[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Paul Kim\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100293612","phase-4-allograft-dysfunction-in-heart-transplant-100293612",false,"NCT03102125","Allograft Dysfunction in Heart Transplant","Defining Mechanisms for Cardiac Allograft Dysfunction to Improve Allograft Longevity and Survival in Heart-Transplant Patients","Inclusion Criteria:\n\n* Age greater than or equal to 18 years old.\n* At least three months status post heart transplantation.\n\nExclusion Criteria:\n\n* Biopsy proven acute rejection episode in the past 3 months.\n* Patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months.\n* Uncontrolled obstructive ventilatory disease including asthma and COPD.\n* History of generalized tonic-clonic seizures.\n* Second or third degree AV nodal block.\n* Sinus node dysfunction.\n* Contraindications to MRI including cardiovascular implantable electronic devices.\n* Renal dysfunction with an estimated GFR less than 30 mL\u002Fmin\u002F1.73m2.\n* Prior adverse reaction to either regadenoson or gadolinium contrast. Prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis.\n* Systolic blood pressure greater than 180 or less than 85 mmHg.\n* Diastolic blood pressure greater than 120 or less than 40 mmHg.\n* Resting heart rate greater than 120 or less than 45 beats per minute. - Severe claustrophobia.","ALL","18 Years",{"count":19,"type":20},376,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.",[26],"Heart Transplant Failure and Rejection",[28,29,30],"heart transplant","acute graft rejection","chronic graft rejection","RECRUITING","2026-04-27",{"date":34,"type":35},"2026-05-01","ACTUAL",{"date":37,"type":35},"2019-10-01",{"date":39,"type":20},"2027-01-02",{"name":41,"class":42},"Paul Kim","OTHER",""]