[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Penn State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":660},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,50,0,25,[9,47,77,99,128,153,184,211,237,259,284,306,329,350,368,389,418,444,473,505,524,553,584,610,630],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100644913","lion-tracks-eeg-pilot-understand-cognitive-responses-to-crossfit-in-mother-child-dyads-100644913",false,"NCT07677345","Lion Tracks EEG Pilot: Understand Cognitive Responses to CrossFit in Mother-Child Dyads","Lion Tracks EEG Pilot","Lion Tracks","Inclusion Criteria\n\n* Adult participant is a mother or female primary caregiver aged 18 years or older.\n* Child participant is at least 3 years of age.\n* Mother and child are willing to participate together as a dyad.\n* Mother and child are able to understand and speak English.\n* Mother and child are willing to attend two study visits at a participating community fitness facility.\n* Mother and child are able to safely participate in moderate-to-vigorous physical activity as determined by health screening procedures.\n* Mother is willing to provide informed consent and child is willing to provide assent when appropriate.\n\nExclusion Criteria \\*Mother\\*\n\n* Pregnancy at the time of participation.\n* Any cardiovascular, metabolic, respiratory, neurological, musculoskeletal, or other medical condition that would make exercise unsafe.\n* Current injury or physical limitation preventing participation in exercise.\n* History of seizure disorder or other condition that may interfere with EEG assessment.\n* Inability to complete study procedures or wear EEG equipment. \\*Child\\*\n* Medical condition, injury, or physical limitation that would make participation in exercise unsafe.\n* Neurological condition or developmental disorder that would prevent completion of study procedures, as determined by the parent and study team.\n* History of seizure disorder or other condition that may interfere with EEG assessment.\n* Inability to tolerate wearing the EEG headset or complete study procedures. \\*Dyad\\*\n* Either the mother or child is unable or unwilling to complete both study visits.\n* Either participant has a contraindication to exercise identified during screening.\n* Either participant has a condition that, in the opinion of the investigators, would make participation unsafe or compromise data quality.",true,"FEMALE","3 Years",{"count":22,"type":23},20,"ESTIMATED","INTERVENTIONAL",[26],"NA","The purpose of this study is to examine how participating in exercise together versus separately influences brain function, cognitive performance, mood, and parent-child connection in mother-child dyads. Mothers and their children will complete two fitness class visits at a participating community fitness facility\u002FCrossFit affiliate. During one visit, mothers and children will exercise in separate age-appropriate classes, and during the other visit they will exercise together in a shared class. Before and after each exercise session, participants will complete brief assessments of cognition, mood, and brain activity using a portable electroencephalography (EEG) device. Findings from this pilot study will help determine the feasibility of conducting community-based neuroscience research and may inform future family-centered physical activity programs designed to support brain, emotional, and social health.",[29],"Cognition",[31,32,33,34],"Mother-Child Dyads","CrossFit","Brain Health","Family-Based Physical Activity","NOT_YET_RECRUITING","2026-06-30",{"date":38,"type":39},"2026-07-02","ACTUAL",{"date":41,"type":23},"2027-01-01",{"date":43,"type":23},"2028-03-01",{"name":45,"class":46},"Penn State University","OTHER",{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":18,"sex":19,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100577459","phase-4-role-of-menopause-in-thermoregulation-100577459","NCT06798571","Role of Menopause in Thermoregulation","The Influence of Estrogen on the Thermoregulatory Responses to Heat Stress in Pre and Postmenopausal Women","Inclusion Criteria:\n\n* Women ages 42-64\n\nExclusion Criteria:\n\n* Chron's disease, diverticulitis, or similar gastrointestinal disease\n* Abnormal resting exercise electrocardiogram (ECG)\n* Tobacco use\n* High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor\n* Assessment\n* Using hormone therapy\n* Using hormonal contraceptives","42 Years","64 Years",{"count":57,"type":23},24,[59],"PHASE4","The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men.\n\nAging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.",[62,63],"Menopause","Aging",[65,66],"Thermoregulation","Heat Stress","RECRUITING","2026-06-23",{"date":70,"type":39},"2026-06-24",{"date":72,"type":39},"2025-03-01",{"date":74,"type":23},"2026-09-01",{"name":45,"class":46},1,{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":24,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":76},"100642880","nature-as-medicine-for-the-healing-brain-utilization-of-a-nature-based-exposure-intervention-for-decreasing-concussion-recovery-timeline-and-symptom-load-100642880","NCT07642739","Nature as Medicine for the Healing Brain: Utilization of a Nature-based Exposure Intervention for Decreasing Concussion Recovery Timeline and Symptom Load","Inclusion Criteria:\n\n1. Require that any participant is 14-35 years old\n2. Required that any participant under 18 years old can be accompanied by a parent or legal guardian for the duration of the study\n3. Required that participants be English speakers\n4. Required that persons be able to provide consent for themselves\n5. Required that the participant must have suffered a clinically diagnoses concussion 5 days or less prior to the first study visit\n6. Concussion must have been diagnosed by a licensed clinical medicine professional.\n7. No additional professional treatment modalities outside of normal clinical concussion recovery recommendations may have been received prior to study participation. These include participation in a separate concussion rehabilitation study, cognitive behavioral therapies, vestibule-ocular therapies (balance), in-patient physical therapy, consumption of stimulant medication, and chiropractic manipulation.\n8. Injury must have been diagnosed as a concussion or mild-traumatic brain injury. Participant must not have been diagnosed with of severe traumatic brain injury, hematoma, fractured skull or facial bones, or comatose.\n\nExclusion Criteria:\n\n1. Exclude persons under 14 years old or over 35 years old\n2. Exclude persons taking anti-inflammatory drugs (both prescription and OTC), or those who will have taken them within 24 hours prior to Visit 1\n3. Exclude smokers and former smokers, as defined by CDC. (Anyone who smokes daily or who has smoked at least 100 cigarettes in their lifetime)\n4. Those with presence of an active infection (including a dental infection)\n5. Exclude persons who have migraines\n6. Exclude persons taking mood stabilizer medications\n7. Exclude persons who have consumed alcohol within 48 hours prior to study participation, participants will be asked this by one of the study members through the exclusion criteria screening form when they first contact the study\n8. Exclude persons who are pregnant.","ALL","14 Years","35 Years",{"count":57,"type":23},[26],"The overall goal of this research is to provide pilot data that informs and drives a larger scale research project, incorporating multiple contemporary measurement modalities, to understand the utility and pathological mechanisms by which exposure to nature-based settings may aid in recovery time and symptom relief of individuals suffering from concussion, and decrease their risk of developing Persistent Post-Concussion Syndrome (PPCS).\n\nWe hypothesize that successful adherence to a nature-based exposure therapy intervention program will decrease recovery time and severity of symptom trajectory of concussion, as measured through multimodal assessments of brain structural and functional integrity.",[90],"Concussion (Diagnosis)","2026-06-09",{"date":93,"type":39},"2026-06-11",{"date":95,"type":23},"2026-07-01",{"date":97,"type":23},"2027-08-01",{"name":45,"class":46},{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":12,"sex":83,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":24,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":125,"leadSponsor":127,"locationsCount":76},"100611036","cardiometabolic-effects-of-pecan-snacking-in-prediabetes-100611036","NCT07235358","Cardiometabolic Effects of Pecan Snacking in Prediabetes","Glycemic Effects of Substituting Pecans for Snacks Higher in Saturated Fat and Added Sugars in Individuals With Prediabetes","Inclusion Criteria:\n\n* Age 25-65 years\n* Prediabetes assessed by an HbA1c of 5.7-6.4% at screening\n* BMI 25-40 kg\u002Fm2 at screening\n* Low habitual nut consumption (\\\u003C3.5 oz-eq\u002Fweek) assessed at the telephone screening\n* Regularly eats snacks higher in saturated fat and\u002For added sugars assessed at the telephone screening\n\nExclusion Criteria:\n\n* LDL-C ≥190 mg\u002FdL at screening\n* Hemoglobin \\\u003C13.2 g\u002FdL at screening\n* Fasting triglycerides \\>350 mg\u002FdL at screening\n* ≥10% change in body weight within the 6 months prior to enrollment\n* Blood pressure \\>140\u002F90 mmHg at screening\n* Type 1 or type 2 diabetes\n* Prescription of anti-hypertensive, lipid-lowering, or glucose-lowering drugs\n* Intake of supplements or over-the-counter medications that affect the outcomes of interest (i.e., lipid, blood pressure, or glucose lowering; vitamin C or multi-vitamins containing vitamin C) and are unwilling to cease during the study period.\n* History of liver, kidney, or autoimmune disease\n* Prior cardiovascular event (e.g., stroke, heart attack)\n* Current pregnancy or intention of pregnancy within the next 12 months\n* Lactation within the prior 6 months\n* Pecan allergy\u002Fintolerance\u002Fsensitivity\u002Fdislike\n* Unwilling\u002Funable to eat 1.5 oz of pecans every day as a snack during the duration of the study\n* Antibiotic use within the prior 4 weeks\n* Oral steroid use within the prior 4 weeks\n* Use of tobacco or nicotine-containing products within the past 6 months\n* History of cancer at any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer within the past 5 years (eligible if ≥5 years without recurrence)\n* Participation in another clinical trial within 60 days of baseline\n* Unwilling to contact study staff before enrolling in other health-related research and avoid participating in any research that may interfere with this study.\n* Currently following a restricted or weight-loss diet\n* Prior bariatric surgery\n* Intake of \\>14 alcoholic drinks\u002Fweek and\u002For not willing to avoid alcohol consumption for 48 hours prior to test visits\n* Principal Investigator discretion related to the potential participant's ability to adhere to the study requirements, including being able to come to attend visits\n* Does not speak and\u002For understand English\n* Unwilling to refrain from donating blood or plasma during the study\n* Weight \\\u003C110 lb\n* If a potential participant takes thyroid medicine, abnormal thyroid stimulated hormone (TSH) concentration (TSH outside of normal range), or change in dose of thyroid medication within the last 6 months","25 Years","65 Years",{"count":109,"type":23},147,[26],"The purpose of this study is to investigate the effects of replacing snacks higher in saturated fats and added sugars with pecans on blood sugar control, heart health and diet quality in individuals with prediabetes. Participants will be randomized into one of two groups. Group 1 will consume 1.5 oz of pecans per day in place of normally consumed snacks higher in saturated fat and added sugars for 16 weeks. Group 2 will be asked to continue consuming their current diet for 16 weeks. Measures will be taken to evaluate blood sugar, heart health and dietary intake at the beginning and 16 weeks later.",[113],"Prediabetes",[115,116,117,118,119,120],"diet","nutrition","nuts","snacking","prediabetes","cardiovascular disease","2026-05-22",{"date":123,"type":39},"2026-05-27",{"date":121,"type":39},{"date":126,"type":23},"2027-09-30",{"name":45,"class":46},{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":18,"sex":83,"minAge":106,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":24,"phases":138,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100638762","cardiometabolic-effects-of-low-fat-and-full-fat-dairy-100638762","NCT07605442","Cardiometabolic Effects of Low-Fat and Full-Fat Dairy","Cardiometabolic Effects of Low-Fat and Full-Fat Dairy in Healthy and Cardiometabolically At-Risk Adults","Inclusion Criteria:\n\n* BMI 18.5 to 39.9 kg\u002Fm2\n* LDL-C ≤190 mg\u002FdL assessed by the Modified Sampson-NIH Equation\n* Currently consume milk, yogurt, and\u002For cheese daily\n* Willing to eat 3 servings of dairy (milk, yogurt, cheese) for two 6-week periods during the study\n\nExclusion Criteria:\n\n* Hemoglobin \\\u003C13.2 g\u002FdL for men or \\\u003C 11.7 g\u002FdL for women at screening\n* Fasting triglycerides \\>350 mg\u002FdL at screening\n* ≥10% change in body weight within the 6 months prior to enrollment\n* Blood pressure \\>140\u002F90 mmHg at screening\n* Fasting glucose ≥126 mg\u002FdL\n* Type 1 or type 2 diabetes\n* Takes any (prescription or over-the-counter) anti-hypertensive, lipid-lowering, glucose-lowering or anti-inflammatory drugs, or drugs that alter body weight\n* Intake of supplements that affect the outcomes of interest (i.e., lipids, blood pressure, glucose, body weight, inflammation and microbiome) and are unwilling to cease during the study period.\n* Unwilling to refrain from starting to take any supplements, vitamins, nutritional products, or health foods that are not prescribed by a doctor for the duration of the study\n* History of liver, kidney, or autoimmune disease\n* Prior cardiovascular event (e.g., stroke, heart attack)\n* Current pregnancy or intention of pregnancy within the next 12 months\n* Lactation within the prior 6 months\n* Dairy allergy\u002Fintolerance\u002Fsensitivity\u002Fdislike\n* Antibiotic use within the prior four weeks\n* Oral steroid use within the prior four weeks\n* Use of tobacco or nicotine-containing products within the past 6 months\n* History of cancer at any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer within the past 5 years (eligible if ≥5 years without recurrence)\n* Participation in another clinical trial within 60 days of baseline\n* Currently following a restricted or weight-loss diet\n* Prior bariatric surgery\n* Intake of \\>14 alcoholic drinks\u002Fweek and\u002For not willing to avoid alcohol consumption for 48 hours prior to test visits\n* Does not speak and\u002For understand English\n* Unwilling to refrain from donating blood and\u002For plasma during the study\n* Weight \\\u003C110 lb\n* Lactose intolerance or sensitivity\n* Unwilling to contact study staff before enrolling in other health-related research and avoid participating in any research that may interfere with this study\n* For individuals taking thyroid medication: abnormal thyroid stimulated hormone (TSH) concentration, or change in dose of thyroid medication within the last 6 months\n* Principal Investigator discretion related to the potential participant's ability to adhere to the study requirements, including being able to come to attend visits","70 Years",{"count":137,"type":23},178,[26],"The purpose of this study is to find out if full-fat dairy and low-fat dairy have similar effects on risk factors for heart disease and diabetes. During the study, participants will consume two types of dairy products: low-fat dairy (milk, yogurt, and cheese) and full-fat dairy (milk, yogurt, and cheese). Each type of dairy will be consumed for 6 weeks with a ≥4-week break between. Measures will be taken to evaluate blood cholesterol, blood sugar, body weight, inflammation, blood pressure, heart health and dietary intake at the beginning and end of each 6 week period.",[141],"Cardiovascular (CV) Risk",[143,115,116,144,120],"dairy","LDL-cholesterol","2026-05-18",{"date":147,"type":39},"2026-05-26",{"date":149,"type":23},"2026-09-08",{"date":151,"type":23},"2028-08-31",{"name":45,"class":46},{"id":154,"slug":155,"hasResults":12,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":18,"sex":83,"minAge":161,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":24,"phases":165,"briefSummary":166,"conditions":167,"keywords":171,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":76},"100607970","smoothie-program-for-achieving-and-resilient-kids-100607970","NCT07195474","Smoothie Program for Achieving and Resilient Kids","Effect of Daily Yogurt Smoothies on Neurocognitive Function in Children","SPARK","Inclusion Criteria:\n\n* Children should be of good health, without presence of any metabolic, gastrointestinal, or developmental disorders (e.g., ADHD, autism, etc.).\n* Children should not be taking medications that impact appetite or cognitive function.\n* Children must be willing to consume and report liking the fermented dairy smoothie.\n* Children should be between the ages of 7-9 years-old at enrollment.\n* Children should speak English fluently.\n\nExclusion Criteria:\n\n* They are not within the age requirements (\\\u003C 7 years-old or \\> 9 years-old) at baseline.\n* They have known emotional or cognitive delays, so that we can be assured that they understand the procedures.\n* They do not speak English fluently.\n* They have parentally reported medical problems that affect the digestive system or ability to eat yogurt (e.g., lactose intolerance, food allergies, Crohn's disease, Celiac disease, Esophagitis) and\u002For are taking a prescription medication that may affect appetite (e.g., Ritalin, methylphenidate, Adderall XR, Concerta, Vyvanse, etc.).\n* They are not from families of rural communities (assessed by National Center for Education Statistics local classifications).\n* Their parent is unable to attend the study visits.","7 Years","9 Years",{"count":164,"type":23},60,[26],"The proposed study will examine whether eating yogurt every day can improve brain and gut health in children. Prior research suggests that yogurt may support cognitive functions like self-control, but more studies are needed to confirm this. The study will follow 60 children from Central Pennsylvania, ages 8 to 10, who will be randomly assigned to drink either fruit juice (control group) or yogurt smoothies once or twice a day for four weeks.\n\nResearchers will compare how different amounts of yogurt affect children's thinking skills (like memory and focus), brain activity, and gut bacteria. These changes will be measured through brain scans, computer-based thinking tasks, surveys, and stool samples. The study will also collect information about children's overall diet. The goal is to find out if yogurt can support healthy brain and gut development and to determine the right amount to include in a child's daily diet. Results will help guide future research on how nutrition supports children's health.",[168,169,170],"Executive Functions (EF)","Microbiome","Dietary Quality",[172,173,174,175,176],"Cognitive Function","daily yogurt smoothies intake","gut and brain health","hippocampal-dependent memory","dose-dependent",{"date":178,"type":39},"2026-05-20",{"date":180,"type":23},"2026-05",{"date":182,"type":23},"2028-09",{"name":45,"class":46},{"id":185,"slug":186,"hasResults":12,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":18,"sex":83,"minAge":161,"maxAge":162,"enrollmentInfo":192,"targetDuration":4,"studyType":194,"phases":4,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":205,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":76},"100444880","resilience-to-the-effects-of-advertising-in-children-100444880","NCT05073185","Resilience to the Effects of Advertising in Children","Characterizing Resilience to Food-cue Induced Overeating in Children","REACH","Child Inclusion Criteria:\n\n1. In order to be enrolled, children must be of good health based on parental self-report.\n2. Have no learning disabilities (e.g., ADHD).\n3. Have no allergies to the foods or ingredients used in the study.\n4. Not be claustrophobic.\n5. Not be taking any medications known to influence body weight, taste, food intake, behavior, or blood flow.\n6. Be 7-9 years-old at enrollment.\n7. The child must speak English.\n\nParent Inclusion Criteria:\n\n1. The parent who has the most knowledge of the child's eating behavior, media access, sleep and behavior must be available to attend the visits with their child. This would be decided among the parents.\n2. The biological mother must have a body mass index either between 18.5 - 25 kg\u002Fm2 (low-risk group) or greater than or equal to 30 kg\u002Fm2 (high-risk group). One parent can report on both parents' BW and height.\n\nExclusion Criteria:\n\nChildren would be excluded if:\n\n1. They are not within the age requirements (\\\u003C than 7 years old or \\> than 9 years-old at baseline).\n2. If they are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow.\n3. If they don't speak English.\n4. If they are colorblind\n5. If they report being claustrophobic.\n6. if they have a learning disability, ADD\u002FADHD, language delays, autism or other neurological or psychological conditions.\n7. if they have a pre-existing medical condition such as type I or type II diabetes, rheumatoid arthritis, Cushing's syndrome, Down's syndrome, food allergies, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, or cerebral palsy.\n8. if they are allergic to foods or ingredients used in the study.\n9. if they have tattoos, permanent makeup, dental ware, pacemakers, or metal implants that would preclude safe completion of the MRI.\n10. if the child has had an X-ray in the month prior to Visits 1 and 6. If so, they will be scheduled at a later date.\n\nParent Exclusion Criteria:\n\n1. if the biological mother has a body mass index \\\u003C 18.5 kg\u002Fm2\n2. if the mother is between 25-30 kg\u002Fm2.\n3. if the parent is unable to attend the study visits\n4. if the family reports plans to move away from the area in the next year.",{"count":193,"type":23},200,"OBSERVATIONAL","Strong empirical evidence shows food marketing promotes excess energy intake and obesity. Yet, not all children are susceptible to its effects and this variability is poorly understood. Identifying sources of this variability is a public health priority not only because it may elucidate characteristics of children who are most susceptible, but also because it may highlight novel sources of resiliency to overconsumption. The proposed research will use state-of-the art, data-driven approaches to identify neural, cognitive and behavioral phenotypes associated with resiliency to food-cue (i.e. food advertisement) induced overeating and determine whether these phenotypes protect children from weight gain during the critical pre-adolescent period.",[197],"Obesity, Childhood",[199,200,201,202,203,204],"Obesity","food-cue reactivity","functional magnetic resonance imaging","eating behaviors","food marketing","food advertisement",{"date":178,"type":39},{"date":207,"type":39},"2022-05-01",{"date":209,"type":23},"2026-12",{"name":45,"class":46},{"id":212,"slug":213,"hasResults":12,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":4,"eligibilityCriteria":217,"healthyVolunteers":18,"sex":83,"minAge":218,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":24,"phases":221,"briefSummary":222,"conditions":223,"keywords":225,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":76},"100618461","mental-health-app-and-impact-on-wellbeing-100618461","NCT07331922","Mental Health App and Impact on Wellbeing","Landing Place: Impact of the Landing Place Mental Health App on Mental Health and Well-being","Inclusion Criteria:\n\n* Penn State Behrend students\n* Over the age of 18\n* Must have an iPhone\n\nExclusion Criteria:\n\n* People outside of Penn State\n* Minors\n* People currently in therapy","18 Years",{"count":220,"type":23},160,[26],"The goal of this clinical trial is to learn if intervention with Landing Place mental health app can support wellness in college students. The main questions it aims to answer are:\n\nCan the app increased well-being in college students? Will the app have increased use and usability by the college students? Researchers will compare two groups of participants to see if the app intervention will increase wellbeing and app usability rates.\n\nParticipants will randomly assigned into group 1 and 2. Group 1 will not use the app at all. Group 2 will use the app almost every day for 4 weeks.",[224],"Well-Being, Psychological",[226,227,228],"Digital Mental Health","College Students","Well-being","2026-05-04",{"date":231,"type":39},"2026-05-06",{"date":233,"type":23},"2026-08",{"date":235,"type":23},"2027-05",{"name":45,"class":46},{"id":238,"slug":239,"hasResults":12,"nctId":240,"briefTitle":241,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":18,"sex":83,"minAge":243,"maxAge":107,"enrollmentInfo":244,"targetDuration":4,"studyType":24,"phases":246,"briefSummary":247,"conditions":248,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":76},"100483256","linking-brain-network-dynamics-to-imminent-smoking-lapse-risk-and-behavior-100483256","NCT05572671","Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior","Inclusion Criteria:\n\n* Participants must be between the ages of 21 and 65.\n* Participants must be fluent English speakers.\n* Participants must pass an MRI safety screening.\n* Participants must report smoking at least six cigarettes per day continuously for at least the 12 preceding months.\n* Participants must have a baseline expired-air carbon monoxide exceeding 10 parts per million in order to verify smoking status.\n\nExclusion Criteria:\n\n* Individuals will be excluded if they report that they are not willing to refrain from using nicotine for 12 hours before the experimental lab visit.\n* Individuals will be excluded if they have any known risk from exposure to high-field strength magnetic fields (e.g., pacemakers), any irremovable metallic foreign objects in their body (e.g., braces), or a questionable history of metallic fragments that are likely to create artifact on the MRI scans.","21 Years",{"count":245,"type":23},150,[26],"Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lead to smoking lapses because it provides a way to measures patterns of brain activity thought to reflect relevant mental processes as they change over time. However, methodological issues have hindered the ability to capitalize on this potential and prevented an understanding of how brain activity and corresponding psychological processes unfold in the critical moments that immediately precede a smoking lapse. The proposed project will address this knowledge gap using a novel fMRI paradigm adapted from a well-validated behavioral lapse task. The goals of the project are to characterize changes in brain activity that lead up to a lapse and to investigate how these changes are related to concurrent affect and subsequent cigarette use.",[249,250],"Smoking","Tobacco Use","2026-04-29",{"date":253,"type":39},"2026-05-05",{"date":255,"type":39},"2023-04-04",{"date":257,"type":23},"2027-08",{"name":45,"class":46},{"id":260,"slug":261,"hasResults":12,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":12,"sex":83,"minAge":218,"maxAge":266,"enrollmentInfo":267,"targetDuration":4,"studyType":24,"phases":268,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":281,"leadSponsor":283,"locationsCount":4},"100631780","exploring-the-influence-of-glucagon-like-peptide--1-glp-1-medications-on-food-cravings-food-selection-and-food-intake-following-exposure-to-food-advertisements-100631780","NCT07505134","Exploring the Influence of Glucagon-like Peptide -1 (GLP-1) Medications on Food Cravings, Food Selection, and Food Intake Following Exposure to Food Advertisements","Exploring the Influence of GLP-1 Medications on External Food Cue Reactivity and Resultant Food Choice and Intake","Inclusion Criteria:\n\n* Adults (18+) with overweight or obesity (BMI \\>25 kg\u002Fm2)\n* On an injectable form of tirzepatide GLP-1 medication at a minimum dose of 7.5 mg, taking it as prescribed by their doctor\n* Not currently taking an incretin-based medication at baseline other than the GLP-1 medication\n* Fluent in English\n\nExclusion Criteria:\n\n* Do not have consistent access to a smart phone that can access the study software\n* Diagnosed with cognitive or physical disability or epilepsy\n* Adults taking a compound GLP-1","85 Years",{"count":5,"type":23},[26],"The purpose of this randomized control trial is to compare how food cravings, food selection, and food consumption change in response to frequent food advertisements compared to non-food advertisements in adults taking GLP-1 (weight loss) medications. The primary question we aim to answer is: do GLP-1 medications reduce an individual's vulnerability to external triggers that drive food cravings and consumption?\n\nParticipants will:\n\n* report daily food consumption for a total of 10 days,\n* receive eight daily prompts to view food or non-food related advertisements, and respond to a short 9-question survey for 7 days,\n* answer several questionnaires,\n* and complete two in-person visits to complete a virtual reality food selection task.",[271],"GLP - 1",[273,274,275,276],"GLP-1","Food choice","Cravings","Food cue reactivity","2026-04-27",{"date":279,"type":39},"2026-05-01",{"date":180,"type":23},{"date":282,"type":23},"2026-09",{"name":45,"class":46},{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":18,"sex":83,"minAge":218,"maxAge":292,"enrollmentInfo":293,"targetDuration":4,"studyType":24,"phases":295,"briefSummary":296,"conditions":297,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":76},"100487699","randomized-trial-of-healthy-family-foundations-100487699","NCT05630482","Randomized Trial of Healthy Family Foundations","Adaptation of an Evidence-based Family Program for Obesity Prevention in Health Care Context","HFF","Inclusion Criteria:\n\n* Two-parent military families (one or more parents are active duty military)\n* Expecting a first child, through 7 months gestation\n\nExclusion Criteria:\n\n* Clinical exclusion criteria for parents apply to males and females (active diagnosis of cancer, AIDS, palliative medicine patients, malabsorptive conditions, uncontrolled multiple sclerosis, and severe cognitive impairment), and to females (multiple gestation)\n* Families will be excluded if both parents do not participate.","60 Years",{"count":294,"type":23},825,[26],"The goal of this clinical trial is to test whether an adaptation of an evidence-based, couple-based preventive intervention at the transition to parenthood improves reduces obesity risk among infants and parents in military families via improved interparental support and coordination around health lifestyle behaviors and parenting.\n\nThe main question it aims to answer is whether an adapted, innovative family-focused approach to obesity prevention can reduce rapid infant weight gain, new mothers' postpartum weight retention, and fathers' weight status.\n\nParticipants randomized to the Healthy Family Foundations (HFF) intervention condition will participate in 10 online group classes (5 prenatal and 5 postnatal).\n\nParticipants randomized to the control condition will receive standard of care and opportunities for education at their site.\n\nResearchers will compare the Healthy Family Foundations (HFF) intervention group with a Standard of Care control group to see if there are differences in weight, coparenting support, parent mental health and parent health behaviors.",[199],"2026-04-09",{"date":300,"type":39},"2026-04-14",{"date":302,"type":39},"2023-05-15",{"date":304,"type":23},"2027-07-15",{"name":45,"class":46},{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":18,"sex":83,"minAge":218,"maxAge":4,"enrollmentInfo":313,"targetDuration":4,"studyType":24,"phases":315,"briefSummary":316,"conditions":317,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":76},"100579378","thrive-initiative-parent-education-programming-study-100579378","NCT06823518","Thrive Initiative Parent-Education Programming Study","Thrive Initiative Domestic and Chlid Abuse Prevention Programming Study","Inclusion Criteria:\n\n* United States Air Force service member or dependent\n* Parent\u002Fcaregiver of a child 0-18 years old\n* 18 years of age or older\n* Willing to participate in the research study\n* Has access to technology that will enable them to receive and respond to various technological aspects of the Thrive Initiative programs and research study\n* Able to speak and understand English proficiently\n* Able to understand and give consent\n\nExclusion Criteria:\n\n* Not an United States Air Force service member or dependent\n* Not a parent\u002Fcaregiver of a child 0-18 years old\n* 17 years of age or younger\n* Unwilling to participate in the research study\n* Does not have access to technology that will enable them to receive and respond to various technological aspects of the Thrive Initiative programs and research study\n* Unable to speak and understand English proficiently\n* Unable to understand and give consent",{"count":314,"type":23},480,[26],"The purpose of this study is to evaluate the effectiveness of the Thrive Initiative's parent-education program delivery methods by comparing hybrid (i.e., a combination of online and group components) program delivery to online-only program delivery. The Thrive Initiative consists of four, universal parent-education programs that correpsond to specific child developmental periods. These programs inlcude: Take Root for parents\u002Fcaregivers of 0-3-year-old children; Sprout for parents\u002Fcaregivers of 3-5-year-old children; Grow for parents\u002Fcaregivres of 5-10-year-old children; and Branch Out for parents\u002Fcaregivers of 10-18-year-old children. The effectiveness of delivery method will be examined for each program. Eligible participants for this study will be United States Air Force service members or dependents who are caregivers of a child 0-18 years old. The study will involve randomization to condition meaning that participants will be assigned to the online-only or hybrid program delivery condition by chance.",[318,319,320],"Child Maltreatment","Parenting","Child Wellbeing","2026-04-02",{"date":323,"type":39},"2026-04-08",{"date":325,"type":39},"2026-03-31",{"date":327,"type":23},"2028-12-31",{"name":45,"class":46},{"id":330,"slug":331,"hasResults":12,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":12,"sex":83,"minAge":106,"maxAge":107,"enrollmentInfo":336,"targetDuration":4,"studyType":24,"phases":338,"briefSummary":339,"conditions":340,"keywords":341,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":4},"100610607","mediterranean-diet-and-blood-sugar-study-100610607","NCT07229781","Mediterranean Diet and Blood Sugar Study","Glycemic Effects of a Mediterranean-Style Dietary Pattern Containing Potatoes in Adults With Prediabetes","Inclusion Criteria:\n\n* Age 25-65 years\n* Prediabetes assessed by an HbA1c of 5.7-6.4% or fasting glucose 100-125 mg\u002FdL at screening\n* BMI 25-40 kg\u002Fm2 at screening\n\nExclusion Criteria:\n\n* HbA1c ≥6.5% at screening\n* LDL-C (calculated with the Martin-Hopkins equation) ≥190 mg\u002FdL at screening\n* Hemoglobin \\\u003C13.2 g\u002FdL at screening\n* Fasting triglycerides \\>350 mg\u002FdL at screening\n\n  -≥10% change in body weight within the 6 months prior to enrollment\n* Blood pressure \\>140\u002F90 mmHg at screening\n* Type 1 or type 2 diabetes\n* Prescription of anti-hypertensive, lipid-lowering, or glucose-lowering drugs\n* Intake of supplements that affect the outcomes of interest (i.e., lipid, blood pressure, or glucose lowering; vitamin C or multi-vitamins containing vitamin C) and are unwilling to cease during the study period.\n* History of liver, kidney, or autoimmune disease\n* Prior cardiovascular event (e.g., stroke, heart attack)\n* Current pregnancy or intention of pregnancy within the next 6 months\n* Lactation within the prior 6 months\n* Allergy\u002Fintolerance\u002Fsensitivity\u002Fdislike of any foods in the study menus\n* Antibiotic use within the prior 1 month\n* Oral steroid use within the prior 1 month\n* Use of tobacco or nicotine-containing products within the past 6 months\n* History of cancer at any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer within the past 5 years (eligible if ≥5 years without recurrence)\n* Participation in another clinical trial within 60 days of baseline\n* Currently following a restricted or weight-loss diet\n* Prior bariatric surgery\n* Intake of \\>14 alcoholic drinks\u002Fweek and\u002For not willing to avoid alcohol consumption for 48 hours prior to test visits\n* Principal Investigator discretion related to the potential participant's ability to adhere to the study requirements, including being able to come to attend visits\n* Does not speak and\u002For understand English\n* Unwilling to refrain from donating blood during the study\n* Weight \\\u003C110 lb",{"count":337,"type":23},74,[26],"The purpose of this research study is to determine if a healthy Mediterranean diet containing one medium potato\u002Fday has equivalent or non-different effects on risk factors for type 2 diabetes and heart disease compared to a healthy Mediterranean diet without potatoes in adults with prediabetes. Participants will be randomly assigned to one of the test diets and be asked to consume this diet for 12 weeks (84 days). Testing will be conducted at the beginning and end of the study.",[113],[119,115,116,342,120],"Mediterranean diet","2026-04-01",{"date":321,"type":39},{"date":346,"type":23},"2026-06-01",{"date":348,"type":23},"2028-04-30",{"name":45,"class":46},{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":18,"sex":83,"minAge":356,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":24,"phases":359,"briefSummary":360,"conditions":361,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":362,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":76},"100604274","lions-hearts-a-community-approach-to-multigenerational-cardiovascular-disease-risk-100604274","NCT07147387","Lions Hearts: A Community Approach to Multigenerational Cardiovascular Disease Risk","Inclusion Criteria:\n\n* Mother-child dyad willing to participate together in the full 12-week intervention and assessment activities\n* Child aged 10-17 years old\n* Mother (or female caregiver)\n* Both mother and child must be able to safely engage in moderate-to-vigorous physical activity, as determined by pre-participation health screening (e.g., PAR-Q+)\n* Access to transportation to attend twice-weekly exercise sessions at a local CrossFit affiliate\n\nExclusion Criteria:\n\n* Presence of a medical condition that would make participation in moderate-to-vigorous physical activity unsafe, as determined by health screening or medical provider (e.g., uncontrolled hypertension, cardiovascular disease, severe orthopedic limitations)","10 Years",{"count":358,"type":23},100,[26],"This pilot study evaluates the feasibility, acceptability, and preliminary effectiveness of Lion Hearts, a community-based, family-centered physical activity intervention designed to improve cardiovascular health among mother-child dyads. Developed through community co-design, the 12-week intervention is delivered in local CrossFit affiliates and includes twice-weekly fitness sessions incorporating functional movement, goal setting, teamwork, and health education. The study aims to assess changes in physical activity, fitness, and cardiovascular health markers, as well as family dynamics and motivation for physical activity. Participants complete baseline, mid-, post-, and 3-month follow-up assessments, including surveys, fitness testing, accelerometry, and optional lab work. Findings will inform the refinement of the intervention for future large-scale trials.",[141],{"date":321,"type":39},{"date":364,"type":23},"2026-08-01",{"date":366,"type":23},"2027-12-01",{"name":45,"class":46},{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":18,"sex":83,"minAge":218,"maxAge":375,"enrollmentInfo":376,"targetDuration":4,"studyType":24,"phases":378,"briefSummary":379,"conditions":380,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":76},"100579040","examining-interactions-between-pals-and-caregivers-100579040","NCT06819124","Examining Interactions Between PALS and Caregivers","Examining Interactions Between Persons With ALS and Caregivers","Inclusion Criteria:\n\nSpeakers with amyotrophic lateral sclerosis (ALS) (PALS-people with ALS)\n\n* diagnosis of ALS following the revised EL Escorial criteria\n* no history of other neurological conditions (e.g., stroke)\n* no cognitive impairment assessed by Telephone Montreal Cognitive Assessment (mini MoCA)\n* detectable speech disturbance according to the ALS Functional Rating Scale-Revised (ALSFRS-R)\n* the ability to produce single words\n* being a native speaker of American English (AE).\n\nCaregivers\n\n* being a caregiver of a participant with ALS\n* being a native speaker of American English (AE).\n\nExclusion Criteria:\n\n\\- None - if volunteer meets the inclusion criteria, then they will be enrolled","90 Years",{"count":377,"type":23},152,[26],"The goal of this clinical trial is to learn about the effect of communicative interaction on verbal communication in people with amyotrophic lateral sclerosis (ALS) and their caregivers.\n\nThe question is, What are the effects of communicative interaction on verbal communication in people with ALS when they interact with their caregivers and does this change over time?\n\nParticipants will read words and sentences while they are interacting with their caregivers.",[381],"Amyotrophic Lateral Sclerosis (ALS)",{"date":383,"type":39},"2026-04-06",{"date":385,"type":39},"2025-01-22",{"date":387,"type":23},"2029-02-28",{"name":45,"class":46},{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":395,"eligibilityCriteria":396,"healthyVolunteers":18,"sex":83,"minAge":218,"maxAge":397,"enrollmentInfo":398,"targetDuration":4,"studyType":24,"phases":400,"briefSummary":401,"conditions":402,"keywords":408,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":414,"completionDateStruct":415,"leadSponsor":417,"locationsCount":76},"100630932","evaluating-care-integration-between-pediatric-primary-care-providers-and-wic-nutritionists-100630932","NCT07494097","Evaluating Care Integration Between Pediatric Primary Care Providers and WIC Nutritionists","Evaluating Care Integration Between Pediatric Primary Care Providers and WIC Nutritionists for Early Obesity Prevention Among WIC Mothers and Children","WEE Baby","Inclusion Criteria:\n\n* People who are a) pregnant and \\>34 weeks' gestation or b) who have an infant \\\u003C2 months old\n* 18-40 years old\n* English and\u002For Spanish speaking and reading\n* Access to a smartphone or internet-connected device\n* Not planning to move out of Pennsylvania within 2 years\n* Not planning to change health care providers outside of Geisinger within 2 years\n* Custody of and lives with (or will live with) the child enrolled in the study\n* Child must have a Geisinger PCP and be a WIC participant or eligible for WIC at enrollment\n\nExclusion Criteria:\n\n* Mother is not interested (or willing) to enroll in WIC\n* Child has a genetic or developmental disorder (e.g., cleft palate) that impacts weight or feeding\n* Child has a terminal condition","40 Years",{"count":399,"type":23},380,[26],"This study looks at whether using secure digital systems to share information between pediatric health care providers (during regular well-child visits) and social care providers (during regular visits with WIC nutritionists) can help mothers receive consistent guidance on responsive parenting to support healthy child growth and development. Responsive parenting means learning how to respond to a baby's needs in ways that support healthy eating, sleep, activity, and emotion regulation habits. The main questions this study aims to answer are:\n\n1. Does using secure digital systems to share information between pediatric health care providers and social care providers help mothers receive consistent guidance on responsive parenting to support healthy growth from birth to 24 months?\n2. Does using secure digital systems to share information between pediatric health care providers and social care providers help mothers receive consistent guidance on responsive parenting, improve responsive parenting practices and child diet quality?\n\nThe investigators will compare the group that receives secure digital systems for sharing information on responsive parenting to a group that receives standard care (does not receive this) to see if secure digital systems for sharing information on responsive parenting work to support healthy child growth and development. The goal is to see if this approach can improve early health behaviors and reduce health disparities for families in rural, low-income communities.",[403,404,405,406,407],"Weight Gain Trajectory","BMI","Responsive Parenting","Diet Quality","Implementation",[409,405,410],"Child Weight","Health Information Technologies","2026-03-19",{"date":413,"type":39},"2026-03-27",{"date":233,"type":23},{"date":416,"type":23},"2029-12",{"name":45,"class":46},{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":422,"acronym":423,"eligibilityCriteria":424,"healthyVolunteers":18,"sex":83,"minAge":425,"maxAge":162,"enrollmentInfo":426,"targetDuration":4,"studyType":24,"phases":427,"briefSummary":428,"conditions":429,"keywords":431,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":76},"100600259","monitoring-eating-across-locations-meal---timing-intake-and-mealtime-evaluation-time-100600259","NCT07095166","Monitoring Eating Across Locations (MEAL) - Timing, Intake, and Mealtime Evaluation (TIME)","MEAL-TIME","Inclusion Criteria:\n\n* children must be between the ages of 6-9 years-old\n* children are of good health with no learning disabilities (e.g., ADHD, determined by parent report)\n* children are not on any medications known to impact body weight, taste, food intake, behavior, or blood flow\n* parents report that children like and are willing to eat study foods\n\nExclusion Criteria:\n\n* Children are not within the age requirements (\\\u003C6 years old or \\> 9 years old)\n* If children are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow.\n* If children don't speak English.\n* If children are colorblind.\n* If children have a learning disability, ADD\u002FADHD, language delays, autism or other neurological or psychological conditions.\n* If children have a pre-existing medical condition such as type I or type II diabetes, rheumatoid arthritis, Cushing's syndrome, Down's syndrome, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, or cerebral palsy.\n* If children are allergic to foods or ingredients used in the study.\n* child received an X-ray in the previous year (to avoid excess radiation exposure due to the DXA scans performed in the research)","6 Years",{"count":358,"type":23},[26],"Increased availability of high-energy dense foods has contributed to a pediatric obesity epidemic, with 23% of United States children currently presenting with the disease. How children eat contributes to both overconsumption and greater adiposity. However, it is unclear if laboratory measures of children's eating style generalize to the home environment, where children consume two thirds of their total energy. The study will 1) test if child eating styles observed in the lab generalize to more ecologically valid home environments and 2) identify aspects of home food environment that amplify obesogenic eating behaviors. We will assess laboratory and home eating styles (e.g., bite rate) in 100 prepubertal 6-9-year-old children to constrain variability in energy requirements. Children will be video-recorded while consuming identical study-provided meals at home and in the laboratory (counter-balanced order) in addition to a 'typical' meal at home. To study how adiposity relates to \"obesogenic\" styles of eating, gold standard dual x-ray absorptiometry will be used.",[430],"Pediatric Obesity",[432,433,434,435],"eating behavior","meal microstructure","child","obesity","2026-03-04",{"date":438,"type":39},"2026-03-06",{"date":440,"type":39},"2025-11-15",{"date":442,"type":23},"2027-10-15",{"name":45,"class":46},{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":83,"minAge":218,"maxAge":451,"enrollmentInfo":452,"targetDuration":4,"studyType":24,"phases":453,"briefSummary":455,"conditions":456,"keywords":458,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":76},"100626218","early-phase-1-effect-of-an-8-week-pickleball-program-for-adults-with-autism-a-feasibility-trial-with-a-delayed-control-design-100626218","NCT07432776","Effect of an 8-Week Pickleball Program for Adults With Autism: A Feasibility Trial With a Delayed-Control Design","Effects of an 8-Week Pickleball Intervention on Sensorimotor Function, Sleep, Depressive Symptoms, and Core Autism Features in Adults With Autism Spectrum Disorder: A Feasibility Trial With a Delayed-Control Design","Inclusion Criteria:\n\n* Aged 18-45 years\n* Clinical diagnosis of autism spectrum disorder (ASD)\n* Able to participate in group-based activities without caregiver support\n* Able to understand English and independently communicate without assistance\n* Available for at least two sessions per week for the intervention dates\n* Access to reliable transportation to the intervention site\n* Able to provide informed consent (i.e., no legally authorized representative)\n* Pre-exercise screening indicates medical clearance is not needed, based on ACSM guidelines\n\nExclusion Criteria:\n\n* Clinical diagnosis of intellectual disability (ID)\n* Does not have normal or corrected-to-normal vision\n* Actively participating in a racquet sport ≥1 time per week\n* Use of mobility aids\n* Moderate-to-severe joint pain (WOMAC pain subscale)\n* Neurologic conditions (cerebral palsy, severe head injury, progressive neurological disorders, epilepsy)\n* Individuals who cannot provide their own informed consent (i.e., have a legally authorized representative)\n* Individuals who require medical clearance for exercise based on the ACSM preparticipation screening questionnaire","45 Years",{"count":5,"type":23},[454],"EARLY_PHASE1","The goal of this clinical trial is to learn if an 8-week, community-based pickleball program can improve sensory-motor function and reduce the severity of core autism symptoms in adults ages 18-45 with autism spectrum disorder (ASD) who can participate independently without a caregiver.\n\nThe main questions it aims to answer are:\n\n1. Does participating in the pickleball program improve sensory-motor function (including visual-motor integration and proprioceptive bias), measured using the HaptiKart task and a pickleball skill assessment?\n2. Does participating in the pickleball program reduce core autism symptom severity, measured by the Social Responsiveness Scale, 2nd edition (SRS-2)?\n\nResearchers will compare an early-start pickleball group to a delayed-start control group (who continues usual activities at first) to see if the pickleball program leads to greater improvements in sensory-motor outcomes and ASD symptom severity.\n\nParticipants will:\n\n* Complete an in-person baseline visit at a local public library to provide written consent, complete surveys (SRS-2, PROMIS Depression and Sleep measures, and WHOQOL-BREF), and complete a video game-based sensory-motor assessment (HaptiKart).\n* Be randomly assigned to either start pickleball classes immediately or after an initial delay period.\n* Attend pickleball classes twice per week for 8 weeks (90 minutes per class; 16 sessions total), led by trained instructors at community indoor court facilities.\n* Continue their usual activities during periods when they are not assigned to pickleball classes.\n* Complete a brief pickleball skill assessment during the intervention period at their first and last class.\n* Complete follow-up assessments after each phase of the study to repeat surveys and sensory-motor testing.\n* Participants will also wear a small activity monitor (ActiGraph) during pickleball sessions to measure in-class physical activity levels, and complete brief online check-ins about safety\u002Finjury and program feedback during the intervention period.",[457],"Autism Spectrum Disorder",[457,459,460,461,462,463,464],"ASD","Autism","Adult","Pickleball","Sensory-Motor","Sensorimotor","2026-02-18",{"date":467,"type":39},"2026-02-25",{"date":469,"type":39},"2026-02-02",{"date":471,"type":23},"2026-07-15",{"name":45,"class":46},{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":479,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":83,"minAge":135,"maxAge":4,"enrollmentInfo":481,"targetDuration":4,"studyType":24,"phases":483,"briefSummary":484,"conditions":485,"keywords":490,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":504},"100509588","researching-efficient-approaches-to-delirium-identification-sustaining-effective-translation-100509588","NCT05915377","Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation","READI-SET-GO:Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation to Create Gero Friendly Organizations","READI-SET-GO","Inclusion Criteria:\n\n* General medicine (hospitalist) service\n* Age 70 or older\n* Expected hospital length of stay of 3 or more days\n\nExclusion Criteria:\n\n* Inability to communicate adequately in English\n* Admitted for terminal care",{"count":482,"type":23},1050,[26],"The goal of this step-wedge trial is to test the implementation of daily nurse screening for delirium in routine care and its impact on outcomes and complications in hospitalized older adults admitted to 6 general medicine\u002Fsurgery units at 3 hospitals in Pennsylvania and Massachusetts.\n\nThe main question\\[s\\] it aims to answer are:\n\n* 1\\. To test the fidelity, accuracy, and durability of implementing daily nurse screening for delirium using the UB-CAM in routine care.\n* 2\\. To evaluate the impact of UB-CAM delirium screening on patient and care partner centered outcomes assessed at one month follow-up interviews 3. To evaluate the impact of UB-CAM screening on rates of delirium complications (falls, pressure injury, aspiration) and adverse delirium management (psychoactive medication use, restraint use).\n\nParticipants (patients) will be assessed for delirium on study days 1, 2 and 3 (or until hospital discharge) and will be asked basic demographics. These patients will be contacted by phone 1 month after enrollment to collect information about inpatient facility use and to administer the Delirium Burden Patient Scale.\n\nParticipants (care partners) will be interviewed at the patient's discharge to complete the Alzheimer's Disease-8 scale. These care partners will be contacted by phone 1 month after enrollment to complete the Delirium Burden Caregiver Scale and to complete a Qualitative Interview which includes questions about communication and collaboration.",[486,487,488,489],"Delirium","Delirium in Old Age","Delirium With Dementia","Delirium Superimposed on Dementia",[486,491,492,493,407,494,495,496],"Confusion","Altered Mental Status","Acute Metabolic Encephalopathy","Screening","Acute Care","Electronic Health Record",{"date":498,"type":39},"2026-02-20",{"date":500,"type":39},"2024-04-03",{"date":502,"type":23},"2028-05",{"name":45,"class":46},2,{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":509,"acronym":4,"eligibilityCriteria":510,"healthyVolunteers":18,"sex":83,"minAge":218,"maxAge":107,"enrollmentInfo":511,"targetDuration":4,"studyType":24,"phases":513,"briefSummary":514,"conditions":515,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":523,"locationsCount":76},"100579763","assessing-perceptual-effects-of-interactive-tasks-100579763","NCT06828523","Assessing Perceptual Effects of Interactive Tasks","Inclusion Criteria:\n\n* passing the remote hearing screening\n* having no known speech, language or neurological disorders per self-report\n* being a native monolingual speaker of American English\n* having no experience communicating with people with dysarthria\n* being between the ages of 18 and 65.\n\nExclusion Criteria:\n\n* None - if volunteer meets the inclusion criteria, then they will be enrolled",{"count":512,"type":23},1300,[26],"In this study, we will evaluate how solo, naive listeners perceive the speech of people with amyotrophic lateral sclerosis (ALS) and age-matched speakers produced across interactive and non-interactive contexts with an unfamiliar, naive interlocutor.",[516],"Amyotrophic Lateral Sclerosis","2026-02-11",{"date":519,"type":39},"2026-02-12",{"date":521,"type":39},"2025-10-17",{"date":387,"type":23},{"name":45,"class":46},{"id":525,"slug":526,"hasResults":12,"nctId":527,"briefTitle":528,"officialTitle":529,"acronym":530,"eligibilityCriteria":531,"healthyVolunteers":12,"sex":83,"minAge":218,"maxAge":4,"enrollmentInfo":532,"targetDuration":4,"studyType":24,"phases":534,"briefSummary":535,"conditions":536,"keywords":538,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":76},"100623735","family-foundations-for-special-education-trial-100623735","NCT07400497","Family Foundations for Special Education Trial","Family Foundations for Special Education","SS-SE","Inclusion Criteria:\n\n* Parents\u002Fparental figures who are over the age of 18, and are involved in childrearing together.\n* Coparenting a child being evaluated for special education services\n* Has not yet had their first IEP meeting.\n* The target child must attend a Philadelphia elementary school (K-8).\n* The target child must be the first child in the family to go through the IEP process.\n* Co-parents must be fluent in English.",{"count":533,"type":23},120,[26],"The goal of this clinical trial is to assess the program's impact on parent self-efficacy and co-parental support around (a) accessing health and educational services and (b) parenting for co-parents of children with disabilities entering the Special Education system before their first Individualized Education Program (IEP) meeting. The main questions it aims to answer are: Does the program improve co-parenting support and coordination and parent efficacy in accessing services for and parenting their child? Does the program improve parent mental health, service access, engagement, and adherence? Does the program improve parenting quality? Does the program improve child adjustment (mental and behavioral health, academic engagement)? Researchers will compare pretest and posttest questionnaires from Treatment Group A with Control Group B to see if the program improves parent and child well-being, co-parenting relations, relations with service providers, ability to access services and meaningfully participate in IEP and other meetings.\n\nParticipants will:\n\n* Complete pre- and post-test questionnaires\n* Treatment Group A will participate in 6 learning sessions, each 1 hour to 1½ hour long, over a 6-8 week period",[537],"Mental Health",[539,540,541,542,543,544],"parenting education","children with disabilities","children with challenging behaviors","parenting relationships","Coparenting","Special Education","2026-02-06",{"date":547,"type":39},"2026-02-10",{"date":549,"type":39},"2025-01-12",{"date":551,"type":23},"2026-12-30",{"name":45,"class":46},{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":558,"acronym":559,"eligibilityCriteria":560,"healthyVolunteers":18,"sex":19,"minAge":561,"maxAge":562,"enrollmentInfo":563,"targetDuration":4,"studyType":24,"phases":565,"briefSummary":566,"conditions":567,"keywords":569,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":583,"locationsCount":76},"100602245","prunes-preventing-bone-loss-in-perimenopause-100602245","NCT07120997","Prunes Preventing Bone Loss in Perimenopause","A Prevention Strategy for the Indication of Prune Consumption in Perimenopausal Females: Can Prunes Attenuate Bone Loss?","Prune-UP","Inclusion Criteria:\n\n* Age 44 to 55 years\n* Not severely obese (BMI \\\u003C35 kg\u002Fm\\^2)\n* Healthy (determined by a screening questionnaire, physical and medical history by a certified nurse practitioner, complete metabolic panel, and complete blood count)\n* Willing to include prunes in their daily diet\n* Not taking any natural dietary supplement containing phenolics, i.e.,\\\u003C 1 cup\u002Fday of blueberries or apples for at least 2 months prior to study entry\n* Non-smoking\n* Ambulatory\n* No menses for ≥60 days but not more than 18 months post final menstrual period\n* Only participants who have a determinable natural (not surgical) final menstrual period date are eligible\n\nExclusion Criteria:\n\n* Subjects who regularly consume prunes, dried apples, prune juice, or heavy consumers of blueberries (1 cup or more\u002Fday)\n* History of vertebral fracture or fragility fracture of the wrist, humerus, hip or pelvis after age 45 yr)\n* Untreated hyper- or hypothyroidism\n* Current hyper- or hypoparathyroidism\n* Significantly impaired renal function\n* Current hypo- or hypercalcemia\n* History of spinal stenosis\n* History of heart attack, stroke, thromboembolism, kidney disease, malabsorption syndrome, or seizure disorders\n* Positive for HIV, Hep-C or Hep-B surface antigen and malignancy\n* Use of the following agents affecting bone metabolism: intravenous bisphosphonates at any time; fluoride (for osteoporosis) within the past 24 months; denosumab at any time; bisphosphonates, parathyroid hormone or strontium within the past 12 months; calcitonin; selective estrogen receptor modulators within the past 12 months; systemic oral or transdermal estrogen within the past 3 months; systemic glucocorticosteroids (≥ 5 mg prednisone equivalent per day for more than 10 days); or tibolone within the past 3 months\n* Hormonal contraception within the past three months\n* Subjects who will not consume study provided dietary items or who will not stop taking their own natural product supplements","44 Years","55 Years",{"count":564,"type":23},124,[26],"Dietary interventions of prune consumption during the transmenopausal period are innovative methods to prevent bone loss. Modern medicine does not intervene to prevent or attenuate this highly vulnerable period of bone loss which, if successfully attenuated, can potentially prevent\u002Fdelay osteoporosis in women. The transmenopausal period represents an opportunistic window for the study because bone loss is at its greatest at this time, with females losing as much as 6-7% of bone. If this project is successful at attenuating bone loss, it can immediately be disseminated to the public to promote prune consumption to slow down and attenuate perimenopausal bone loss. As such, this project could improve the long-term bone health of females and avoid or delay osteoporosis and improve quality of life. The long-term goal of this study is to test the novel hypothesis that prune consumption for 18 months during the 3-year transmenopausal period prevents the dramatic rate of bone loss in perimenopausal females during a window of heightened physiological vulnerability. At Penn State University, the study will compare the effects of 18 months of daily dietary consumption of 50 g of prunes (5-6) versus a no-prune control group on bone outcomes (bone mineral density, bone geometry), mechanistic factors (bone and inflammatory markers, inflammatory response of ex vivo cultured peripheral blood mononuclear cells, monocytes), and gut microbiome.",[568],"Perimenopausal Bone Loss",[570,571,572,568,62,573,574,575,576,577],"Female","Transmenopause","Perimenopause","Human","Osteoporosis","Non-pharmacologic therapy","Prune intake","Dried Plum",{"date":579,"type":39},"2026-02-04",{"date":581,"type":39},"2025-12-11",{"date":416,"type":23},{"name":45,"class":46},{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":589,"acronym":4,"eligibilityCriteria":590,"healthyVolunteers":18,"sex":83,"minAge":218,"maxAge":397,"enrollmentInfo":591,"targetDuration":4,"studyType":194,"phases":4,"briefSummary":593,"conditions":594,"keywords":597,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":606,"completionDateStruct":607,"leadSponsor":609,"locationsCount":76},"100578019","impact-of-depression-on-thermoregulation-100578019","NCT06805851","Impact of Depression on Thermoregulation","Thermoregulatory Responses to Heat Stress in Adults With Major Depressive Disorder With and Without Antidepressant Treatment","Inclusion Criteria:\n\n* Non-depressed adults aged 18-40 years;\n* OR adults aged 18-40 years with clinically diagnosed major depressive disorder according to DSM-V criteria not currently receiving antidepressant treatment;\n* OR adults aged 18-40 years with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a selective serotonin reuptake inhibitor;\n* OR aged 18-40 years adults with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a serotonin norepinephrine reuptake inhibitor;\n* All participants will be asymptomatic and no signs\u002Fsymptoms of disease according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription (chest pain or pressure, dizziness, joint pain, and signs of cardiovascular disease);\n* Systolic blood pressure 140 mmHg and diastolic pressure 90 mmHg at screening;\n* Non-diabetic\n* Not taking any other medications that might affect the physiological variables of interest (beta blockers, tricyclic antidepressants, antipyretics, diuretics, etc.);;\n* Between the 20th and 80th percentiles for sex- and age-appropriate VO2max according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription;\n* English proficiency;\n* Capable of providing informed consent.\n\nExclusion Criteria:\n\n* BMI \\> 35\n* Are pregnant or planning to become pregnant in the next 12 months;\n* Concurrently participate in another study involving physical activity or weight loss;\n* Plan to have surgery or relocate outside the area within the next year;\n* Medications that could alter cardiovascular or thermoregulatory responses to exercise (beta blockers, antipyretics, tricyclic antidepressants, diuretics, etc.);\n* Allergy to latex or adhesive;\n* Tobacco use;\n* Illegal\u002Frecreational drug use;\n* Exertional chest pain or musculoskeletal pain;\n* Contraindications to a maximal exercise test or an indication for early termination of the exercise test according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription;\n* Abnormal resting or exercise electrocardiogram (ECG);\n* Any bleeding disorders, gastric ulcers, allergies to NSAIDS, asthma, kidney\u002Fliver disorders, and taking any other anticoagulants;\n* History of Crohn's disease, diverticulitis, or similar gastrointestinal disease;\n* Co-morbid psychiatric disorders (psychosis, schizophrenia, bipolar disorder, panic disorder, obsessive compulsive disorder, etc.);\n* Active suicidal ideation (moderate or high suicidality);\n* Use of psychoactive or psychopharmacological drugs other than SSRI and SNRIs within one year of participating.",{"count":592,"type":23},64,"The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.",[595,596],"Depression","Selective Serotonin Reuptake Inhibitor",[598,599,600,601,602],"thermoregulation","heat stress","depression","selective serotonin reuptake inhibitors","serotonin norepinephrine reuptake inhibitors","2026-01-30",{"date":605,"type":39},"2026-02-03",{"date":72,"type":39},{"date":608,"type":23},"2027-01-30",{"name":45,"class":46},{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":615,"acronym":4,"eligibilityCriteria":616,"healthyVolunteers":18,"sex":83,"minAge":106,"maxAge":292,"enrollmentInfo":617,"targetDuration":4,"studyType":24,"phases":619,"briefSummary":620,"conditions":621,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":623,"lastUpdatePostDateStruct":624,"startDateStruct":625,"completionDateStruct":627,"leadSponsor":629,"locationsCount":76},"100532735","the-effects-of-healthy-diets-with-plant-oils-on-heart-and-metabolic-health-100532735","NCT06216678","The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health","The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health: A Randomized, Crossover, Controlled-feeding Study","Inclusion Criteria:\n\n* LDL-C ≥100 mg\u002FdL and ≤190 mg\u002FdL\n* BMI of 25-40 kg\u002Fm2\n* Blood pressure \\\u003C140\u002F90 mmHg\n* Fasting blood glucose \\\u003C126 mg\u002FdL\n* Fasting triglycerides \\\u003C350 mg\u002FdL\n* ≤10% change in body weight for 6 months prior to enrollment\n\nExclusion Criteria:\n\n* Type 1 or type 2 diabetes or fasting blood glucose ≥126 mg\u002FdL\n* Prescription of anti-hypertensive, lipid lowering or glucose lowering drugs\n* Intake of supplements that affect the outcomes of interest and unwilling to cease during the study period\n* Diagnosed liver, kidney, or autoimmune disease\n* Prior cardiovascular event (e.g., stroke, heart attack)\n* Current pregnancy or intention of pregnancy within the next 6 months\n* Lactation within prior 6 months\n* Follows a vegetarian or vegan diet\n* Food allergies\u002Fintolerance\u002Fsensitives\u002Fdislikes of foods included in the study menu\n* Antibiotic use within the prior 1 month\n* Oral steroid use within the prior 1 month\n* Use of tobacco or nicotine containing products with in the past 6 months\n* Cancer any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer with in the past 5 years (eligible if ≥5 years without recurrence)\n* Participation in another clinical trial within 30 days of baseline\n* Currently following a restricted or weight loss diet\n* Prior bariatric surgery\n* Intake of \\>14 alcoholic drinks\u002Fweek and\u002For lack of willingness to consume a maximum of two standard drinks per week while enrolled in the study and\u002For not willing to avoid alcohol consumption for 48 hour prior to test visits",{"count":618,"type":23},52,[26],"This study will examine the effect of a healthy diet containing cottonseed oil compared to healthy diets containing other commonly consumed plant oils on biomarkers of heart and metabolic health after 4 weeks.",[622],"Cardiovascular Diseases","2026-01-29",{"date":469,"type":39},{"date":626,"type":39},"2024-09-09",{"date":628,"type":23},"2027-12",{"name":45,"class":46},{"id":631,"slug":632,"hasResults":12,"nctId":633,"briefTitle":634,"officialTitle":635,"acronym":4,"eligibilityCriteria":636,"healthyVolunteers":12,"sex":83,"minAge":637,"maxAge":638,"enrollmentInfo":639,"targetDuration":4,"studyType":24,"phases":640,"briefSummary":643,"conditions":644,"keywords":647,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":653,"lastUpdatePostDateStruct":654,"startDateStruct":655,"completionDateStruct":657,"leadSponsor":659,"locationsCount":76},"100622479","phase-1-enhancing-orthographic-communication-and-literacy-outcomes-for-aac-learners-100622479","NCT07384156","Enhancing Orthographic Communication and Literacy Outcomes for AAC Learners","Enhancing Orthographic Communication and Literacy Outcomes for AAC Learners: Investigating Effective Instructional Strategies","Inclusion Criteria:\n\n* Have complex communication needs and use AAC,\n* are ages 5-12,\n* per report can follow two-step directions,\n* symbolic communicators with at least 75 words on the CDI and mean length of utterance greater than 2\n* can match letters and words with greater than 90% accuracy,\n* can identify letter-sound correspondences from a field of 4 with greater than 70% accuracy\n* can identify common photographs used to represent words in the study (e.g., touch the picture of a hat, touch hot) with greater than 80% accuracy,\n* can sit to work in a minimum of 5 min. intervals\n* decoding or encoding at less than 40% accuracy based on parent or provider report and screening results;\n* demonstrate functional vision and hearing\n\nExclusion Criteria:\n\n* • Do not have complex communication needs \u002F can speak and do not need AAC,\n\n  * Younger than 5 or older than 12 years of age,\n  * Can not follow two-step directions,\n  * Are not symbolic communicators with at least 75 words on the CDI and not combining at least 2 symbols\n  * Can not match letters and words with \\>90% accuracy,\n  * Can not identify letter-sound correspondences from a field of 4 with greater than 70% accuracy\n  * Can not identify common photographs used to represent words in the study (e.g., touch the picture of a hat, touch hot) with greater than 80% accuracy,\n  * Can not attend to work for 5 mins.\n  * decoding or encoding at more than 40% accuracy based on parent or provider report and screening results;\n  * Do not have corrected or functional vision and hearing","5 Years","12 Years",{"count":164,"type":23},[641,642],"PHASE1","PHASE2","The goal of this clinical trial is to determine whether adding Integrated Decoding and Encoding instruction to the ALLSTAR literacy program improves reading outcomes for students with significant literacy and communication needs. The study will also examine how students' reading skills change over time across instructional conditions.\n\nThe main questions it aims to answer are:\n\nDo students who receive ALLSTAR with Integrated Decoding and Encoding instruction demonstrate greater improvements in literacy outcomes than students who receive ALLSTAR as standard care alone? How do students' literacy skills change from baseline to mid-intervention and post-intervention across the two instructional conditions? Researchers will compare two groups using a randomized controlled trial design. One group will receive 60 lessons of ALLSTAR as the standard of care (ALLSTAR-SC), and the other group will receive 60 lessons of ALLSTAR with the addition of Integrated Decoding and Encoding lessons (ALLSTAR-I\\*). Literacy outcomes will be measured using repeated assessment probes at baseline (0 Lessons), after 30-40 lessons, and after 60 lessons to evaluate differences between groups and changes over time in the individuals.",[645,646],"Literacy","Communication, Nonverbal",[648,649,650,651,460,652],"literacy","augmentative and alternative communication","nonverbal","Communication","Intellectual Disabilities","2026-01-26",{"date":605,"type":39},{"date":656,"type":23},"2026-03-01",{"date":658,"type":23},"2031-02-28",{"name":45,"class":46},""]