additionally, identification of new causes of febrile illness will help in prevention and control of these infectious diseases at public health level.",[27,28],"Febrile Illness","Fever Without Source",[30],"Febrile Illnes","RECRUITING","2025-07-29",{"date":34,"type":35},"2025-08-03","ACTUAL",{"date":37,"type":35},"2025-07-04",{"date":39,"type":21},"2026-10-01",{"name":41,"class":42},"Patan Academy of Health Sciences","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100539471","comparison-between-drinking-water-and-normal-saline-in-irrigating-traumatic-wound-100539471","NCT06304272","Comparison Between Drinking Water and Normal Saline in Irrigating Traumatic Wound","Comparison Between Drinking Water and Normal Saline in Irrigating Traumatic Wound: Noninferiority Trial","Inclusion Criteria:\n\n* Laceration wound presenting within 6 hours of duration\n* Lacerations involving upper and lower limbs, scalps, head and neck\n\nExclusion Criteria:\n\n* Lacerations involving, lips, ears, mucosal surface, perineal and peri anal region\n* Punctured or penetrating wound\n* Bite wounds by human or animals or snakes\n* Dirty wound requiring surgical debridement\n* Patient requiring irrigation of wound with more than 1 liter of fluid\n* Wounds involving tendon, joint or bone\n* Wound associated with open fracture\n* Patient on corticosteroid, antibiotics or immunosuppressant\n* Patient who are not able to come for follow-up\n* Immunocompromised patient\n* Patient with history of significant peripheral vascular disease",{"count":52,"type":21},440,[24],"There is a controversy regarding the roles of the Normal saline and Tap water in irrigation of the wound. It has been suggested that antiseptic solution including normal saline has cytotoxic effect while tap water damages the fibroblast. There are no high level evidence to support one type of solution over other, systematic review have found no difference in wound infection between irrigation with normal saline vs tap water. There are ten randomized controlled trial comparing tap water with normal saline for irrigating wound published between 1992 to 2016. These RCT are analyzed in three systemic review and meta-analysis published on 2016, 2019, 2022, which showed that tap water and normal saline has no difference in terms of infection rate. The infection rate observed in various studies ranges from 0-11.5% in normal saline group and 0-12.6% in tap water group with no statistically significant difference.",[56],"Trauma",[58,59],"Traumatic Wound","Wound Infection","NOT_YET_RECRUITING","2024-03-04",{"date":63,"type":35},"2024-03-12",{"date":65,"type":21},"2024-03",{"date":67,"type":21},"2027-12",{"name":41,"class":42},""]